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远端脊髓节段星形胶质细胞活化介导神经损伤诱发的播散性疼痛

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解剖学报 2024年第2期55卷 167-173页

作者：金思璇于宁孙丰润马超中国医学科学院基础医学研究所北京协和医学院基础学院人体解剖学与组织学胚胎学系北京100005 重大疾病共性机制研究全国重点实验室北京100005

目的探讨中枢神经系统中远端脊髓节段胶质细胞活化与播散性疼痛的关系。方法50只雌性大鼠随机分为假手术(sham)组、眶下神经慢性压迫性损伤(CCI-ION)组、CCI-ION+米诺环素(Mino)组、CCI-ION+L-2-氨基己二酸(LAA)组和CCI-ION+生理盐水(NS... 详细信息

目的探讨中枢神经系统中远端脊髓节段胶质细胞活化与播散性疼痛的关系。方法50只雌性大鼠随机分为假手术(sham)组、眶下神经慢性压迫性损伤(CCI-ION)组、CCI-ION+米诺环素(Mino)组、CCI-ION+L-2-氨基己二酸(LAA)组和CCI-ION+生理盐水(NS)组,每组n=10。建立CCI-ION模型,鞘内注射Mino、LAA和生理盐水,利用免疫荧光染色分别检测延髓、颈段、胸段、腰段脊髓节段中活化的星形胶质细胞标记物自身免疫性胶质纤维酸性蛋白(GFAP)和小胶质细胞标记物离子钙结合衔接分子1(IBA1);在第7、14、21、28天,使用von Frey纤维丝评估大鼠触须垫机械痛阈值,并采用电子von Frey仪测量大鼠前足、胸部及后足机械痛阈值,用辐射热痛刺激仪测量大鼠后足热痛阈值。结果结果显示,鞘内注射Mino抑制小胶质细胞后,各脊髓节段活化的小胶质细胞减少,鞘内注射LAA抑制星形胶质细胞后,各脊髓节段活化的星形胶质细胞减少,且注射Mino和LAA后,模型组大鼠触须垫机械痛阈升高,损伤部位的神经病理性疼痛缓解。鞘内注射Mino后,模型组大鼠后足热痛阈和机械痛阈未发现明显变化;鞘内注射LAA后,后足热痛阈和机械痛阈显著升高,播散性疼痛缓解。结论远端脊髓节段星形胶质细胞活化介导外周神经损伤诱发的播散性疼痛。

关键词：慢性痛播散性疼痛小胶质细胞星形胶质细胞免疫荧光大鼠

判别两个或两个以上深能级是否属于同一中心的方法

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物理学报 1989年第9期38卷 1391-1399页

作者：陈开茅金泗轩武蓝青谭雪清北京大学物理系

本文分别研究了两个或两个以上深能级之间的耦合和非耦合两种情况所对应的光电容瞬态,根据这两种瞬态的本质差别,提出一个判别两个或两个以上深能级是否属于同一深中心的方法。它具有适用于两个以上的多个深能级的样品以及方法简单和测... 详细信息

本文分别研究了两个或两个以上深能级之间的耦合和非耦合两种情况所对应的光电容瞬态,根据这两种瞬态的本质差别,提出一个判别两个或两个以上深能级是否属于同一深中心的方法。它具有适用于两个以上的多个深能级的样品以及方法简单和测量时间短等优点。作为例子,将它应用于判别硅中和金有关的施主和受主两能级,结果证实它们确实是属于和金有关的同一中心,而不是分属于两个中心。

关键词：半导体深能级光电容瞬态

蓝光LED InGaN有源区的制备及其发光特性研究

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光电子．激光 2000年第2期11卷 117-119页

作者：童玉珍李非杨志坚金泗轩丁晓民张国义北京大学物理系

本文报导了运用 L P- MOCVD制备蓝光 L ED In Ga N有源区的最近进展 ,以及高温生长技术带来的优越性。通过对 Zn掺杂 In Ga N薄膜发光特性的分析 ,发现其光致荧光 (PL )谱中 ,与 Zn掺杂有关的发光峰的强度受该生长温度下 Zn在 In Ga N... 详细信息

本文报导了运用 L P- MOCVD制备蓝光 L ED In Ga N有源区的最近进展 ,以及高温生长技术带来的优越性。通过对 Zn掺杂 In Ga N薄膜发光特性的分析 ,发现其光致荧光 (PL )谱中 ,与 Zn掺杂有关的发光峰的强度受该生长温度下 Zn在 In Ga N中的溶解度的限制。利用我们的实验方法 ,使得 In Ga N有源区的发光波长在蓝光区内可任意调节 ,并给出了得到的几个典型的荧光谱。

关键词： InGaN有源区发光性质发光二极管蓝光

Enhanced solid-electrolyte interface efficiency for practically viable hydrogen-air fuel cell systems

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Journal of Energy Chemistry 2025年第1期100卷 356-368页

作者： Venkitesan Sakthivel Dong jin Yoo Graduate School Department of Energy Storage/Conversion Engineering (BK21 FOUR) Hydrogen and Fuel Cell Research Center Jeonbuk National University Jeonju Department of Life Science Jeonbuk National University

Proton exchange membrane fuel cells （PEMFCs） provide an appealing sustainable energy system,with the solid-electrolyte membrane playing a crucial role in its overall ***,sulfonated poly（1,4-phenylene ether-ether sulfone）(SPEES),an aromatic hydrocarbon polymer,has garnered considerable attention as an alternative to Nafion ***,the long-term durability and stability of SPEES present a significant *** this context,we introduce a potential solution in the form of an additive,specifically a core–shell-based amine-functionalized iron titanate （A–Fe2TiO5）,which holds promise for improving the lifetime,proton conductivity,and power density of SPEES in *** modified SPEES/A–Fe2TiO5composite membranes exhibited notable characteristics,including high water uptake,enhanced thermomechanical stability,and oxidative ***,the SPEES membrane loaded with 1.2 wt%of A–Fe2TiO5demonstrates a maximum proton conductivity of 155 mS cm-1,a twofold increase compared to the SPEES membrane,at 80°C under 100%relative humidity （RH）.Furthermore,the 1.2 wt%of A–Fe2TiO5/SPEES composite membranes exhibited a maximum power density of 397.37 mW cm-2and a current density of 1148 mA cm-2at 60°C under 100%RH,with an opencircuit voltage decay of 0.05 m V/h during 103 h of continuous *** study offers significant insights into the development and understanding of innovative SPEES nanocomposite membranes for PEMFC applications.

关键词： Acid-base Hybrid membrane Proton conductivity Polymer electrolyte fuel cell single-cell performance

Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 192-201页

作者： Shuai Li Zhen Ma jin-Hua Gao School of Science Hebei University of Science and Technology School of Electronics and Information Zhengzhou University of Light Industry School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and Technology

We theoretically investigate the spin resolved Friedel oscillation （FO） and quasiparticle interference （QPI） in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r-2in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as *** spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment (***ález-Herrero et al.,Science 352,437 （2016）).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states （FT-LDOS）.Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

消除载流子分布的不均匀性的影响准确测量深中心俘获载流子的截面

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物理学报 1984年第4期 486-495页

作者：陈开茅秦国刚王忠安金泗轩北京大学物理系

Zylbersztejn指出在空间电荷区边界层中,由于势垒的存在而引起的载流子分布的不均匀性,对测量深中心对载流子的俘获截面的不良影响,并且提出一种消除这种影响的方法。可惜的是,他的方法只适用于在能级相当深的情况下,测量低温时载流子... 详细信息

Zylbersztejn指出在空间电荷区边界层中,由于势垒的存在而引起的载流子分布的不均匀性,对测量深中心对载流子的俘获截面的不良影响,并且提出一种消除这种影响的方法。可惜的是,他的方法只适用于在能级相当深的情况下,测量低温时载流子的俘获截面。本文在详细分析结电容瞬态动力过程的基础上,提出一种消除载流子分布不均匀(包括边界层中载流子分布不均匀和体内浅施主或浅受主浓度不均匀)的影响,准确测量俘获截面的方法,不受测量温度及样品中的能级情况的严重限制。这对于研究俘获截面与温度的关系以及进而研究俘获动力学机制是很关键的。以硅中的金受主中心为例,应用这种方法进行了测量,结果表明,消除载流子不均匀分布的影响后,确实提高了测量俘获截面的准确性。

关键词：俘获截面费密能深能级电子能态载流子分布空间电荷区不均匀性准确测量

Fibrinogen’s potential role in connecting cerebrovascular abnormalities with glymphatic dysfunction in Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 203-204页

作者： Vishal singh Arnab Choudhury Hyung jin Ahn Department of Pharmacology Physiology and NeurosciencesRutgers-New Jersey Medical SchoolNewarkNJUSA Brain Health Institute Rutgers UniversityPiscatawayNJUSA

Alzheimer’s disease(AD)stands out as the primary manifestation of age-related dementia,portraying a chronic neurodegenerative disorder distinguished by the accumulation of fibrillar amyloid-β(Aβ)plaques and neurofibrillary tangles of hyperphosphorylated ***,from a clinical standpoint,AD presents itself as a complex condition with a spectrum of dysfunctions rather than a singular pathological *** often-overlooked aspect of the disease is the presence of extensive cerebrovascular abnormalities,given that the majority of AD patients experience altered cerebral blood flow,damaged vasculature,increased microinfarcts and *** models of AD further support this observation,showing cerebrovascular dysfunction such as impaired cerebral blood flow and altered cerebrovascular reactivity(Tataryn et al.,2021;Gareau et al.,2023).

关键词： cerebrovascular dysfunction Alzheimer

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo jin Cho Xuelian jin Byung Gon Kim Jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

注氮GaAs中的深能级及其对自由载流子的补偿

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物理学报 1996年第3期45卷 491-498页

作者：陈开茅金泗轩贾勇强邱素娟吕云安何梅芬刘鸿飞北京大学物理系北京100871 电子工业部13所石家庄050051 北京有色金属研究总院北京100088

详细研究了注氮n型GaAs中深的和浅的杂质缺陷的电学性质。深能级瞬态谱(DLTS)技术测量表明,能量为140keV和剂量为1×10^(13)cm^(-2)的氮离子注入并经800℃退火30min的GaAs中存在四个电子陷阱,E_1(0.111),E_2(0.234),E_3(0.415),E_4(0.669)和一个空穴陷阱H(0.545),而在能量为20keV和剂量为5×10^(14)cm^(-2)的氮离子注入并经同样退火的同种GaAs中,只观测到E_4和H(0.545)两种缺陷,E_2和E_3是高能量注入损伤缺陷,E_4可能是本征缺陷和注入损伤的络合物,H(0.545)是与氮有关的深能级,它可能与掺氮n型GaAs中的自由载流子受到严重补偿有关。

关键词：砷化镓注氮深能级载流子