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New perspectives on the therapeutic potential of quercetin in non-communicable diseases:Targeting Nrf2 to counteract oxidative stress and inflammation

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Journal of Pharmaceutical Analysis 2024年第6期14卷 805-822页

作者： Li Zhang Li-Yue Xu Fei Tang Dong Liu Xiao-Lan Zhao jing-nan Zhang Jia Xia Jiao-Jiao Wu Yu Yang Cheng Peng Hui Ao State Key Laboratory of Southwestern Chinese Medicine Resources School of PharmacyChengdu University of Traditional Chinese MedicineChengdu611137China Innovative Institute of Chinese Medicine and Pharmacy Chengdu University of Traditional Chinese MedicineChengdu611137China

Non-communicable diseases(NCDs),including cardiovascular diseases,cancer,metabolic diseases,and skeletal diseases,pose significant challenges to public health *** complex pathogenesis of these diseases is closely linked to oxidative stress and inflammatory *** factor erythroid 2-related factor 2(Nrf2),a critical transcription factor,plays an important role in regulating antioxidant and anti-inflammatory responses to protect the cells from oxidative damage and inflammation-mediated ***,Nrf2-targeting therapies hold promise for preventing and treating ***(Que)is a widely available flavonoid that has significant antioxidant and anti-inflammatory *** modulates the Nrf2 signaling pathway to ameliorate oxidative stress and *** modulates mitochondrial function,apoptosis,autophagy,and cell damage biomarkers to regulate oxidative stress and inflammation,highlighting its efficacy as a therapeutic agent against ***,we discussed,for the first time,the close association between NCD pathogenesis and the Nrf2 signaling pathway,involved in neurodegenerative diseases(NDDs),cardiovascular disease,cancers,organ damage,and bone ***,we reviewed the availability,pharmacokinetics,pharmaceutics,and therapeutic applications of Que in treating *** addition,we focused on the challenges and prospects for its clinical *** represents a promising candidate for the treatment of NCDs due to its Nrf2-targeting properties.

关键词： Quercetin Nrf2 Non-communicable diseases Antioxidant Anti-inflammatory Availability

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基于毫米波深度传感的抗伴生干扰的眨眼检测

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仪器仪表学报 2024年第1期45卷 288-300页

作者：荆楠刘冠男张楠王林燕山大学信息科学与工程学院秦皇岛066004 河北省信息传输与信号处理重点实验室秦皇岛066004

眨眼检测在多种实际应用场景中起着关键作用,如眼病检测、人机交互、疲劳驾驶预防等。针对来自人体的伴生干扰会严重影响眨眼信号的特征提取问题,本文提出一种非线性独立分量分析框架的自监督深度对比学习方法来分离眨眼和伴生干扰。本... 详细信息

眨眼检测在多种实际应用场景中起着关键作用,如眼病检测、人机交互、疲劳驾驶预防等。针对来自人体的伴生干扰会严重影响眨眼信号的特征提取问题,本文提出一种非线性独立分量分析框架的自监督深度对比学习方法来分离眨眼和伴生干扰。本文设计一个基于时间相关性的分离网络ES-Net1,该网络将具有时间相关和时间不相关的两个正负样本序列作为网络的输入,通过ES-Net1内部的特征提取器恢复眨眼和伴生干扰信号的时间结构,从而实现非线性混合信号的分离。本文基于TI公司的AWR1642毫米波雷达平台实现mmBlinkSEN原型系统,通过14 000组数据验证mmBlinkSEN的有效性。实验结果表明,在存在人体伴生干扰情况下,mmBlinkSEN对眨眼频率的检测精度高达88%。

关键词：眨眼检测伴生干扰深度对比学习毫米波雷达非线性独立分析

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Long-term prognosis and its associated predictive factors in patients with eosinophilic gastroenteritis

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World Journal of Gastroenterology 2024年第2期30卷 146-157页

作者： Kai-Wen Li Ge-Chong Ruan Shuang Liu Tian-Ming Xu Ye Ma Wei-Xun Zhou Wei Liu Peng-Yu Zhao Zhi-Rong Du Ji Li jing-nan Li Department of Gastroenterology Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Department of Allergy Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Department of Pathology Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Department of Radiology Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Affairs Office Chinese Academy of Medical Sciences and Peking Union Medical College Hospital(West campus)Beijing 100032China

BACKGROUND Eosinophilic gastroenteritis(EGE)is a chronic recurrent disease with abnormal eosinophilic infiltration in the gastrointestinal *** remain the most common treatment ***,disease relapse and glucocorticoid dependence remain notable *** date,few studies have illuminated the prognosis of EGE and risk factors for disease *** To describe the clinical characteristics of EGE and possible predictive factors for disease relapse based on long-term *** This was a retrospective cohort study of 55 patients diagnosed with EGE admitted to one medical center between 2013 and *** records were collected and ***-Meier curves and log-rank tests were conducted to reveal the risk factors for long-term relapse-free survival(RFS).RESULTS EGE showed a median onset age of 38 years and a slight female predominance(56.4%).The main clinical symptoms were abdominal pain(89.1%),diarrhea(61.8%),nausea(52.7%),distension(49.1%)and vomiting(47.3%).Forty-three(78.2%)patients received glucocorticoid treatment,and compared with patients without glucocorticoid treatments,they were more likely to have elevated serum immunoglobin E(IgE)(86.8%vs 50.0%,P=0.022)and descending duodenal involvement(62.8%vs 27.3%,P=0.046)at *** a median follow-up of 67 mo,all patients survived,and 56.4%had at least one *** variables at baseline might have been associated with the overall RFS rate,including age at diagnosis24 kg/m^(2)(HR 0.3922,95%CI:0.1916-0.8027,P=0.014),disease duration from symptom onset to diagnosis>3.5 mo(HR 2.4725,95%CI:1.220-5.0110,P=0.011),vomiting(HR 3.1259,95%CI:1.5246-6.4093,P=0.001),total serum IgE>300 KU/L at diagnosis(HR 0.2773,95%CI:0.1204-0.6384,P=0.022)and glucocorticoid treatment(HR 6.1434,95%CI:2.8446-13.2676,P=0.003).CONCLUSION In patients with EGE,younger onset age,longer disease c

关键词： Eosinophilic gastroenteritis Prognosis Relapse Glucocorticoid Glucocorticoid dependence

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Clinical manifestation,lifestyle,and treatment patterns of chronic erosive gastritis:A multicenter real-world study in China

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World Journal of Gastroenterology 2024年第9期30卷 1108-1120页

作者： Ying-Yun Yang Ke-Min Li Gui-Fang Xu Cheng-Dang Wang Hua Xiong Xiao-Zhong Wang Chun-Hui Wang Bing-Yong Zhang Hai-Xing Jiang jing Sun Yan Xu Li-Juan Zhang Hao-Xuan Zheng Xiang-Bin Xing Liang-jing Wang Xiu-Li Zuo Shi-Gang Ding Rong Lin Chun-Xiao Chen Xing-Wei Wang jing-nan Li Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China Department of Gastroenterology Nanjing Drum Tower HospitalNanjing 21000Jiangsu ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Gastroenterology Renji HospitalShanghai 200127China Department of Gastroenterology Union Hospital of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Gastroenterology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastroenterology and Hepatology The People’s Hospital of Zhengzhou UniversityThe Henan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai Jiao Tong UnivesrityRuijin HospitalSchool MedicineShanghai 200025China Department of Gastroenterology and Hepatology China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Gastroenterology Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina Department of Gastroenterology Nanfang HospitalGuangzhou 510080Guangdong ProvinceChina Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina Department of Gastroenterology The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Gastroenterology Shandong University Qilu HospitalJinan 250012Shandong ProvinceChina Department of Gastroenterology Peking University Third HospitalBeijing 100191China Department of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei Pr

BACKGROUND Although chronic erosive gastritis(CEG)is common,its clinical characteristics have not been fully *** lack of consensus regarding its treatment has resulted in varied treatment *** To explore the clinical characteristics,treatment patterns,and short-term outcomes in CEG patients in *** We recruited patients with chronic non-atrophic or mild-to-moderate atrophic gastritis with erosion based on endoscopy and *** and treating physicians completed a questionnaire regarding history,endoscopic findings,and treatment plans as well as a follow-up questionnaire to investigate changes in symptoms after 4 wk of *** Three thousand five hundred sixty-three patients from 42 centers across 24 cities in China were *** pain(68.0%),abdominal distension(62.6%),and postprandial fullness(47.5%)were the most common presenting *** was classified as chronic non-atrophic in 69.9%of *** those with erosive lesions,72.1%of patients had lesions in the antrum,51.0%had multiple lesions,and 67.3%had superficial flat *** patients with epigastric pain,the combination of a mucosal protective agent(MPA)and proton pump inhibitor was more *** those with postprandial fullness,acid regurgitation,early satiety,or nausea,a MPA appeared more *** CEG is a multifactorial disease which is common in Asian patients and has non-specific *** may play a major role in its detection and *** should be individualized based on symptom profile.

关键词： Chronic erosive gastritis Symptom Endoscopic findings Treatment pattern Real-world

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Clinical manifestations,diagnosis and long-term prognosis of adult autoimmune enteropathy:Experience from Peking Union Medical College Hospital

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World Journal of Gastroenterology 2024年第19期30卷 2523-2537页

作者： Mu-Han Li Ge-Chong Ruan Wei-Xun Zhou Xiao-Qing Li Sheng-Yu Zhang Yang Chen Xiao-Yin Bai Hong Yang Yu-Jie Zhang Peng-Yu Zhao Ji Li jing-nan Li Department of Gastroenterology Chinese Academy of Medical Sciences&Peking Union Medical College HospitalBeijing 100730China Department of Pathology Chinese Academy of Medical Scinences&Peking Union Medical College HospitalBeijing 100730China Department of Pathology Tianjin First Central HospitalNankai UniversityTianjin 300192China Affairs Office Chinese Academy of Medical Sciences&Peking Union Medical College Hospital(West campus)Beijing 100032China

BACKGROUND Autoimmune enteropathy(AIE)is a rare disease whose diagnosis and long-term prognosis remain challenging,especially for adult AIE *** To improve overall understanding of this disease’s diagnosis and *** We retrospectively analyzed the clinical,endoscopic and histopathological characteristics and prognoses of 16 adult AIE patients in our tertiary medical center between 2011 and 2023,whose diagnosis was based on the 2007 diagnostic *** Diarrhea in AIE patients was characterized by secretory *** common endoscopic manifestations were edema,villous blunting and mucosal hyperemia in the duodenum and *** blunting(100%),deep crypt lymphocytic infiltration(67%),apoptotic bodies(50%),and mild intraepithelial lymphocytosis(69%)were observed in the duodenal ***,there were other remarkable abnormalities,including reduced or absent goblet cells(duodenum 94%,ileum 62%),reduced or absent Paneth cells(duodenum 94%,ileum 69%)and neutrophil infiltration(duodenum 100%,ileum 69%).Our patients also fulfilled the 2018 diagnostic criteria but did not match the 2022 diagnostic criteria due to undetectable anti-enterocyte *** patients received glucocorticoid therapy as the initial medication,of which 14/16 patients achieved a clinical response in 5(IQR:3-20)*** were administered to 9 patients with indications of steroid dependence(6/9),steroid refractory status(2/9),or intensified maintenance medication(1/9).During the median of 20.5 months of followup,2 patients died from multiple organ failure,and 1 was diagnosed with non-Hodgkin’s *** cumulative relapse-free survival rates were 62.5%,55.6%and 37.0%at 6 months,12 months and 48 months,*** Certain histopathological findings,including a decrease or disappearance of goblet and Paneth cells in intestinal biopsies,might be potential diagnostic criteria for adult *** long-term prognosis is still unsatisfac

关键词： Autoimmune enteropathy Clinical manifestations Diagnostic criteria Pathological features Long-term prognosis

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市政污水处理厂改扩建工程BIM技术应用研究

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中国给水排水 2024年第14期40卷 79-84页

作者：张宁邓京楠湖南省建筑设计院集团股份有限公司湖南长沙410000

长沙市某污水处理厂一期(现状)规模为10×10^(4)m^(3)/d,二期改扩建工程建成后规模将扩大至19×10^(4)m^(3)/d,采用新型高浓度复合粉末载体生物流化床(HPB)+加砂高效沉淀工艺。针对改扩建工程存在的建设用地紧张、厂区地下管线复杂且迁... 详细信息

长沙市某污水处理厂一期(现状)规模为10×10^(4)m^(3)/d,二期改扩建工程建成后规模将扩大至19×10^(4)m^(3)/d,采用新型高浓度复合粉末载体生物流化床(HPB)+加砂高效沉淀工艺。针对改扩建工程存在的建设用地紧张、厂区地下管线复杂且迁改工程量大、单体数量多且结构形式复杂、工期紧张需合理排布时序等重难点问题,发挥BIM技术的可视性、优化性、模拟性等优势,制定全过程BIM实施规划。设计阶段通过Revit软件和二次开发工具完成厂区现状管线、三维地质以及BIM数据创建,基于模型校核多专业设计方案,提前发现问题,减少后期设计变更;并重点探究了Revit二次开发系统架构、代码调用方式和功能控制逻辑等,研究对比了不同格式实景模型与BIM模型的融合效果,以提高实景模型的材质稳定性,验证了Revit模型与计算流体力学(CFD)分析软件的数据交互可行性。施工阶段以BIM协同管理平台为核心,实现全厂多源模型数据集成、轻量化展示、云端更新,并集成场地布置模拟、管线迁改方案模拟、建设时序计划模拟分析等专项BIM应用成果,通过三维现场交底提高参建方协作效率,有效把控施工现场进度并辅助质量管理。

关键词： BIM技术污水处理厂改扩建工程

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HPV、TCT检查在子宫颈癌前病变筛查中的价值分析

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四川生理科学杂志 2024年第4期46卷 867-869页

作者：南静王静灵宝市第二人民医院病理科河南灵宝472500 灵宝市第二人民医院妇产科河南灵宝472500

目的:分析人乳头瘤病毒(Human Papilloma Virus,HPV)、宫颈液基细胞学检查(Thin-Cytologic Test,TCT)在子宫颈病变筛查中的临床价值。方法:选取2020年7月至2023年7月期间在本院进行子宫颈癌前病变筛查的疑似子宫颈癌前病变患者2614例作... 详细信息

目的:分析人乳头瘤病毒(Human Papilloma Virus,HPV)、宫颈液基细胞学检查(Thin-Cytologic Test,TCT)在子宫颈病变筛查中的临床价值。方法:选取2020年7月至2023年7月期间在本院进行子宫颈癌前病变筛查的疑似子宫颈癌前病变患者2614例作为研究对象。所有患者均进行HPV与TCT检查,将病理学的检验结果作为本研究的金标准,比较HPV与TCT这两种检验方法的检查结果,分析HPV、TCT检查分别在子宫颈癌前病变早期筛查中的实际临床价值。结果:2614例疑似子宫颈癌前病变患者中经病理检查,阳性检出率为8.22%。HPV检查阳性检出率为8.11%,与病理学检验结果间的Kappa值为0.6855;经TCT检查阳性检出率为2.98%,与病理学检验结果间的Kappa值为0.4182;联合检查阳性检出率为8.19%,与病理学检验结果间的Kappa值为0.7383;对子宫颈癌前病变诊断的检查灵敏度、特异度、准确度、阳性预测值和阴性预测值分别如下,HPV检查为69.77%、97.62%、95.33%、72.46%、97.30%;TCT检查为30.23%、99.46%、93.46%、83.33%、94.09%;联合检查为74.88%、97.79%、95.91%、75.23%、97.75%;结论:HPV和TCT检查均适用于在早期子宫颈癌前病变的筛查,且其更加简单快捷,对患者的创伤较小,推荐在临床使用。

关键词：人乳头瘤病毒宫颈液基细胞学检查子宫颈癌前病变早期筛查

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清代宫廷交椅鉴赏

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林产工业 2024年第7期61卷 78-83页

作者：刘琳琳周京南故宫博物院北京100009

交椅由胡床演变而来,是古人精湛工艺及文化思想的集合体,因其便携性,促使我国古代起居方式变得更为灵活多样,特别是在行军、出游等活动中。自宋代以来,交椅在营事活动中逐渐发展成为身份地位的象征,其装饰外观受礼制约束。本文通过梳理... 详细信息

交椅由胡床演变而来,是古人精湛工艺及文化思想的集合体,因其便携性,促使我国古代起居方式变得更为灵活多样,特别是在行军、出游等活动中。自宋代以来,交椅在营事活动中逐渐发展成为身份地位的象征,其装饰外观受礼制约束。本文通过梳理不同朝代相关交椅的古籍、绘画等资料,以故宫博物院馆藏3把清代交椅实物为例,进行鉴赏及历史文化挖掘,解读交椅在装饰中的制度性、实用性与艺术性,以期让交椅的设计者与使用者更好地了解其所承载的文化内涵。

关键词：交椅栲栳样历史文化礼制研究家具装饰

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价值期待视域下高校大学生思想政治教育的期待实现和期待满足策略研究

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黑龙江教师发展学院学报 2024年第4期43卷 36-40页

作者：靖楠徐州工程学院商学院江苏徐州221018

高校大学生思想政治教育以人为本,以学生为中心,着力满足学生的发展需求和价值期待,是高校大学生思想政治教育的根本旨归和目标方向。思想政治教育工作者要明确和重视高校大学生思想政治教育工作满足大学生价值期待的重要意义,了解大学... 详细信息

高校大学生思想政治教育以人为本,以学生为中心,着力满足学生的发展需求和价值期待,是高校大学生思想政治教育的根本旨归和目标方向。思想政治教育工作者要明确和重视高校大学生思想政治教育工作满足大学生价值期待的重要意义,了解大学生价值期待的基本特征,针对性做好大学生价值期待满足工作,提升高校大学生思想政治教育的亲和力、针对性和实效性,更好地落实立德树人根本任务。

关键词：高校大学生思想政治教育价值期待满足策略

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载体材料类型对黄体酮固体分散体体外性质的影响

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药学学报 2024年第3期59卷 735-742页

作者：权静楠程艺周静宇李蒙王增明刘楠赵子明张慧郑爱萍徐州医科大学药学院江苏徐州221004 军事科学院军事医学研究院毒物药物研究所北京100850

本研究考察了不同载体材料对黄体酮固体分散体体外性质的影响,以流变学性质为考察指标,采用热熔挤出技术制备难溶性药物黄体酮固体分散体,并对固体分散体的体外性质进行表征。扫描电子显微镜显示固体分散体具有粗糙的表面和团聚的微观结... 详细信息

本研究考察了不同载体材料对黄体酮固体分散体体外性质的影响,以流变学性质为考察指标,采用热熔挤出技术制备难溶性药物黄体酮固体分散体,并对固体分散体的体外性质进行表征。扫描电子显微镜显示固体分散体具有粗糙的表面和团聚的微观结构,呈不规则块状颗粒。差示扫描量热法和粉末X-射线衍射法显示固体分散体中黄体酮晶型的变化,由结晶态转变为无定型态。体外溶出度研究显示不同载体材料制备的固体分散体可以有效地改善药物的溶出速度。研究结果表明,载体材料类型对固体分散体的体外性质具有显著影响,为固体分散体在难溶性药物控释方面的研究提供了参考。

关键词：黄体酮热熔挤出载体材料固体分散体溶出度

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