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C2-phenyl-substituted benzimidazolium-based covalent organic framework as efficient catalyst for CO_(2) conversion without solvents,metals,and cocatalysts

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Science China Chemistry 2024年第2期67卷 551-557页

作者： zhenzhen Wu jing Wang Lili Liu Shang Guo Juan Li Xianming Zhang Shanxi Institute for Functional Food Shanxi Agricultural UniversityTaiyuan030031China Institute of Crystalline Materials Shanxi UniversityTaiyuan030006China Key Laboratory of Interface Science and Engineering in Advanced Materials College of ChemistryTaiyuan University of TechnologyTaiyuan030024China

Covalent organic frameworks(COFs) are a potential platform for carbon dioxide(CO_(2)) conversion owing to their periodic permanent porosity,adjustable structure,and chemical *** good catalytic performance in CO_(2) conversion,collaborative multifunctions should be strategically integrated into the catalytic system design and *** this study,a four-in-one high-efficiency catalyst was synthesized and tested for CO_(2) cycloaddition to form cyclic *** obtained Tp-MPB-BrCOF had a high nitrogen content,which enhanced its CO_(2) affinity through substantial Lewis acid-base or dipole-quadrupole interactions;moreover,the acid(protons transferring from oxygen(–OH) to nitrogen(–NH)),hydrogen bond donor(hydroxyl group),and Br-(nucleophile group) served as three active sites,further improving the catalyst *** results provide a basis for designing efficient and stable CO_(2)-conversion catalysts.

关键词： covalent organic framework C2-phenyl-substituted benzimidazolium CO_(2)conversion four-in-one catalyst

CD146,a therapeutic target involved in cell plasticity

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Science China(Life Sciences) 2024年第8期67卷 1563-1578页

作者： zhenzhen Wu Yuzhe Zang Chuyi Li Zhiheng He jingyu Liu Zhaoqi Du Xinran Ma Lin jing Hongxia Duan jing Feng Xiyun Yan CAS Engineering Laboratory for Nanozyme Key Laboratory of BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Nanozyme Laboratory in Zhongyuan Henan Academy of Innovations in Medical ScienceZhengzhou 451163China Joint Laboratory of Nanozymes in Zhengzhou University School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001China

Since its identification as a marker for advanced melanoma in the 1980s,CD146 has been found to have multiple functions in both physiological and pathological processes,including embryonic development,tissue repair and regeneration,tumor progression,fibrosis disease,and *** research has revealed that CD146 is involved in various signaling pathways as a receptor or coreceptor in these *** correlation between CD146 and multiple diseases has sparked interest in its potential applications in diagnosis,prognosis,and targeted *** better comprehend the versatile roles of CD146,we have summarized its research history and synthesized findings from numerous reports,proposing that cell plasticity serves as the underlying mechanism through which CD146 contributes to development,regeneration,and various *** CD146 would consequently halt cell state shifting during the onset and progression of these related ***,the development of therapy targeting CD146 holds significant practical value.

关键词： CD146 cell plasticity therapeutic target

Mild synthesis of ultra-bright carbon dots with solvatochromism for rapid lipid droplet monitoring in varied physiological processes

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Regenerative Biomaterials 2024年第3期3卷 30-42页

作者： Borui Su Dong Gao Nini Xin Kai Wu Mei Yang Shichao Jiang Yusheng Zhang Jie Ding Chengheng Wu jing Sun Dan Wei Hongsong Fan zhenzhen Guo National Engineering Research Center for Biomaterials College of Biomedical EngineeringSichuan UniversityChengduSichuan 610064China Institute of Regulatory Science for Medical Devices Sichuan UniversityChengduSichuan 610064China Department of Gastroenterology Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610o72China

Lipid droplets(LDs)participating in various cellular activities and are increasingly being *** imaging provides powerful tool for dynamic tracking of LDs,however,most current LDs probes remain inconsistent performance such as low Photoluminescence Quantum Yield(PLQY),poor photostability and tedious washing ***,a novel yellow-emissive carbon dot(OT-cD)has been synthesized conveniently with high PLQY up to 90%.Besides,OT-CD exhibits remarkable amphiphilicity and solvatochromic property with lipid-water partition coefficient higher than 2,which is much higher than most LDs *** characters enable OT-CD high brightness,stable and wash-free LDs probing,and feasible for in vivo ***,detailed observation of LDs morphological and polarity variation dynamically in different cellular states were recorded,including ferroptosis and other diseases ***,fast whole imaging of zebrafish and identifed LD enrichment in injured liver indicate its further feasibility for in vivo *** contrast to the reported studies to date,this approach provides a versatile conventional synthesis system for high-performance LDs targeting probes,combing the advantages of easy and high-yield production,as well as robust brightness and stability for long-term imaging,facilitating investigations into organelle interactions and LD-associated diseases.

关键词： lipid droplet probe carbon dots fluorescence imaging wash-free dynamic monitoring

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软物态方程支持大质量中子星机制概述

原子核物理评论 2014年第3期31卷 359-365页

作者：文德华荆珍珍华南理工大学物理系广州510641

重离子碰撞实验分析及相关理论研究认为高密度非对称核物质可能具有较软的物态方程;在约2～3倍饱和核密度下超子等奇异物质的出现也可能会使物态方程变软。然而,软物态方程却无法支持大质量中子星。脉冲星PSR J1614-2230具有大质量(1.97... 详细信息

重离子碰撞实验分析及相关理论研究认为高密度非对称核物质可能具有较软的物态方程;在约2～3倍饱和核密度下超子等奇异物质的出现也可能会使物态方程变软。然而,软物态方程却无法支持大质量中子星。脉冲星PSR J1614-2230具有大质量(1.97±0.04)M⊙的观测发现使这一矛盾变得尤为突出。为了解决该矛盾,人们提出了各种可能的物理机制:包括考虑修正的引力理论、修改描述高密度物质物态的理论模型等。在概述和讨论这些能使软物态方程支持大质量中子星的可能物理机制的基础上,还计算和讨论了强电场、强磁场对中子星最大质量的影响,发现强电磁场可以有效地增大中子星的最大质量。

关键词：中子星物态方程非牛顿引力

核物质对称能斜率对快转中子星性质的约束(英文)

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原子核物理评论 2015年第2期32卷 161-169页

作者：文德华荆珍珍华南理工大学物理系广州510641 华南理工大学数学系广州510641

在过去的十余年中,对非对称核物质的对称能的研究无论从实验还是理论上都取得了较大的突破,这对中子结构及其物态方程的理解具有十分重要的意义。本研究将采用一个相对保守的对称能斜率范围(25 Me V1.5M⊙)。

关键词：对称能中子星自转

The application and perspective of NMR and MS based strategies for functional compounds mining in medicinal and dietary plants

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Food Science and Human Wellness 2024年

作者： Bodou Zhang Sheng Li zhenzhen Liang Yinling Wei jing Dong Hongyan Wen Lingli Guo Xiaojiang Hao Yu Zhang University of Chinese Academy of Sciences State Key Laboratory of Phytochemistry and Plant Resources in West China， Kunming Institute of Botany， Chinese Academy of Sciences

Medicinal and dietary plants provide numerous nutritional and functional compounds and also have various potential health benefits to humanity. The specific and efficient techniques for accurate identification of nutritional compounds and functional metabolites is crucial for the development of functional foods from medicinal and dietary plants. Nuclear magnetic resonance (NMR) and mass spectrometry (MS) are indispensable and essential technologies that provide an unsurpassed wealth of untargeted identification， quantitative and qualitative analysis， and structural information in the study of food and plant products. In the past decade， the rapid development of modern analytical technology has led to the emergence of new approaches and strategies for natural products discovery. Especially the application of novel NMR- and MS-based identification and dereplication strategies aided by artificial intelligence and machine learning algorithms have brought about a significant shift in the natural products discovery process. These developments and changes in the natural products filed have given us insights into how to accurately target and mining nutritional， functional， and bioactive compounds. Thus， we have summarized recent research on novel NMR and MS based strategies and methods focusing on functional compounds， accurate identification and efficient discovery mainly in medicinal and dietary plants. This review could provide a comprehensive perspective for a better understanding of novel strategies and methods based on NMR and MS technologies， which could provide valuable insights and ideas for functional compounds mining.

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Elevated Kallistatin promotes the occurrence and progression of non-alcoholic fatty liver disease

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1730-1744页

作者： zhenzhen Fang Gang Shen Yina Wang Fuyan Hong Xiumei Tang Yongcheng Zeng Ting Zhang Huanyi Liu Yanmei Li Jinhong Wang jing Zhang Anton Gao Weiwei Qi Xia Yang Ti Zhou Guoquan Gao Department of Biochemistry Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China Department of VIP Medical Center the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Physical Examination Center the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Department of Clinical Laboratory Guangzhou First People's HospitalGuangzhou 510080China Guangdong Key Laboratory of Liver Disease Research the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 51008China Department of Health Sciences College of Health SolutionsArizona State UniversityTempeUSA Guangdong Engineering&Technology Research Center for Gene Manipulation and Biomacromolecular Products Sun Yat-Sen UniversityGuangzhou 510080China Guangdong Province Key Laboratory of Diabetology Guangzhou 510o80China Guangdong Province Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China

Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide,and the development of nonalcoholic steatohepatitis(NASH)might cause irreversible hepatic ***(HLP)is the leading risk factor for *** study aims to illuminate the causative contributor and potential mechanism of Kallistatin(KAL)mediating HLP to NAFLD.221 healthy control and 253 HLP subjects,62 healthy control and 44 NAFLD subjects were *** plasma KAL was significantly elevated in HLP subjects,especially in hypertriglyceridemia(HTG)subjects,and positively correlated with liver ***,KAL levels of NAFLD patients were significantly *** transgenic mice induced hepatic steatosis,inflammation,and fibrosis with time and accelerated inflammation development in high-fat diet(HFD)*** contrast,KAL knockout ameliorated steatosis and inflammation in high-fructose diet(HFruD)and methionine and choline-deficient(MCD)diet-induced NAFLD ***,KAL induced hepatic steatosis and NASH by down-regulating adipose triglyceride lipase(ATGL)and comparative gene identification 58(CGl-58)by LRP6/Gas/PKA/GSK3βpathway through down-regulating peroxisome proliferator-activated receptor(PPARy)and up-regulating kruppel-like factor four(KLF4),***-58 is bound to NF-kB p65 in the cytoplasm,and diminishing CGl-58 facilitated p65 nuclear translocation and TNFa ***,hepatic CGl-58-overexpress reverses NASH in KAL transgenic ***,free fatty acids up-regulated KAL against thyroid hormone in ***,Fenofibrate,one triglyceride-lowering drug,could reverse hepatic steatosis by down-regulating *** results demonstrate that elevated KAL plays a crucial role in the development of HLP to NAFLD and may be served as a potential preventive and therapeutic target.

关键词： GSK3β inflammation elevated

Effect of GnRH analogs in advanced male breast cancer:10-year experience from the Henan Breast Cancer Center and literature review

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Chinese Medical Journal 2024年第13期137卷 1623-1625页

作者： Mengwei Zhang Huimin Lyu Limin Niu zhenzhen Liu Huiai Zeng Shengnan Zhao jing Wang Huihui Sun Min Yan Department of Breast Disease Henan Breast Cancer CenterThe Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhouHenan 450008China

To the Editor:Male breast cancer is relatively rare,accounting for just 1%of all breast cancer cases.[1]The management strategies for male breast cancer are mainly based on a limited number of retrospective studies and speculation based on female breast *** study presents a comprehensive account of a decade-long observation of male metastatic breast cancer(mMBC)in our *** Affiliated Cancer Hospital of Zhengzhou University database had records of 2853 advanced breast cancer cases that were treated from January 1,2010 to December 31,*** of the total number,18 cases were identified as *** analysis encompassed data about the treatment administered,the treatment’s effectiveness,and the patient’s survival *** present investigation entails a retrospective examination of our institution’s 10-year experience with patients diagnosed with mMBC and a comprehensive evaluation of relevant literature.

关键词： breast Cancer cancer

配合比参数对C30高性能混凝土抗碳化性能影响算法分析

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混凝土 2024年第5期 122-125,148页

作者：黄波李静马臻臻信阳职业技术学院河南信阳464000 河南职业技术学院河南郑州450046

基于配合比参数,对C30高性能混凝土抗碳化性能的影响进行了探讨,得出了随着矿粉用量的增加,21 d抗压强度随之提高;随着粉煤灰掺量的降低,21 d抗压强度随之提高;C30混凝土126 d的碳化深度明显小于21 d的碳化深度,C30各组试件的21 d的平... 详细信息

基于配合比参数,对C30高性能混凝土抗碳化性能的影响进行了探讨,得出了随着矿粉用量的增加,21 d抗压强度随之提高;随着粉煤灰掺量的降低,21 d抗压强度随之提高;C30混凝土126 d的碳化深度明显小于21 d的碳化深度,C30各组试件的21 d的平均碳化深度为7.57 mm;126 d平均碳化深度为6.51 mm。随着矿物粉用量的增大,粉煤灰用量的减小,混凝土的抗碳化能力增强。以C30-07矿粉与水泥混合料的比例为38%时,C30水泥混合料的最佳混合比例为C30-07矿粉与水泥混合料的最佳混合比例。在龄期从21 d提高到126 d时,随粉煤灰掺量比例的下降,C30混凝土试件碳化深度下降值随之减小,从1.31 mm降低为0.91 mm。利用试验数据,对混凝土的碳化过程进行了预测,结果发现,影响粉煤灰混凝土的碳化的因素比较复杂,将各模型使用应和工程相结合,对混凝土的碳化深度更好预测。利用Matlab对水泥砂浆的碳化厚度进行了线性回归分析,得到了水泥砂浆21 d后碳化厚度的计算方法。

关键词：配合比参数抗碳化性能混凝土预测模型