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Genes & Diseases 2024年第2期11卷 524-527页

作者： Noemi Gonzalez-Abuin Tirso Pons Teresa Fuster Isabel Quintana Mariona Terradas Gemma Aiza joan Brunet Gabriel Capellá Heather Hampel Laura Valle Hereditary Cancer Program Catalan Institute of OncologyOncobell ProgramIDIBELLHospitalet de LlobregatBarcelona 08908Spain Department of Immunology and Oncology National Center for BiotechnologySpanish National Research Council (CNB-CSIC)Madrid 28049Spain Centro de Investigación Biomédica en Red de Cáncer (CIBERONC) Madrid 28029Spain Catalan Institute of Oncology IDIBGiGirona 17007Spain Division of Clinical Cancer Genomics Department of Medical Oncology & Therapeutic ResearchCity of Hope National Cancer CenterDuarteCA 91010USA

Germline activating variants in WWP1,which encodes an E3 ubiquitin ligase that antagonizes PTEN tumor suppressive function,have been proposed as an alternative mechanism of PTEN inactivation in PTEN-hamartoma-tumor syndrome(PHTS)-like patients with wildtype PTEN.1 More specifically,heterozygous,potentially activating wwP1 variants were first identified by Lee et al in patients affected with gastrointestinal oligopolyposis,including adenomatous,hyperplastic/serrated,and hamartomatous polyps,and occasionally with colorectal cancer(Table 1).Subsequently,based on the PHTS phenotypic features,wWP1 mutational screening was performed in patients with thyroid nodules,2 or normocephalic autism spectrum disorder(ASD),3 where germline WWP1 variants were also identified(Table S1).

关键词： WWP1 gastrointestinal polyposis

Effect of the Density of Molten Metal on the Raining Phenomenon in Horizontal Centrifugal Casting

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Open Journal of Applied Sciences 2024年第7期14卷 1918-1926页

作者： Miguel A. Barron joan Reyes Departamento de Materiales Universidad Autonoma Metropolitana Azcapotzalco Ciudad de Mexico Mexico

In this work the influence of the density of the molten metal on the emergence of the raining phenomenon in the horizontal centrifugal casting process is numerically studied. Transient 2D numerical simulations were carried out using Computational Fluid Dynamics software. Three molten metals with different density, namely aluminum, iron and lead, and three angular frequencies, namely 50, 66 and 77 rad/s were considered. It is found that the density of the molten metal significantly affects the emergence, transient or permanent, of the rain phenomenon. However, the magnitude and duration of the rain phenomenon depend on the angular frequency of the rotating mold. Likewise, since gravitational forces affect the metal according to its density, the value of the critical rotation speed of the mold is also affected.

关键词： Angular Frequency Centrifugal Force Computational Fluid Dynamics Critical Rotation Speed G Factor Horizontal Centrifugal Casting Molten Metal Density

The Influence of Social Media on College Choice among Undergraduates Majoring in Big Data Management and Application in China:Taking Guilin University of Electronic Technology as an Example

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Journal of Contemporary Educational Research 2024年第10期8卷 128-138页

作者： Junchao Dong joan P.Lazaro Graduate School University of the EastManilaPhilippines

This study aims to investigate the influence of social media on college choice among undergraduates majoring in Big Data Management and Application in *** study attempts to reveal how information on social media platforms such as Weibo,WeChat,and Zhihu influences the cognition and choice process of prospective *** employing an online quantitative survey questionnaire,data were collected from the 2022 and 2023 classes of new students majoring in Big Data Management and Application at Guilin University of Electronic *** aim was to evaluate the role of social media in their college choice process and understand the features and information that most attract prospective *** media has become a key factor influencing the college choice decision-making of undergraduates majoring in Big Data Management and Application in *** tend to obtain school information through social media platforms and use this information as an important reference in their decision-making *** education institutions should strengthen their social media information dissemination,providing accurate,timely,and attractive *** is also necessary to ensure effective management of social media platforms,maintain a positive reputation for the school on social media,and increase the interest and trust of prospective ***,educational decision-makers should consider incorporating social media analysis into their recruitment strategies to better attract new student *** study provides a new perspective for understanding higher education choice behavior in the digital age,particularly by revealing the importance of social media in the educational decision-making *** has important practical and theoretical implications for higher education institutions,policymakers,and social media platform operators.

关键词： Social media Big Data Management and Application Undergraduate college choice Student decision-making behavior Chinese higher education

Temperature Drop of Molten Metals in Open Channels

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World Journal of Engineering and Technology 2024年第3期12卷 493-500页

作者： Miguel A. Barron-Meza joan Reyes-Miranda Departamento de Materiales Universidad Autonoma Metropolitana Azcapotzalco Ciudad de Mexico Mexico

The temperature drop of molten metal flowing in open channels is numerically determined. Rectangular, trapezoidal and triangular geometries are considered. The overall heat transfer coefficients for the bottom, side walls and free surface of the channel have been taken from the literature. For each geometry, the volumetric flow rate, mean residence time and temperature drop as a function of the channel inclination angle were determined. The rectangular and trapezoidal geometries present the smallest temperature drops, while the triangular geometry presents the greatest temperature drop. The factors that most affect this drop are the value of the free surface area of the channel, and the average residence time of the molten metal in the channel.

关键词： Free Surface Heat Transfer Molten Metal Open Channel Geometry Residence Time Temperature Drop

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Open Journal of Civil Engineering 2024年第2期14卷 214-224页

作者： joan Anyika Otike Charles Kabubo Victoria Okumu Kenya National Highways Authority Nairobi Kenya Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya

The performance of bridge projects in Kenya is poor in terms of completion by schedule, cost, and quality (scope). Yet, there is less evidence of empirical research on what factors contribute to this outcome. This study aimed to bridge this gap by examining the effects of contractor-related factors on the performance of bridge construction projects in Kenya through a case study of the Bridge projects Implemented by the Kenya National Highway Agency (KeNHA). The theory of constraints (TOC) was adopted as its theoretical framework. Descriptive research was used, and the target population was 18 bridge construction projects, which were the units of analysis from 2012 to 2022. In each of these projects, 18 respondents, namely clients, consultants, contractors, engineers, environment and social guards, project managers, stakeholders, subcontractors, technical advisors, and inspectors, were included in a target population of 144 respondents. A census was conducted and a structured questionnaire was administered from which a response rate of 68% was achieved. The information was analyzed using descriptive, correlation, and multiple linear regression analysis. The contractor-related factors considered in the study were staff and management factors. The findings indicated that staff and management factors had a positive and significant outcome on performance of bridge construction projects. The study recommends continuous training and a safe learning environment for staff to improve their skills and performance in future projects. The study also recommends that a special category for bridge contractors be created in Kenya’s National Construction Authority rankings to ensure that only qualified contractors implement the Bridge projects.

关键词： Staff Factors Management Factors Performance Bridge Projects KeNHA

Low-power SiPM readout BETA ASIC for space applications

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Nuclear Science and Techniques 2024年第3期35卷 153-169页

作者： Anand Sanmukh Sergio Gómez Albert Comerma joan Mauricio Rafel Manera Andreu Sanuy Daniel Guberman Roger Catala Albert Espinya Marina Orta Oscar de la Torre David Gascon Departament de Física Quàntica i Astrofísica(FQA) Institut de Ciències del Cosmos(ICCUB)Universitat de Barcelona(UB)08028 BarcelonaSpain Institut d’Estudis Espacials de Catalunya(IEEC) 08034 BarcelonaSpain Electronics Department Serra Hunter fellow at Polytechnic University of Catalonia(UPC)08019 BarcelonaSpain

The BETA application-specific integrated circuit(ASIC)is a fully programmable chip designed to amplify,shape and digitize the signal of up to 64 Silicon photomultiplier(SiPM)channels,with a power consumption of approximately~1 mW/*** to its dual-path gain,the BETA chip is capable of resolving single photoelectrons(phes)with a signal-to-noise ratio(SNR)>5 while simultaneously achieving a dynamic range of~4000 ***,BETA can provide a cost-effective solution for the readout of SiPMs in space missions and other applications with a maximum rate below 10 *** this study,we describe the key characteristics of the BETA ASIC and present an evaluation of the performance of its 16-channel version,which is implemented using 130 nm *** ASIC also contains two discriminators that can provide trigger signals with a time jitter down to 400 ps FWHM for 10 *** linearity error of the charge gain measurement was less than 2%for a dynamic range as large as 15 bits.

关键词： Radiation detectors Silicon photomultipliers Photon sensors Front-end electronics Mixed-mode ASICs Space technology

Severe respiratory syncytial virus disease

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Journal of Intensive Medicine 2024年第4期4卷 405-416页

作者： Yolanda Pena-López joan Sabater-Riera Prithvi Raj Microbiome Research Laboratory(MRL) Department of ImmunologyUniversity of Texas Southwestern Medical CenterDallasTXUSA Pediatric Critical Care Department Hospital Universitari Vall d’HebronBarcelonaSpain Global Health eCore Vall d’Hebron Institute of ResearchBarcelonaSpain Intensive Care Department Servei de Medicina IntensivaIDIBELL-Hospital Universitari de BellvitgeL´Hospitalet de LlobregatBarcelonaSpain Bellvitge Biomedical Research Institute(IDIBELL) L’Hospitalet de LlobregatBarcelonaSpain

The burden of respiratory syncytial virus(RSV)disease is widely *** risk factors for severe disease,such as extreme ages,chronic cardiopulmonary conditions,and immunosuppression,typically coincide withpoorer *** the majority of RSV hospitalizations involve healthy children,a higher proportion ofhospitalized adults with underlying conditions need intensive ***,treatment primarily consists ofsupportive ***-induced wheezing should be distinguished from respiratory tract thickening,withoutresponse to *** RSV disease frequently overlaps with viral ***-invasivemechanical ventilation and high-flow oxygen therapy represented significant advancements in the managementof severe RSV disease in children and may also hold considerable importance in specific phenotypes of RSV diseasein *** severe infections manifest with refractory hypoxemia necessitating more advanced ventilatorysupport and/or extracorporeal membrane oxygenation *** bacterial co-infection rates are low,they have been associated with worse *** prescription rates are *** diagnosingbacterial co-infections remains a *** evidence and antibiotic stewardship policies advise againstindiscriminate antibiotic usage,even in severe *** role of currently developing antiviral therapies in severeRSV disease will be elucidated in the coming years,contingent upon the success of new vaccines and immunepassive strategies involving nirsevimab.

关键词： RSV Bronchiolitis Co-infection Pneumonia ARDS Respiratory failure

Olfactory receptors in neural regeneration in the central nervous system

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Neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： Rafael Franco Claudia Garrigós Toni Capó joan Serrano-Marín Rafael Rivas-Santisteban Jaume Lillo Molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain CiberNed Network Center for Biomedical Research in Neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain School of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagnostics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechanisms underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

Non-Darcy Flow in Molding Sands

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Open Journal of Applied Sciences 2024年第4期14卷 976-982页

作者： Miguel A. Barron-Meza joan Reyes-Miranda Daniel Flores-Sanchez Departamento de Materiales Universidad Autonoma Metropolitana Azcapotzalco Ciudad de Mexico Mexico

Darcy’s law is widely used to describe the flow in porous media in which there is a linear relationship between fluid velocity and pressure gradient. However, it has been found that for high numbers of Reynolds this law ceases to be valid. In this work, the Ergun equation is employed to consider the non-linearity of air velocity with the pressure gradient in casting sands. The contribution of non-linearity to the total flow in terms of a variable defined as a non-Darcy flow fraction is numerically quantified. In addition, the influence of the shape factor of the sand grains on the non-linear flow fraction is analyzed. It is found that for values of the Reynolds number less or equal than 1, the contribution of non-linearity for spherical particles is around 1.15%.

关键词： Darcy’s Law Molding Sands Non-Darcy Flow Reynolds Number Shape Factor

苏州精神与工业记忆的结合——苏州新达产业园改造

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当代建筑 2024年第5期 92-99页

作者：张海翱 joan Pik Kuan Chin 上海交通大学设计学院奥默默工作室

1场地位置。项目北邻阳澄湖大道,东靠亭新街,西达龙会街,南邻唯和路,位于交通便利地带。人们可以通过北京-上海高速公路、城铁园区站及多条公交线路(包括169路、161路、228路、127路、129路等)便捷到达项目所在地。原主出入口位于亭新... 详细信息

1场地位置。项目北邻阳澄湖大道,东靠亭新街,西达龙会街,南邻唯和路,位于交通便利地带。人们可以通过北京-上海高速公路、城铁园区站及多条公交线路(包括169路、161路、228路、127路、129路等)便捷到达项目所在地。原主出入口位于亭新街道。

关键词： “工改工”微更新建筑改造工业上楼苏州精神