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International Journal of Oral Science 2010年第1期2卷 15-20页

作者： Jacob M.ten cate Department of Cariology EndodontologyPedodontologyAcademic Centre for Dentistry Amsterdam (ACTA)

Aim The effect of Galla chinensis on de-/re-mineralization of advanced enamel lesions was investigated by using micro-CT in a prolonged in vitro experiment. Methodology Baseline mineral contents of sound enamels were first analyzed. Then lesions were produced in an acidic buffer solution （2.2 mmol.L-1 Ca（NO3）2, 2.2 mmol-L1 KH2PO4, and pH=4.5） for 21 days, with thrice daily three-minute treatments, divided into four groups： Group A, 4 000 ppm crude aqueous extract of Galla chinensis （GCE）; Group B, 4 000 ppm gallic acid; Group C, 1 000 ppm F aq. （as NaF, positive control）; Group D, deionized water （negative control）. Next, the blocks were immersed in a remineralization solution （1.5 *** CaC12, 0.9 mmol.L1 KH2PO4, 0.1 ppm F, and pH=7,0） for 200 days. Mineral loss （ML） in each region of interest （ROI） and integrated mineral loss （IML） of the lesions were calculated （comparing with baseline mineral content of sound enamel） at different time points. Results After 21 days demineralization, fluoride treatment showed a statistically significant demineralization-inhibiting effect among the four groups, and after 200 days of remineralization, mineral content recovery was ordered （lowest to highest） as A=C〈B〈D. Conclusion GCE could slow down the remineralization of enamel in the surface layer and thereby facilitate ion transport into the lesion body. The mechanism of Galla chinensis in enhancing the remineralization of dental caries is different from fluoride.

关键词： demineralization remineralization advanced enamel lesion Galla chinensis

Simultaneous One-Step Approximations of Real and Reactive Power Flow

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Journal of Power and Energy Engineering 2014年第10期2卷 28-33页

作者： Arie ten cate Retired Berkel en Rodenrijs The Netherlands

This paper presents two new non-iterative approximations of the power flow in a network. Real and reactive power are simultaneously modelled in complex equations. Also, resistances are not set to zero. This is a generalization of the DC approximation, where only real power is modelled with zero line resistance. Hence the proposed approximations are more accurate than the DC approximation. The voltage lag over a link in a short, low voltage, network link is ten times as accurate as with the DC approximation. In the Appendix a new mathematical constant is introduced.

关键词： Power Flow Modeling Non-Iterative Modeling Taylor Expansion Taylor Approximation

Chemical composition of Galla chinensis extract and the effect of its main component(s) on the prevention of enamel demineralization in vitro

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International Journal of Oral Science 2012年第3期4卷 146-151页

作者： Xue-Lian Huang Ming-Dong Liu Ji-Yao Li Xue-Dong Zhou Jacob M ten cate State Key Laboratory of Oral Diseases Sichuan UniversityChengduChina West China Hospital of Stomatology Sichuan UniversityChengduChina Department of Cariology Endodontology Pedodontology Academic Centre for Dentistry Amsterdam(ACTA)University of Amsterdam and Free University AmsterdamAmsterdamThe Netherlands Department of Analytical Toxicology West China School of Preclinical and Forensic MedicineSichuan UniversityChengduChina

To determine the chemical composition of Galla chinensisextract （GCE） by several analysis techniques and to compare the efficacy of GCE and its main component（s） in inhibition of enamel demineralization, for the development of future anticaries agents, main organic composition of GCE was qualitatively determined by liquid chromatography-time of flight-mass spectrometry （LC-TOF-MS） and quantified by high-performance liquid chromatography-diode array detector （HPLC-DAD）. Inorganic ions were tested by inductively coupled plasma-atomic emission spectroscopy and F was especially measured by ion chromatography. Then, bovine enamel blocks were randomly divided into four treatment groups and were subjected to a pH-cycling regime for 12 times. Each cycle included 5-min applications with one of four treatments： 4g.L-1 GCE solution, 4g.L-1 gallic acid （GA） solution, I g.L-1 NaF solution （positive control）, deionized water （DDW, negative control）, and then 60-min application in pH 5.0 acidic buffer and 5-min application in neutral buffer. Acidic buffers were retained for calcium analysis. The main organic composition of GCE were GA and its isomer, and, to a lesser extent, small molecule gallotannins. The content of GA in GCE was 71.3%±0.2% （w/w）. Inorganic ions were present in various amounts, of which Ca was （136±2.82） μg.g-1, and Zn was （6.8±0.1） μg.g-1. No F was detected in GCE. in pH cycling, GA showed an effect similar to GCE in inhibiting enamel demineralization （P〉0.05）. GA was found to be the main effective, demineralization inhibiting component of GCE and could be a promising agent for the development of anticaries agents.

关键词： active component Galla chinensis gallic acid composition dental caries

Complement activation and long-term graft function in ABO-incompatible kidney transplantation

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World Journal of Nephrology 2019年第6期8卷 95-108页

作者： Marit S van Sandwijk Astrid Klooster Ineke jm ten Berge Arjan Diepstra Sandrine Florquin Joris J Hoelbeek Frederike J Bemelman Jan-Stephan Sanders Department of Nephrology Amsterdam University Medical CentersAmsterdam NL-1105 AZNetherlands Dianet Dialysis Center Amsterdam NL-1105 AZNetherlands Department of Pathology and Medical Biology University Medical Center GroningenUniversity of GroningenGroningen NL-9700 RBNetherlands Department of Pathology Pathology FrieslandLeeuwarden NL-8917 ENNetherlands Department of Pathology Amsterdam University Medical CentersAmsterdam NL-1105 AZNetherlands Department of Internal Medicine Division of NephrologyUniversity Medical Center GroningenUniversity of GroningenGroningen NL-9700 RBNetherlands

BACKGROUND ABO-incompatible and ABO-compatible kidney transplantation are equivalent in terms of short-term graft and patient survival. This is thought to be the result of ABO-incompatible graft accommodation, which occurs when anti-blood group antibodies re-occur after transplantation but somehow do not yield their detrimental effect. The underlying mechanism is unclear, but one of the hypotheses is that this is the result of complement inhibition. Since virtually all ABO-incompatible graft biopsies are C4d positive, this complement inhibition must occur somewhere in the complement cascade after the formation of C4d has already taken place, but where exactly is unclear. It is also unclear whether complement inhibition is complete. Incomplete accommodation could explain why recent studies have shown that long-term graft function in ABOincompatible transplantation is somewhat inferior to ABO-compatible kidney *** To unravel the relationship between pre-transplant anti-ABO antibodies,complement activation, and long-term graft *** We included all 27 ABO-incompatible transplantations that were performed between 2008 and 2013 at the Academic Medical Center Amsterdam and the University Medical Center Groningen. For each ABO-incompatible transplantation, we included four ABO-compatible controls matched by age, sex,and transplantation *** Graft and patient survival were not significantly different. The slope of kidney function during five-year follow-up was also not significantly different, but ABOincompatible recipients did have a lower kidney function at three months(creatinine clearance 58 vs 69 mL/min, P = 0.02, Modification of Diet in Renal Disease 46 vs 52 mL/min/1.73 m^2, P = 0.08), due to a high rate of early rejection(33% vs 15%, P = 0.03), mostly T-cell mediated. Pre-transplant anti-ABO Ig G titers were positively correlated with C5b-9 staining, which itself was positively correlated with the occurrence of T-cell mediated reje

关键词： ABO-incompatible Kidney transplantation Complement Graft function Rejection

Comparative Analysis in Vitro of the Application of blue m Oral Gel versus Chlorhexidine on Porphyromonas gingivalis:A Pilot Study

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Advances in Microbiology 2020年第4期10卷 194-201页

作者： Tatiana Miranda Deliberador Suyany Gabriely Weiss Felipe Rychuv Gabriele Cordeiro Michele Caroline Lima ten cate Lucas Leonardi Joao Armando Brancher Rafaela Scariot Department of Dentistry School of Health SciencesUniversidade PositivoCuritibaBrazil

Oxygen is an essential nutrient for cellular metabolism, especially energy production. The substance is involved in multiple processes including oxidative killing of bacteria, reepithelialization, angiogenesis, and collagen synthesis. In order to test and compare the effects of the oxygen gel blue?m in vitro on Porphyromonas gingivalis, four groups were evaluated: 100% oxygen gel (B1), 75% oxygen gel (B2), 50% oxygen gel (B3), and 100% 0.12% chlorhexidine digluconate solution (C1). For this purpose, evaluations of the proportion of bacterial growth were performed, using the Agar diffusion test. The results demonstrated that blue?m at a dose of 100% and 75% is similar to chlorhexidine (p > 0.05);however blue?m at a concentration of 50% showed a lower inhibition halo when compared to chlorhexidine (p = 0.024). blue?m at higher concentrations provided inhibitory halo of Porphyromonas gingivalis similar to chlorhexidine digluconate, while blue?m at lower concentration had a lower bacterial inhibition halo compared to chlorhexidine.

关键词： Porphyromonas gingivalis Periodontics Chlorhexidine Oxygen

生物膜对氟化钠和纳米羟磷灰石再矿化效果影响的体外研究

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生物膜对氟化钠和纳米羟磷灰石再矿化效果影响的体外研究

Stark characteristics of cesium atom studied in a thermionic bulb

2014年第九次全国牙体牙髓病学学术会议

作者：张敏何利邦 Exterkate RAM 程磊李继遥 ten cate jm Crielaard W 邓动梅四川大学华西口腔医院口腔疾病研究国家重点实验室阿姆斯特丹大学阿姆斯特丹自由大学阿姆斯特丹牙学院预防牙科系中山大学光华口腔医学院·附属口腔医院广东省口腔医学重点实验室

目的:研究生物膜对氟化钠和纳米羟基磷灰石对牙釉质人工龋再矿化效果的影响。方法:在预先造龋并连接在高通量处理模型上的牛牙釉质表面接种变异链球菌C180-2,培养两天形成生物膜。相同数量的样本在同样的培养基中培养两天,但是不接种细...

目的:研究生物膜对氟化钠和纳米羟基磷灰石对牙釉质人工龋再矿化效果的影响。方法:在预先造龋并连接在高通量处理模型上的牛牙釉质表面接种变异链球菌C180-2,培养两天形成生物膜。相同数量的样本在同样的培养基中培养两天,但是不接种细菌。两天后,将所有样本放入pH循环培养基中培养,培养基pH分别为4.5(2小时/天)和7.0(22小时/天)。每天对样本进行不同的处理:去离子水,10%纳米羟基磷灰石混悬液或350ppm氟化钠,处理方法为浸泡5分钟,每天两次,持续18天。处理结束后,收集样本表面的生物膜,并对其产乳酸能力、活细菌数以及钙含量进行检测。牙釉质样本中的矿物含量通过显微放射照相技术进行测量。结果:不同处理组中生物膜产乳酸能力(约21mM)和活细菌数(约10CFU/样本)均没有明显差异。纳米羟基磷灰石处理后的生物膜中钙含量为60.7±15.3μmol/g湿重,高于其他两组约8倍。经氟化钠处理的牙釉质,在没有生物膜存在的组内表现为净再矿化,而在有生物膜存在时表现为净脱矿。纳米羟基磷灰石处理组在没有生物膜存在时表现为净脱矿。相对于去离子水处理组该组脱矿被明显抑制,而当存在生物膜时这一抑制脱矿作用明显增强。结论:生物膜的存在会影响防龋产品的使用效果,对于不同产品影响不同。这提示我们在筛选以及评价防龋产品时应该将生物膜的影响考虑在内。

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Chinese Science Bulletin 1997年第22期42卷 1877-1880页

作者： Gu, SH Liu, BM Wang, jm Dai, ZY Gong, SS Chinese Acad Sci Wuhan Inst Phys & Math Lab Magnet Resonance & Atom & Mol Phys Wuhan 430071 Peoples R China

MOST of the spectral studies of atomic strong electric effect are carried out by means of atomicbeam and pulse laser. The spectral linewidth is ranged from the order of one to ten GHz. Inrecent years, with the applica... 详细信息

关键词： cesium atom electric fleld Rydberg state spectrum.

肥厚梗阻性心肌病经酒精室间隔消融后左室重构的早期发生和进展

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世界核心医学期刊文摘（心脏病学分册） 2005年第10期1卷 36-37页

作者： Van Dockum W. G. Beek A. M. ten cate F. J. 姜朝晖 Department of Cardiology VU University Medical Center De Boelelaan 1117 1081 HV Amsterdam Netherlands

Alcohol septal ablation(ASA) reduces left ventricular outflow tract(LVOT) pressure gradient in patients with hypertrophic obstructive cardiomyopathy(HOCM),which leads to left ventricular remodeling. We sought to describe the early to midterm changes and modulating factors of the remodeling process using cardiac MRI(CMR). Methods and Results-CMR was performed at baseline and 1 and 6 months after ASA in 29 patients with HOCM(age 52± 16 years). Contrast enhanced CMR showed no infarct-related hyperenhancement outside the target septal area. Septal mass decreased from 75± 23 g at baseline to 68± 22 and 58± 19 g(P< 0.001) at 1-and 6-month follow-up, respectively. Remote, nonseptal mass decreased from 141± 41 to 132± 40 and 111± 27 g(P< 0.001), respectively. Analysis of temporal trends revealed that septal mass reduction was positively associated with contrast-enhanced infarct size and transmural or left-sided septal infarct location at both 1 and 6 months. Remote mass reduction was associated with infarct location at 6 months but not with contrast-enhanced infarct size. By linear regression analysis, percentage remote mass reduction correlated significantly with LVOT gradient reduction at 6-month follow-up(P=0.03). Conclusions-Left ventricular remodeling after ASA occurs early and progresses on midterm follow-up, modulated by CMR infarct size and location. Remote mass reduction is associated with infarct location and correlates with reduction of the LVOT pressure gradient. Thus, myocardial hypertrophy in HOCM is, at least in part, afterload dependent and reversible and is not exclusively caused by the genetic disorder.

关键词：左室重构室间隔压力阶差梗死范围左室流出道调控因素后负荷靶室间隔区线性回归

Variation in chromosome number in the seedling progeny of a somaclone of Paspalum dilatatum

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Cell Research 1994年第1期4卷 65-78页

作者： ZHU jm LJ DAVIES D COHEN RE ROWLAND(Horticulture & Food Research Institute of New Zealand, Private Bag 11030, Palmerston North, New Zealand.)(Department of Botany, Massey University, Palmerston North, New Zealand.) Horticulture & Food Research Institute of New Zealand Palmerston North New Zealand Department of Botany Massey University Palmerston North New Zealand

The somaclone, C39, derived by tissue culture from the obligate apomict Paspalum dilatatum cv Raki (2n=50), had 50 chromosomes and a karyotype apparently identical to ***2 seedlings of C39 showed a high degree of phenotypic variation which was of ten associated with increased chromosome numbers, but some of the variant seedlings were karyotypically indistinguishable from Raki or C39. Plants with increased chromosome numbers exhibited a high degree of intraplant chromosome variation (aneusomaty). In one of the SC2seedlings, the chromosome number of root tip cells varied from 58 to 82 and in several other seedlings the range was more than 10. The results suggested that the ability to form seed apomictically was much reduced in C39 and that this plant showed some capacity for sexual reproduction and the resulting seedlings, with a chromosome number of about 70, were genetically unstable. Of 11 SC2 seedlings examined cytolog ically, 6 did not produce any viable seed. Seedlings grown from seed of the remaining 5 plants showed that aneusomaty persisted in the SC3 generation. SC3 seedlings which were phenotypically similar to their maternal parent showed a similar range of chromosome numbers to that parent. Some of the SC3 seedlings exhibited an even wider range of chromosome numbers (e.g.56-136), and these plants were all dwarfs.

关键词： Paspalum somaclone chromosome number apomixis sexual reproduction