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Monotropein Induced Apoptosis and Suppressed Cell Cycle Progression in Colorectal Cancer Cells

Chinese Journal of Integrative Medicine 2024年第1期30卷 25-33页

作者： GAO Quan li lin ZHANG Qi-man SHENG Qin-song ZHANG Ji-liang jin li-jun SHANG Rui-yan School of Pharmacy and Department of Medical Oncology the Affiliated Hospital of Hangzhou Normal UniversityHangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou(311121)China Department of Colorectal Surgery the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Beijing Tong Ren Tang Chinese Medicine Co. Ltd.Beijing(100000)China Department of Traditional Chinese Medicine Hangzhou Shangcheng District People's HospitalHangzhou(310006)China Department of Gynecology Hangzhou Women's HospitalHangzhou(310008)China

Objective: To determine whether monotropein has an anticancer effect and explore its potential mechanisms against colorectal cancer(CRC) through network pharmacology and molecular docking combined with experimental verification. Methods: Network pharmacology and molecular docking were used to predict potential targets of monotropein against CRC. Cell counting kit assay, plate monoclonal assay and microscopic observation were used to investigate the antiproliferative effects of monotropein on CRC cells HCT116, HT29 and LoVo. Flow cytometry and scratch assay were used to analyze apoptosis and cell cycle, as well as cell migration, respectively in HCT116, HT29, and LoVo cells. Western blotting was used to detect the expression of proteins related to apoptosis, cell cycle, and cell migration, and the expression of proteins key to the Akt pathway. Results: The Gene Ontology and Reactome enrichment analyses indicated that the anticancer potential of monotropein against CRC might be involved in multiple cancer-related signaling pathways. Among these pathways, RAC-beta serine/threonine-protein kinase(Akt1, Akt2), cyclin-dependent kinase 6(CDK6), matrix metalloproteinase-9(MMP9), epidermal growth factor receptor(EGFR), cell division control protein 42 homolog(CDC42) were shown as the potential anticancer targets of monotropein against CRC. Molecular docking suggested that monotropein may interact with the 6 targets(Akt1, Akt2, CDK6, MMP9, EGFR, CDC42). Subsequently, cell activity of HCT116, HT29 and LoVo cell lines were significantly suppressed by monotropein(PlinD1, CDK4 and CDK6, inhibited cell migration by suppressing the expressions of CDC42 and MMP9(Pling pathway. Conclusions: Monotropein exerts its antitumor

关键词： monotropein Chinese medicine anticancer activity colorectal cancer cells network pharmacology

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杭州地区大气臭氧浓度垂直分布

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中国环境科学 2024年第9期44卷 4754-4764页

作者：齐冰徐晓飞靳军莉杨欣洁牛彧文张金强杭州市气象局浙江杭州310051 浙江临安大气成分本底国家野外科学观测研究站浙江杭州311307 中国气象局气象探测中心北京100081 浙江省气象科学研究所浙江杭州310056 中国科学院大气物理研究所中层大气与全球环境观测重点实验室北京100029 中国科学院大学地球与行星科学学院北京100049

利用国产双池型电化学反应臭氧探空仪在杭州开展为期1年(2021年12月~2022年11月)观测,分析了该地区臭氧廓线垂直分布、臭氧柱总量以及对流层臭氧柱含量特征,并评估AIRS和MLS反演的臭氧廓线产品以及AIRS、OMIDOAS和TROPOMI反演的臭氧柱... 详细信息

利用国产双池型电化学反应臭氧探空仪在杭州开展为期1年(2021年12月~2022年11月)观测,分析了该地区臭氧廓线垂直分布、臭氧柱总量以及对流层臭氧柱含量特征,并评估AIRS和MLS反演的臭氧廓线产品以及AIRS、OMIDOAS和TROPOMI反演的臭氧柱总量产品.结果表明,臭氧探空仪与地面原位臭氧分析仪观测结果具有高一致性.杭州地区臭氧垂直结构呈显著月变化特征,5月在上对流层-下平流层区域(12~16km高度范围)呈现高浓度臭氧的下传结构.4~9月在边界层附近1.5km高度以下观测到高浓度臭氧含量层.边界层内臭氧含量夏季最高,垂直变化不明显;其次是春季、秋季和冬季,均表现为随高度增加而增大.臭氧探空廓线与卫星反演臭氧垂直廓线吻合较好,在对比高度范围内相对偏差大多<10%.杭州地区臭氧柱总量和对流层柱含量平均值分别为302.1DU和40.5DU,呈明显季节变化特征.臭氧柱总量和对流层柱含量最高的季节分别为春季和夏季,5月对流层臭氧柱含量最高.臭氧探空柱总量与AIRS、OMI DOAS和TROPOMI反演臭氧柱总量一致性较好,相关系数分别为0.78、0.88和0.76.

关键词：臭氧探空臭氧垂直分布臭氧柱总量卫星反演杭州地区

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新时代硕士研究生培养质量提升路径探析

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黑龙江教师发展学院学报 2024年第7期43卷 44-49页

作者：靳利军孙永军罗艳梅黑龙江大学经济与工商管理学院哈尔滨150080

硕士研究生人才培养是我国研究生教育的重要组成部分。近年来,我国硕士研究生教育快速发展,招生人数不断增加,专业学位研究生占比不断提高。目前,硕士研究生教育在培养模式、师资队伍、经费投入、过程管理、学位点建设等方面存在的问题... 详细信息

硕士研究生人才培养是我国研究生教育的重要组成部分。近年来,我国硕士研究生教育快速发展,招生人数不断增加,专业学位研究生占比不断提高。目前,硕士研究生教育在培养模式、师资队伍、经费投入、过程管理、学位点建设等方面存在的问题,影响了硕士研究生培养质量的进一步提高。鉴于此,针对存在的问题并结合新时代党和政府对研究生教育提出的要求,提出培养模式创新、导师指导能力提升、经费投入改善、培养过程强化质量控制、充分发挥学位点作用等新时代硕士研究生培养质量提升路径。

关键词：新时代硕士研究生人才培养质量提升路径

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Biological sulfate removal from acrylic fiber manufacturing wastewater using a two-stage UASB reactor

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Journal of Environmental Sciences 2012年第2期24卷 343-350页

作者： jin li jun Wang Zhaokun Luan Zhongguang Ji lian Yu State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

A two-stage UASB reactor was employed to remove sulfate from acrylic fiber manufacturing *** operation（35±0.5℃） was performed with hydraulic retention time（HRT） varied between 28 and 40 *** liquor suspended solids（MLSS） in the reactor was maintained about 8000 mg/*** results indicated that sulfate removal was enhanced with increasing the ratio of COD/SO24-.At low COD/SO42-,the growth of the sulfate-reducing bacteria（SRB） was *** optimal sulfate removal efficiencies were 75% when the HRT was no less than 38 *** mainly happened in the sulfate-reducing stage,while methanogenesis in the methane-producing *** in sulfate-reducing stage performed granulation better than that in methaneproducing *** extracellular polymeric substances（EPS） content in sulfate-reducing stage helped to adhere and connect the flocculent sludge particles *** accounted for about 31% both in sulfate-reducing stage and methane-producing stage at COD/SO42-ratio of 0.5,while it dropped dramatically from 34% in sulfate-reducing stage to 10% in methane-producing stage corresponding to the COD/SO42-ratio of *** and MPA were predominant in sulfate-reducing stage and methane-producing stage respectively.

关键词： a two-stage UASB reactor sulfidogenesis granule fluorescence in situ hybridization(FISH)

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Dynamic Behavior of Entanglement Between Two Spatially Separated Atoms in Two Dissipative and Driven Cavity Fields

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Communications in Theoretical Physics 2009年第3期51卷 509-513页

作者： CUI Hui-Ping li Jian liU jin li jun-Gang Department of Physics School of Science Beijing Institute of Technology Beijing 100081 China

We consider two two-level atoms, interacting with two independent dissipative cavities, each of which is driven by an external source. The two cavity fields are both initially prepared in the coherent states, and the two two-level atoms are initially prepared in the singlet state ｜ψ^-〉 =（｜eg〉 - ｜ge〉） / √2. We investigate the influence of the damping constant n, the intensity of the external sources F, and the relative difference of the atomic couplings r on the entanglement between the two atoms. In the dispersive approximation, we find that the entanglement between the two atoms decreases with the time evolution, and the decreasing rate of entanglement depends on the values of F/k, k/ω, and r. For the given small values of F/k and k/ω, on the one hand, the increasing of r favors entanglement decreasing of the atomic system, on the other hand, when r → 1 the entanglement decreasing becomes slower. With the increasing of the value of k/ω, the influence of r on the decreasing rate of entanglement becomes smaller, and gradually disappears for the big value of k/ω.

关键词： entanglement dissipation driven field

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黑龙江大学MPAcc项目学位论文质量管理与提升策略探析

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黑龙江教育（高教研究与评估） 2024年第10期 51-56页

作者：靳利军姜艳萍邸家琴黑龙江大学黑龙江哈尔滨150080

学位论文既是研究生人才培养的核心环节,也是评价研究生培养质量的关键指标。基于MPAcc项目的发展背景和现状,分析了黑龙江大学MPAcc项目的现状、特色、学位论文选题状况以及学位论文质量管理措施。研究发现,项目虽然在学位论文质量管... 详细信息

学位论文既是研究生人才培养的核心环节,也是评价研究生培养质量的关键指标。基于MPAcc项目的发展背景和现状,分析了黑龙江大学MPAcc项目的现状、特色、学位论文选题状况以及学位论文质量管理措施。研究发现,项目虽然在学位论文质量管理方面取得了一定成效,但仍存在选题创新性不足、理论方法集中度高、质量评价体系不完善等问题,进而提出了鼓励学位论文创新、改进质量控制标准、优化学位论文管理流程和强化学术道德等提升学位论文质量的建议,旨在促进学位论文管理工作的规范化和高效化,全面提升MPAcc学位论文的学术水平和实践价值。

关键词：黑龙江大学 MPAcc 学位论文质量管理

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Formation of Na_(1+x)V_3O_8 Nanoribbon Thin Film from V_2O_5 Xerogel on Sodium Silicate Glass Substrate

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Chemical Research in Chinese Universities 2007年第4期23卷 381-383页

作者： GUO Yi XU jin-jie li jun YANG Wen-sheng College of Chemistry Jilin University Changchun 130012 P. R. China

Na1＋xV3O8 nanoribbon thin film was successfully fabricated by annealing the V2O5 xerogel film on sodium sili-cate glass substrate at 450℃. It has been identified that the amount of sodium ions diffused into the V2O5 xerogel film increases with the high temperature of annealing treatment. The sodium glass substrate serves as a limited sodium source to induce the transformation from V2O5 to Na1＋xV3O8.

关键词： Vanadium pentoxide Sodium silicate glass Nanoribbon Cathode materials

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Application value of biofluid-based biomarkers for the diagnosis and treatment of spinal cord injury

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Neural Regeneration Research 2022年第5期17卷 963-971页

作者： Hong-Da Wang Zhi-Jian Wei jun-jin li Shi-Qing Feng Department of Orthopedics Tianjin Medical University General HospitalTianjinChina International Science and Technology Cooperation Base of Spinal Cord Injury Tianjin Key Laboratory of Spine and Spinal CordTianjin Medical University General HospitalTianjinChina Department of Orthopedics Qilu HospitalCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Shandong University Center for Orthopedics Cheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina

Recent studies in patients with spinal cord injuries(SCIs)have confirmed the diagnostic potential of biofluid-based biomarkers,as a topic of increasing interest in relation to SCI diagnosis and *** paper reviews the research progress and application prospects of recently identified SCI-related *** structural proteins,such as glial fibrillary acidic protein,S100-β,ubiquitin carboxy-terminal hydrolase-L1,neurofilament light,and tau protein were correlated with the diagnosis,American Spinal Injury Association Impairment Scale,and prognosis of SCI to different *** factors,including interleukin-6,interleukin-8,and tumor necrosis factorα,are also good biomarkers for the diagnosis of acute and chronic SCI,while non-coding RNAs(micro RNAs and long non-coding RNAs)also show diagnostic potential for *** elements(Mg,Se,Cu,Zn)have been shown to be related to motor recovery and can predict motor function after SCI,while humoral markers can reflect the pathophysiological changes after *** factors have the advantages of low cost,convenient sampling,and ease of dynamic tracking,but are also associated with disadvantages,including diverse influencing factors and complex level *** various proteins have been verified as potential biomarkers for SCI,more convincing evidence from large clinical and prospective studies is thus required to identify the most valuable diagnostic and prognostic biomarkers for SCI.

关键词： biomarker diagnosis inflammatory cytokine motor recovery non-coding RNA prognosis spinal cord injury structural protein trace element

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Effect of expansive fillings on fracture seepage

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Mining Science and Technology 2009年第6期19卷 824-828页

作者： CHEN jin-gang YANG jun-li ZHANG jing-fei Department of Engineering Mechanics Zhengzhou University Zhengzhou Henan 450001 China

Based on an investigation of the damage process of fractures filled with expansion media,samples of filling media collected on the spot,were obtained. The physical water properties of fracture fillings were tested by a WZ-2 type Dilatometer. Given our test results of the hydrated properties of fracture fillings and the mechanical parameters of altered rock mass collected from the Daye Iron Mine and comparisons between the expansion stress of fracture fillings and mechanical parameters of altered rock mass,the effects of the mechanical response of fillings on fracture seepage are discussed. The results show that the ratio of filling swell pressure to tensile strength of altered rock specimen varied between 11.79 and 36.77 and the ratio of filling swell pressure to shear strength of these rock specimen ranged from 72.11 to 171.18. Therefore,fillings have an important effect on fracture seepage,and the effect of deformation of the fracture caused by swell pressure of the filling mechanics cannot be ignored either. The multiple hydraulic coupling effects of fillings on the impact of fracture permeability are discussed according to theoretical analyses. It is shown that the effect of expansion of fracture fillings greatly affects the deformation of altered rock masses. Both tensile effect and shear effect produced by fracture fillings greatly increase the permeability of fractures. The plastic and liquefaction effects of fracture fillings also improve the permeability of fractures. On the basis of this analysis,a mechanical seepage model of filled fracture is established.

关键词： expansion filling medium fracture seepage

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Investigation on the influence of vortex generator on particle resuspension

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Particuology 2024年第3期86卷 126-136页

作者： Dongchi Yu jun-li lin jin-Han Xie ASML 80W Tasman DrSan Jose95134CaliforniaUSA Department of Mechanics and Engineering Science at College of Engineering and State Key Laboratory for Turbulence and Complex Systems Peking UniversityBeijing100081China

The vortex generator(VG)and its well-known effect in flow optimization are widely studied and employed across different engineering ***,while the same working principles of VG may be well suited for the applications on surface-cleaning technologies,such promising potential is hardly,if any,explored in the published ***,in the present study,the influence on flow-induced particle resuspension brought by a rectangular vG in a channel flow is investigated with the help of highfidelity computational fluid dynamics *** increases of particle removal forces and resuspension rates are discovered in long,strip-like regions with reduced boundary-layer thickness resulted from the vG-induced vortices,and the enhancement effect is especially significant for configurations with the VG installed at a greater angle of *** is also shown that while the resuspension enhancements on the lower and the upper surfaces of the channel exhibit distinct statistical characteristics,having a VG in the channel improves the overall particle-removing capability of the channel flow by introducing higher surface-averaged removal forces and particle resuspension *** but not least,the increase of resuspension rate is especially significant for the smaller,micron-scale particles which are otherwise hardly disturbed by a VG-less channel flow,and such resuspension-enhancement effectgenerally subsides with increasing particle size.

关键词： Particle resuspension Vortexgenerator CFD Surface cleaning

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