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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-yan Sun lingyun Nie jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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连续与离散变量协同分析的非平稳非高斯工业过程异常检测

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电子学报 2024年第10期52卷 3291-3300页

作者：蔡美玲罗迪肖敬日李婧妍刘金平湖南师范大学信息科学与工程学院湖南长沙410081 湘江实验室湖南长沙410205 湖南师范大学数学与统计学院湖南长沙410081

工业过程数据涵盖离散和连续变量,它们之间内在的统计分布特性是揭示系统运行状况的关键.然而,现有的监测模型多聚焦于高斯假设下的连续过程变量,忽略了离散变量、连续变量的多模分布特性以及数据中的噪声、离群点对模型的影响,难以精... 详细信息

工业过程数据涵盖离散和连续变量,它们之间内在的统计分布特性是揭示系统运行状况的关键.然而,现有的监测模型多聚焦于高斯假设下的连续过程变量,忽略了离散变量、连续变量的多模分布特性以及数据中的噪声、离群点对模型的影响,难以精准反映数据的真实分布特性,对非高斯、非平稳过程的异常检测效果欠佳.因此,本文提出一种鲁棒的工业过程异常检测方法——连续和离散变量协同分析的变分贝叶斯混合判别方法(Continuous and Discrete Variables-Concurrent Analysis-based Variational Bayesian Mixture Discriminant,CDVCA-VBMD).通过构建基于变分贝叶斯推断的面向连续变量的混合学生分布模型与面向离散多变量的混合多项分布模型,有效解决过程变量非高斯分布特性难以有效提取的问题,实现了过程变量复杂相关性的高效处理与分析;同时,在过程监测中引入了持续学习的理念,确保对非平稳时变工业过程异常的有效检测.以数值仿真系统和田纳西·伊斯曼过程为例,进行了大量验证性和对比性实验.结果表明,CDVCA-VBMD能准确估计非平稳工业过程多变量的混合多模分布特性,并对数据中的噪声和离群点具有较强的鲁棒性,从而实现工业异常的准确检测,为非高斯复杂工业过程的长期、鲁棒监测提供了有力支持.

关键词：混合学生分布混合多项分布非平稳过程非高斯过程变分贝叶斯推断持续学习

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Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： jing li Zixuan He Weitai Chai Meng Tian Huali Yu Xiaoxiao He Xiaojuan Zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

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Regulating crystallization and retarding oxidation in Sn-Pb perovskite via 1D cation engineering for high performance all-perovskite tandem solar cells

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Journal of Energy Chemistry 2025年第1期100卷 646-652页

作者： Ranran liu Xin Zheng Zaiwei Wang Miaomiao Zeng Chunxiang Lan Shaomin yang Shangzhi li Awen Wang Min li jing Guo Xuefei Weng Yaoguang Rong Xiong li Michael Gr?tzel Center for Mesoscopic Solar Cells Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced Technology Chinese Academy of Sciences School of Physics and Optoelectronic Engineering Hainan University Suzhou Institute of Nano-Tech and Nano-Bionics (SINANO) Chinese Academy of Sciences School of Chemistry Chemical Engineering and Life Sciences State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology

All-perovskite tandem solar cells have the potential to surpass the theoretical efficiency limit of single junction solar cells by reducing thermalization ***,the challenges encompass the oxidation of Sn2+to Sn4+and uncontrolled crystallization kinetics in Sn-Pb perovskites,leading to nonradiative recombination and compositional heterogeneity to decrease photovoltaic efficiency and operational ***,we introduced an ionic liquid additive,1-ethyl-3-methylimidazolium iodide （EMIMI） into Sn-Pb perovskite precursor to form low-dimensional Sn-rich/pure-Sn perovskites at grain boundaries,which mitigates oxidation of Sn2+to Sn4+and regulates the film-forming dynamics of Sn/Pb-based perovskite *** optimized single-junction Sn-Pb perovskite devices incorporating EMIMI achieved a high efficiency of 22.87%.Furthermore,combined with wide-bandgap perovskite sub-cells in tandem device,we demonstrate 2-terminal all-perovskite tandem solar cells with a power conversion efficiency of 28.34%,achieving improved operational stability.

关键词： All-perovskite tandem solar cells Sn-Pb perovskite 1D Regulated crystallization Antioxidation

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Unraveling post-growth mechanisms of monolayer CsPbBr3 nanocubes:Laser-enhanced transformations and cathodoluminescence-electron microscopy correlations

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Journal of Energy Chemistry 2025年第1期100卷 146-156页

作者： Mingxing li Xiaoge Wang Xiaofan Cao Zhiqun He Chunjun liang Mingxing Chen jing Ju Fangtian You Key Laboratory of Luminescence and Optical Information Ministry of Education Institute of Optoelectronic Technology Beijing Jiaotong University Beijing National Laboratory for Molecular Sciences (BNLMS) College of Chemistry and Molecular Engineering Peking University

Lead-halide perovskite nanoparticles（LHP NPs） are highly promising materials for next-generation displays and solid-state lighting due to their exceptional optical properties. However, their inherent instability presents a significant challenge. Recent advances have demonstrated that optoelectronic devices based on monolayer nanoparticle films exhibit both high luminescence efficiency and long-term *** research demonstrates that mobility limitations and anisotropic alignments in CsPbBr3nanocube monolayer films are key to their stabilization, hindering spontaneous growth through face-to-face fusion and resulting in the formation of connecting necks in a diagonal direction. Introducing laser irradiation confirmed this by significantly accelerating nanocubes growth, increasing mobility, and enhancing local structural ordering, leading to larger and more regularly shaped nanosheets. Fourier transform infrared spectroscopy and energy dispersive spectroscopy line-scan analyses indicated that laser irradiation did not disrupt the ligand structure. Transmission electron microscopy and correlative cathodoluminescence electron microscopy revealed the effects of post-growth and heterogeneous structures, including enhanced luminescence and inhomogeneous intensity in the nanosheets. These findings deepen the understanding of the post-growth mechanism of monolayer nanoparticles and the structure-emission correlation and highlight the unique role of laser irradiation in directing the formation of well-defined and regular nanostructures.

关键词： Energy dispersive spectroscopy

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Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu liu Xiandeng li Mi li Xian Wu Xiaohui Huang Ajing Xu yan liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

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Stepwise assembly to construct stable copper(I) cluster-based circularly polarized luminescent MOFs

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Science China Chemistry 2025年

作者： jing-Wen Xie Meng-Ting Wang yan Jin Si li Jian-Hua Qin Shuang-Quan Zang Tomas C.W.Mak College of Chemistry Henan Key Laboratory of Crystalline Molecular Functional Materials Zhengzhou University College of Chemistry and Chemical Engineering Luoyang Normal University Department of Chemistry The Chinese University of Hong Kong

Circularly polarized luminescence （CPL） materials have been extensively studied in recent years owing to their widespread applications in 3D display,optical storage,optical anti-counterfeiting,and biological imaging,***（I） clusters have emerged as a promising candidate for CPL materials,driven by their cost-effectiveness,superior luminescent properties,precise structure,and low ***,the poor environmental stability of copper（I） clusters renders their synthesis and preservation challenging,thereby significantly impeding their ***,we have designed and synthesised a chiral double-coordinated ligand in order to construct copper（I） cluster nodes that can be further *** anticipated,by utilizing stepwise assembly strategy,a Cu4cluster node co-modified by chiral alkynyl ligands and triphenylphosphine was further assembled with Cd2+ions to obtain 2D layers structure,L/*** L/D-Cu4-Cd exhibits excellent stability and optical properties,including bright yellow emission,solvent-responsive luminescence,and CPL activity with a maximum glumup to 2.0×10-3,which shows potential applications in the WLED and *** interestingly,the material also exhibits deflection ability towards different wavelengths of linearly polarized light,showing certain potential in the preparation of circular polarizer.

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi li Yin Wang Peifeng li Hai Zhu Dong Wang jing li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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A Mild Enantioselective Organocatalytic Decarboxylative Aldol Reaction of （Thio）esters with Trifluoromethyl Ketones

A Mild Enantioselective Organocatalytic Decarboxylative Aldo...

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氟化学与美好生活——中国化学会第十一届全国氟化学会议

作者： Xiao-Juan li,jing Nie,yan Zheng,Jun-An Ma~* Department of Chemistry,Tianjin University,Tianjin 300072,China

＜正＞Nature uses enzymatic activation of malonic acid half thioesters（MAHTs）to selectively generate a thioester enolate,or its equivalent,in the presence of another thioester,achieving a selective cross-Claisen ***...

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Low-dose carvedilol reduces transmural heterogeneity of ventricular repolarization in congestive heart failure

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Acta Pharmacologica Sinica 2007年第8期28卷 1161-1165页

作者： Jiang-hua ZHONG~(2,3) Xiao-pan CHEN~2 Mei-ling YUN~2 Wei-jing li~2 yan-fang CHEN~3 Zhen YAO~(2,4) ~2Department of Cardiology Affiliated Hospital of Hainan Medical College,Haikou 570102,China ~3Department of Pharmacology and Toxicology Wright State University,Ohio 45435,USA Department of Cardiology Affiliated Hospital of Hainan Medical College Haikou China Department of Pharmacology and Toxicology Wright State University Ohio USA

Aim:To study the effects of carvedilol on the transmural heterogeneity of ven-tricular repolarization in rabbits with congestive heart failure(CHF).Methods:Rabbits were randomly divided into 3 groups:control,CHF and carvedilol treatedCHF *** action potential duration(MAPD)in the 3 myocardiallayers was simultaneously ***:All the rabbits in the CHF grouphad signs of severe *** with the control group,the mean bloodpressure and cardiac output were significantly decreased,while peripheral resis-tance was significantly increased in the CHF *** proved that the CHFmodel was successful created with adriamycin in this *** to thecontrol group,the ventricular fibrillation threshold(VFT)was remarkably decreasedand all MAPD of the 3 myocardial layers were extended in rabbits with ***,the extension of MAPD in the midmyocardium was more *** dispersion of repolarization(TDR)was significantly increased in ***-dose carvedilol(0.25 mg/kg,twice daily)had no effects on *** with low-dose carvedilol significantly increased ***-though the MAPD of the 3 myocardial layers were further prolonged in the carvediloltreated CHF group,the prolongation of MAPD in the midmyocardium was shorterthan those in the epicardium and *** with low-dose carvedilolsignificantly decreased TDR in ***:In the present study,the trans-mural heterogeneity of ventricular repolarization increased in the rabbits ***-dose carvedilol decreased the transmural heterogeneity of ventricularrepolarization in CHF,which may be related to its direct electropbysiological pro-perty rather than its effect on ventricular remodeling.

关键词： carvedilol congestive heart failure midmyocardium monophasic action potential duration repolarization

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