Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar
Objective To investigate the effectiveness of compound Chai jin jie Yu Tablets(CJJYT)in ameliorating cognitive impairment associated with depression and its potential mechanism of *** In vitro experiments,the hippocam...
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Objective To investigate the effectiveness of compound Chai jin jie Yu Tablets(CJJYT)in ameliorating cognitive impairment associated with depression and its potential mechanism of *** In vitro experiments,the hippocampus was isolated from the whole brain of the fetal rat and cultured into hippocampal neuron cells.50μM corticosterone(CORT)was added to each group 18 h before the experiment for modeling depression,with the exception of the control *** modeling,the blank serum group was added with 10%blank serum,the CJJYT group and the venlafaxine group were added with the corresponding 10%drug-containing serum,and the control group and the model group were added with equal volumes of culture *** intracellular Ca^2+mean fluorescence intensity,miniature excitatory postsynaptic current(mEPSC)current amplitude,and frequency of different hippocampal neurons were evaluated as indicators of synaptic function in the hippocampal *** addition,the expression of synaptic plasticity related proteins,synaptophysin-α(SYN-α),N-methyl-D-aspartate receptor 2A(NR2A),N-methyl-Daspartate receptor 2B(NR2B),post synaptic density 95 protein(PSD-95),calcium/calmodulin dependent protein kinaseⅡ(CaMKⅡ)and synaptic associated protein(SynGAP)were detected in the hippocampal neurons by immunofluorescence staining and high content analysis(HCA)***,reverse transcription-polymerase chain reaction(RT-PCR)was used to detect the mRNA expression levels of SYN-α,NR2A,NR2B,PSD-95,CaMKⅡand *** in vivo experiments,except for those in the blank control group,all rats were treated within a single cage for chronic unpredictable stress-induced depression modeling and subjected to corresponding drug *** tests were used to detect depressive behavior and determine learning,memory and other cognitive abilities,whereas enzyme-linked immunosorbent assay(ELISA)was used to detect the CORT ***-Cox staining was used to observe changes in the syna
The effect of carbonation on the chloride resistance of low-carbon steel and two Cr-bearing alloy steels in simulated concrete pore solutions was *** chloride threshold values of steels were determined on the basis of...
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The effect of carbonation on the chloride resistance of low-carbon steel and two Cr-bearing alloy steels in simulated concrete pore solutions was *** chloride threshold values of steels were determined on the basis of corrosion potential(Ecorr)and polarization resistance(Rp).Moreover,the chloride-induced corrosion behavior of steels was evaluated using electrochemical impedance spectroscopy,cyclic voltammetry,cathodic potentiodynamic polarization,and scanning electron microscopy/energy dispersive X-ray spectroscopy *** steels have higher chloride resistance than low-carbon steel in carbonated and non-carbonated concrete pore *** chloride resistance of alloy steels improves with increasing Cr *** addition,the chloride resistance of all steels is negatively affected by the carbonation of concrete pore solution,especially for alloy steel with high Cr content in the presence of high chloride content.
Corrosion inhibitors for steel, such as sodium phosphate (Na3PO4), sodium nitrite (NaNO2), and benzotriazole (BTA), in simulated concrete pore solutions (saturated Ca(OH)2) were investigated. Corrosion behav...
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Corrosion inhibitors for steel, such as sodium phosphate (Na3PO4), sodium nitrite (NaNO2), and benzotriazole (BTA), in simulated concrete pore solutions (saturated Ca(OH)2) were investigated. Corrosion behaviors of steel in different solutions were studied by means of corrosion potential (Ecorr), linear polarization resistance (LPR), electrochemical impedance spectroscopy (EIS), and potentiodynamic polarization (PDP). A field emission scanning electron microscope (FESEM) equipped with energy dispersive X-ray analysis (EDXA) was used for observing the microstructures and morphology of corrosion products of steel. The results indicate that, compared with the commonly used nitrite-based inhibitors, Na3PO4 is not a good inhibitor, while BTA may be a potentially effective inhibitor to prevent steel from corrosion in simulated concrete pore solutions.
Electrochemical impedance spectroscopy, cyclic potentiodynamic polarization measurements, and scanning electron microscopy in conjunction with energy-dispersive X-ray spectroscopy were used to investigate the influenc...
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Electrochemical impedance spectroscopy, cyclic potentiodynamic polarization measurements, and scanning electron microscopy in conjunction with energy-dispersive X-ray spectroscopy were used to investigate the influence of mill scale and rust layer on the passivation capability and chloride-induced corrosion behaviors of conventional low-carbon(LC) steel and low-alloy(LA) steel in simulated concrete pore solution. The results show that mill scale exerts different influences on the corrosion resistance of both steels at various electrochemical stages. We propose that the high long-term corrosion resistance of LA steel is mainly achieved through the synergistic effect of a gradually formed compact, adherent and well-distributed Cr-enriched inner rust layer and the physical barrier protection effect of mill scale.
Space scientific exploration is rapidly becoming the primary battlefield for humankind to explore the *** worldwide have launched numerous space exploration *** calibration of the detectors on the ground is a crucial ...
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Space scientific exploration is rapidly becoming the primary battlefield for humankind to explore the *** worldwide have launched numerous space exploration *** calibration of the detectors on the ground is a crucial element for space science satellites to obtain observational *** the purpose of providing calibration for various satellite-borne detectors,multiple monochromatic X-rays facilities have been built at the National Institute of Metrology,***(NIM).These facilities mainly pertain to grating diffraction and Bragg diffraction,and the energy range of the produced monochromatic X-rays is 0.218–301 ke *** facilities have a high performance in terms of energy stability,monochromaticity,and flux *** monochromaticity was greater than 3.0%.The energy stability of the facility is 0.02%at 25 ke V over 8 h,and the flux stability was within 1.0%at 25 ke V over 8 *** experiments on the properties of satellite-borne detectors,such as energy linearity,energy resolution,detection efficiency,and temperature response,can be conducted at the *** far,the calibration of two satellites has been completed by the authors,and the work on three other satellites is in *** study will contribute to the advancement of X-ray astronomy the development of Chinese space science.
In order to improve the autonomous navigation capability of satellite,a pulsar/CNS(celestial navigation system) integrated navigation method based on federated unscented Kalman filter(UKF) is *** celestial navigat...
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In order to improve the autonomous navigation capability of satellite,a pulsar/CNS(celestial navigation system) integrated navigation method based on federated unscented Kalman filter(UKF) is *** celestial navigation is a mature and stable navigation ***,its position determination performance is not satisfied due to the low accuracy of horizon *** pulsar navigation is a new navigation method,which can provide highly accurate range *** major drawback of single pulsar navigation is that the system is completely *** two methods are complementary to each other,the federated UKF is used here for fusing the navigation data from single pulsar navigation and *** to the traditional celestial navigation method and single pulsar navigation,the integrated navigation method can provide better navigation *** simulation results demonstrate the feasibility and effectiveness of the navigation method.
The liquid droplet evaporation character is important for not only combustion chamber design process but also high-accuracy spray combustion simulation. In this paper, the suspended droplets' evaporation character wa...
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The liquid droplet evaporation character is important for not only combustion chamber design process but also high-accuracy spray combustion simulation. In this paper, the suspended droplets' evaporation character was measured in a quiescent high-temperature environment by micro high-speed camera system. The gasoline and kerosene experimental results are consistent with the reference data. Methanol, common kerosene and aviation kerosene droplet evaporation characteristics, as well as their evaporation rate changing with temperature, were obtained. The evaporation rate experimental data were compared with the prediction result of Ranz-Marshall boiling temperature model(RMB), Ranz-Marshall low-temperature model(RML), drift flux model(DFM), mass analogy model(MAM), and stagnant film model(SFM). The disparity between the experimental data and the model prediction results was mainly caused by the neglect of the natural convection effect, which was never introduced into the droplet evaporation concept. A new droplet evaporation model with consideration of natural convection buoyancy force effect was proposed in this paper. Under the experimental conditions in this paper, the calculation results of the new droplet evaporation model were agreed with the experimental data for kerosene, methanol and other fuels, with less than 20% relative deviations. The relative deviations between the new evaporation model predictions for kerosene and the experimental data from the references were within 10%.
In this study, two types of reinforcing steels(conventional low-carbon steel and a novel duplex alloy steel with Cr and Mo) were exposed to chloride-contaminated extract solutions(ordinary Portland cement(OPC) extract...
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In this study, two types of reinforcing steels(conventional low-carbon steel and a novel duplex alloy steel with Cr and Mo) were exposed to chloride-contaminated extract solutions(ordinary Portland cement(OPC) extract and alkali-activated slag(AAS) extract) to investigate their pitting corrosion resistance. The results confirm that the pitting corrosion resistance of the alloy steel is much higher than that of the low-carbon steel in both extract solutions with various Na Cl concentrations. Moreover, for each type of steel, the AAS extract contributes to a higher pitting corrosion resistance compared with the OPC extract in the presence of chloride ions, likely because of the formation of flocculent precipitates on the steel surface.
In resonance with the Fukushima Daiichi Nuclear Power Plant accident lesson, a novel fuel design to enhance safety regarding severe accident scenarios has become increasingly appreciated in the nuclear power industry....
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In resonance with the Fukushima Daiichi Nuclear Power Plant accident lesson, a novel fuel design to enhance safety regarding severe accident scenarios has become increasingly appreciated in the nuclear power industry. This research focuses on analysis of the neutronic properties of a silicon carbide(SiC) cladding fuel assembly, which provides a greater safety margin as a type of accident-tolerant fuel for pressurized water reactors. The general physical performance of SiC cladding is explored to ascertain its neutronic performance. The neutron spectrum, accumulation of ^(239)Pu, physical characteristics,temperature reactivity coefficient, and power distribution are analyzed. Furthermore, the influences of a burnable poison rod and enrichment are explored. SiC cladding assemblies show a softer neutron spectrum and flatter power distribution than conventional Zr alloy cladding fuel assemblies. Lower enrichment fuel is required when SiC cladding is adopted. However, the positive reactivity coefficient associated with the SiC material remains to be offset. The results reveal that SiC cladding assemblies show broad agreement with the neutronic performance of conventional Zr alloy cladding fuel. In the meantime, its unique physical characteristics can lead to improved safety and economy.
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