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Berberine Inhibits Ferroptosis and Stabilizes Atherosclerotic Plaque through NRF2/SLC7A11/GPX4 Pathway

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Chinese Journal of Integrative Medicine 2024年第10期30卷 906-916页

作者： wang Ting-ting yu li-li ZHENG jun-meng HAN xin-yi jin Bo-yuan hua cheng-jun chen yu-shan SHANG Sha-sha liANG Ya-zhou wang jian-ru Heart Center the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China

Objective:To investigate potential mechanisms of anti-atherosclerosis by berberine(BBR)using ApoE-/-***:Eight 8-week-old C57BL/6J mice were used as a blank control group(normal),and 568-week-old AopE-/-mice were fed a high-fat diet for 12 weeks,according to a completely random method,and were divided into the model group,BBR low-dose group(50 mg/kg,BBRL),BBR medium-dose group(100 mg/kg,BBRM),BBR high-dose group(150 mg/kg,BBRH),BBR+nuclear factor erythroid 2-related factor 2(NRF2)inhibitor group(100 mg/kg BBR+30 mg/kg ML385,BBRM+ML385),NRF2 inhibitor group(30 mg/kg,ML385),and positive control group(2.5 mg/kg,atorvastatin),8 in each *** 4 weeks of intragastric administration,samples were collected and serum,aorta,heart and liver tissues were *** kits were used to detect serum lipid content and the expression levels of malondialdehyde(MDA)and superoxide dismutase(SOD)in all experimental *** pathological changes of atherosclerosis(AS)were observed by aorta gross Oil Red O,aortic sinus hematoxylin-eosin(HE)and Masson *** lipopathy was observed in mice by HE *** morphology of mitochondria in aorta cells was observed under transmission electron *** cytometry was used to detect reactive oxygen species(ROS)expression in aorta of mice in each *** content of ferrous ion Fe^(2+)in serum of mice was detected by biochemical *** mRNA and protein relative expression levels of NRF2,glutathione peroxidase 4(GPX4)and recombinant solute carrier family 7 member 11(SLC7A11)were detected by quantitative real time polymerase chain reaction(RT-q PCR)and Western blot,***:BBRM and BBRH groups delayed the progression of AS and reduced the plaque area(Pchanges of ferroptosis were rarely observed in BBR-treated AS mice,and the content of Fe^(2+)in BBR group was significantly lower than that in the model group(P<0.01).BBR decreased ROS and MDA levels in mouse

关键词： berberine ApoE−/− ferroptosis atherosclerosis oxidative stress NRF2/SLC7A11/GPX4 pathway

SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury

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Signal Transduction and Targeted Therapy 2022年第1期7卷 295-309页

作者： Meng-li Wu Feng-liang liu jing Sun xin li Xiao-Yan He Hong-Yi Zheng Yan-Heng zhou Qihong Yan ling chen guo-Ying yu junbiao chang Xia jin jincun Zhao xin-Wen chen Yong-Tang Zheng jian-hua wang College of life Science Henan Normal UniversityXinxiang 453007China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510182China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou 510530China Bioland Laboratory Guangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou 510005China Shanghai Public Health Clinical Center Affiliated to Fudan University Shanghai 201508China University of Chinese Academy of Sciences Beijing 100039China

SARS-CoV-2 infection-induced hyper-inflammation links to the acute lung injury and COVID-19 *** the primary mediators that initiate the uncontrolled hypercytokinemia is essential for *** cells(MCs)are strategically located at the mucosa and beneficially or detrimentally regulate immune *** this study,we showed that SARS-CoV-2-triggered MC degranulation initiated alveolar epithelial inflammation and lung ***-CoV-2 challenge induced MC degranulation in ACE-2 humanized mice and rhesus macaques,and a rapid MC degranulation could be recapitulated with Spike-RBD binding to ACE2 in cells;MC degranulation altered various signaling pathways in alveolar epithelial cells,particularly,the induction of pro-inflammatory factors and consequential disruption of tight ***,the administration of clinical MC stabilizers for blocking degranulation dampened SARS-CoV-2-induced production of pro-inflammatory factors and prevented lung *** findings uncover a novel mechanism for SARS-CoV-2 initiating lung inflammation,and suggest an off-label use of MC stabilizer as immunomodulators for COVID-19 treatments.

关键词： inflammation lung alveolar

Stepped-up development of accelerator mass spectrometry method for the detection of ^(60)Fe with the HI-13 tandem accelerator

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Nuclear Science and Techniques 2024年第4期35卷 136-143页

作者： Yang Zhang Sheng-Quan Yan ming He Qing-Zhang Zhao Wen-Hui Zhang Chao-xin Kan jian-ming zhou Kang-Ning li Xiao-Fei wang jian-cheng liu Zhao-hua Peng Zhuo liang Ai-ling li jian Zheng Qi-Wen Fan yun-Ju li You-Bao wang Zhi-Hong li Yang-Ping Shen Ding Nan Wei Nan yu-Qiang Zhang Jia-Ying-Hao li jun-Wen Tian jiang-lin Hou chang-xin guo Zhi-cheng Zhang ming-Hao Zhu yu-Wen chen yu-chen jiang Tao Tian jin-Long Ma Yi-Hui liu jing-yu Dong Run-Long liu Mei-yue-Nan Ma Yong-Shou chen Wei-Ping liu Bing guo China Institute of Atomic Energy P.O.Box 275(10)Beijing 102413China College of Science Southern University of Science and TechnologyShenzhen 518055China School of Physics Xi’an Jiaotong UniversityXi’an 710049China

The Moon provides a unique environment for investigating nearby astrophysical events such as *** samples retain valuable information from these events,via detectable long-lived“fingerprint”radionuclides such as^(60)*** this work,we stepped up the development of an accelerator mass spectrometry(AMS)method for detecting^(60)Fe using the HI-13tandem accelerator at the China Institute of Atomic Energy(CIAE).Since interferences could not be sufficiently removed solely with the existing magnetic systems of the tandem accelerator and the following Q3D magnetic spectrograph,a Wien filter with a maximum voltage of±60 kV and a maximum magnetic field of 0.3 T was installed after the accelerator magnetic systems to lower the detection background for the low abundance nuclide^(60)Fe.A 1μm thick Si_(3)N_(4) foil was installed in front of the Q3D as an energy *** particle detection,a multi-anode gas ionization chamber was mounted at the center of the focal plane of the ***,an^(60)Fe sample with an abundance of 1.125×10^(-10)was used to test the new AMS *** results indicate that^(60)Fe can be clearly distinguished from the isobar^(60)*** sensitivity was assessed to be better than 4.3×10^(-14)based on blank sample measurements lasting 5.8 h,and the sensitivity could,in principle,be expected to be approximately 2.5×10^(-15)when the data were accumulated for 100 h,which is feasible for future lunar sample measurements because the main contaminants were sufficiently separated.

关键词： Accelerator mass spectrometry Wien filter Isobar separation Supernovae chang'e-5 lunar samples

Safety profile of 0.0015%tafluprost eye drops in China:a post-marketing observational study

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 108-114页

作者： Xue-li chen Yan-jing Fu Bo Qu Ye-Wei wang xin Tang yu-Hong wang guo-Yi zhou ming-Kai lin jing-yuan Shen jin Yao Su-Yan li Miao-Qin Wu hua-Zong Peng ming-Ying Lai Ren-Yi Wu Yi-Nong Zhang Yan li Xiao-jun Wu ming-chang Zhang Su-Ping guo xing-huai Sun Department of Ophthalmology Eye&ENT Hospital of Fudan UniversityShanghai 200000China Department of Ophthalmology Daqing Ophthalmologic HospitalDaqing 163000Heilongjiang ProvinceChina Department of Ophthalmology the Fourth Affiliated Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina Department of Ophthalmology Da Lian He Eye Specialist HospitalDalian 116000Liaoning ProvinceChina Department of Ophthalmology Beijing Tongren HospitalBeijing 100000China Department of Ophthalmology Xiamen Eye Center of Xiamen UniversityXiamen 361000Fujian ProvinceChina Department of Ophthalmology Yueqing People’s HospitalWenzhou 325600Zhejiang ProvinceChina Department of Glaucoma Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510000Guangdong ProvinceChina Department of Ophthalmology Shengzhou Shen’s Eye HospitalShaoxing 312400Zhejiang ProvinceChina Department of Ophthalmology the Affiliated Eye Hospital of Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina Department of Ophthalmology Xuzhou No.1 Peoples HospitalXuzhou 221000Jiangsu ProvinceChina Department of Ophthalmology Zhejiang Provincial People’s HospitalHangzhou 310000Zhejiang ProvinceChina Department of Ophthalmology Wuhan Eyegood Ophthalmic HospitalWuhan 430014Hubei ProvinceChina Department of Ophthalmology Shenzhen Eye HospitalShenzhen 518001Guangdong ProvinceChina Department of Glaucoma Shanghai Heping Eye HospitalShanghai 200000China Department of Ophthalmology Wuxi Second People’s HospitalWuxi 214000Jiangsu ProvinceChina Department of Ophthalmology First Affiliated Hospital of Kunming Medical UniversityKunming 650000Yunnan ProvinceChina Department of Ophthalmology Union Shenzhen Hospital(Nanshan Hospital)Shenzhen 518000Guangdong ProvinceChina Department of Ophthalmology Wuhan Union HospitalWuhan 430000Hubei ProvinceChina Department of Ophthalmology Shengyang He Eye Specialist HospitalShenyang 110000Liaoning ProvinceChina

AIM:To investigate the treatment pattern and safety of tafluprost for glaucoma and ocular hypertension(OH)in clinical practice in ***:This post-marketing observational study included patients who received tafluprost to lower intraocular pressure(IOP)within 30d between September 2017 and March 2020 in 20 hospitals in *** drug reactions(ADRs)during tafluprost treatment and within 30d after the treatment were ***:A total of 2544 patients were included in this study,of them 58.5%(1488/2544)had primary open angle glaucoma(POAG),21.9%(556/2544)had OH and 19.7%(500/2544)used tafluprost for other *** 359 ADRs occurred in 10.1%(258/2544)patients,and no serious adverse event *** most common ADR was conjunctival hyperemia(128 ADRs in 124 patients,4.9%).Totally 1670 participants(65.6%)combined tafluprost with carbonic anhydrase inhibitors(CAIs;37.1%,620/1670),sympathomimetics(33.5%,559/1670),β-blockers(33.2%,555/1670),other prostaglandin analogs(PGAs;15.6%,260/1670)and other eye drops(15.1%,253/1670).The highest incidence of conjunctival hyperemia was noted in patients who received tafluprost in combination with other PGAs(23 ADRs in 23 patients,8.8%,23/260)and the lowest was in combination with CAIs(16 ADRs in 16 patients,2.6%,16/620).Tafluprost was applied in primary angle-closure glaucoma(41.6%,208/500),after glaucoma surgery(17.8%,89/500)and after non-glaucoma surgery(15.8%,79/500).CONCLUSION:Tafluprost is safe for POAG and OH,and tolerable when combined with other eye drops and under various clinical circumstances.

关键词： tafluprost glaucoma ocular hypertension intraocular pressure adverse drug reactions

Significant loss of soil inorganic carbon at the continental scale

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National Science Review 2022年第2期9卷 13-20页

作者： Xiao-Dong Song Fei Yang hua-Yong Wu jing Zhang De-cheng li Feng liu yu-guo Zhao jin-ling Yang Bing Ju Chong-Fa Cai Biao huang huai-yu Long Ying Lu yue-yu Sui Qiu-Bing wang Ke-Ning Wu Feng-Rong Zhang ming-Kui Zhang zhou Shi Wan-Zhu Ma Gang xin Zhi-Ping Qi Qing-Rui chang En Ci Da-Gang yuan Yang-Zhu Zhang jun-Ping Bai Jia-Ying chen Jie chen Yin-jun chen yun-Zhong Dong Chun-Lan Han ling li li-ming liu jian-jun Pan Fu-Peng Song Fu-jun Sun Deng-Feng wang Tian-Wei wang Xiang-hua Wei Hong-Qi Wu Xia Zhao Qing zhou Gan-lin Zhang State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences College of Advanced Agricultural Sciences University of Chinese Academy of Sciences College of Resources and Environment Huazhong Agricultural University Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences College of Natural Resources and Environment South China Agricultural University Northeast Institute of Geography and Agroecology Chinese Academy of Sciences College of Land and Environment Shenyang Agricultural University School of Land Science and Technology China University of Geosciences College of Land Science and Technology China Agricultural University College of Environmental and Resource Sciences Zhejiang University Institute of Digital Agriculture Zhejiang Academy of Agricultural Sciences College of Agriculture Heilongjiang Bayi Agricultural University Tropical Crops Genetic Resources Institute Chinese Academy of Tropical Agricultural Sciences College of Natural Resources and Environment Northwest A & F University College of Resources and Environment Southwest University College of Resources Sichuan Agricultural University College of Resources and Environment Hunan Agricultural University Institute of Agricultural Product Quality Standard and Testing Research Tibet Academy of Agricultural and Animal Husbandry Sciences School of Agricultural Sciences Zhengzhou University Institute of Agriculture Environment and Resources Research Shanxi Academy of Agricultural Sciences College of Resources and Environment Henan Agricultural University College of Resources and Environment China Agricultural University College of Resources and Environmental Sciences Nanjing Agricultural University College of Resources and Environment Shandong Agricultural University Agricultural College Guangxi University College of Grassland and Environment Science Xinjiang Agricultural University College of Geographical Science Qinghai Normal University

Widespread soil acidification due to atmospheric acid deposition and agricultural fertilization may greatly accelerate soil carbonate dissolution and ***,to date,few studies have addressed these ***,we use meta-analysis and nationwide-survey datasets to investigate changes in soil inorganic carbon(SIC) stocks in *** observe an overall decrease in SIC stocks in topsoil(0-30 cm)(11.33 g C m-2yr-1) from the 1980 s to the 2010 *** SIC stocks have decreased by～8.99±2.24%(1.37±0.37 Pg C).The average SIC losses across China(0.046 Pg C yr-1) and in cropland(0.016 Pg C yr-1) account for～17.6%-24.0% of the terrestrial C sink and 57.1% of the soil organic carbon sink in cropland,*** deposition and climate change have profound influences on SIC *** estimate that～19.12%-19.47% of SIC stocks will be further lost by *** consumption of SIC may offset a large portion of global efforts aimed at ecosystem carbon sequestration,which emphasizes the importance of achieving a better understanding of the indirect coupling mechanisms of nitrogen and carbon cycling and of effective countermeasures to minimize SIC loss.

关键词： China soil inorganic carbon stocks global change carbonate soil acidification

Advanced Space-based Solar Observatory(ASO-S):an overview

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Research in Astronomy and Astrophysics 2019年第11期19卷 3-10页

作者： Wei-Qun Gan cheng Zhu yuan-Yong Deng Hui li Yang Su Hai-Ying Zhang Bo chen Zhe Zhang jian Wu Lei Deng yu huang jian-Feng Yang Ji-jun Cui jin chang Chi wang Ji Wu Zeng-Shan Yin Wen chen cheng Fang Yi-hua Yan jun lin Wei-ming Xiong Bin chen Hai-Chao Bao Cai-Xia Cao Yan-Ping Bai Tao wang Bing-Long chen xin-yu li Ye Zhang li Feng jiang-Tao Su Ying li Wei chen You-Ping li Ying-Na Su Hai-Yan Wu Mei Gu Lei huang Xue-jun Tang Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210034China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201203China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Nanjing Institute of Astronomical Optics&Technology National Astronomical ObservatoriesChinese Academy of SciencesNanjing 210042China changchun Institute of Optics Fine Mechanics and PhysicsChangchun 130033China Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China National Space Science Center Chinese Academy of SciencesBeijing 100190China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China yunnan Observatories Chinese Academy of SciencesKunming 650011China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 101408China Beijing Special Engineering and Design Institute Beijing 100028China Beijing Institute of Tracking and Telecommunications Technology Beijing 100094China Shanghai Academy of Spaceflight Technology Shanghai 201109China

The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed for the 25 th solar maximum by the Chinese solar *** scientific objectives are to study the relationships between the solar magnetic field,solar flares and coronal mass ejections(CMEs).Three payloads are deployed:the Full-disk vector Magneto Graph(FMG),the Lyman-αSolar Telescope(LST)and the Hard X-ray Imager(HXI).ASO-S will perform the first simultaneous observations of the photospheric vector magnetic field,non-thermal imaging of solar flares,and the initiation and early propagation of CMEs on a single ***-S is scheduled to be launched into a 720 km Sun-synchronous orbit in *** paper presents an overview of the mission till the end of Phase-B and the beginning of Phase-C.

关键词： space vehicles instruments-Sun magnetic fields-Sun flares-Sun CMEs-Sun UV radiation-Sun X-ray,gamma-rays

Site testing campaign for the Large Optical/infrared Telescope of China:overview

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Research in Astronomy and Astrophysics 2020年第6期20卷 81-95页

作者： Lu Feng jin-xin Hao Zi-huang Cao jin-Min Bai Ji Yang Xu zhou Yong-Qiang Yao jin-liang Hou Yong-Heng Zhao yu liu Teng-Fei Song li-Yong liu Jia Yin hua-lin chen Chong Pei Ali Esamdin Lu Ma Chun-Hai Bai Peng Wei jing Xu Guang-xin Pu guo-Jie Feng Xuan Zhang liang ming Abudusaimaitijiang Yisikandee jian-Rong Shi jian li yuan Tian Zheng wang Xia wang Xiao-jun jiang jian-Feng wang jian-Feng Tian Yan-Jie Xue jian-Sheng chen jing-Yao Hu Zhi-Xia Shen yun-Ying jiang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China yunnan Observatories Chinese Academy of SciencesKunming 650216China xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210033China University of Chinese Academy of Sciences Beijing 100049China

The Large Optical/infrared Telescope(LOT)is a ground-based 12 m diameter optical/infrared telescope which is proposed to be built in the western part of China in the next *** on satellite remote sensing data,along with geographical,logistical and political considerations,three candidate sites were chosen for ground-based astronomical performance *** sites include:Ali in Tibet,Daocheng in Sichuan and Muztagh-ata in *** until now,all three sites have continuously collected data for two *** this paper,we will introduce this site testing campaign,and present its monitoring results obtained during the period between March 2017 and March 2019.

关键词： techniques telescope-site testing

Genome assembly of autotetraploid Actinidia arguta highlights adaptive evolution and enables dissection of important economic traits

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Plant Communications 2024年第6期5卷 173-192页

作者： Xue-Mei Lu Xiao-Fen yu guo-Qiang li ming-Hao Qu huan wang Chuang liu yu-Ping Man Xiao-Han jiang Mu-Zi li jian wang Qi-Qi chen Rui Lei cheng-cheng Zhao yun-Qiu zhou Zheng-wang jiang Zuo-zhou li Shang Zheng chang Dong Bai-lin wang Yan-Xiang Sun Hui-Qin Zhang Jie-Wei li Quan-Hui Mo Ying Zhang xin Lou Hai-Xu Peng Ya-Ting Yi He-xin wang Xiu-jun Zhang Yi-Bo wang Dan wang li li Qiong Zhang Wen-Xia wang Yongbo liu Lei Gao jin-Hu Wu Yan-chang wang CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenChinese Academy of SciencesWuhanHubeiChina Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhouGansuChina College of life Sciences University of Chinese Academy of SciencesBeijingChina Wuhan Frasergen Bioinformatics Co. LtdWuhanHubeiChina Institute of Soil and Fertilizer Anhui Academy of Agricultural SciencesHefeiChina College of Agricultural Sciences Xichang UniversityXichangSichuanChina Department of Horticulture Heilongjiang Academy of Agricultural SciencesHarbinHeilongjiangChina College of life Sciences Langfang Normal UniversityLangfangHebeiChina Institute of Horticulture Zhejiang Academy of Agricultural SciencesHangzhouZhejiangChina Guangxi Institute of Botany Chinese Academy of SciencesGuilinGuangxiChina Xi’an Botanical Garden of Shaanxi Province Institute of Botany of Shaanxi ProvinceXi’anShaanxiChina Institute of Modern Agricultural Research Dalian UniversityDalianLiaoningChina Bioinformatics Center College of Plant Science and TechnologyBeijing University of AgricultureBeijingChina College of Agriculture Eastern Liaoning UniversityDandongLiaoningChina Dalian Institute of Chemical Physics Chinese Academy of SciencesDalianLiaoningChina State Environmental Protection Key Laboratory of Regional Eco-process and Function Assessment Chinese Research Academy of Environmental SciencesBeijingChina Hubei Hongshan Laboratory WuhanHubeiChina The New Zealand Institute for Plant and Food Research limited AucklandNew Zealand

Actinidia arguta,the most widely distributed Actinidia species and the second cultivated species in the genus,can be distinguished from the currently cultivated Actinidia chinensis on the basis of its small and smooth fruit,rapid softening,and excellent cold *** evolution of tetraploid Actinidia species and the genetic basis of their important agronomic traits are still ***,we generated a chromosome-scale genome assembly of an autotetraploid male *** *** genome assembly was 2.77 Gb in length with a contig N50 of 9.97 Mb and was anchored onto 116 *** and clustering of 101 geographically representative accessions showed that they could be divided into two geographic groups,Southern and Northern,which first diverged 12.9 million years *** underwent two prominent expansions and one demographic bottleneck from the midPleistocene climate transition to the late *** genomics studies using paleoclimate data enabled us to discern the evolution of the species’adaptation to different historical *** genes(AaCEL1,AaPME1,and AaDOF1)related to flesh softening were identified by multi-omics analysis,and their ability to accelerate flesh softening was verified through transient expression assays.A set of genes that characteristically regulate sexual dimorphism located on the sex chromosome(Chr3)or autosomal chromosomes showed biased expression during stamen or carpel *** chromosome-level assembly of the autotetraploid *** genome and the genes related to important agronomic traits will facilitate future functional genomics research and improvement of ***.

关键词： kiwiberry dioecism adaptive evolution paleoclimate GEA rapid softening

Towards the full realization of the RIBLL2 beam line at the HIRFL-CSR complex

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Science Bulletin 2018年第2期63卷 78-80页

作者： Bao-hua Sun jian-Wei Zhao Xue-Heng Zhang li-Na Sheng Zhi-yu Sun Isao Tanihata Satoru Terashima Yong Zheng li-hua Zhu li-Min Duan liu-Chun He Rong-jiang Hu Guang-Shuai li Wen-jian lin Wei-Ping lin Chuan-Ye liu Zhong liu chen-Gui Lu xin-Wen Ma li-jun Mao Yi Tian Feng wang Meng wang Shi-Tao wang Jia-Wen Xia Xiao-Dong Xu Hu-Shan Xu Zhi-guo Xu jian-cheng Yang Da-yu Yin You-jin yuan Wen-Long Zhan yu-Hu Zhang Xiao-Hong zhou School of Physics and Nuclear Energy Engineering Beihang University Beijing 100191 China International Research Center for Nuclei and Particles in the Cosmos Beijing 100191 China Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China

More than 99%of the mass in the visible universe—the material that makes up ourselves,our planet,stars—is in the atomic *** the matter has existed for billions of years,only over the past few decades have we had the tools and the knowledge necessary to get a basic understanding of the structure and dynamic of *** physicists around the world have made tremendous strides by initiating a broad range of key

关键词： HIRFL-CSR 横梁建筑群排队原子核物理学家试验性世界