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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue jin Yusong Yuan Bo Ma Wenyong Xie na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina national Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

数学英语的主要特点与数学符号表征——兼谈数学话语语料库研制的基本内容

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外语电化教学 2019年第3期 28-35页

作者：金娜娜彭宣维深圳大学

针对学术英语及其符号表征的教学改革瓶颈问题,本研究从数学英语的语法特点、词汇特点、基本的数学符号以及数学表达式与英语表征的对应关系四个方面,讨论了我国高校数学英语教育教学需要关注的基本语言与符号问题,以期明确数学英语的... 详细信息

针对学术英语及其符号表征的教学改革瓶颈问题,本研究从数学英语的语法特点、词汇特点、基本的数学符号以及数学表达式与英语表征的对应关系四个方面,讨论了我国高校数学英语教育教学需要关注的基本语言与符号问题,以期明确数学英语的特点以及与其他学科英语的共性,为英语教师提供教改内容与教学资源,也为其他相关学科提供数学英语的表述基础。

关键词：数学英语词汇语法数学符号语料库

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动词的评价功能

外语研究 2009年第4期26卷 39-43页

作者：金娜娜深圳大学外国语学院广东深圳518060

语篇中评价意义无处不在,评价手段多种多样。具有显性评价意义的一些词类如形容词、副词等已为人们所熟知,本文着重探讨隐性评价词类——动词。动词的语法多样性特征是语篇分析中不可忽视的部分。本文提出了考察动词评价意义的三个切入... 详细信息

语篇中评价意义无处不在,评价手段多种多样。具有显性评价意义的一些词类如形容词、副词等已为人们所熟知,本文着重探讨隐性评价词类——动词。动词的语法多样性特征是语篇分析中不可忽视的部分。本文提出了考察动词评价意义的三个切入点:态度性动词、投射动词和近义动词中的低频词,并通过对学术类、广告类和说明简介类语篇中动词表达评价意义的观测、统计和分析得出结论:(1)动词是一种特别的评价性手段,具有隐性评价功能;(2)科技学术类语篇依赖动词表达评价意义的倾向强过它类语篇。

关键词：动词评价意义语篇分析

Boosting Oxygen Evolution Reaction Performance on NiFe‑Based Catalysts Through d‑Orbital Hybridization

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nano-Micro Letters 2025年第1期17卷 281-292页

作者： Xing Wang Wei Pi Sheng Hu Haifeng Bao na Yao Wei Luo State Key Laboratory of New Textile Materials and Advanced Processing Technology Key Laboratory of New Textile Materials and Applications of Hubei ProvinceSchool of Materials Science and EngineeringWuhan Textile UniversityWuhan 430200People’s Republic of China College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072People’s Republic of China

Anion-exchange membrane water electrolyzers(AEMWEs)for green hydrogen production have received intensive attention due to their feasibility of using earth-abundant NiFe-based *** introducing a third metal into NiFe-based catalysts to construct asymmetrical M-NiFe units,the d-orbital and electronic structures can be adjusted,which is an important strategy to achieve sufficient oxygen evolution reaction(OER)performance in ***,the ternary NiFeM(M:La,Mo)catalysts featured with distinct M-NiFe units and varying d-orbitals are reported in this *** and theoretical calculation results reveal that the doping of La leads to optimized hybridization between d orbital in NiFeM and 2p in oxygen,resulting in enhanced adsorption strength of oxygen intermediates,and reduced rate-determining step energy barrier,which is responsible for the enhanced OER *** critically,the obtained NiFeLa catalyst only requires 1.58 V to reach 1 A cm^(−2) in an anion exchange membrane electrolyzer and demonstrates excellent long-term stability of up to 600 h.

关键词： NiFe-based catalysts d-orbital coupling Oxygen evolution reaction Anion exchange membrane electrolyzer

[Progress in applications of ambient ionization mass spectrometry for lipids identification]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 22-32页

作者： Xiao-Rong Wang Yi-Yan Yin jin Ouyang na na Key Laboratory of Radiopharmaceuticals Ministry of Education College of Chemistry Beijing Normal University Beijing 100875 China. Department of Chemistry College of Arts and Sciences Beijing Normal University Zhuhai 519087 China.

Lipids are indispensable components of living organisms and play pivotal roles in cell-membrane fluidity, energy provision, and neurotransmitter transmission and transport. Lipids can act as potential biomarkers of diseases given their abilities to indicate cell-growth status. For example, the lipid-metabolism processes of cancer cells are distinct from those of normal cells owing to their rapid proliferation and adaptation to ever-changing biological environments. As a result, the ability to rapidly detect, identify, and monitor lipid components is critical for tracking life-related processes and may enhance cancer diagnosis and treatment efficacy. Mass spectrometry (MS) is regarded to be among the most efficient methods for directly obtaining molecular-structural information, and is distinctly advantageous for identifying lipids. Recent years have witnessed the emergence of ambient mass spectrometry (AMS), which enables direct analyte sampling and ionization without the need for sample preprocessing. These characteristics endow AMS with special advantages for identifying and monitoring lipids. Furthermore, the ongoing development of soft ionization technologies has led to the widespread use of AMS for the detection of complex and diverse lipid molecules. Electrospray ionization (ESI) is a gentle ionization method that can be used to detect medium-to-high-polarity compounds and provide detailed chemical information for lipids by producing a fine mist of charged droplets from a liquid sample. Consequently, a series of ESI-based ionization methods have been developed for fabricating different AMS systems capable of rapidly detecting lipids in a simple manner. For example, desorption electrospray ionization (DESI) is among the most extensively employed ambient ionization techniques, and has been used to detect a wide range of samples, including solids, liquids, and gases. DESI involves spraying a charged solvent onto the surface of a sample, after which the solvent is

关键词： ambient mass spectrometry (AMS) ionization techniques lipid lipid fine structure tandem mass spectrometry (MS/MS)

Prion-Like Activity of Pathological Tau Species Derived from Alzheimer's Brain

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神经药理学报 2019年第Z1期 34-35页

作者： LIU Fei LI Long-fei ZHOU Yan GU Jian-lan MIAO jin SHI Rui-rui jin na-na CHU Dan-dan TUNG Yunn Chyn HU Wen GONG Cheng-Xin Khalid Iqbal Department of Neurochemistry Inge Grundke-Iqbal Research FloorNew York State Institute for Basic Research in Developmental Disabilities Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education of China Co-innovation Center of Neuroregeneration

Background:Neurofibrillary tangles(NFTs),the insoluble and fibrillar intraneuronal accumulations of hyperphosphorylated tau protein,are a defining histopathological hallmark of the Alzheimer’s disease(AD) brain. NFTs initiate in subcortical regions,transentorhinal area,and entorhinal cortex,then appear in the hippocampal formation and some parts of the neocortex,followed by most of the neocortex. The distribution of tau pathology correlates with the progression of AD. Injection of misfolded tau aggregates derived from AD and transgenic mouse brains or generated in vitro induces tau pathology not only at the injection sites,but also in the anatomically connected brain regions in a time-dependent manner,introducing the concept of "prion-like propagation of tau pathology". The prion-like activity of the pathological tau species and the role of tau hyperphosphorylation in seeding and propagation of tau pathology are currently under debate. Methods:To determine the prion-like activity of pathological tau species in AD brain,we isolated different pathological tau species,soluble tau(S-tau),heat-stable soluble tau(HS-tau),oligomeric tau(O-tau),sarkosyl insoluble tau 1(SI1-tau),and sarkosyl insoluble tau 2(SI2-tau),from AD brains,analyzed their truncation and phosphorylation by Western blots and determined their prion-like activity by capturing normal tau in vitro and seeding tau aggregation in cultured cells,and inducing tau pathology in vivo. Results:We found that these tau species isolated from AD brain showed differences in truncation,site-specific phosphorylation,and SDSand reducing agent-resistant high molecular weight aggregation. S-tau,AD O-tau and SI1-tau,but not HS-tau and SI2-tau,captured tau151-391 from cell lysates and induced tau aggregation in cultured cells. AD O-tau showed the highest prion-like activity. Dephosphorylation of AD O-tau ameliorated its prion-like activity to capture tau in vitro,to seed tau aggregation in cultured cells and to induce tau path

关键词： tau Alzheimer Prion-Like Activity of Pathological Tau Species Derived from Alzheimer’s Brain Tau Activity

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol na J.Jay Liu Young-Ju Kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Carbon capture and utilization

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基于谐波小波分析的矿井提升机故障诊断

煤炭技术 2015年第2期34卷 263-265页

作者：孙玉峰郑晟晋娜娜太原理工大学信息工程学院太原030024 山西燃气规划设计研究院太原030024

矿井提升机早期检测的核心技术就是故障检测,而故障引发的动态信号往往具有非平稳性且比较微弱。谐波小波具有很强的微弱信号提取能力,而且在频域具有"盒形"紧支特性和完美的滤波特性等优势,提出了基于谐波小波分析的故障检测方法。首... 详细信息

矿井提升机早期检测的核心技术就是故障检测,而故障引发的动态信号往往具有非平稳性且比较微弱。谐波小波具有很强的微弱信号提取能力,而且在频域具有"盒形"紧支特性和完美的滤波特性等优势,提出了基于谐波小波分析的故障检测方法。首先提取了信号的时域、频域图,由于频域分辨率差,辨识度不高,于是采用db5小波和谐波小波分别对信号频域进行3层分解,结果证明谐波小波有更好的故障诊断效果。

关键词：矿井提升机微弱信号故障诊断

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探究电气化铁道供电系统新技术的发展

中小企业管理与科技 2021年第6期5卷 168-169页

作者：靳娜娜洛阳铁路信息工程学校河南洛阳471000

伴随着我国经济的快速增长以及科学技术的持续提升,电气化铁路供电系统在发展中也获得了新技术以及新突破。同样,科学技术的发展也为人们带来了很大的便利,同时也为运输业带来了较多的机遇以及巨大的挑战。人们在旅行当中对交通的选择... 详细信息

伴随着我国经济的快速增长以及科学技术的持续提升,电气化铁路供电系统在发展中也获得了新技术以及新突破。同样,科学技术的发展也为人们带来了很大的便利,同时也为运输业带来了较多的机遇以及巨大的挑战。人们在旅行当中对交通的选择呈现出多样化的趋势,他们非常重视交通的安全性以及舒适性。通常情况下,首选的铁路运输属于运输系统当中非常重要的运输方式。在铁路运输当中,供电系统占据非常重要的地位。论文主要简单地介绍电气铁道供电系统新技术的发展情况,希望可以给大家带去一些启发。

关键词：电气化铁道新技术

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营养支持在胃肠肿瘤患者中的应用进展

现代诊断与治疗 2020年第8期31卷 1200-1202页

作者：金娜娜海滨人民医院临床营养科天津300280

胃肠肿瘤主要包括胃癌、食管癌、胰腺癌、结直肠癌等,当前我国胃肠肿瘤的发生率较高,且患病人数呈现连年增长的趋势。胃肠肿瘤是一种消耗性的疾病,患者机体的应激状态和肿瘤组织的不断增殖会消耗自身的营养,且肿瘤组织会消耗比正常组织... 详细信息

胃肠肿瘤主要包括胃癌、食管癌、胰腺癌、结直肠癌等,当前我国胃肠肿瘤的发生率较高,且患病人数呈现连年增长的趋势。胃肠肿瘤是一种消耗性的疾病,患者机体的应激状态和肿瘤组织的不断增殖会消耗自身的营养,且肿瘤组织会消耗比正常组织更多的葡萄糖。同时在手术及化疗后,众多因素会影响患者的进食,营养摄入不足,导致患者存在不同程度的营养不良问题,需进行营养支持。基于此,本研究对营养支持在胃肠肿瘤患者中的应用进展进行综述。

关键词：胃肠肿瘤营养支持肠内营养肠外营养