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A proton-catalyzing prodrug for PDT and glycolysis inhibition-synergistic therapy of tumor in spatiotemporal dimensions

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Science China Chemistry 2024年第9期67卷 3162-3178页

作者： Miao Li Xueying Sun Xiuqin Ma Yang Tan xiaoyi jin Yi Wang Fan Yang Qian Li Honglei Zhan Xiaojun Peng School of Biological Engineering Dalian Polytechnic UniversityDalian 116034China State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China

The reactive oxygen species(ROS)generation from photosensitizer in photodynamic therapy(PDT)is limited by tumor *** type-I photosensitizers,e.g.,sulfur-substituted Nile blue,still rely on oxygen as the main center for transferring electrons to generate *** off the pathway of oxygen consumption in tumor can help photosensitizers overcome the limitation of low oxygen,in order to efficiently generate more *** is known that glycolysis inhibitor 3-bromopyruvic acid(3-BP),which could specially target mitochondria,can provide more oxygen by inhibiting oxidative ***,we successfully designed and synthesized a new 3-BP-coupled sulfur-substituted Nile blue as prodrug(NBBP)for chemical/photodynamic synergistic *** results indicated that the protons in tumor catalyzed the hydrolysis of NBBP,inhibited photoinduced electron transfer between 3-BP and the photosensitizer in NBBP and further assisted the photosensitizer to be localized in mitochondria,utilizing local oxygen as much as possible and kill tumor cells more ***,the glycolysis inhibition-induced autophagy was combined with PDT-induced autophagy,which could promote the deaths of tumor *** other remedies exploiting nanomaterials,this construction method of NBBP achieves the efficient synergy of photodynamic therapy and glycolysis inhibition,stronger than their theoretical addition,in spatiotemporal *** study provides not only a highly efficient platform for tumor therapy but also a design approach for prodrugs with synergistic effects.

关键词： photodynamic therapy prodrug glycolysis inhibition autophagy tumor synergistic therapy

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柔性手术机器人牵引钢丝绳与弹簧管的关系分析

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机械设计与研究 2024年第2期40卷 73-78,89页

作者：钱亚玮金晓怡奚鹰孔维彪上海工程技术大学机械与汽车工程学院上海201620 同济大学机械与能源工程学院上海201804 上海熠达光电科技有限公司上海201108

内窥镜进入被检体后无法通过传回的画面准确判断内窥镜整体形态,为更精准的控制弯曲部的蛇骨弯曲,需要分析插入导管及其内藏物的相互关系。分析内藏物中弹簧管与钢丝绳的部分,提出了插入导管中牵引钢丝绳和弹簧管在不受力时位置关系的... 详细信息

内窥镜进入被检体后无法通过传回的画面准确判断内窥镜整体形态,为更精准的控制弯曲部的蛇骨弯曲,需要分析插入导管及其内藏物的相互关系。分析内藏物中弹簧管与钢丝绳的部分,提出了插入导管中牵引钢丝绳和弹簧管在不受力时位置关系的理论模型,基于Ramberg-Osgood模型推出了钢丝绳受拉后钢丝绳弹性变形量,结合实验数据利用最小二乘法拟合出了钢丝绳长度变化量与拉力、盘曲半径和盘曲角度之间的关系公式。经实验验证在钢丝绳不受力时误差在10%以内,在钢丝绳受拉后理论公式与实验数据的误差在16%以下的数据点占总数据点的90%。

关键词：柔性手术机器人 Ramberg-Osgood模型内窥镜牵引钢丝绳盘曲半径盘曲角度

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Research on the theory and application of adsorbed natural gas used in new energy vehicles： A review

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Frontiers of Mechanical Engineering 2016年第3期11卷 258-274页

作者： Zhengwei NIE Yuyi LIN xiaoyi jin Department of Mechanical & Aerospace Engineering University ofMissouri Columbia MO 65211 USA College of Mechanical Engineering Shanghai University of EngineeringScience Shanghai 201620 China

Natural gas, whose primary constituent is methane, has been considered a convincing alternative for the growth of the energy supply worldwide. Adsorbed natural gas （ANG）, the most promising methane storage method, has been an active field of study in the past two decades. ANG constitutes a safe and low-cost way to store methane for natural gas vehicles at an acceptable energy density while working at substantially low pressures （3.5- 4.0 MPa）, allowing for conformable store tank. This work serves to review the state-of-the-art development reported in the scientific literature on adsorbents, adsorption theories, ANG conformable tanks, and related technolo- gies on ANG vehicles. Patent literature has also been searched and discussed. The review aims at illustrating both achievements and problems of the ANG technologies-based vehicles, as well as forecasting the development trends and critical issues to be resolved of these technologies.

关键词： adsorbed natural adsorption theory conformable (NGVs) gas (ANG) adsorbent tank natural gas vehicles

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核电厂核岛双钢板混凝土结构制作及焊接变形控制

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焊接技术 2024年第7期53卷 127-132页

作者：靳孝义惠维山金劲辉中广核工程有限公司广东深圳518124

文中分析了核电厂双钢板混凝土结构的上游技术条件,通过选用合理分配焊接子模块,制作焊接防变形胎膜,优化焊接工艺和优化焊接顺序等方式,并结合双钢板混凝土结构的制作流程制订相应的焊接质量控制的措施,最终实现焊接防变形控制的效果... 详细信息

文中分析了核电厂双钢板混凝土结构的上游技术条件,通过选用合理分配焊接子模块,制作焊接防变形胎膜,优化焊接工艺和优化焊接顺序等方式,并结合双钢板混凝土结构的制作流程制订相应的焊接质量控制的措施,最终实现焊接防变形控制的效果。结果表明:按照所制订的工序和质量控制措施所制作的双钢板混凝土结构符合设计要求,为其他同类型的钢结构制作和焊接变形控制提供借鉴。

关键词：核电厂核岛双钢板混凝土结构焊接变形控制

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Trajectory Optimization and Motion Simulation of a Flexible Polishing Industrial Robot for Watchcases

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Journal of Donghua University(English Edition) 2021年第2期38卷 129-139页

作者： YANG jingjing jin xiaoyi XIE Tengxiao XI Ying School of Mechanical and Automotive Engineering Shanghai University of Engineering ScienceShanghai 201620China College of Mechanical Engineering Tongji UniversityShanghai 201802China

To optimize the working time of the flexible polishing industrial robot for watchcases,the polishing efficiency should be *** on the quintic B-spline fitting curve trajectory planning method associated with the optimal time interval and the trajectory point angle,the trajectory route of the flexible polishing industrial robot for case parts was optimized by the Matlab *** operation time of the flexible polishing industrial robot could reach the optimal *** joints of the robot can be cooperated with each other to ensure that the motion track of the end-effector of the robot arm is closer to the expected motion *** on the Adams software,the obtained trajectory curve of multi-objective optimization was simulated,which verified the trajectory fitted after multi-objective *** angular acceleration and angular plus acceleration curves were *** guidance was carried out for the subsequent experiment by Matlab and Adams simulation analysis.

关键词： trajectory optimization multi-objective optimization Matlab software Adams software industrial robot

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Deepening People-to-People Exchanges and Promoting Practical Cooperation——CAFIU Delegation Visits Bangladesh,India and Sri Lanka

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International Understanding 2011年第2期 28-33页

作者： Wu jin Wang xiaoyi

At the invitation of Bangladesh-China People's Friendship Association(BCPFA),Delhi Study Group of India(DSG) and Sri Lanka Association for International Understanding(SLAFIU),a 5-member CAFIU delegation headed by Deputy Secretary-General *** Hongkui visited Bangladesh,India and Sri Lanka from May 5 to 16.I was lucky to be one of the delegation members and

关键词：孟加拉国斯里兰卡代表团印度交往合作务实国际交流

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Delegation of Australian,Indian and South African NGOs Visits China

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International Understanding 2011年第4期 58-59页

作者： Wu jin Wang xiaoyi

At the invitation of the Chinese Association for International Understanding (CAFIU), a 13-member delegation composed of representatives andscholars of friendly organizations from Australian,India and South Africa vis... 详细信息

关键词：摘要编辑部编辑工作读者

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The Necessary and Sufficient Conditions of Exponential Stability for Heat and Wave Equations with Memory

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Journal of Systems Science & Complexity 2024年第3期37卷 1037-1051页

作者： LI Lingfei ZHANG xiaoyi ZHOU Xiuxiang School of Science Northeast Electric Power UniversityJilin 132012China School of Mathematics and Statistics Lingnan Normal UniversityZhanjiang 524048China

This paper is addressed to a study of the stability of heat and wave equations with *** necessary and sufficient conditions of the exponential stability are investigated by the theory of Laplace transform. The results show that the stability depends on the decay rate and the coefficient of the kernel functions of the memory. Besides, the feedback stabilization of the heat equation is obtained by constructing finite dimensional controller according to unstable eigenvalues. This stabilizing procedure is easy to operate and can be applicable for other parabolic equations with memory.

关键词： Memory stability stabilization

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高龄农业转移人口非农就业影响因素研究

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系统工程理论与实践 2021年第3期41卷 613-624页

作者：胡钊源靳小怡崔烨西安交通大学公共政策与管理学院西安710049 南京财经大学社会保障研究院南京210046

高龄农业转移人口群体规模不断扩大,其非农就业问题不仅决定了个人老年福利,更对新型城镇化质量提升,经济社会发展可持续与养老方式创新有着重要意义.本文基于就业能力理论,结合农业转移人口迁移特点,确定了个人,组织,家庭,环境四个影... 详细信息

高龄农业转移人口群体规模不断扩大,其非农就业问题不仅决定了个人老年福利,更对新型城镇化质量提升,经济社会发展可持续与养老方式创新有着重要意义.本文基于就业能力理论,结合农业转移人口迁移特点,确定了个人,组织,家庭,环境四个影响维度.研究发现,中低龄与高龄农业转移人口非农就业影响因素存在显著差异;高龄群体过早面临就业困境,是劳动力供需层级不匹配和农业转移人口后期技能提升缺失的双重作用结果,其本质原因在于产业转型升级形势下的人力资本投入不足.因此,改善高龄农业转移人口的非农就业,一方面要加大人力资本投资力度,整体提升农业转移人口就业能力,另一方面要寻找更合理的老年人口红利开发模式和养老方式的创新.

关键词：高龄农业转移人口非农就业就业能力

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Lightweight foam-like nitrogen-doped carbon nanotube complex achieving highly efficient electromagnetic wave absorption

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Journal of Materials Science & Technology 2024年第1期168卷 114-123页

作者： Zongcheng Li jin Liang Zhiheng Wei Xin Cao Jiahui Shan Chunwei Li xiaoyi Chen Dong Zhou Ruizhe Xing Chunjia Luo Jie Kong MOE Key Lab of Materials Physics and Chemistry in Extraordinary Conditions Shaanxi Key Laboratory of Macromolecular Science and TechnologySchool of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Key laboratory of Flexible Electronics of Zhejiang Province Ningbo Institute of Northwestern Polytechnical UniversityNingbo 315103China Polymer Materials and Engineering Department School of Materials Science and EngineeringChang’an UniversityXi’an 710064China

With the increased electromagnetic wave(EMW)threat to military and human health,the develop-ment of EMW-absorbing materials is ***-organic framework derivatives containing magnetic nanoparticles and a carbon matrix are potential candidates for designing efficient EMW-absorbing ***,a zeolitic imidazolate framework-67(ZIF-67)-embedded three-dimensional melamine foam is pyrolyzed to afford carbon foam-based nitrogen-doped carbon nanotube composites,named 3D foam-like CoO/Co/*** CoO/Co particles are confined in the dielectric carbon nanotube *** carbon nanotubes provide considerable conductive loss,while CoO/Co magnetic particles are con-ducive to providing magnetic loss and adjusting impedance ***,the numerous defect structures introduced by heteroatomic doping(nitrogen)cause dipole polarization and simultaneously adjust impedance ***,the unique porous nanotube structure promotes multiple re-flections and scattering of EMWs,further optimizing impedance ***/Co/N-CNTs composites exhibit a minimum reflection loss of−52.3 dB at a matching thickness of 2.0 mm,while the correspond-ing effective absorption bandwidth is 5.28 GHz at a matching thickness of 2.2 *** study reports a novel approach to fabricating a lightweight high-performance EMW-absorbing material.

关键词： Lightweight porous carbon materials Carbon nanotubes CoO/Co magnetic particles Electromagnetic synergistic effect Impedance matching

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