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Altered spontaneous brain activity patterns in hypertensive retinopathy using fractional amplitude of low-frequency fluctuations:a functional magnetic resonance imaging study

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1665-1674页

作者： xue-Lin Wang Xu-Jun Zheng Li-juan Zhang jin-Yu Hu Hong Wei Qian Ling Liang-Qi He Cheng Chen Yi-Xin Wang Xu Chen Yi Shao Department of Ophthalmology the First Affiliated Hospital of Jiangxi Medical CollegeEye Hospital of Shangrao CityShangrao 334000Jiangxi ProvinceChina Jiangxi Medical College Shangrao 334000Jiangxi ProvinceChina Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Eye DiseasesShanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghai 200080China Department of Ophthalmology The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina School of Optometry and Vision Science Cardiff UniversityCardiff CF244HQWalesUK Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburg ProvincieNetherlands

AIM:To study functional brain abnormalities in patients with hypertensive retinopathy(HR)and to discuss the pathophysiological mechanisms of HR by fractional amplitude of low-frequency fluctuations(fALFFs)***:Twenty HR patients and 20 healthy controls(HCs)were respectively *** age,gender,and educational background characteristics of the two groups were *** functional magnetic resonance imaging(fMRI)scanning,the subjects’spontaneous brain activity was evaluated with the fALFF *** operating characteristic(ROC)curve analysis was used to classify the ***,we used Pearson’s correlation analysis to explore the relationship between fALFF values in specific brain regions and clinical behaviors in patients with ***:The brain areas of the HR group with lower fALFF values than HCs were the right orbital part of the middle frontal gyrus(RO-MFG)and right lingual *** contrast,the values of fALFFs in the left middle temporal gyrus(MTG),left superior temporal pole(STP),left middle frontal gyrus(MFG),left superior marginal gyrus(SMG),left superior parietal lobule(SPL),and right supplementary motor area(SMA)were higher in the HR *** results of a t-test showed that the average values of fALFFs were statistically significantly different in the HR group and HC group(P<0.001).The fALFF values of the left middle frontal gyrus in HR patients were positively correlated with anxiety scores(r=0.9232;P<0.0001)and depression scores(r=0.9682;P<0.0001).CONCLUSION:fALFF values in multiple brain regions of HR patients are abnormal,suggesting that these brain regions in HR patients may be dysfunctional,which may help to reveal the pathophysiological mechanisms of HR.

关键词： hypertensive retinopathy fractional amplitude of low-frequency fluctuation brain region magnetic resonance imaging

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心血管病的循证医学方法

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复旦学报（医学版） 2017年第6期44卷 707-712页

作者：陈灏珠金雪娟复旦大学附属中山医院上海200032 上海市心血管病研究所上海200032

实施循证医学(evidence-based medicine,EBM)意味着医生需要综合考虑最佳临床研究证据、医生的临床经验和患者的意见进行临床决策。本文针对心血管疾病临床实践中临床决策的EBM框架进行了探讨。认为获得最佳证据,需要对不同来源的证据... 详细信息

实施循证医学(evidence-based medicine,EBM)意味着医生需要综合考虑最佳临床研究证据、医生的临床经验和患者的意见进行临床决策。本文针对心血管疾病临床实践中临床决策的EBM框架进行了探讨。认为获得最佳证据,需要对不同来源的证据进行科学的评估和解读。EBM对心血管疾病诊疗领域产生了深远的影响,肯定了某些备受争议干预措施的疗效,而一些曾经认为有效的药物因被证明患者无获益而退出临床应用。我国心血管病的科学证据资源不足,影响到循证实践的能力。建议开展更高质量的随机临床试验,以支持有效的循证医学临床实践。

关键词：循证医学心血管病临床实践

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侧脑室注射L-精氨酸对大鼠运动能力和下丘脑一氧化氮含量的影响

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中国应用生理学杂志 2013年第2期29卷 158-161页

作者：薛金娟刘鸿宇第四军医大学唐都医院放射科陕西西安710038 中北大学运动医学研究所山西太原030051

目的:探讨中枢一氧化氮(NO)与运动疲劳应激的关系,研究NO前体L-精氨酸(L-Arg)对大鼠运动能力和力竭后脑内NO含量的影响。方法:在大鼠侧脑室植入套管,手术恢复后连续4 d分别注射生理盐水或L-Arg,然后用动物跑台建立一次性力竭模型(速度为... 详细信息

目的:探讨中枢一氧化氮(NO)与运动疲劳应激的关系,研究NO前体L-精氨酸(L-Arg)对大鼠运动能力和力竭后脑内NO含量的影响。方法:在大鼠侧脑室植入套管,手术恢复后连续4 d分别注射生理盐水或L-Arg,然后用动物跑台建立一次性力竭模型(速度为18 m/min,坡度为5°)。记录运动至力竭的时间并计算运动量(即运动能力),检测血浆、下丘脑和海马中硝酸根/亚硝酸根(NO3-/NO2-,NOx-)含量。结果:与对照组相比,L-Arg组力竭时间延长51.8%(P<0.05),运动量增加50.08%(P<0.05)。力竭运动后L-Arg组下丘脑NOx-含量(8.93±1.83)μmol/gpro明显高于对照组(4.25±0.79)μmol/g pro(P<0.01)。两组之间血浆和海马NOx-浓度均无显著差别。大鼠总的运动量与力竭状态下下丘脑NOx-浓度呈正相关性(P<0.01),而与海马NOx-浓度无相关性。结论:侧脑室注射L-Arg可能通过下丘脑L-Arg—NO信号通路促进中枢NO合成而提高大鼠运动能力,下丘脑可能是中枢NO参与运动能力调节的主要脑区之一。

关键词：一氧化氮 L-精氨酸运动能力下丘脑海马

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A Review on Engineering Transition Metal Compound Catalysts to Accelerate the Redox Kinetics of Sulfur Cathodes for Lithium–Sulfur Batteries

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Nano-Micro Letters 2024年第5期16卷 300-332页

作者： Liping Chen Guiqiang Cao Yong Li Guannan Zu Ruixian Duan Yang Bai Kaiyu xue Yonghong Fu Yunhua Xu juan Wang Xifei Li Shaanxi Key Laboratory of Nanomaterials and Nanotechnology Xi’an University of Architecture and TechnologyXi’an 710055People’s Republic of China Institute of Advanced Electrochemical Energy and School of Materials Science and Engineering Xi’an University of TechnologyXi’an 710048People’s Republic of China Yulin University Yulin 719000People’s Republic of China School of Materials Science and Engineering Fuzhou UniversityFuzhou 350108People’s Republic of China

Engineering transition metal compounds(TMCs)catalysts with excellent adsorption-catalytic ability has been one of the most effec-tive strategies to accelerate the redox kinetics of sulfur ***,this review focuses on engineering TMCs catalysts by cation doping/anion doping/dual doping,bimetallic/bi-anionic TMCs,and TMCs-based heterostructure *** is obvious that introducing cations/anions to TMCs or constructing heterostructure can boost adsorption-catalytic capacity by regulating the electronic structure including energy band,d/p-band center,electron filling,and valence ***,the elec-tronic structure of doped/dual-ionic TMCs are adjusted by inducing ions with different electronegativity,electron filling,and ion radius,resulting in electron redistribution,bonds reconstruction,induced vacancies due to the electronic interaction and changed crystal structure such as lat-tice spacing and lattice *** from the aforementioned two strategies,heterostructures are constructed by two types of TMCs with different Fermi energy levels,which causes built-in electric field and electrons transfer through the interface,and induces electron redistribution and arranged local atoms to regulate the electronic ***,the lacking studies of the three strategies to comprehensively regulate electronic structure for improving catalytic performance are pointed *** is believed that this review can guide the design of advanced TMCs catalysts for boosting redox of lithium sulfur batteries.

关键词： Lithium–sulfur battery Redox kinetic Transition metal compounds catalyst Multiple metals/anions

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临床试验计量重复测量资料的统计

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复旦学报（医学版） 2003年第6期30卷 607-609页

作者：金雪娟葛均波复旦大学附属中山医院心内科上海200032

目的探讨药物临床试验计量重复测量资料统计分析方法的选择。方法通过实例列出各种分析方法并进行比较。结果临床药物研究资料常为重复测量资料,比较治疗组与对照组测量值是否有显著性差别,在统计方法选择策略上一种是对一个代表性... 详细信息

目的探讨药物临床试验计量重复测量资料统计分析方法的选择。方法通过实例列出各种分析方法并进行比较。结果临床药物研究资料常为重复测量资料,比较治疗组与对照组测量值是否有显著性差别,在统计方法选择策略上一种是对一个代表性值进行比较,采用传统的统计方法如两独立样本t检验、方差分析和协方差分析;另一种策略是采用混合效应模型对整个研究过程中所有时点的测量值进行分析。结论两种统计策略均可以采用,但混合效应模型是较好的分析方法。药物临床试验研究资料常是重复测量资料,各时点值之间存在相关性。混合效应模型可以充分利用信息,既可以分析随机效应和相关性,又能处理缺损值。

关键词：临床试验重复测量资料统计方法循证医学降压药物

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Advanced Materials for NH_(3)Capture:Interaction Sites and Transport Pathways

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Nano-Micro Letters 2024年第11期16卷 119-155页

作者： Hai‑Yan Jiang Zao‑Ming Wang xue‑Qi Sun Shao‑juan Zeng Yang‑Yang Guo Lu Bai Ming‑Shui Yao Xiang‑Ping Zhang Key Laboratory of Green Process and Engineering State Key Laboratory of Mesoscience and EngineeringBeijing Key Laboratory of Ionic Liquids Clean ProcessInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190People’s Republic of China School of Future Technology University of Chinese Academy of SciencesBeijing 100049People’s Republic of China China University of Petroleum Beijing 102249People’s Republic of China Institute for Integrated Cell‑Material Sciences(iCeMS) Kyoto UniversitySakyo‑KuYoshidaKyoto 606‑8501Japan

Ammonia(NH3)is a carbon-free,hydrogen-rich chemical related to global food safety,clean energy,and environmental *** an essential technology for meeting the requirements raised by such issues,NH3 capture has been intensively explored by researchers in both fundamental and applied *** four typical methods used are(1)solvent absorption by ionic liquids and their derivatives,(2)adsorption by porous solids,(3)abadsorption by porous liquids,and(4)membrane *** in the development of advanced materials for NH3 capture,we conducted a coherent review of the design of different materials,mainly in the past 5 years,their interactions with NH3 molecules and construction of transport pathways,as well as the structure–property relationship,with specific examples ***,the challenges in current research and future worthwhile directions for NH3 capture materials are proposed.

关键词： Ammonia capture Solvents Porous solids Porous liquids Membranes

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Dietary Lipid Intervention in the Prevention of Brain Aging

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Engineering 2024年第6期37卷 128-137页

作者： Wei Xiong Bing Fang Xiaoyu Wang Ming Zhang Min Du Jiazeng Sun juan Chen Yixuan Li Changhao Sun Xingen Lei xue Zhang Fazheng Ren Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and HealthChina Agricultural UniversityBeijing 100083China Key Laboratory of Functional Dairy Co-Constructed by the Ministry of Education and Beijing MunicipalityCollege of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China School of Food Science and Chemical Engineering Beijing Technology and Business UniversityBeijing 100048China Department of Animal Science Washington State UniversityPullmanWA 99164USA Department of Nutrition and Food Hygiene School of Public HealthHarbin Medical UniversityHarbin 150028China Department of Animal Science Cornell UniversityIthacaNY 14853USA National Health Commission(NHC)and Chinese Academy of Medical Sciences(CAMS)Key Laboratory of Molecular Probe and Targeted Theranostics Harbin Medical UniversityHarbin 150028China

As people live longer,the burden of aging-related brain diseases,especially dementia,is *** aging increases the risk of cognitive impairment,which manifests as a progressive loss of neuron function caused by the impairment of synaptic plasticity via disrupting lipid ***,supplemental dietary lipids have the potential to prevent brain *** review summarizes the important roles of dietary lipids in brain function from both structure and mechanism *** and animal studies have provided evidence of the functions of polyunsaturated fatty acids(PUFAs)in brain *** results of interventions indicate that phospholipids—including phosphatidylcholine,phosphatidylserine,and plasmalogen—are efficient in alleviating cognitive impairment during aging,with plasmalogen exhibiting higher efficacy than *** is a recognized nutrient used in clinical trials due to its special vinyl ether bonds and abundance in the postsynaptic membrane of *** research should determine the dose-dependent effects of plasmalogen in alleviating brain-aging diseases and should develop extraction and storage procedures for its clinical application.

关键词： Brain aging Nutritional intervention Phospholipids Phosphatidylcholine Phosphatidylserine Plasmalogen

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Effects of Lactobacillus paracasei N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis

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World Journal of Gastroenterology 2024年第11期30卷 1556-1571页

作者： Yan-Chao Hu Xiang-Chun Ding Hui-juan Liu Wan-Long Ma xue-Yan Feng Li-Na Ma Department of Infectious Disease General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Infectious Disease Clinical Research Center of Ningxia Yinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Hepatitis B cirrhosis(HBC)is a chronic disease characterized by irreversible diffuse liver damage and aggravated by intestinal microbial imbalance and metabolic *** the relationship between certain single probiotics and HBC has been explored,the impact of the complex ready-to-eat Lactobacillus paracasei N1115(LP N1115)supplement on patients with HBC has not been *** To compare the changes in the microbiota,inflammatory factor levels,and liver function before and after probiotic treatment in HBC *** This study included 160 HBC patients diagnosed at the General Hospital of Ningxia Medical University between October 2018 and December *** were randomly divided into an intervention group that received LP N1115 supplementation and routine treatment and a control group that received routine treatment *** samples were collected at the onset and conclusion of the 12-wk intervention *** structure of the intestinal microbiota and the levels of serological indicators,such as liver function and inflammatory factors,were *** Following LP N1115 intervention,the intestinal microbial diversity significantly increased in the intervention group(P<0.05),and the structure of the intestinal microbiota was characterized by an increase in the proportions of probiotic microbes and a reduction in harmful ***,the intervention group demonstrated notable improvements in liver function indices and significantly lower levels of inflammatory factors(P<0.05).CONCLUSION LP N1115 is a promising treatment for ameliorating intestinal microbial imbalance in HBC patients by modulating the structure of the intestinal microbiota,improving liver function,and reducing inflammatory factor levels.

关键词： Hepatitis B cirrhosis N1115 ready-to-eat lactobacillus Inflammation Liver function Lachnospiraceae incertae sedis Probiotic

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NaHSO3和KMnO4组合可渗透反应栅对苯胺的去除特性

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中国环境科学 2020年第7期40卷 2960-2969页

作者：叶倩王城晨王明新韩莹薛金娟常州大学环境与安全工程学院江苏常州213164 江苏省石油化工安全与环保工程研究中心江苏常州213164

采用亚硫酸氢钠(NaHSO3)强化高锰酸钾(KMnO4)去除苯胺(AN).通过批次处理实验研究了AN去除率与反应条件的关系,分析了KMnO4投加量、NaHSO3投加量、初始pH值和反应时间之间的交互作用;以石蜡为胶结剂分别制备基于NaHSO3和KMnO4的可渗透反... 详细信息

采用亚硫酸氢钠(NaHSO3)强化高锰酸钾(KMnO4)去除苯胺(AN).通过批次处理实验研究了AN去除率与反应条件的关系,分析了KMnO4投加量、NaHSO3投加量、初始pH值和反应时间之间的交互作用;以石蜡为胶结剂分别制备基于NaHSO3和KMnO4的可渗透反应栅(PRB),对模拟AN污染地下水进行连续处理,研究不同PRB的释放规律和组合PRB对AN的去除特性.结果表明,NaHSO3可显著强化KMnO4对AN的降解速率,当AN初始浓度为5mg/L,NaHSO3/KMnO4/AN为5/5/1时,AN去除率达99.2%,高于单独KMnO4处理的85.6%.AN去除率与KMnO4投加量、NaHSO3投加量和反应时间线性正相关,与溶液初始pH值线性负相关.采用二次多项式和逐步回归法拟合了AN去除率与反应条件间的关系,模拟值与验证实验结果相近,模型精度较好.PRB中NaHSO3溶出速率显著大于KMnO4.当Na HSO3和KMnO4混合的可渗透反应栅(SB/PM-PRB)质量为5g,进水流速和AN浓度分别为0.1m L/min和10mg/L时,168h内AN的去除率保持在99%以上,且克服了KMnO4单独处理出水色度过高的问题.傅里叶变换红外光谱分析表明,反应前后PRB成分没有显著变化,PRB稳定性较好.紫外光谱扫描结果表明,AN和苯环特征峰强度均显著下降,表明SB/PM-PRB能使AN开环降解和破坏氨基结构.

关键词：高锰酸钾亚硫酸氢钠响应面法可渗透反应栅

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Ultra-high-rate Bi anode encapsulated in 3D lignin-derived carbon framework for sodium-ion hybrid capacitors

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Rare Metals 2024年第3期43卷 1037-1047页

作者： Ze-Hua Lin xue-Qing Qiu Xi-Hong Zu Xiao-Shan Zhang Lei Zhong Shi-Rong Sun Shu-Hua Hao Ying-juan Sun Wen-Li Zhang School of Chemical Engineering and Light Industry Guangdong University of Technology(GDUT)Guangzhou510006China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang515200China School of Advanced Manufacturing Institute of Green Chemistry and Advanced MaterialsGuangdong University of TechnologyJieyang515200China

Bismuth(Bi),as an alloy-based anode material,has attracted much atte ntion in the developme nt of sodiumion hybrid capacitors(SIHCs)due to its high theoretical ***,the volume expansion of the Bi-based anode during the sodiation/desodiation process results in limited rate *** the present work,a porous Bi-based composite was constructed by a one-step hydrothermal method,and Bi was encapsulated in ligninderived nitrogen-doped porous carbon(Bi@LNPC)after *** obtained Bi nanoparticles could effectively adapt to the strain and shorten the diffusion distance of Na^(+).In addition,porous carbon skeleton provides a rigid conductive network for electronic ***,the assembled sodium-ion half-cell with Bi@LNPC anode shows ultra-high-rate *** the current density was enhanced from 0.1 to 50 A·g^(-1),the specific capacity decreased slightly from 351.5 to 342.8 mAh·g^(-1).Even at an extremely high current density of 200 A·g^(-1),it retains 81.3%capacity retention when compared to a current density of 1 A·g^(-1).The SIHCs assembled by Bi@LNPC show a high energy density of 63 Wh·kg^(-1).This work provides an effective method for developing high-rate Bi anode materials for sodium-ion hybrid capacitors(SIHCs)and sodium-ion batteries(SIBs).

关键词： Bismuth Lignin Sodium-ion batteries Sodium-ion hybrid capacitors Rate Porous carbon

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