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Detecting the epidermal growth factor receptors status in non-small cell lung cancer

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Chinese Medical Journal 2011年第24期124卷 4324-4329页

作者： MENG Xue yu jin-ming Department of Radiation Oncology Key Laboratory of RadiationOncology of Shandong Province Shandong Cancer Hospital andInstitute Jinan Shandong 250117 China

Non-small cell lung cancer is one of the leading causes of all cancer deaths, but despite years of research, it is still difficult to predict the response and clinical outcome of the disease. In recent years, new treatment strategies targeting the epidermal growth factor receptors （EGFR） have been developed. EGFR is one of the most frequently over expressed proteins in various cancers, including lung cancer, and signaling through this receptor has been known to cause tumor progression as well as resistance to different treatments. Therefore, EGFR has become an attractive target for various treatment strategies. However, it is important to note that not all patients with lung cancer are suitable for targeted treatment, and that patients should be selected for this treatment. Several studies have proven that the status of the EGFR can be both an indicator of suitability for treatment with, and predict the likelihood of response to EGFR targeted therapy. There are many standard techniques to be used for the detection of EGFR. This overview summarizes the ongoing and future investigations to determine the status of the EGFR.

关键词： lung cancer epidermal growth factor receptors molecular imaging

Ion-Induced Beam Instability in an Electron Storage Ring

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Chinese Physics Letters 2000年第12期17卷 877-878页

作者： LI Yong-Jun jin yu-ming LI Wei-Min LIU Zu-Ping National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029

In a small electron storage ring,such as the Hefei Light Source(HLS)ring,the newly generated ions,which can not escape from the beam potential and then are trapped from turn to turn,will lead to the beam *** ions created by the leading bunches can perturb the trailing bunches and also themselves during their subsequent passage,which will make the amplitude of beam oscillation be damped and anti-damped periodically.A computer simulation based on the strong-weak model shows a good agreement with our analytical model using the linear theory.

关键词： theory beam Electron

Potential of Gd-EOB-DTPA as an imaging biomarker for liver injury estimation after radiation therapy

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 354-359页

作者： Xiao-Li Sun Xue Jiang yu Kuang Lei Xing Lu-Yi Bu Shuang-Hu yuan jin-ming yu Shu-Sen Zheng Department of Radiation Oncology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Medical Physics Program University of NevadaLas VegasNV 89154USA Department of Radiation Oncology Stanford University School of MedicineStanfordCA 94305USA Department of Radiation Oncology Shandong Cancer Hospital Affiliated to Shandong UniversityShandong Academy of Medical SciencesJinan 250117China Key Laboratory of Combined Multi-organ Transplantation Ministry of Public HealthDepartment of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Background:Hepatic radiation injury severely restricts irradiation treatment for liver *** purpose of this study was to investigate the clinical application of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid(Gd-EOB-DTPA)-enhanced MRI(EOB-MRI)in the assessment of liver function after external radiation therapy and to determine the relationship between focal liver reaction(FLR)and liver ***:A total of 47 patients with liver malignancies who underwent external beam radiation therapy were ***-MRI was performed on each patient at approximately one month *** hepatobiliary(HPB)phase images from EOB-MRI were fused with the planning CT images,and the isodose lines from the patients’treatment plans were overlaid onto the fused *** correlation of the EOB-MR image intensity distribution with the isodose lines was *** also compared liver function in patients between pre-treatment and ***:Decreased uptake of Gd-EOB-DTPA,which was manifested by well-demarcated focal hypointensity of the liver parenchyma or FLR to high-dose radiation,was observed in the irradiated areas of 38 *** radiotherapy isodose line of decreased uptake area of Gd-EOB-DTPA was 30–46 *** median corresponding dose curve of FLR was 34.4 *** patients showed the absence of decreased uptake area of Gd-EOB-DTPA in the irradiated *** to the 38 patients with the presence of decreased uptake area of Gd-EOB-DTPA,9 patients with the absence of decreased uptake area of Gd-EOB-DTPA showed significant higher levels of total bile acid,total bilirubin,direct bilirubin and alpha-fetoprotein(P0.05).Conclusions:Visible uptake of Gd-EOB-DTPA by the liver parenchyma was significantly associated with liver function ***-MRI can be a valu

关键词： MRI biomarker Radiation-induced liver disease Liver carcinoma

Advances of radiation oncology in China

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Chinese Medical Journal 2009年第19期122卷 2231-2235页

作者： MENG Xue yu jin-ming Department of Radiation Oncology Shandong Cancer Hospital and Institute Medical College of Shandong University Jinan Shandong 250117 China

Radiation therapy is one of the main treatment .modalities used in cancer management. It is the primary curative modality for about 30% of patients with cancer, and more than half of all cancer patients received radiation therapy sometime during the course of their disease. It is estimated that 70% of the patients with cancer required radiation therapy in China.1 Radiation oncology is based on the development of radiological physics, radiological biology and clinical oncology.

关键词： advance radiation oncology China

Breast cancer radiotherapy： controversies and prospectives

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Chinese Medical Journal 2008年第20期121卷 1957-1959页

作者： yu jin-ming WANG Yong-sheng Breast Cancer Center Shandong Cancer Hospital Jinan Shandong 250117 China

Despite consensus on breast cancer radiotherapy, there are still some controversies over post-mastectomy radiotherapy （PMRT） in patients with 1-3 positive lympn nodes, accelerated partial breast irradiation （APBI）, appropriate sequence of radiotherapy, chemotherapy and hormonal treatment, and radiotherapy after preoperative systemic therapy.

关键词：多数赞同乳房乳房切除术乳腺肿瘤

Nuclear medical molecular imaging of tumor angiogenesis： current status and future prospects

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Chinese Medical Journal 2013年第14期126卷 2741-2746页

作者： HU Xu-dong XING Li-gang yu jin-ming Department of Radiation Oncology Key Laboratory of Radiation Oncology of Shandong Province Shandong Tumor Hospital & Institute Jinan Shandong 250117 China Postdoctoral Working Station of Tianjin Medical University Tianjin 300072 China

Objective To review the current status and progress on nuclear medical molecular imaging of angiogenesis. Data sources A literature search was performed in Medline and PubMed published in English up to May 31, 2012. The search terms were molecular imaging, nuclear medicine and angiogenesis. Study selection Articles studying molecular imaging of angiogenesis using radionuclide were selected and reviewed. Results Molecular imaging has been used for studying angiogenesis by targeting integrin aVI33, VEGF/VEGFR, and matrix metalloproteinases （MMPs） with radionuclide-labeled tracers. The technology has been shown to be able to assess the angiogenesis status and/or predict the efficacy of anti-angiogenic therapy. Future directions of the research on the molecular imaging of angiogenesis include development of new tracers with better tumor targeting efficacy, desirable pharmacokinetics, and easy translation to clinical applications. Conclusion Advances in molecular imaging of angiogenesis using radioculcide will make the technology a valuable tool for personalized anti-angiogenesis treatment.

关键词： molecular imaging nuclear medicine angiogenesis

The Research on Two–dimensional Gaussian Graphic Algorithm based on Random Vectors Simulation Method

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The Research on Two–dimensional Gaussian Graphic Algorithm ...

Value of ^(18)F-FDG PET-CT in surveillance of postoperative colorectal cancer patients with various carcinoembryonic antigen concentrations

The 2011 Fourth International Symposium on Knowledge Acquisition and Modeling（KAM 2011）

作者： jin yu-ming Department of Information and Engineering Sciences The City College Of Jiangsu（Changzhou）

The basic thoughts of Gaussian graphic algorithm are generating a Gaussian matrix according to the two–dimensional normal distribution formula. When calculating every point in the new graph, we can make the center of Gaussian matrix aim to the point in the initial graph, and use the method of weighted average for all points according to the corresponding points on Gaussian matrix. The two–dimensional Gaussian graphic algorithm is often used to reduce the size of the graph. This paper makes the preliminary study based on the random vectors simulation method. The algorithm realizes correlative codes by using Matlab and experiments demonstrate that this is an efficient and fast algorithm.

关键词： random vectors two–dimensional graphic algorithm Gaussian matrix simulation method

来源： cnki会议评论

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World Journal of Gastroenterology 2014年第21期20卷 6608-6614页

作者： Yan Zhang Bin Feng Guo-Li Zhang Man Hu Zheng Fu Fen Zhao Xiao-Li Zhang Li Kong jin-ming yu Graduate school of Tianjin Medical University Department of Radiation Oncology Shandong Tumor Hospital and Institute (Shandong Academy of Medical Sciences) Affiliated Hospital of Shandong Academy of Medical Sciences Jinan 250031Shandong ProvinceChina Department of Nuclear Medicine Shandong Tumor Hospital and Institute (Shandong Academy of Medical Sciences) Medical College Shandong University School of Medicine and Life Sciences University of Jinan

AIM:To evaluate the value of positron emission tomography(PET)/computerized tomography(CT)in surveillance of colorectal cancer(CRC)patients with different carcinoembryonic antigen(CEA)***:One hundred and six postoperative CRC patients who had suspected recurrence or metastasis and received fluorodeoxyglucose(FDG)PET/CT within one week were included in this *** final diagnosis was confirmed by histological examination or clinicalfollow-up over at least six ***:The sensitivity,specificity,and accuracy of FDG PET/CT were 95.2%,82.6%,and 92.5%,and94.8%,81.4%and 92.8%,respectively,in the caseand lesion-based *** sensitivity and accuracy of FDG PET/CT significantly differed from CT in both analyses(χ2=8.186,P=0.004;χ2=6.201,P=0.013;χ2=13.445,P=0.000;χ2=11.194,P=0.001).In the lesion-based analysis,the sensitivity,specificity,and accuracy of FDG PET/CT in the abnormal CEA group were97.8%,82.6%,and 95.6%,compared with 81.3%,80%,and 80.6%for patients with normal CEA *** case-based analysis,the sensitivity,specificity,and accuracy of FDG PET/CT were 97.2%,77.8%,and 95%in abnormal CEA *** in lesion-based analysis,the sensitivity and accuracy of FDG PET/CT in the abnormal CEA group were significantly superior to those in the normal CEA group(χ2=6.432,P=0.011;χ2=7.837,P=0.005).FDG PET/CT changed the management in 45.8%of patients with positive ***:FDG PET/CT showed superior diagnostic value and is an advisable option in surveillance of postoperative CRC patients with a vague diagnosis.

关键词： Colorectal cancer Carcinoembryonic antigen Fluorodeoxyglucose positron emission tomography/computed tomography Recurrence Metastasis

Effect of a conserved peptide derived from Kunitz domain of hepatitis B virus x protein on the cell cycle and apoptosis of HepG2 cells via the proteasome pathway

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Chinese Medical Journal 2009年第4期122卷 460-465页

作者： LIU Hong YE Lin WANG Qing-wei YAN Qiu-xia yu jin-ming Cancer Research -Center Qilu Hospital Shandong UniversityJinan Shandong 250012 China Department of Health Care Shandong Provincial Hospital JinanShandong 250012 China Department of Radiation Oncology Shandong Cancer HospitalJinan Shandong 250117 China

Background Hepatitis B virus （HBV） x protein （HBx） in HepG2 cells causes a moderate decrease in proteolysis activity of the proteasome. A highly conserved Kunitz-type serine protease inhibitor domain within 154 amino acid residues of HBx has been identified. In this study, a peptide chain derived from the Kunitz domain （PKD） was used to study its effect on the cell cycle and apoptosis of HepG2 cells, and investigated the function of PKD on the activities of proteasomes and AAA-ATPase p97, which involves in the ubiquitin-proteasome protein degradation pathway. Methods The PKD peptide （Phe-Val-Leu-Gly-Gly-Cys-Arg-His-Lys） was chemically synthesized. MTT assays were used to determine the effects of PKD on HepG2 cell growth. Mouse anti-p97 antibody was developed for Western blotting to detect the expression of p97. ATPase activity of proteasomes was measured using a colorimetric assay. Peptidase activities of proteasomes were analyzed with various peptidase-specific fluorogenic peptide substrates. Flow cytometry was used to determinate cell cycle phase and apoptosis. Results Viability of HepG2 cells decreased in a PKD-dose-dependent manner. Cells exhibited significant cytotoxicity in the presence of 15 mmol/L of PKD. Western blotting analysis showed that expression of p97 was suppressed in HepG2 cells treated with PKD compared to untreated cells. The ATPase activity of proteasomes from immunoprecipitates of HepG2 cells pretreated with PKD was apparently decreased. Chymotryptic activity of proteasomes in HepG2 cells was significantly inhibited by 10mmol/L PKD; tryptic activity and peptidylglutamyl peptide hydroiase activity of proteasomes were less inhibited by PKD than chymotryptic activity. The cell cycle phase of HepG2 cells treated with PKD for 36 hours was blocked largely at the G0-G1 phase, while untreated control cells were mainly in S phase. PKD also significantly induced apoptosis. Conclusions The peptide derived from Kunitz domain of HBx protein induces H

关键词： peptides ubiquitin proteasome p97 valosin-containing protein carcinoma hepatocellular apoptosis