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Protection against hepatic ischemia/reperfusion injury via downregulation of toll-like receptor 2 expression by inhibition of Kupffer cell function

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World Journal of Gastroenterology 2005年第28期11卷 4423-4426页

作者： jin-Xiang zhang He-Shui Wu Yang Wang Hui Wang jin-Hui zhang Qi-Chang Zheng Department of Emergency Surgery Union Hospital Tongji Medical CollegeHuazhong University of Science and Technology Wuhan 430030Habei Province China Hereditary Department Tongji Medical CollegeHuazhong University of Science and Technology Wuhan 430030Habei Province China Department of General Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China

AIM： To elucidate the mechanism of liver protection by inhibition of Kupffer cells （KCs） function.METHODS： All the animals were randomly divided into three groups. Blockade group （gadolinium chloride solution （GdCl3） injection plus ischemia/reperfusion （I/R） injury）：GdCl3 solution was injected once every 24 h for 2 d via the tail vein before I/R injury. Non-blockade group （saline solution injection plus I/R injury）： saline instead of GdCl3 as a control was injected as in the blockade group. Sham group： saline was injected without I/R injury. Liver samples were collected 4 h after blood inflow restoration. The blockade of the function of KCs was verified by immunostaining with an anti-CD68 mAb. Toll-like receptor2 （TLR2） was immunostained with a goat antimouse polydonal anti-TLR2 antibody. Membrane proteins were extracted from the liver samples and TLR2 protein was analyzed by Western blot. Portal vein serum and plasma were taken respectively at the same time point for further detection of the levels of tumor necrosis factor-α （TNF-α） and alanine aminotransferase （ALT）, an indicator of liver function.I/R injury via downregulation of theexpression of TLR2.RESULTS： Compared to non-blockade group, CD^68＋ cells significantly reduced in blockade group （OPTDI, optical density integral）： 32.97±10.55 vs 185.65±21.88, P〈0.01） and the liver function impairment was relieved partially （level of ALT： 435.89±178.37 U/L vs 890.21±272.91 U/L,P〈0.01）. The expression of TLR2 protein in blockade group significantly decreased compared to that in non- group（method of immunohistochemistry, OPDTI： 75.74±17.44 vs 170.58±25.14, P〈0.01; method of Western blot, A value： 125.89±15.49 vs 433.91±35.53, P〈0.02）. The latter correlated with the variation of CD68 staining （r = 0.745,P〈0.05）. Also the level of portal vein TNF-α decreased in blockade group compared to that in non-blockade group （84.45±14.73 ng/L vs 112.32±17.56 ng/L, P〈0.05）, butwas still higher than that in sham group （84.45±14.73

关键词： Toll-like receptor 2 Reperfusion injury Kupffer cell Liver

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Kinesin 26B modulates M2 polarization of macrophage by activating cancer-associated fibroblasts to aggravate gastric cancer occurrence and metastasis

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World Journal of Gastroenterology 2024年第20期30卷 2689-2708页

作者： Lian-Meng Huang Ming-jin zhang Department of General Surgery The 901st Hospital of PLAHefei 230031Anhui ProvinceChina

BACKGROUND The regulatory effects of KIF26B on gastric cancer(GC)have been confirmed,but the specific mechanism still needs further ***-cancer analysis shows that the KIF26B expression is highly related to immune infiltration of cancerassociated fibroblasts(CAFs),and CAFs promote macrophage M2 polarization and affect cancers’*** To investigate the regulatory functions of KIF26B on immune and metastasis of *** We analyzed genes’mRNA levels by quantitative real-time polymerase chain *** levels of target proteins were detected by immunohistochemistry,ELISA,and Western *** injected AGS cells into nude mice for the establishment of a xenograft tumor model and observed the occurrence and metastasis of *** degree of inflammatory infiltration in pulmonary nodes was observed through hematoxylin-eosin *** and wound healing assays were performed for the evaluation of cell invasion and migration *** formation assay was used for detecting angiogenesis.M2-polarized macrophages were estimated by immunofluorescence and flow *** KIF26B was significantly overexpressed in cells and tissues of GC,and the higher expression of KIF26B was related to GC metastasis and *** to in vivo experiments,KIF26B promoted tumor formation and metastasis of ***26B expression was positively associated with CAFs’degree of ***,CAFs could regulate M2-type polarization of macrophages,affecting GC cells’migration,angiogenesis,invasion,and epithelial-mesenchymal transition *** KIF26B regulated M2 polarization of macrophage through activating CAFs,regulating the occurrence and metastasis of GC.

关键词： metastasis invasion macrophage

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A Mild Oxidant for the Regeneration of Carbonyl Compounds from Oximes in Nonaqueous Condition

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Chinese Chemical Letters 2001年第2期12卷 99-102页

作者： Qing Zhi zhang Shen Song zhang Xin Ming LIU jin Ming zhang College of Chemistry and Environmental Science Henan Normal UniversityXinxiang 453002

Dioxane-NO2 was employed to oxidize oximes to corresponding aldehydes and ketones in high yield in nonaqueous condition at room temperature. Thr reaction proved to be mild and selective.

关键词： Dioxane-NO2 oxidize oximes ketones aldehydes.

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Performance of biological phosphorus removal and characteristics of microbial community in the oxic-settling-anaerobic process by FISH analysis

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第7期9卷 1004-1010页

作者： Jian-fang WANG Qing-liang ZHAO Wen-biao jin Shi-jie YOU jin-na zhang School of Municipal and Environmental Engineering Harbin Institute of Technology Harbin 150090 China Department of Urban and Civil Engineering Harbin Institute of Technology Shenzhen Graduate School Shenzhen 518055 China

Performance of biological phosphorus removal in the oxic-settling-anaerobic(OSA) process was investigated. Cell staining and fluorescent in situ hybridization(FISH) were used to analyze characteristics and microbial community of sludge. Experimental results showed that phosphorus removal efficiency was near 60% and the amount of biological phosphorus accumulation in aerobic sludge of the OSA system was up to 26.9 mg/g. Biological phosphorus removal efficiency was partially inhibited by carbon sources in the continuous OSA system. Contrasted to the OSA system,biological phosphorus removal efficiency was enhanced by 14% and the average total phosphorus(TP) contents of aerobic sludge were increased by 0.36 mg/g when sufficient carbon sources were supplied in batch experiments. Staining methods indicated that about 35% of microorganisms had typical characteristics of phosphorus accumulating organisms(PAOs) . FISH analysis demonstrated that PAOMIX-binding bacteria were predominant microbial communities in the OSA system,which accounted for around 28% of total bacteria.

关键词： Excess sludge reduction Biological phosphorus removal Phosphate accumulating organisms (PAOs) DAPI(4' 6'-diamidino-2-phenyl indol dihydrochloride) Fluorescent in situ hybridization (FISH)

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First-Arrival Picking Method for Active Source Data with Ocean Bottom Seismometers Based on Spatial Waveform Variation Characteristics

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Journal of Ocean University of China 2024年第4期23卷 970-980页

作者： LIU Hongwei XING Lei ZHU Henghua zhang jin zhang jing LIU Huaishan Key Laboratory of Submarine Geosciences and Prospecting Techniques Ministry of EducationCollege of Marine GeosciencesOcean University of ChinaQingdao 266100China Laboratory for Marine Mineral Resources Qingdao Marine Science and Technology CenterQingdao 266071China College of Underwater Acoustic Engineering Harbin Engineering UniversityHarbin 150001China Shandong Institute of Geological Survey Jinan 250014China

The precision and reliability of first-arrival picking are crucial for determining the accuracy of geological structure inversion using active source ocean bottom seismometer(OBS)refraction *** methods for first-arrival picking based on sample points are characterized by theoretical errors,especially in low-sampling-frequency OBS data because the travel time of seismic waves is not an integer multiple of the sampling *** this paper,a first-arrival picking method that utilizes the spatial waveform variation characteristics of active source OBS data is ***,the distribution law of theoretical error is examined;adjacent traces exhibit variation characteristics in their ***,a label cross-correlation superposition method for extracting highfrequency signals is presented to enhance the first-arrival picking *** from synthetic and field data verify that the proposed approach is robust,successfully overcomes the limitations of low sampling frequency,and achieves precise outcomes that are comparable with those of high-sampling-frequency data.

关键词： first-arrival picking spatial waveform variation label cross-correlation superposition method

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Electrochemical corrosion and oxidation resistances of Zr_(60)Ni_(21)Al_(19) bulk amorphous alloys

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Science China(Physics,Mechanics & Astronomy) 2010年第12期53卷 2223-2226页

作者： jinG Qin zhang Bing zhang jin MA MingZhen LIU RiPing State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004China

Electrochemical corrosion and oxidation resistances of Zr 60 Ni 21 Al 19 amorphous alloy were studied. The ternary amorphous alloy exhibits greater positive potential than its crystalline counterpart and 0Cr19Ni9Ti stainless steel. Its weight loss result measured in 2 mol/L HCl solution is in agreement with the potentiodynamic curve. But there is no obvious difference in the oxidation resistances between Zr 60 Ni 21 Al 19 amorphous and its crystalline alloys. They both exhibit high oxidation resistance.

关键词： bulk amorphous alloy electrochemical corrosion oxidation

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Dual-band-stop filters with unsymmetrical T-shape DGS resonators

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The Journal of China Universities of Posts and Telecommunications 2013年第4期20卷 112-115页

作者： zhang jin-ling zhang Hong-xin LU Ying-hua zhang Li-kun School of Telecommunication Engineering Beijing University of Posts and Telecommunications Translation Department

A kind of dual-band-stop filter with an unsymmetrical T-shape defected ground structure （DGS） is proposed. The filter has two band gap centers at 4.9 GHz and 7.35 GHz, respectively, where the two centre frequencies are just the second and third harmonics 2.45 GHz. The filters with high band-stop performance and wideband spurious suppression can be achieved by cascading miniaturized unsymmetrical T-shape DGS. The attenuation of three-cascaded T-shape DGS filter is 30.77 dB at 4.9 GHz and 17.96 dB at 7.35 GHz respectively. The above experimental results are in good agreement with the simulation results, especially for the third harmonic.

关键词： DGS band-stop filter dual-resonant characteristics unsymmetrical T-shape

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Deactivation mechanisms and anti-deactivation strategies of molecular sieve catalysts for NO_(x)reduction

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Chinese Chemical Letters 2024年第3期35卷 8-18页

作者： Fuli Wang Penglu Wang jin zhang Dengchao Peng Mengmeng Wei Dengsong zhang School of Environmental and Chemical Engineering State Key Laboratory of Advanced Special SteelInternational Joint Laboratory of Catalytic ChemistryCollege of SciencesShanghai UniversityShanghai 200444China

Molecular sieve catalysts,owing to their unique chemical properties,are widely used as catalysts among various catalytic *** Br?nsted acid sites in molecular sieve catalysts usually enable active components to disperse well on the catalyst surface,and help to adsorb a large number of gas molecules to achieve maximum catalytic ***,a variety of molecular sieve catalysts have been developed and used in the selective catalytic reduction of NO_(x)by NH_(3)(NH_(3)-SCR).For example,Cu molecular sieve catalysts such as Cu-SSZ-13 and Cu-SAPO-34 with wide temperature windows and stable structure are considered and applied as commercial catalysts for NO_(x)removal in diesel vehicles for a long *** molecular sieve catalysts possess many advantages,they still cannot avoid the serious deactivation caused by various factors in practical *** this review,reasons leading to the deactivation of molecular sieve catalysts for NO_(x)reduction in actual working conditions were *** deactivation mechanisms of molecular sieve catalysts for NO_(x)reduction were analyzed and the corresponding anti-deactivation strategies were ***,challenges and prospects of molecular sieve catalysts for NO_(x)reduction were also proposed.

关键词： Environmental catalysis NO_(x) reduction Molecular sieve catalysts Deactivation mechanism Anti-deactivation

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Output Model of Steel Plant

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Journal of Iron and Steel Research International 2008年第3期15卷 27-30,46页

作者： zhang Long-qiang TIAN Nai-yuan zhang jin XU An-jun Metallurgical and Ecological Engineering School University of Science and Technology Beijing Beijing 100083 China

Based on the requirement of compactivity, continuity, and high efficiency, and taking full advantage of cushion capability of flexible parts such as external refining in new generation steel plant, an output model of steel plant was established in terms of matching between BOF and caster. Using this model, the BOF nominal capacity is selected, the caster output and equipment amount are computed, and then the steel plant output is computed.

关键词： steel plant output BOF nominal capacity caster matching

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Lobe-dominatedγ-Ray Emission of Compact Symmetric Objects

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Research in Astronomy and Astrophysics 2024年第2期24卷 196-205页

作者： Ying-Ying Gan Hai-Ming zhang Xing Yang Ying Gu jin zhang School of Physics Beijing Institute of TechnologyBeijing 100081China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China

Theγ-ray emitting compact symmetric objects(CSOs)PKS 1718-649,NGC 3894,and TXS 0128+554 are lobedominated in the radio *** order to investigate theirγ-ray radiation properties,we analyze the~14yr Fermi/LAT observation data of the three *** all show the low luminosity(1041-1043 erg s-1)and no significant variability in theγ-ray ***γ-ray average spectra can be well fitted by a power-law *** properties ofγ-rays are clearly different from theγ-ray emitting CSOs CTD 135 and PKS 1413+135,for which theγ-rays are produced by a restarted aligned *** the L_(γ)-Γ_(γ)plane,the three CSOs are also located at the region occupied by radio galaxies(RGs)while CTD 135 and PKS 1413+135 display a similar feature to *** with a similar radio emission property toγ-ray emitting RGs Cen A and Fornax A,we speculate that theγ-rays of the three CSOs stem from their extended *** broadband spectral energy distributions of the three CSOs can be well explained by the two-zone leptonic model,where theirγ-rays are produced by the inverse Compton process of the relativistic electrons in extended *** extrapolating the observed Fermi/LAT spectra to the very high energy band,we find that TXS 0128+554 among the three CSOs may be detected by the Cherenkov Telescope Array in the future.

关键词： galaxies active-galaxies jets-radio continuum galaxies-gamma-rays galaxies

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