检索结果-南通市图书馆

Cytochrome P45026A1 Contributes to the Maintenance of Neuropathic Pain

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第3期40卷 293-309页

作者： De-Li Cao ling-jie Ma Bao-Chun Jiang Qiang Gu Yong-jing Gao Institute of Pain Medicine and Special Environmental Medicine Co-innovation Center of NeuroregenerationNantong UniversityNantong226019China Nantong University Medical School Nantong226001China Department of Pain Management The Affiliated Hospital of Nantong UniversityNantong226001China

The cytochrome P450 proteins(CYP450s)have been implicated in catalyzing numerous important biological reactions and contribute to a variety of ***26A1,a member of the CYP450 family,carries out the oxidative metabolism of retinoic acid(RA),the active metabolite of vitamin *** we report that CYP26A1 was dramatically upregulated in the spinal cord after spinal nerve ligation(SNL).CYP26A1 was mainly expressed in spinal neurons and *** analysis displayed that the content of all-trans-RA(at-RA),the substrate of CYP26A1,was reduced in the spinal cord on day 7 after *** of CYP26A1 by siRNA or inhibition of CYP26A1-mediated at-RA catabolism by talarozole relieved the SNL-induced mechanical allodynia during the maintenance phase of neuropathic *** also reduced SNL-induced glial activation and proinflammatory cytokine production but increased anti-inflammatory cytokine(IL-10)*** RA receptors RARα,RXRβ,and RXRγwere expressed in spinal neurons and glial *** promoter of Il-10 has several binding sites for RA receptors,and at-RA directly increased Il-10 mRNA expression in ***,intrathecal IL-10 attenuated SNL-induced neuropathic pain and reduced the activation of astrocytes and ***,the inhibition of CYP26A1-mediated at-RA catabolism alleviates SNL-induced neuropathic pain by promoting the expression of IL-10 and suppressing glial ***26A1 may be a potential therapeutic target for the treatment of neuropathic pain.

关键词： CYP26A1 Microglia Astrocytes ERK P38 IL-10 Neuropathic pain

Anti-epileptic and Neuroprotective Effects of Ultra-low Dose NADPH Oxidase Inhibitor Dextromethorphan on Kainic Acid-induced Chronic Temporal Lobe Epilepsy in Rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第5期40卷 577-593页

作者： jing-jing Yang Ying-Xin Liu Yan-Fang Wang Bi-Ying Ge Ying Wang Qing-Shan Wang Sheng Li Jian-jie Zhang ling-ling Jin Jau-Shyong Hong Sheng-Ming Yin jie Zhao College of Basic Medical Sciences Dalian Medical UniversityDalian116044China Department of Neurology The First Affiliated Hospital of Dalian Medical UniversityDalian116011China National and Local Joint Engineering Research Center for Drug Research and Development of Neurodegenerative Diseases Dalian116044China School of Public Health Dalian Medical UniversityDalian116044China Neurobiology Laboratory National Institute of Environmental Health SciencesNational Institutes of HealthResearch Triangle ParkDurhamNC27709USA

Neuroinflammation mediated by microglia and oxidative stress play pivotal roles in the development of chronic temporal lobe epilepsy(TLE).We postulated that kainic acid(KA)-Induced status epilepticus triggers microglia-dependent inflammation,leading to neuronal damage,a lowered seizure threshold,and the emergence of spontaneous recurrent seizures(SRS).Extensive evidence from our laboratory suggests that dextromethorphan(DM),even in ultra-low doses,has anti-inflammatory and neuroprotective effects in many animal models of neurodegenerative *** results showed that administration of DM(10 ng/kg per day;subcutaneously via osmotic minipump for 4 weeks)significantly mitigated the residual effects of KA,including the frequency of SRS and seizure *** addition,DM-treated rats showed improved cognitive function and reduced hippocampal neuronal *** found suppressed microglial activation-mediated neuroinflammation and decreased expression of hippocampal gp91^(phox) and p47^(phox) proteins in KA-induced chronic TLE ***,even after discontinuation of DM treatment,ultra-low doses of DM continued to confer long-term anti-seizure and neuroprotective effects,which were attributed to the inhibition of microglial NADPH oxidase 2 as revealed by mechanistic studies.

关键词： Temporal lobe epilepsy Dextromethorphan NADPH oxidase Ultra-low dose

Synergistic redox reactions toward co-production of H_(2)O_(2)and value-added chemicals:Dual-functional photocatalysis to achieving sustainability

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

SusMat 2024年第3期4卷 36-72页

作者： Brenden jing Su Joel jie Foo Grayson Zhi Sheng ling Wee-Jun Ong School of Energy and Chemical Engineering Xiamen University MalaysiaSelangor Darul EhsanMalaysia Center of Excellence for NaNo Energy&Catalysis Technology Xiamen University MalaysiaSelangor Darul EhsanMalaysia State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamenChina Gulei Innovation Institute Xiamen UniversityZhangzhouChina Shenzhen Research Institute Xiamen UniversityShenzhenChina

IntegratingH_(2)O_(2)evolution with oxidative organic synthesis in a semiconductordriven photoredox reaction is highly attractive since H_(2)O_(2)and high-value chemicals can be concurrently produced using solar light as the only energy *** dual-functional photocatalytic approach,free from sacrificial agents,enables simultaneous production of H_(2)O_(2)and high-value organic *** strategy promises a green and sustainable organic synthesis with minimal greenhouse gas *** this review,we first elucidate the fundamental principles of cooperative photoredox integration of H_(2)O_(2)synthesis and selective organic oxidation with simultaneous utilization of photoexcited electrons and holes over semiconductor-based ***,a thorough review on the recent advancements of cooperative photoredox synthesis of H_(2)O_(2)and value-added chemicals is ***,in-depth discussions and insights into the techniques for unravelling the photoredox reaction mechanisms are ***,critical challenges and prospects in this thriving field are comprehensively *** is envisioned that this review will serve as a pivotal guidance on the rational design of such dual-functional photocatalytic system,thereby further stimulating the development of economical and environmentally benignH_(2)O_(2)and high-value chemicals production.

关键词： cooperative photoredox synthesis dual-functional photocatalysts H_(2)O_(2) photocatalysis selective organic oxidation

A Simple Proof of ACC for Minimal Log Discrepancies for Surfaces

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2024年第2期40卷 425-434页

作者： jing Jun HAN Yu jie LUO Shanghai Center for Mathematical Sciences Fudan UniversityJiangwan CampusShanghai 200438P.R.China Department of Mathematics Johns Hopkins UniversityBaltimoreMD 21218USA

Following Shokurov's idea,we give a simple proof of the ACC conjecture for minimal log discrepancies for surfaces.

关键词： Ascending chain condition minimal log discrepancies minimal model program surface

Parametric resonance of axially functionally graded pipes conveying pulsating fluid

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 239-260页

作者： jie jing Xiaoye MAO Hu DING Liqun CHEN Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Frontier Science Center of MechanoinformaticsShanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200444China Shanghai Institute of Aircraft Mechanics and Control Shanghai 200092China

Based on the generalized Hamilton's principle,the nonlinear governing equation of an axially functionally graded(AFG)pipe is *** non-trivial equilibrium configuration is superposed by the modal functions of a simply supported *** the direct multi-scale method,the response and stability boundary to the pulsating fluid velocity are solved analytically and verified by the differential quadrature element method(DQEM).The influence of Young's modulus gradient on the parametric resonance is investigated in the subcritical and supercritical *** general,the pipe in the supercritical region is more sensitive to the pulsating *** nonlinearity changes from hard to soft,and the non-trivial equilibrium configuration introduces more frequency components to the ***,the increasing Young's modulus gradient improves the critical pulsating flow velocity of the parametric resonance,and further enhances the stability of the *** addition,when the temperature increases along the axial direction,reducing the gradient parameter can enhance the response *** work further complements the theoretical analysis of pipes conveying pulsating fluid.

关键词： pipe conveying fluid axially functionally graded supercritical resonance multi-scale method parametric resonance

Reducibility of Three Dimensional Skew Symmetric System with High Dimensional Weak Liouvillean Frequencies

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2024年第10期40卷 2388-2410页

作者： jie LIU Yuan SHAN jing WANG School of Mathematics and Statistics Nanjing University of Science and Technology School of Statistics and Data Science Nanjing Audit University

In this paper, we consider the reducibility of three-dimensional skew symmetric *** obtain a reducibility result if the base frequency is high-dimensional weak Liouvillean and the parameter is sufficiently small. The ... 详细信息

关键词： 34C20 37J40 high-dimensional weak Liouvillean KAM theory three dimensional skew-symmetric system

Meibomian glands segmentation in infrared images with limited annotation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第3期17卷 401-407页

作者： Jia-Wen Lin ling-jie Lin Feng Lu Tai-Chen Lai jing Zou Lin-ling Guo Zhi-Ming Lin Li Li College of Computer and Data Science Fuzhou UniversityFuzhou 350108Fujian ProvinceChina Fujian Provincial Key Laboratory of Networking Computing and Intelligent Information Processing Fuzhou UniversityFuzhou 350108Fujian ProvinceChina Shengli Clinical Medical College of Fujian Medical University Fuzhou 350001Fujian ProvinceChina Department of Ophthalmology Fujian Provincial Hospital South BranchFujian Provincial HospitalFuzhou 350001Fujian ProvinceChina

●AIM:To investigate a pioneering framework for the segmentation of meibomian glands(MGs),using limited annotations to reduce the workload on ophthalmologists and enhance the efficiency of clinical diagnosis.●METHODS:Totally 203 infrared meibomian images from 138 patients with dry eye disease,accompanied by corresponding annotations,were gathered for the study.A rectified scribble-supervised gland segmentation(RSSGS)model,incorporating temporal ensemble prediction,uncertainty estimation,and a transformation equivariance constraint,was introduced to address constraints imposed by limited supervision information inherent in scribble *** viability and efficacy of the proposed model were assessed based on accuracy,intersection over union(IoU),and dice coefficient.●RESULTS:Using manual labels as the gold standard,RSSGS demonstrated outcomes with an accuracy of 93.54%,a dice coefficient of 78.02%,and an IoU of 64.18%.Notably,these performance metrics exceed the current weakly supervised state-of-the-art methods by 0.76%,2.06%,and 2.69%,***,despite achieving a substantial 80%reduction in annotation costs,it only lags behind fully annotated methods by 0.72%,1.51%,and 2.04%.●CONCLUSION:An innovative automatic segmentation model is developed for MGs in infrared eyelid images,using scribble annotation for *** model maintains an exceptionally high level of segmentation accuracy while substantially reducing training *** holds substantial utility for calculating clinical parameters,thereby greatly enhancing the diagnostic efficiency of ophthalmologists in evaluating meibomian gland dysfunction.

关键词： infrared meibomian glands images meibomian gland dysfunction meibomian glands segmentation weak supervision scribbled annotation

Privacy-Preserving Frank-Wolfe on Shuffle Model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2024年第4期40卷 887-907页

作者： ling-jie ZHANG Shi-song WU Hai ZHANG School of Mathematics Northwest UniversityXi’an 710127China School of Mathematics and Information Science Baoji University of Arts and SciencesBaoji 721013China China Southern Power Grid Artificial Intelligence Technology Company Limited Guangzhou 510700China

In this paper,we design the differentially private variants of the classical Frank-Wolfe algorithm with shuffle model in the optimization of machine *** weak assumptions and the generalized linear loss(GLL)structure,we propose a noisy Frank-Wolfe with shuffle model algorithm(NoisyFWS)and a noisy variance-reduced Frank-Wolfe with the shuffle model algorithm(NoisyVRFWS)by adding calibrated laplace noise under shuffling scheme in thel_(p)(p∈[1,2])-case,and study their privacy as well as utility guarantees for the H?lder smoothness *** particular,the privacy guarantees are mainly achieved by using advanced composition and privacy amplification by *** utility bounds of the Noisy FWS and NoisyVRFWS are analyzed and obtained the optimal excess population risksO(n-(1+α/4α+log(d)√log(1/δ)/n∈and O(n-1+α/4α+log(d)√log1(+δ)/n^(2)∈with gradient complexity O(n(1+α)^(2)/4α^(2)forα∈[1/√3,1].It turns out that the risk rates under shuffling scheme are a nearly-dimension independent rate,which is consistent with the previous work in some *** addition,there is a vital tradeoff between(α,L)-Holder smoothness GLL and the gradient *** linear gradient complexity O(n)is showed by the parameterα=1.

关键词： differential privacy Frank-Wolfe algorithm privacy amplification shuffle model

Revealing effect of Al content on oxidation of novel Co-Cr-Nb-W carbide-strengthened superalloy

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第9期43卷 4521-4534页

作者： Chen ling Shang-Ping Li jie Hou He-Li Luo Central Iron&Steel Research Institute Beijing 100081China Beijing GAONA Materials&Technology Co. Ltd.Beijing 100081China

The high-temperature oxidation behavior of novel Co-Cr-Nb-W carbide-strengthened wear-resistance alloys with different Al contents(1wt%,2wt%and 3wt%)at 950,1000 and 1050℃was thoroughly investigated by scanning electron microscopy,X-ray diffraction,X-ray photoelectron spectroscopy and field emission electron probe *** porous property of NbC in-situ oxidation products(Nb_(2)O_(5),Co Nb_(2)O_(6)and Co_(4)Nb_(2)O_(9))induces a multi-layered oxide scale with micropores and ***-Cr-Nb-W alloy with 1 wt%Al undergoes catastrophic oxidation and spalling above 1000℃.The outward transportation of Cr and Co is effectively restrained by a continuous Al_(2)O_(3)scale formed around NbC in-situ oxidation region when Al content reaches 3 wt%.The β-Co Al in Co-Cr-Nb-W alloy with 3 wt%Al has an oxidation priority over eutectic carbides and the alloy matrix which are both enriched with Cr,thereby preventing the formation of Cr-depletion area and improving the self-healing ability of the oxide film.A slight change in Al content has a remarkable influence on the cooperative effect of Al and Cr and multiplies the antioxidant capacity of Co-Cr-Nb-W alloy above 1000℃.

关键词： High-temperature oxidation behavior Oxidation kinetics Superalloy Wear-resistant alloy Microstructure