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Construction of prognostic markers for gastric cancer and comprehensive analysis of pyroptosis-related long non-coding RNAs

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2281-2295页

作者： Yu Wang Di Li jing xun Yu Wu Hong-Lei Wang Department of Gastrointestinal Surgery Hospital of Integrated Chinese and Western MedicineTianjin UniversityTianjin 300100China

BACKGROUND China's most frequent malignancy is gastric cancer(GC),which has a very poor survival rate,and the survival rate for patients with advanced GC is *** has been connected to the genesis and development of *** function of pyroptosis-related long non-coding RNAs(PRLs)in GC,on the other hand,remains *** To explore the construction and comprehensive analysis of the prognostic characteristics of long non-coding RNA(lncRNA)related to pyroptosis in GC *** The TCGA database provided us with 352 stomach adenocarcinoma samples,and we obtained 28 pyroptotic genes from the Reactome *** examined the correlation between lncRNAs and pyroptosis using the Pearson correlation ***-related PRLs were identified through univariate Cox analysis.A predictive signature was constructed using stepwise Cox regression analysis,and its reliability and independence were *** facilitate clinical application,a nomogram was created based on this *** analyzed differences in immune cell infiltration,immune function,and checkpoints between the high-risk group(HRG)and low-risk group(LRG).RESULTS Five hundred and twenty-three PRLs were screened from all lncRNAs(absolute correlation coefficient>0.4,P<0.05).Nine PRLs were included in the risk prediction signature that was created through stepwise Cox regression *** determined the risk score for GC patients and employed the median value as the dividing line between HRG and *** ability of the risk signature to predict the overall survival(OS)of GC is demonstrated by the Kaplan-Meier analysis,risk curve,receiver operating characteristic curve,and decision curve analysis *** risk signature was shown to be an independent prognostic factor for OS in both univariate and multivariate Cox regression *** showed a more efficient local immune response or modulation compared to LRG,as indicated by the predicted signal pathway analysis and examinatio

关键词： Gastric cancer Pyroptosis Prognosis Immune checkpoint Long non-coding RNA Immune cell infiltrating

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Reduction behavior of iron ore powder by high-volatile coal in thermogravimetric-gas chromatographic and kinetic analysis

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Journal of Iron and Steel Research International 2024年第1期31卷 92-107页

作者： Rui-meng Shi Qi-yuan Mi Bin Li Xiao Shi Chong Zou jing guo Han-jie guo School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina China International Engineering Consulting Corporation Beijing100048China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China

The reduction behavior of iron ore powder by high-volatile coal was investigated,and its kinetic mechanism was *** effect of volatiles in coal on the reduction reaction of iron ore was compared by utilizing a Xinjiang lignite with a high volatile content and its pyrolysis carbon produced by high-temperature pyrolysis to remove volatiles,serving as a *** mass loss and gas composition of the samples during the reduction process were detected using thermo-gravimetric analysis and gas chromatography,and the morphological changes of iron ore powder were observed through scanning electron *** kinetic parameters of the iron oxide reduction reaction were calculated by the Flynn-Ozawa-Wall method,and the kinetic mechanism of volatile participation in the iron oxide reduction reaction was determined through the Coats-Redfern *** results indicate that the coupling effect between the high-volatile coal pyrolysis and reduction reactions occurs during the second stage of the entire coupling process,which corresponds to the late stage of coal pyrolysis with a substantial release of H_(2)and *** volatiles in coal actively participated in the reduction reaction,reducing the initiation temperature of the reaction by around 200℃.The reduction of iron oxides by high-volatile coal was jointly promoted by the"hydrogen cycle"and"carbon cycle",resulting in a higher reduction extent and metallization rate at the end of the *** high-volatile coal was used as the reductant,the average activation energy for the entire process was 76.5 kJ/mol,a significant decrease compared to the employment of pyrolysis carbon without volatiles as the reductant(1167 kJ/mol).

关键词： Direct reduction High-volatile coal Volatile Kinetics Reduction mechanism

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Characteristics and stability of oxide+carbonitride in H13 steel at 1250℃

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Journal of Iron and Steel Research International 2024年第1期31卷 134-142页

作者： Xiao-lin Sun Han-jie guo jing guo Fei Wang Dong Xu Gao-yang Song Shuai Wang School of Materials Science and Engineering Hebei University of EngineeringHandan056038HebeiChina School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China High Temperature Materials Research Institute Central Iron and Steel Research Institute Co.Ltd.Beijing100081China Technology Innovation Center for High Quality Cold Heading Steel of Hebei Province Hebei University of EngineeringHandan056038HebeiChina

The morphology,size,quantity,and composition of complex oxide+carbonitride in H13 steel held at 1250℃for 5,10,and 15 h were *** results show that the ratio and number of complex carbonitrides with cores in H13 steel are gradually increased when holding at 1250℃compared with those in the original H13 steel,and the core size *** are one or more oxide cores in(Ti_(x),V_(1-x))(Cy,N_(1-y)),including xCaO·zAl_(2)O_(3),xCaO·yMgO·zAl_(2)O_(3),and CaO after holding at 1250℃,in addition to MgO·Al_(2)O_(3)and Al_(2)O_(3)in the original *** equilibrium temperature for(Ti_(x),V_(1-x))(Cy,N_(1-y))precipitation at the solidification front and decomposition in the solid state was theoretically analyzed,which was affected by the x value and the product of Ti and N contents in H13 ***,the composition of(Ti_(x),V_(1-x))(Cy,N_(1-y))is influenced by the oxide *** is convinced that(Ti_(x),V_(1-x))(Cy,N_(1-y))with oxide cores has a higher stability,especially for oxides with a high Al_(2)O_(3)*** treatment at high temperature facilitates a more reasonable analysis of oxide+carbonitride,and the generation mechanism of oxide+carbonitride was discussed.

关键词： Complex carbonitride Decomposition Oxide core Characteristic Stability

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煤矿瓦斯爆炸事故的应急救援物资调度模型研究

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安全与环境学报 2015年第5期15卷 104-107页

作者：许胜铭景国勋河南理工大学安全科学与工程学院瓦斯地质与瓦斯治理国家重点实验室培育基地河南焦作454000

矿井瓦斯爆炸事故是煤矿安全生产中最严重的事故之一。为确保事故后应急救援的高效开展及减少应急物资调度过程中的经济损失,在以调度时间为第一的前提下,结合煤矿瓦斯爆炸事故实际,引入伤亡性和经济性两个优化目标,构建了一种在多出救... 详细信息

矿井瓦斯爆炸事故是煤矿安全生产中最严重的事故之一。为确保事故后应急救援的高效开展及减少应急物资调度过程中的经济损失,在以调度时间为第一的前提下,结合煤矿瓦斯爆炸事故实际,引入伤亡性和经济性两个优化目标,构建了一种在多出救点、多物资和多受灾点约束条件下的多目标应急物资调拨模型,并运用加权算法基本思想,确定了决策效用函数,同时结合瓦斯爆炸事故的时间紧迫度,在保证物资连续消耗的条件下,求解最优物资调度方案,并通过实例验证了可行性。

关键词：安全工程瓦斯爆炸物资调度多目标模型多物资最优路径

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A Local Macroscopic Conservative(LoMaC)Low Rank Tensor Method with the Discontinuous Galerkin Method for the Vlasov Dynamics

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Communications on Applied Mathematics and Computation 2024年第1期6卷 550-575页

作者： Wei guo Jannatul Ferdous Ema jing-Mei Qiu Department of Mathematics and Statistics Texas Tech UniversityLubbockTX70409USA Department of Mathematical Sciences University of DelawareNewarkDE19716USA

In this paper,we propose a novel Local Macroscopic Conservative(LoMaC)low rank tensor method with discontinuous Galerkin(DG)discretization for the physical and phase spaces for simulating the Vlasov-Poisson(VP)*** LoMaC property refers to the exact local conservation of macroscopic mass,momentum,and energy at the discrete *** recently developed LoMaC low rank tensor algorithm(arXiv:2207.00518)simultaneously evolves the macroscopic conservation laws of mass,momentum,and energy using the kinetic flux vector splitting;then the LoMaC property is realized by projecting the low rank kinetic solution onto a subspace that shares the same macroscopic *** paper is a generalization of our previous work,but with DG discretization to take advantage of its compactness and flexibility in handling boundary conditions and its superior accuracy in the long *** algorithm is developed in a similar fashion as that for a finite difference scheme,by observing that the DG method can be viewed equivalently in a nodal *** the nodal DG method,assuming a tensorized computational grid,one will be able to(i)derive differentiation matrices for different nodal points based on a DG upwind discretization of transport terms,and(ii)define a weighted inner product space based on the nodal DG grid *** algorithm can be extended to the high dimensional problems by hierarchical Tucker(HT)decomposition of solution tensors and a corresponding conservative projection *** a similar spirit,the algorithm can be extended to DG methods on nodal points of an unstructured mesh,or to other types of discretization,e.g.,the spectral method in velocity *** numerical results are performed to showcase the efficacy of the method.

关键词： Hierarchical Tucker(HT)decomposition Conservative SVD Energy conservation Discontinuous Galerkin(DG)method

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Macrocyclic peptides:up-and-coming weapons to combat antimicrobial resistance

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1786-1787页

作者： Wen-jing Wang Xiang-Min Dong guo-Bo L Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuanChina Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education Department of Medicinal ChemistryWest China School of PharmacySichuan UniversityChengduSichuanChina

Recently,two companion papers published in Nature reported a first-in-class tethered macrocyclic peptide antibiotic targeting carbapenem-resistant ***(CRAB)and unveiled their unique antibacterial mechanism,which invol... 详细信息

关键词： outer macrocyclic Macrocyclic

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CH_4/CO_2混合气体爆燃特性研究进展

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爆炸与冲击 2012年第2期32卷 203-210页

作者：郑远攀景国勋张亚丽郑州轻工业学院计算机与通信工程学院河南郑州450002 应急平台信息技术河南省工程实验室河南郑州450002 河南理工大学安全科学与工程学院河南焦作454003 郑州轻工业学院新校区建设指挥部河南郑州450002

掌握甲烷与二氧化碳混合气体的爆燃特性对高含二氧化碳天然气的勘探、开发和利用具有安全保障作用,对涉及甲烷和二氧化碳的其他工业过程如煤炭气化、惰化、抑爆、泄爆等应急处置和安防设计具有指导价值。为推动相关学科的进步,分类回顾... 详细信息

掌握甲烷与二氧化碳混合气体的爆燃特性对高含二氧化碳天然气的勘探、开发和利用具有安全保障作用,对涉及甲烷和二氧化碳的其他工业过程如煤炭气化、惰化、抑爆、泄爆等应急处置和安防设计具有指导价值。为推动相关学科的进步,分类回顾了甲烷与二氧化碳混合气体爆燃特性的实验和理论研究进展,涉及爆燃范围、爆燃压强、惰化等爆燃特性的实验研究以及爆燃范围领域的理论研究,系统分析和评价了各个研究领域取得的成果、存在的问题,并从提高实验数据的完整性、可比性和适用面,理论预测方法可靠性的评价方法与指标,理论预测方法的适用面从常温常压条件向更复杂的情形扩展3个方面展望了未来的研究重点。

关键词：爆炸力学爆燃特性甲烷二氧化碳应急进展

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Tracing the sources of nutrients through the Tsushima/Korea Strait

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Acta Oceanologica Sinica 2024年第6期43卷 142-152页

作者： jing Zhang Xinyu guo Lei Zhu Jianlong Feng Liang Zhao Key Laboratory of Marine Resource Chemistry and Food Technology Ministry of EducationTianjin 300457China College of Marine and Environmental Science Tianjin University of Science and TechnologyTianjin 300457China Center for Marine Environmental Studies Ehime UniversityMatsuyama 790-8577Japan

The nutrients from the East China Sea(ECS) through the Tsushima/Korea Strait(TS) strongly impact the eco system of the Japan Sea(JS).The complex origins of the Tsushima Warm Current and the various nutrient sources in the ECS result in complex spatial-temporal variations in nutrients in the *** a physical-biological model with a tracking technique,we studied the effects of nutrient sources from the ECS on the *** all the nutrient sources,the Kuroshio has the highest nutrient concentrations in the *** maximum concentration occurs at the bottom,while those of rivers and atmospheric depo sition occur at the surface,and that of the Taiwan Strait occurs in the middle *** nutrient transport through the TS exhibits similar seasonal variations,as does the volume *** transport of nutrients from the Kuroshio accounts for more than 85% of the *** transport of nutrients from the Taiwan Strait is greater during autumn and *** transport of dissolved inorganic nitrogen(DIN) from both rivers and atmospheric deposition through the TS peak in *** transport cannot be equated with volume *** DIN in the less saline zone originates not only from rivers but also from atmospheric deposition and the *** transport of nutrients from the Taiwan Strait is not as significant as its volume transport in the TS.

关键词： dissolved inorganic nitrogen dissolved inorganic phosphate East China Sea Japan Sea nutrient transport

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Identification of FIR systems under difference-driven scheduled quantized observations

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Control Theory and Technology 2024年第2期22卷 163-172页

作者： Dong Liang Ruizhe Jia Fengwei jing Yong Song Jin guo School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing100083China Key Laboratory of Knowledge Automation for Industrial Processes Ministry of EducationBeijing100083China National Engineering Research Center for Advanced Rolling and Intelligent Manufacturing University of Science and Technology BeijingBeijing100083China

In networked system identification,how to effectively use communication resources and improve convergence speed is the focus of ***,there is an inherent contradiction between the two *** this paper,the event-driven communication is used to save communication resources for the identification of finite impulse response systems,and the input design is carried out to meet the requirements of convergence ***,a difference-driven communication is ***,the performance of the communication mechanism is analyzed,and the calculation method of its communication rate is *** that,according to the communication rate and the convergence rate of the identification algorithm,the input design problem is transformed into a constrained optimization problem,and the algorithm for finding the optimal solution is *** addition,considering the case that the output is quantized by multiple thresholds,the way to calculate its communication rate is given and the influence of threshold number on communication rate is ***,the effectiveness of the algorithm is verified by simulation.

关键词： System identification FIR system Difference-driven Quantized observation

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基于MATLAB的采空区自燃发火的数值模拟分析

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煤炭技术 2011年第4期30卷 103-104页

作者：彭信山景国勋河南理工大学安全科学与工程学院河南焦作4540032 河南省煤矿瓦斯与火灾防治重点实验室河南焦作454003

运用MATLAB分析了11502工作面采空区内风流速度、氧气浓度和温度分布对采空区自燃发火的影响程度。得出采空区自燃发火主要影响因素取决于煤自身的氧化放热性能、供氧条件及蓄热环境。

关键词：采空区自燃发火数值模拟影响因素

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