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The GYF domain protein CD2BP2 is critical for embryogenesis and podocyte function

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分子细胞生物学报:英文版 2015年第5期7卷 402-414页

作者： Gesa I.Albert Christoph Schell Karin M.Kirschner Sebastian Schafer Ronald Naumann Alexandra Muller Oliver Kretz Benno Kuropka Mathias Girbig Norbert Hubner Eberhard Krause Holger Scholz Tobias B.Huber klaus-peter Knobeloch Christian Freund Institute for Chemistry and Biochemistry Freie Universitat Berlin14195 BerlinGermany Leibniz-Institut fuer Molekulare Pharmakologie 13125 BerlinGermany Renal Division University Hospital Freiburg79106 FreiburgGermany Speman Graduate School for Medicine and Biology University of Freiburg79106 FreiburgGermany Faculty of Biology University Freiburg79106 FreiburgGermany Institute fuer Vegetative Physiologie Charité-Universitatsmedizin Berlin10117 BerlinGermany Experimental Genetics and Cardiovascular Diseases MDC13125 BerlinGermany Transgenic Core Facility Max-Planck-Institute of Molecular Cell Biology and GeneticsDresdenGermany Institute of Neuropathology University of Freiburg79106 FreiburgGermany Institute of Cell Biology&Anatomy University of Freiburg79106 FreiburgGermany BIOSS Centre for Biological Signaling Studies Albert-Ludwigs-University79106 FreiburgGermany

Scaffolding proteins play pivotal roles in the assembly of macromolecular machines such as the *** adaptor protein CD2BP2,originally identified as a binding partner of the adhesion molecule CD2,is a pre-spliceosomal assembly factor that utilizes its glycine-tyrosine-phenylalanine(GYF)domain to co-localize with spliceosomal *** far,its function in vertebrates is *** conditional gene targeting in mice,we show that CD2BP2 is crucial for embryogenesis,leading to growth retardation,defects in vascularization,and premature death at embryonic day 10.5 when *** of the protein in bone marrow-derived macrophages indicates that CD2BP2 is involved in the alternative splicing of mRNA transcripts from diverse *** the molecular level,we identified the phosphatase PP1 to be recruited to the spliceosome via the N-terminus of *** the strong expression of CD2BP2 in podocytes of the kidney,we use selective depletion of CD2BP2,in combination with next-generation sequencing,to monitor changes in exon usage of genes critical for podocyte functions,including VEGF and actin ***2BP2-depleted podocytes display foot process effacement,and cause proteinuria and ultimately lethal kidney failure in ***,our study defines CD2BP2 as a non-redundant splicing factor essential for embryonic development and podocyte integrity.

关键词： GYF domain CD2BP2 alternative splicing PP1 podocytes VEGF

MAX-DOAS and OMI Measurements of Tropospheric NO2 and HCHO over Eastern China

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Journal of Geodesy and Geoinformation Science 2020年第4期3卷 1-13页

作者： Ka-Lok CHAN Zhuoru WANG Aijun DING klaus-peter HEUE Nan HAO Mark WENIG Remote Sensing Technology Institute(IMF) German Aerospace Center(DLR)Oberpfaffenhofen 82234Germany School of Atmospheric Sciences Nanjing UniversityNanjing 210000China European Organisation for the Exploitation of Meteorological Satellites(EUMETSAT) Darmstadt 64283Germany Meteorological Institute Ludwig-Maximilians-Universit t MünchenMünchen 80331Germany

In this paper,we present long term observations of atmospheric nitrogen dioxide(NO2)and formaldehyde(HCHO)in Nanjing using a Multi-AXis Differential Optical Absorption Spectroscopy(MAX-DOAS)*** based MAX-DOAS measurements were performed from April 2013 to February *** MAX-DOAS measurements of NO2 and HCHO vertical column densities(VCDs)are used to validate OMI satellite observations over *** comparison shows that the OMI observations of NO2 correlate well with the MAX-DOAS data with Pearson correlation coefficient(R)of *** comparison result of MAX-DOAS and OMI observations of HCHO VCD shows a good agreement with R of 0.75 and the slope of the regression line is *** age weighted backward propagation approach is applied to the MAX-DOAS measurements of NO2 and HCHO to reconstruct the spatial distribution of NO2 and HCHO over the Yangtze River Delta during summer and winter *** reconstructed NO2 fields show a distinct agreement with OMI satellite ***,due to the short atmospheric lifetime of HCHO,the backward propagated HCHO data does not show a strong spatial correlation with the OMI HCHO *** result shows the MAX-DOAS measurements are sensitive to the air pollution transportation in the Yangtze River Delta,indicating the air quality in Nanjing is significantly influenced by regional transportation of air pollutants.

关键词： MAX-DOAS OMI NO2 formaldehyde pollution transport

Patch occupancy by the Chinese Grouse(Tetrastes sewerzowi)in a fragmented landscape

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Chinese Birds 2013年第3期4卷 232-239页

作者： Siegfried klaus Winfried VOIGT 方昀 peter SELSAM 孙悦华德国马普生物地球化学研究所德国耶拿大学生态学研究所中国科学院动物研究所动物生态与保护生物学重点实验室北京100101 德国耶拿大学地理学研究所

The Chinese Grouse (Tetrastes sewerzowi) is a rare, endemic bird in China, inhabiting conifer-dominated mountain forests. Both the natural fragmentation and heavy cutting of mature forests have resulted in patchy grouse habitats. We used SPOT (XS-sensor) satellite imagery to discriminate between open land and conifer or broadleaf forests. The area analyzed is about 120000 ha in size and includes the Lianhuashan Nature Reserve and the Yeliguan Forestry Park. We identiifed 4111 ha of mature coniferous forests in 229 patches (maximum 332 ha, mean 18 ha) as the habitat used by Chinese Grouse throughout the year. We examined 31 forest islands of different sizes and degrees of isolation for the presence of Chinese Grouse. We used generalized linear models (GLM) with binomial error structure and logit link function to estimate the probability of Chinese Grouse occupancy in a forest fragment. Habitat patch size (hs) and distance to the next occupied fragment (doc) were used as predictor variables, important for occupancy. Small habitat islands were disproportionately less likely to be occupied than large, nearby habitats. There was a clear speciifc habitat size of about 40 ha, above which habitat fragments were occupied more often. Suitable habitat fragments isolated by more than 2 km appeared to be inaccessible to Chinese Grouse. The results have been used in reforestation projects to establish linking corridors in the study area.

关键词： Tetrastes sewerzowi habitat fragmentation patch size isolation Lianhuashan reserve China

Promotion of Adhesive Polymer Bonding by Plasma Modification Using Defined Ambient Conditions and Process Gases

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Journal of Energy and Power Engineering 2017年第2期11卷 135-139页

作者： Vitali Fischer Elisabeth Stammen klaus Dilger Marko Eichler Sascha Paulmann Claus-peter Klages Institute of Joining and Welding Technische Universitgit Braunschweig Braunschweig 38106 Germany Fraunhofer Institute for Surface Engineering and Thin Films Braunschweig 38108 Germany

Adhesive bonding technology is often the preferred solution for the joining of polymers. In many cases a wet chemical pretreatment has to he used to achieve sufficient adhesion strength and durability of the adhesive joint. Since several years, plasma treatment has been a proven method to attain these goals. However, conventional treatments in oxidizing gases such as air are often not satisfying. In this work, the PP （polymers polypropylene）, PVDF （polyvinylidene fluoride）, PA6 （polyamide 6）, POM （polyoxymethylene） and PC （polycarbonate） were pretreated by means of a plasma jet running at atmospheric pressure in a virtually oxygen-free atmosphere. The goal was the grafting of reactive nitrogen-containing functional groups on the plastic surfaces in order to increase the adhesive strength.

关键词： Plasma modification functionalization functional groups atmospheric pressure plasma oxygen-free atmosphere.

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细胞培养过程的氧气含量测量

流程工业 2021年第2期 41-43页

作者： klaus-peter Mang Mettler Toledo公司

在没有氧气的情况下,无法进行发酵和细胞培养——氧气对于生命至关重要,只有在氧气的消耗和供给之间达到良好的平衡时,才能确保细胞培养拥有最佳条件。那么操作者在选择传感器时应该考虑什么?为何光学传感器成为氧气测量的趋势呢?

关键词：细胞培养光学传感器氧气含量最佳条件操作者

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利用热成型加工技术加工泡沫材料

现代制造 2014年第10期 36-37页

作者： klaus-peter Welsch

一提到热成型加工，多数人最初联想到的是塑料膜或者塑料板制作的零件或产品，有些人也许会想到生产空心半成品的Twin—Sheet—Verfahren工艺技术。目前，在这方面有了新的进展，在该技术基础上的最新研究成果是利用泡沫薄膜生产出有用... 详细信息

一提到热成型加工，多数人最初联想到的是塑料膜或者塑料板制作的零件或产品，有些人也许会想到生产空心半成品的Twin—Sheet—Verfahren工艺技术。目前，在这方面有了新的进展，在该技术基础上的最新研究成果是利用泡沫薄膜生产出有用的成品件。

关键词：成型加工技术泡沫材料利用薄膜生产 Sheet Twin 研究成果半成品

pH酸碱度检测的革命——新型PH酸碱度检测电极的研发：革命还是创新？

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流程工业 2007年第7期 48-49页

作者： klaus-peter Mang 梅特勒-托利多公司

传统的玻璃电极还有着长期的生存空间，不可能在短期内被淘汰，并且还将会是pH酸碱度检测中的标准检测器具。那么可以对它进行怎样的改进呢？随着单棒检测仪、耐冲击的Gel电极（Gelelektrode）和无膜的高分子聚合物电极的研发成功，似... 详细信息

传统的玻璃电极还有着长期的生存空间，不可能在短期内被淘汰，并且还将会是pH酸碱度检测中的标准检测器具。那么可以对它进行怎样的改进呢？随着单棒检测仪、耐冲击的Gel电极（Gelelektrode）和无膜的高分子聚合物电极的研发成功，似乎是完成了技术创新的最后一步，开始了技术革命的第一步。

关键词：检测电极技术创新酸碱度研发 pH PH 高分子聚合物玻璃电极

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巴丹吉林高大沙山表层孔隙水现象的疑义

水科学进展 2004年第6期15卷 695-699页

作者：顾慰祖陈建生汪集旸赵霞谢民陆家驹 klaus-peter Seiler 南京水利科学研究院江苏南京210029 河海大学同位素水文研究所江苏南京210098 中国科学院地质与地球物理研究所北京100029 Institute of Hydrology GSFMunichenGermany

1997-2003年对巴丹吉林沙漠中不同位置共7个高大沙山和1个流动沙丘表层2m内的孔隙水情况用常规方法作了观测,每年均在相近日期进行。孔隙水量随深度而增大,历年观测期间2m附近的体积含水量约3%,达到相应实测最大持水量的约65%或更高,25c... 详细信息

1997-2003年对巴丹吉林沙漠中不同位置共7个高大沙山和1个流动沙丘表层2m内的孔隙水情况用常规方法作了观测,每年均在相近日期进行。孔隙水量随深度而增大,历年观测期间2m附近的体积含水量约3%,达到相应实测最大持水量的约65%或更高,25cm至1m孔隙水δ18O的正值表明它经过了反复补给-蒸发过程。观测了雨后入渗深度及其在沙丘120m坡面上的分布,另由历年短期能量平衡测验获得沙山陆面蒸发和凝结概念。认为当地年降水量和凝结量不足以对沙山2m表层内的孔隙水现象作出解释,疑另有与大尺度地下水系统相关的补给源。

关键词：巴丹吉林眇漠高大沙山孔隙水蒸发凝结饱和度环境同位素