检索结果-南通市图书馆

Chinese Medical Journal 2012年第17期125卷 3069-3073页

作者： XIE Wan-mu DAI Hua-ping jin mu-lan WANG Zhen YANG Yuan-hua ZHAI Zhen-guo WANG Chen Department of Respiratory and Critical Care Medicine Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Department of Pathology Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Bei)ing Key Laboratory of Respiratory and Pulmonary Circulation Beijing Institute of Respiratory MedicineBeijing 100020China Beijing Hospital of Ministry of Health Beijing 1007-30China

Background Pulmonary capillary hemangiomatosis （PCH） is a rare disease and no Chinese case has been reported yet. The disease is often misdiagnosed and its clinical characteristics are incompletely described. The aim of this study was to describe two Chinese cases and to clarify the clinical and radiographic parameters of patients with PCH. Methods Two PCH cases were presented and other cases were searched from the English literature. All available clinical and radiographic data were collected from 62 literature reported PCH cases. A pooled analysis of total 64 cases was made. Results Dyspnea and hemoptysis were the most common clinical symptoms of PCH. Pulmonary hypertension （PH） was found in 78% of the reported cases. PCH typically showed characteristic diffuse or patchy ground-glass opacities （GGOs） and/or multiple ill-defined centrilobular nodules in the computed tomography. Conclusions The diagnosis of PCH requires a high clinical suspicion. However, both clinical presentations and radiographic studies often provide clues to the diagnosis, which may prompt early lung biopsy for a definite diagnosis.

关键词： pulmonary capillary hemangiomatosis pulmonary hypertension lung biopsy

Characteristics of pulmonary inflammation in combined pulmonary fibrosis and emphysema

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2012年第17期125卷 3015-3021页

作者： ZHAO Ying CUI Ai WANG Feng WANG Xiao-juan CHEN Xing jin mu-lan HUANG Ke-wu Division of Pulmonary and Critical Care Medicine Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China Basic Medical Research Center Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China Department of Pathology Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China Beijing Institute of Respiratory Medicine Beijing 100020 China Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders Beijing 100020 China

Background The condition of concomitant upper lobe emphysema and lower lobe fibrosis as identified by computer tomography is known as combined pulmonary fibrosis and emphysema （CPFE）. CPFE has distinct clinical characteristics compared with emphysema alone （EA） and idiopathic pulmonary fibrosis （IPF） without emphysema. However, the pulmonary inflammation characteristics of CPFE are not well known, and the differences between CPFE and the other two diseases with regards to pulmonary inflammation need to be explored. The pulmonary inflammatory characteristics were investigated in CPFE patients and compared with EA and IPF. Methods Fraction exhaled nitric oxide （Fe,NO） and differential cell counts, the concentrations of monokine induced by interferon gamma （MIG/CXCL9）, interferon-inducible protein 10 （IP-10/CXCL10）, and interferon-inducible T cell alpha chemoattractant （I-TAC/CXCL11） were measured in induced sputum obtained from subjects with CPFE （n=22）, EA （n=22）, IPF （n=14）, and healthy volunteers （HV, n=12）. In addition, immunohistochemistry was used to quantify the expression of nitric oxide synthases in alveolar macrophages in 23 lung tissues from patients and control subjects. Results The CPFE group had higher alveolar NO than subjects in the EA and HV groups （P=0.009, P=-0.001, respectively） but not than the IPF group （P 〉0.05）. Numbers of sputum eosinophils were significantly elevated in CPFE and IPF groups compared with the HV group （P=-0.001, P=-0.008）. In contrast, eosinophil counts in EA group did not differ from those in the HV group. Compared with the EA and HV groups, the CPFE group had a lower concentration of I-TAC/CXCL11 in sputum supernatants （P=0.003, P=0.004）. Immunoreactivity for inducible nitric oxide synthase （iNOS） was higher in the CPFE group than in the EA group （P=-0.018, P=0.006, respectively）. Conclusions The pulmonary inflammation of CPFE group is more similar to IPF group, while the distal airway inflammation is more significant in CPFE and IPF groups than in EA group. Lung eosinophi

关键词： pulmonary fibrosis emphysema airway inflammation exhaled nitric oxide

Management of gastric cancer in patients with sinistral portal hypertension

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2013年第2期126卷 387-388页

作者： DING Xue-mei jin mu-lan ZHOU Yi-ming ZHANG Chuan GAO Jun SUN Wen-bing Department of Hepatobiliary Surgery Beijing Chaoyang Hospital Affiliated to CapitalMedical University Beijing 100043 China Department of Pathology Beijing Chaoyang Hospital Affiliated to CapitalMedical University Beijing 100043 China Department ofInterventional Radiology Beijing Chaoyang Hospital Affiliated to CapitalMedical University Beijing 100043 China Department of DigestionBeijing Chaoyang Hospital Affiliated to CapitalMedical University Beijing 100043 China

Sinistral portal hypertension （SPH） is usually caused by pancreatic pathology and is characterized bysplenic vein thrombosis with or without portal vein thrombosis.1 The increased pressure caused by splenic vein occlusion is transmitted via the short gastric and gastroepiploic veins to the portal system. The reversal of blood flow in the left gastric vein results in gastric varices. In patiems with SPH, especially those with occlusion of both the splenic and portal veins, the main or even the only pathway of splenic venous return to the portal vein is via the gastric varices, and these patiems require special management during gastric surgery.

关键词： gastric cancer sinistral portal hypertension management

Semi-rigid thoracoscopy for undiagnosed exudative pleural effusions： a comparative study

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2008年第15期121卷 1384-1389页

作者： WANG Zhen TONG Zhao-hui LI Hong-jie ZHAO Ting-ting LI Xu-yan XU Li-li LUO jing jin mu-lan LI Rui-sheng WANG Chen Department of Respiratory Diseases Beijing Chaoyang Hospital Beijing Institute of Respiratory Diseases Capital Medical University Beijing 100020 China Department of Pathology Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China

Background Thoracoscopy is highly sensitive and accurate for detecting pleural effusions. However, most respiratory physicians are not familiar with the use of the more common rigid thoracoscope or the flexible bronchoscope, which is difficult to manipulate within the pleural cavity. The semi-rigid thoracoscope combines the best features of the flexible and rigid instruments. Since the practice with this instrument is limited in China, the diagnostic utility of semi-rigid thoracoscopy （namely medical thoracoscopy） under local anesthesia for undiagnosed exudative pleural effusions was evaluated . Methods In 50 patients with undiagnosed pleural effusions who were studied retrospectively, 23 received routine examinations between July 2004 and June 2005 and the rest 27 patients underwent medical thoracoscopy during July 2005 and June 2006. Routine examinations of the pleural effusions involved biochemistry and cytology, sputum cytology, and thoracentesis. The difference in diagnostic sensitivity, costs related to pleural fluid examination and complications were compared directly between the two groups. Results Medical thoracoscopy revealed tuberculous pleurisy in 6 patients, adenocarcinoma in 7, squamous-cell carcinoma in 2, metastatic carcinoma in 3, mesothelioma in 2, non-Hodgkin＇s lymphoma in 1, and others in 4. Only 2 patients could not get definite diagnoses. Diagnostic efficiency of medical thoracoscopy was 93% （25/27）. Only 21% patients were diagnosed after routine examinations, including parapneumonic effusion in 2 patients, lung cancer in 2 and undetermined metastatic malignancy in 1. Twelve patients with tuberculous pleurisy were suspected by routine examination. Costs related to pleural effusion testing showed no difference between the two groups （P=0.114）. Twenty-three patients in the routine examination group underwent 97 times of thoracentesis. Two pleural infection patients and 2 pneumothorax patients were identified and received antibiotic treatment and drainage. Medical thoracoscopy could be well tol

关键词： medical thoracoscopy pleural effusion semirigid thoracoscope diagnosis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

腹膜播散性平滑肌瘤病6例临床病理分析

诊断病理学杂志 2024年第4期31卷 291-295页

作者：曾贝贝金木兰谢燕陈红首都医科大学附属北京朝阳医院石景山院区病理科

目的通过分析临床病理特征，提高对腹膜播散性平滑肌瘤病(LPD)的认识，为临床诊治提供帮助。方法本文回顾性分析本院术后病理确诊的6例LPD患者，结合文献复习其临床特征及病理组织学等特点。结果患者均有子宫肌瘤切除既往史，且本次... 详细信息

目的通过分析临床病理特征，提高对腹膜播散性平滑肌瘤病(LPD)的认识，为临床诊治提供帮助。方法本文回顾性分析本院术后病理确诊的6例LPD患者，结合文献复习其临床特征及病理组织学等特点。结果患者均有子宫肌瘤切除既往史，且本次术后病理均符合腹膜播散性平滑肌瘤病。免疫组化结果：SMA、H-caldesmon均为阳性；ER和PR为弥漫阳性；Ki-67指数平均为4%(值域：1%～8%)。结论 LPD的确诊需结合临床及病理特征，提示临床工作中应尽量减少因医源性因素导致LPD发生的可能，且对于术后病理亚型为富于细胞型的子宫平滑肌瘤应加强随访。

关键词：腹膜播散性平滑肌瘤病平滑肌瘤腹膜肿瘤子宫肿瘤平滑肌瘤病

A case of metastatic scalp angiosarcoma presenting as multiple thin-walled lung cysts and pneumothorax

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2013年第21期126卷 4197-4197页

作者： Xu, Li-li Dai, Hua-ping Chen, Wen-hui jin, mu-lan Zhang, Yu-hui Capital Med Univ Beijing Chao Yang Hosp Beijing Inst Resp Med Beijing 100020 Peoples R China Capital Med Univ Beijing Chao Yang Hosp Beijing Key Lab Resp & Pulm Circulat Disorders Beijing 100020 Peoples R China Capital Med Univ Beijing Chao Yang Hosp Dept Resp Med Beijing 100020 Peoples R China Capital Med Univ Beijing Chao Yang Hosp Dept Pathol Beijing 100020 Peoples R China

To the editor： We read with a great interest the article by Olsen et al.） They described a good case of metastatic scalp angiosarcoma with rapidly enlarging lung cysts and pleural effusion. Scalp angiosarcoma is rare and has a predilection for pulmonary metastases,z~ The metastases on chest radiographs are initially subtle and easily missed. We report a patient who presented with multiple thin-walled lung cysts and pneumothorax, and was delayed in the diagnosis for more than three months.

关键词： metastatic scal multiple thin-walled lung cysts pneumothorax

Blood Oxygenation Level-dependent Magnetic Resonance Imaging of Breast Cancer： Correlation with Carbonic Anhydrase IX and Vascular Endothelial Growth Factor

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2017年第1期130卷 71-76页

作者： YingWang Min Liu mu-lan jin Department of Pathology Beijing Chaoyang Hospital of Capital Medical University Beijing 100020 China Department of Radiology China-Japan Friendship Hospital Beijing 100029 China

Background： Blood oxygenation level-dependent magnetic resonance imaging （BOLD-MRI） is a functional MRI technique which involves using the paramagnetic properties of deoxyhemoglobin to image the local tissue oxygen concentration. The purpose of this study was to investigate whether BOLD-MRI could evaluate hypoxia and angiogenesis of breast invasive ductal carcinoma （IDC）. Methods： Ninety-eight female patients with IDC were retrospectively included in this research. All patients underwent breast BOLD-MRI at 3.0 T before surgery. R2＊ values of BOLD-MR1 were measured. The expression of carbonic anhydrase IX （CA IX） and vascular endothelial growth factor （VEGF） was analyzed by immunohistochemistry. Spearman＇s correlation analysis was used to correlate R2＊ value with CA IX and VEGF levels. Results： Heterogeneous intensity on BOLD-MRI images was the main finding of IDCs. The mean R2＊ value was 52.8 ± 18.6 Hz. The R2＊ values in patients with axillary lymph node metastasis were significantly higher than the R2＊ values in patients without axillary lymph node metastasis （t = 2.882, P = 0.005）. R2＊ values increased with CA IX level and positively correlated with the level of CA 1X （r = 0.616, P 〈 0.001）; however, R2＊ value had no significantly correlation with the level of VEGF （r = 0.110, P = 0.281）. Conclusion： B OLD-MRI could noninvasively evaluate chronic hypoxia of IDC, but not angiogenesis.

关键词： Angiogenesis Blood Oxygenation Level-dependent Magnetic Resonance Imaging Carbonic Anhydrase IX Hypoxia Invasive Ductal Carcinoma Vascular Endothelial Growth Factor

Pulmonary Capillary Hemangiomatosis Associated with CREST Syndrome： A Challenge of Diagnosis and Treatment

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2017年第21期130卷 2645-2646页

作者： Xiao-Li Diao Xiang-Dong mu mu-lan jin Department of Pathology Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Department of Pulmonary and Critical Care Medicine Peking University First HospitalBeijing 100034China

To the Editor： A 65-year-old woman with calcinosis, Raynaud＆#39;s phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia （CREST） syndrome was admitted to hospital because of progressive dyspnea on exertion for about 1 year. In the past, she had been diagnosed as gastroesophageal reflux disease and scleroderma for 10 years. Physical examination showed masked face, Raynaud＇s phenomenon, finger sclerodactyly, and skin telangiectasia on her neck and back [Figure 1a and 1b]. The titer of anticentromere antibody in serum increased to 1： 1000. Analysis of arterial gas on room air revealed the partial pressure of arterial oxygen （PaO2） was 54 mmHg （1 mmHg = 0.133 kPa） and carbon dioxide （PaCO2） was 32 mmHg. Echocardiogram showed severe tricuspid regurgitation and elevated pulmonary arterial pressure of 78 mmHg.

关键词： CREST Syndrome Pulmonary Capillary Hemangiomatosis Associated

Atomic force microscopy-based nanoscale infrared techniques for liquid environments

在线全文

学校读者我要写书评

暂无评论

Science Bulletin 2024年第2期69卷 151-153页

作者： Jian Li jing Liang mu-Hao lan Xing-Hua Xia State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Infrared(IR)light energy matches well with the vibration and rotation of chemical bonds in molecules,hence IR spectroscopy is commonly used for accurate molecular identification[1].Conventional IR analysis involves bulk samples,providing averaged information of the entire sample.The spatially-resolved investigation of heterogeneous sample properties is constrained by the micrometer-level spatial resolution of optical IR microscopy.

关键词： spatially hence rotation

成人原发胃Burkitt淋巴瘤6例临床病理学分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

诊断病理学杂志 2024年第5期31卷 414-418页

作者：胡秀梅代向阳李云龙赵宏颖路军李雪金木兰首都医科大学附属北京朝阳医院病理科

目的探讨成人原发胃Burkitt淋巴瘤(APSBL)的临床及病理特征。方法收集首都医科大学附属北京朝阳医院病理科2017-02—2023-11诊断的APSBL共6例，总结其临床特征、组织学形态、免疫表型和荧光原位杂交(FISH)并对预后进行随访。结果 6例A... 详细信息

目的探讨成人原发胃Burkitt淋巴瘤(APSBL)的临床及病理特征。方法收集首都医科大学附属北京朝阳医院病理科2017-02—2023-11诊断的APSBL共6例，总结其临床特征、组织学形态、免疫表型和荧光原位杂交(FISH)并对预后进行随访。结果 6例APSBL均为男性，平均年龄37.3岁；均为溃疡型病变，直径3～13 cm; 5例为经典BL形态学特征；肿瘤细胞均表达CD20、CD10、bcl-6,Ki-67均大于90%,C-myc均大于80%,bcl-2均为阴性；mum-1在2例(2/6)中表达；5例行EBER原位杂交染色均阴性；6例均检测到MYC基因断裂，未检测bcl-2和bcl-6基因断裂；4例得以随访，随访时间为6～75个月，均无病生存。结论 APSBL较为罕见，病理诊断需结合临床症状、组织学形态、免疫表型及FISH检测综合判断。

关键词：成人胃 Burkitt淋巴瘤诊断预后