检索结果-南通市图书馆

Polarization-based range-gated imaging in birefringent medium:Effect of size parameter

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2018年第12期27卷 282-290页

作者： Heng Tian jing-ping zhu Shu-Wen Tan jing-jing Tian Yun-Yao Zhang Xun Hou Key laboratory for Physical Electronics and Devices of the Ministry of Education and Shaanxi Key laboratory of Information Photonic Technique Xi'an Jiaotong University School of Physics and Electronic Information Engineering Henan Polytechnic University Electronic Materials Research laboratory Key Laboratory of the Ministry of Education Xi'an Jiaotong University

We have investigated the effect of size parameter of the scatterer on the image quality obtained with polarization-based range-gated imaging in birefringent turbid medium. Both linearly and circularly polarized light were utilized for *** simulated results indicate that the improvement of visibility is more pronounced using circularly polarized light for the birefringent medium composed of smaller-sized scatterers at lower values of optical thickness and the birefringent medium comprising larger-sized scatterers. In contrast, linearly polarized light provides better image quality for the birefringent medium composed of smaller-sized scatterers at larger values of optical thickness. The evolution of the polarization characteristics of backscattered light and target light under the conditions mentioned above was measured to account for these numerical results.

关键词： polarization Monte Carlo simulation birefringence scattering

在线全文

学校读者我要写书评

暂无评论

保肝颗粒对大鼠酒精性肝损伤的早期干预作用

科学技术与工程 2024年第12期24卷 4895-4901页

作者：朱正望高达郭桓博赵静涵王琳琳苗明三朱平生河南中医药大学第一临床医学院郑州450046 河南中医药大学药学院郑州450046

观察保肝颗粒对大鼠酒精性肝损伤的早期干预作用。将144只大鼠随机分为空白组、模型组、联苯双酯组、保肝颗粒低、中、高剂量组,给药1 h后除空白组外,其余各组按10 mL/kg灌胃50%乙醇,1 h后重复灌胃50%乙醇一次,空白组灌胃等体积蒸馏水,... 详细信息

观察保肝颗粒对大鼠酒精性肝损伤的早期干预作用。将144只大鼠随机分为空白组、模型组、联苯双酯组、保肝颗粒低、中、高剂量组,给药1 h后除空白组外,其余各组按10 mL/kg灌胃50%乙醇,1 h后重复灌胃50%乙醇一次,空白组灌胃等体积蒸馏水,连续6 d。于实验开始的第2、3、4、6天每组分别随机处死大鼠6只,腹主动脉取血,检测血清中丙氨酸氨基转移酶(alanine aminotransferase,ALT)、天门冬氨酸氨基转移酶(aspartate aminotransferase,AST)、碱性磷酸酶(alkaline phosphatase,ALP)、总胆红素(total bilirubin,TBIL)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白介素-6(interleukin-6,IL-6)、α-谷胱甘肽-S-转移酶(α-glutathione S-transferase,α-GST)、谷氨酸脱氢酶(glutamate dehydrogenase,GLDH)、精氨酸酶1(arginase 1,Arg-1)、嘌呤核苷酸磷酸化酶(purine nucleotide phosphorylase,PNP)水平;肝匀浆中超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(malondialdehyde,MDA)水平。结果表明:与空白组比,模型组大鼠血清AST、ALT、ALP、TBIL、TNF-α、IL-6、α-GST、GLDH、Arg-1、PNP水平明显升高(P1),肝组织MDA水平明显升高、SOD水平明显降低(P1);与模型组比,保肝颗粒可以明显降低血清AST、ALT、ALP、TBIL、TNF-α、IL-6、α-GST、GLDH、Arg-1、PNP的水平,提高肝组织中SOD的活性,降低MDA的含量(P1)。说明保肝颗粒早期干预大鼠酒精性肝损伤有较好的保肝作用。

关键词：保肝颗粒酒精性肝病大鼠早期生物标志物

Dynamic evaluation of a scaled-down heat pipe-cooled system during start-up/shut-down processes using a hardware-in-the-loop test approach

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2023年第11期34卷 174-198页

作者： Jiao‑Long Deng Tian‑Shi Wang En‑ping zhu Shuo Yuan Xiao‑jing Liu Xiang Chai School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Micro-mobile heat pipe-cooled nuclear power plants are promising candidates for distributed energy resource power genera-tors and can be flexibly deployed in remote places to meet increasing electric power ***,previous steady-state simulations and experiments have deviated significantly from actual micronuclear system ***,a transient analysis is required for performance optimization and safety *** this study,a hardware-in-the-loop(HIL)approach was used to investigate the dynamic behavior of scaled-down heat pipe-cooled *** real-time features of the HIL architecture were interpreted and validated,and an optimal time step of 500 ms was selected for the thermal *** power transient was modeled using point kinetic equations,and a scaled-down thermal prototype was set up to avoid mod-eling unpredictable heat transfer behaviors and feeding temperature samples into the main program running on a desktop PC.A series of dynamic test results showed significant power and temperature oscillations during the transient process,owing to the inconsistency of the rapid nuclear reaction rate and large thermal *** proposed HIL approach is stable and effective for further studying of the dynamic characteristics and control optimization of solid-state small nuclear-powered systems at an early prototyping stage.

关键词： Micro-heat pipe-cooled nuclear reactor Hardware-in-the-loop Dynamic evaluation Start-up/shut-down processes

ERRATUM TO:Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival

在线全文

学校读者我要写书评

暂无评论

Science china(Life Sciences) 2024年第7期67卷 1548-1548页

作者： Jialiang Yang Yuhong Chen Tongdan Zou Bai Xue Fang Yang Xiangzhou Wang Yibo Huo Boyun Yan Yuxia Xu Shiyu He Yi Yin jing Wang Xiong zhu Lin Zhang Yu Zhou Zhengfu Tai ping Shuai Man Yu Qian Luo Yilian Cheng Bo Gong Xianjun zhu jing Zhang Xinghuai Sun Ying Lin Houbin Zhang Zhenglin Yang Key laboratory for Human Disease Gene Study of Sichuan Province and Institute of laboratory Medicine Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of Ophthalmology and Visual Science Eye and Ear Nose Throat(ENT)HospitalFudan UniversityShanghai 200032China School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Institute of Chengdu Biology Sichuan Translational Medicine HospitalChinese Academy of SciencesChengdu 610093China Department of Ophthalmology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengdu 610072China

Erratum to:SCIENCE china Life Sciences,Volume 66,Issue 2:2.1.225(2022),https://***/10.1007/s11427-021-2126-2 This paper contains an error in Figure 4C,where the representative images of filipin staining of retinal sections from 6-month-old mice were *** provide the correct picture for Figure 4C as *** statistical result in Figure 4D was corrected as *** new Figure 4 does not affect the conclusion of this article.

关键词： Figure critical conclusion

ERRATUM TO: Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science china Life Sciences 2024年

作者： Jialiang Yang Yuhong Chen Tongdan Zou Bai Xue Fang Yang Xiangzhou Wang Yibo Huo Boyun Yan Yuxia Xu Shiyu He Yi Yin jing Wang Xiong zhu Lin Zhang Yu Zhou Zhengfu Tai ping Shuai Man Yu Qian Luo Yilian Cheng Bo Gong Xianjun zhu jing Zhang Xinghuai Sun Ying Lin Houbin Zhang Zhenglin Yang Key laboratory for Human Disease Gene Study of Sichuan Province and Institute of laboratory Medicine Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Department of Ophthalmology Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Department of Ophthalmology and Visual Science Eye and Ear Nose Throat (ENT) Hospital Fudan University Institute of Chengdu Biology Sichuan Translational Medicine Hospital Chinese Academy of Sciences School of Optoelectronic Science and Engineering University of Electronic Science and Technology of China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital

Erratum to:SCIENCE china Life Sciences, Volume 66, Issue 2:2.1.225 (2022), https://***/10.1007/s11427-021-2126-2This paper contains an error in Figure 4C, where the representative images of filipin staining of retinal sections from 6-month-old mice were *** provide the correct picture for Figure 4C as follows. The statistical result in Figure 4D was corrected as well. This new Figure 4does not affect the conclusion of this article.

关键词：

How hepatitis C virus invades hepatocytes: The mystery of viral entry

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第13期20卷 3457-3467页

作者： Yong-Zhe zhu Xi-jing Qian ping Zhao Zhong-Tian Qi Department of Microbiology Shanghai Key Laboratory of Medical BiodefenseSecond Military Medical University

Hepatitis C virus(HCV)infection is a global health problem,with an estimated 170 million people being chronically *** cell entry is a complex multi-step process,involving several cellular factors that trigger virus uptake into the *** high-density lipoprotein receptor scavenger receptor class B type I,tetraspanin CD81,tight junction protein claudin-1,and occludin are the main receptors that mediate the initial step of HCV *** addition,the virus uses cell receptor tyrosine kinases as entry regulators,such as epidermal growth factor receptor and ephrin receptor *** review summarizes the current understanding about how cell surface molecules are involved in HCV attachment,internalization,and membrane fusion,and how host cell kinases regulate virus *** advances of the potential antiviral agents targeting this process are introduced.

关键词： Hepatitis C virus Virus entry Hepatocytes Receptor Host kinase Antiviral target

Synthesis and Properties Investigation of Thiophene-aromatic Polyesters: Potential Alternatives for the 2,5-Furandicarboxylic Acid-based Ones

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2020年第10期38卷 1082-1091,I0005页

作者： jing Gang Wang Xiao-Qin Zhang Ang Shen Jin zhu ping An Song Hao Wang Xiao Qing Liu Ningbo Institute of Materials technology and Engineering Chinese Academy of SciencesNingbo 315201China Universty of Chinese Academy ofSciences Bejing 100049China university of Southern Queensland SpringfieldQLD 4300Australia

In order to explore new substitutes for 2,5 furandicarboxylic acid(FDCA)or poly(ethylene 2,5 furandicarboxylate)(PEF)and try to develop more ideal bio based polyesters,several thiophene aromatic polyesters(PETH,PPTH,PBTH,and PHTH)were synthesized from dimethyl thiophene 2,5-dicarboxylate(DMTD)and different diols,including ethylene glycol,1,3-propanediol,1,4-butanediol,and 1,*** chemical structures of obtained polyesters were confirmed by nuclear magnetic resonance spectroscopy(H-NMR and 1'C-NMR).Determined by GPC measurement,their average molecular weight(M.)varied from 5.22 x 10*g/mol to 7.94 x 10*g/mol with the molar-mass dispersity of *** on the DSC and TGA results,the synthesized polyesters PETH,PPTH,and PBTH displayed comparable or even better thermal properties when compared with their FDCA-based *** PETH to PHTH,their Tg varied from 64.6°Cto-1°C while Tsm ranged from 409 C to 380°C in nitrogen atmosphere,PETH showed elongation at break as high as 378%,tensile strength of 67 MPa,and tensile modulus of 1800 ***,the CO2 and O2 barrier of PETH was 12.0 and 6.6 folds higher than those of PET,respectively,and similar to those of *** the overall properties,the synthesized thiophene aromatic polyesters,especially PETH,showed great potential to be used as an excellent bio based packaging material in the future.

关键词： 2,5-Thiophenedicarboxlic acid(TDCA) 2,5 Furandicarborxylic acid(FDCA) Bio based polyesters Brrier properties

A validated UPLC–MS/MS method for simultaneous determination of imatinib, dasatinib and nilotinib in human plasma

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2017年第6期7卷 374-380页

作者： jing Zeng Hualin Cai Zhiping Jiang Qing Wang Yan zhu ping Xu Xielan Zhao Department of Pharmacy the Second Xiangya Hospital Central South University Institute of Clinical Pharmacy Central South University Department of Hematology Xiangya Hospital Central South University

A sensitive, rapid, simple and economical ultra-performance liquid chromatography-tandem mass spectrometric method （UPLC-MS/MS） was developed and validated for simultaneous determination of imatinib, dasatinib and nilotinib in human plasma using gliquidone as internal standard （IS）. Liquid-liquid extraction method with ethyl acetate was used for sample pre-treatment. The separation was performed on an Xtimate Phenyl column using isocratic mobile phase consisting of A （aqueous phase： 0.15% formic acid and 0.05% ammonium acetate） and B （organic phase： aeetonitrile）（A：B=40：60, v/v）. The flow rate was 0.25 mL/min and the total run time was 6 min. The multiple reaction monitoring （MRM） transitions, m/z 494.5-394.5 for imatinib, 488.7-401.5 for dasatinib, 530.7-289.5 for nilotinib and 528.5-403.4 for IS, were chosen to achieve high selectivity in the simultaneous analyses. The method exhibited great improvement in sensitivity and good linearity over the concentration range of 2.6-5250.0 ng/mL for imatinib, 2.0-490.0 ng/mL for dasatinib, and 2.4-4700.0 ng/mL for nilotinib. The method showed acceptable results on sensitivity, specificity, recovery, precision, accuracy and stability tests. This UPLC-MS/MS assay was successfully used for human plasma samples analysis and no significant differences were found in imatinib steady-state trough concentrations among the SLC22A5 -1889T 〉 C or SLCOIB3 699G 〉 A genotypes （P 〉 0.05）. This validated method can provide support for clinical therapeutic drug monitoring and pharmacokinetic investigations of these three tyrosine kinase inhibitors （TKIs）.

关键词： UPLC-MS/MS Imatinib Dasatinib Nilotinib Polymorphism

shRNA-mediated Slc38a1 silencing inhibits migration, but not invasiveness of human pancreatic cancer cells

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2013年第5期25卷 514-519页

作者： jing Xie Zhen Chen Luming Liu ping Li Xiaoyan zhu Huifeng Gao Zhiqiang Meng Department of Integrative Oncology Fudan University Shanghai Cancer Center Department of Oncology Shanghai Medical CollegeFudan University Stem Cell Research Center Renji HospitalSchool of MedicineShanghai Jiao Tong University

Objective：Early metastasis is a major biological feature of pancreatic *** current study examined whether silencing Slc38a1,a gene involved in energy metabolism,using short hairpin RNA （shRNA） could inhibit the growth,migration,and invasiveness of pancreatic cancer ***：A series of Slc38a1 shRNAs were designed and cloned into the pGPU6/GFP/Neo *** shRNA with the most efficacious inhibitory action on SCL38A1 expression （65％ inhibition） upon screening in DH5α bacteria was used to transfect SW1990 human pancreatic cancer *** growth,migration,and invasiveness were examined using cell counting kit-8,Boyden chamber without and with Matrigel,***：Transfection of SW1990 cells with the SLCs38A1 shRNA significantly decreased the proliferation （P＜0.0001） and migratory potential （by 46.7％,P=0.0399） of the cancer ***,however,was not ***：Inhibiting Slc38a1 using shRNA technology could decrease the growth and migration of representative pancreatic cancer ***,the fact that invasiveness was not affected suggested that SLC38A1 is unlikely to be responsible for early metastasis.

关键词： Slc38a1 shRNA pancreatic cancer