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Bruceine D inhibits HIF-1α-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT/β-catenin interaction

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Acta Pharmaceutica Sinica B 2021年第11期11卷 3481-3492页

作者： Rui Huang Lijun Zhang jinmei jin Yudong Zhou Hongwei Zhang Chao Lv Dong Lu Ye Wu Hong Zhang Sanhong Liu Hongzhuan Chen Xin Luan Weidong Zhang Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese MedicineShanghai 201203China School of Pharmacy Second Military Medical UniversityShanghai 200433China Department of Chemistry and Biochemistry College of Liberal ArtsUniversity of MississippiUniversityMS 38677-1848USA

Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-related deaths,characterized by highly hypoxic tumor ***-inducible factor-1α(HIF-1α)is a major regulator involved in cellular response to changes of oxygen levels,supporting the adaptation of tumor cells to *** D(BD)is an isolated natural quassinoid with multiple anti-cancer ***,we identified BD could significantly inhibit the HIF-1α expression and its subsequently mediated HCC cell *** biophysical proteomics approaches,we identified inhibitor of β-catenin and T-cell factor(ICAT)as the functional target of *** targeting ICAT,BD disrupted the interaction of bcatenin and ICAT,and promoted β-catenin degradation,which in turn induced the decrease of HIF-1α ***,BD could inhibit HCC cells proliferation and tumor growth in vivo,and knockdown of ICAT substantially increased resistance to BD treatment in *** data highlight the potential of BD as a modulator of β-catenin/HIF-1α axis mediated HCC metabolism.

关键词： Hepatocellular carcinoma Bruceine D HIF-1α Metabolism ICAT β-Catenin Tumor microenvironment Hypoxia

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肠道菌与肿瘤及抗肿瘤药物关系的研究进展

上海中医药大学学报 2019年第4期33卷 101-108页

作者：靳金美石海莲吴晓俊上海市复方中药重点实验室教育部中药标准化重点实验室上海中医药大学中药研究所

从肠道菌与肿瘤的病理进程、肠道菌与抗肿瘤药物的相互作用及中药调控肠道菌等方面综述肠道菌与肿瘤及抗肿瘤药物的关系。正常肠道菌群由高度多样化的微生物组成,肠道微生物群稳态对宿主正常生理功能的维持具有重要作用。肠道菌介导多... 详细信息

从肠道菌与肿瘤的病理进程、肠道菌与抗肿瘤药物的相互作用及中药调控肠道菌等方面综述肠道菌与肿瘤及抗肿瘤药物的关系。正常肠道菌群由高度多样化的微生物组成,肠道微生物群稳态对宿主正常生理功能的维持具有重要作用。肠道菌介导多种肿瘤的病理进程,如结直肠癌、胃癌、肝癌、乳腺癌等,对肿瘤细胞和组织具有促进或抑制的双重作用。肠道菌与抗肿瘤药物相互作用,肿瘤化疗药物可改变体内肠道菌群平衡;肠道菌可通过免疫调节、代谢、酶降解、降低多样性等途径调控化疗药物的疗效或毒性;肠道菌亦有助于增强肿瘤免疫治疗药物的疗效,延长患者的生存期。多种中药具有调控肠道菌群的作用,抗肿瘤中药及复方的应用能有效抑制肿瘤复发、转移,减轻不良反应,提高患者的生存质量,具有广阔前景。

关键词：肠道菌肿瘤抗肿瘤药物中药综述

小豆蔻明对人三阴性乳腺癌MDA-MB-231细胞葡萄糖摄取能力的影响

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上海中医药大学学报 2021年第4期35卷 54-60页

作者：靳金美邱水平石海莲张德高吴晓俊上海市复方中药重点实验室教育部中药标准化重点实验室国家中医药管理局中药新资源与品质评价重点研究室上海中医药大学中药研究所上海201203 上海交通大学医学院附属新华医院崇明分院药剂科/药物临床试验机构办公室上海202150

目的:考察小豆蔻明对人三阴性乳腺癌MDA-MB-231细胞葡萄糖摄取能力的影响,并探讨其分子机制。方法:将MDA-MB-231细胞分为小豆蔻明不同浓度(0、10、20、40、80μmol/L)组,分别予以相应浓度药物干预24 h。CCK-8法检测细胞活力,2-NBDG法检... 详细信息

目的:考察小豆蔻明对人三阴性乳腺癌MDA-MB-231细胞葡萄糖摄取能力的影响,并探讨其分子机制。方法:将MDA-MB-231细胞分为小豆蔻明不同浓度(0、10、20、40、80μmol/L)组,分别予以相应浓度药物干预24 h。CCK-8法检测细胞活力,2-NBDG法检测细胞葡萄糖摄取能力,PCR法检测细胞葡萄糖转运体(GLUT)mRNA表达,Western blot法检测细胞GLUT蛋白表达。皮下接种MDA-MB-231细胞构建荷瘤裸鼠模型,小豆蔻明(0.3、1.0、3.0 mg/kg)腹腔注射给药4周后,分离荷瘤小鼠乳腺癌组织,Western blot法检测乳腺癌组织GLUT蛋白表达。结果:小豆蔻明(20、40、80μmol/L)能剂量依赖性抑制MDA-MB-231细胞的活力(P0.05)。小豆蔻明(0.3、1.0、3.0 mg/kg)能够显著降低荷瘤裸鼠乳腺癌组织GLUT1蛋白表达(P<0.01),而小豆蔻明(1.0、3.0 mg/kg)能够显著下调GLUT3蛋白表达(P<0.01)。结论:小豆蔻明可能通过下调GLUT mRNA和蛋白表达,降低人三阴性乳腺癌MDA-MB-231细胞的活力和葡萄糖摄取能力。

关键词：小豆蔻明乳腺癌细胞活力葡萄糖摄取葡萄糖转运体

Modulated symbol-based one-time pad secure transmission scheme using physical layer keys

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Science China(Information Sciences) 2024年第1期67卷 221-239页

作者： Xiaoyan HU Zheng WAN Kaizhi HUANG Liang jin Mengyao YAN Yajun CHEN jinmei YANG Information Engineering University Purple Mountain Laboratories for Network and Communication Security

This paper proposes a novel modulated symbols-based one-time pad(SOTP) secure transmission scheme using physical layer *** classical physical layer key generation and exclusive OR(XOR)encryption in the discrete binary space,we design a framework for modulated symbols-based one-time pad(OTP) encryption,where the cryptographic primitive and mathematical model of SOTP is given to build a practical cryptographic *** with existing physical layer encryption(PLE) schemes,we provide rigorous proof that the framework can meet perfect secrecy and correctness *** addition,we provide a specific scheme of physical layer OTP secure transmission for quadrature amplitude modulation(QAM) and phase-shift keying(PSK) symbols based on physical layer *** scheme realizes the unification of bit encryption and symbol encryption,which can adaptively select the quantization level according to the signal-to-noise ratio(SNR) to minimize the symbol error rate(SER).Further,we analyze the performance quantitatively and derive the closed-form expressions of SER,which indicates that the proposed scheme has a lower ***,simulation results verify that the proposed symbol-wise OTP secure transmission scheme can achieve perfect secrecy and high reliability.

关键词： physical layer security one-time pad wireless channel physical layer encryption perfect secrecy

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Physical-Layer Key Generation Based on Multipath Channel Diversity Using Dynamic Metasurface Antennas

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China Communications 2023年第4期20卷 153-166页

作者： Zheng Wan Yangming Lou Xiaoming Xu jinmei Yang Wenyu Jiang Kaizhi Huang Liang jin Information Engineering University Zhengzhou 450001China Purple Mountain Laboratories for Network and Communication Security Nanjing 210096China

Physical layer key generation(PKG)technology leverages the reciprocal channel randomness to generate the shared secret *** low secret key capacity of the existing PKG schemes is due to the reduction in degree-of-freedom from multipath fading channels to multipath combined *** improve the wireless key generation rate,we propose a multipath channel diversity-based PKG *** by dynamic metasurface antennas(DMA),a two-stage multipath channel parameter estimation algorithm is proposed to efficiently realize super-resolution multipath parameter *** proposed algorithm first estimates the angle of arrival(AOA)based on the reconfigurable radiation pattern of DMA,and then utilizes the results to design the training beamforming and receive beamforming to improve the estimation accuracy of the path *** multipath separation and parameter estimation,multi-dimensional independent path gains are utilized for generating secret ***,we analyze the security and complexity of the proposed scheme and give an upper bound on the secret key capacity in the high signal-to-noise ratio(SNR)*** simulation results demonstrate that the proposed scheme can greatly improve the secret key capacity compared with the existing schemes.

关键词： physical layer security multipath channel diversity physical layer key generation dynamic metasurface antennas

Full-length transcriptome sequence and SSR marker development for genetic diversity research in yellowfin seabream Acanthopagrus latus

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Journal of Oceanology and Limnology 2023年第3期41卷 1073-1083页

作者： jin ZHANG jinmei LIU Chong HAN Cheng PENG Yong LI Junhong XIA Yong ZHANG Shuisheng LI Haoran LIN State Key Laboratory of Biocontrol Institute of Aquatic Economic Animals and Guangdong Province Key Laboratory for Aquatic Economic AnimalsSchool of Life SciencesSun Yat-Sen UniversityGuangzhou 510275China Zhuhai Modern Agriculture Development Center Zhuhai 519000China Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesGuangzhou 510260China

Yellowfin seabream Acanthopagrus latus is an important economic fish in Chinese coastal *** its narrow distribution and overfishing,the genetic diversity of yellowfin seabream has been restricted for artificial breeding and *** performed full-length transcriptome sequencing and assembly of the genome of yellowfin seabream.A total of 68086 unigenes were obtained,with an N50 of 3391 bp on average length of 2933 bp.A total number of 50593 expressed sequence tags linked to simple sequence repeats(EST-SSR)were identified,among them dinucleotide repeats(40.6%)and AC/GT motifs(38.5%)were the most *** the 190 EST-SSRs for which PCR primer pairs were designed,150 primer pairs successfully amplified target loci and 15 SSRs showed high *** alleles per locus ranged 6-50 on average of *** expected and observed heterozygosity varied from 0.632 to 0.969 and from 0.519 to 0.953,*** polymorphic index content(PIC)values of each locus ranged 0.587-0.966 on average of *** six yellowfin seabream population samples preliminarily tested for genetic diversity and differentiation,the Fangchenggang(FCG)population in Guangxi Province had the highest mean observed heterozygosity(H_(o))value(0.786),whereas the Zhangzhou(ZZ)population in Fujian Province had the lowest(0.678).The pairwise fixation index(Fst)values indicated significant population differentiation among six yellowfin seabream *** study provided evidence for the usefulness of the transcriptomic resource information and EST-SSR markers for natural resource conservation,population genetics,and breeding studies of yellowfin seabream in South China.

关键词： yellowfin seabream Acanthopagrus latus full-length transcriptome expressed sequence tags linked to simple sequence repeats(EST-SSR)marker genetic diversity

Effect and safety of acupotomy in treatment of knee osteoarthritis:a systematic review and Meta-analysis

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Journal of Traditional Chinese Medicine 2020年第3期40卷 355-364页

作者： Fang Ting Li Qi Zhou Fanyuan Liu Fushui Liu Zhongyong Zhao Meimei Chen Mei You Jianyu jin Yuli Xie jinmei Department of Acupotomy Chiropractors The Affiliated Hospital of Jiangxi University of Traditional Chinese MedicineNanchang 330006China Jiangxi Normal University Nanchang 330022China College of Clinical Medicine Jiangxi University of Traditional Chinese MedicineNanchang 330004China Department of Cardiovascular Medicine The Affiliated Hospital of Jiangxi University of Traditional Chinese MedicineNanchang 330006China

OBJECTIVE: To evaluate the clinical efficacy and safety of acupotomy in treatment of knee osteoarthritis(OA).METHODS: Extensive literature searches were carried out in PubMed, EMBASE, Cochrane Library(Issue 5, 2017), Chinese Biomedical Literature Database, China National Knowledge Infrastructure Database, China Science and Technology Journal Database and Wanfang Database. All databases were retrieved from their inception until May 31, *** controlled trials incorporating acupotomy versus intra-articular sodium hyaluronate for knee osteoarthritis were included. According to Cochrane Reviews’ Handbook(5.2), two reviewers screened each article and extracted data independently and were blinded to the findings of each reviewer. Meta-analysis was performed by the Cochrane Collaboration’s RevMan 5.3 ***: We identified 12 studies involving 1150 patients aged between 40 and 78 years old. The pooled analysis indicated that acupotomy showed a significant improvement for short-term effect[cure rate: odds ratio(OR) = 2.04, 95% confidence interval(CI)(1.46, 2.85), P < 0.01;total effective rate:OR = 2.25, 95% CI(1.55, 3.28), P < 0.01;pain score:standard mean difference(SMD) =-1.02;95% CI(-1.72,-0.31);P = 0.005;Western Ontario and McMaster Universities Questionnaire(WOMAC) score:SMD =-0.74;95% CI(-1.11,-0.37);P < 0.01];and also for long-term effect [total effective rate:OR = 2.99, 95%CI(1.88, 4.76), Z = 4.64, P < 0.01;pain score: SMD =-1.68;95% CI(-2.14,-1.22);P <0.001;WOMAC score: SMD =-0.91;95% CI(-1.40,-0.41);P < 0.001]. In addition, there was no obvious difference between acupotomy group and control group in adverse events [OR = 2.13, 95% CI(0.14, 32.28), P = 0.58].CONCLUSION: Acupotomy is a safe and effective treatment for KOA. However, due to the methodological deficiency of the included studies, well-designed randomized controlled trials are required to further confirm the findings.

关键词： Osteoarthritis knee Hyaluronic acid Acupuncture therapy Review Meta-analysis

The quality control and hypoglycemic effect of Cinnamomi Cortex aqueous extract

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Journal of Future Foods 2024年第2期4卷 167-172页

作者： Xuting Hao Ziheng jin Ruiyu Gao Shiming Li Changqin Li Lijun Liu jinmei Wang National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Key Laboratory of Natural Pigment Preparation of Henan Province Luohe 462600China Department of Food Science Rutgers University New BrunswickNJ 08901USA Joint International Research Laboratory of Food&Medicine Resource Function of Henan Province Kaifeng 475004China Huaihe Hospital of Henan University Kaifeng 475000China

Cinnamomi Cortex was a material as medicinal and edible resources and it has been demonstrated that Cinnamomi Cortex aqueous extract(CCAE)possess hypoglycemic effect,but there were no active compounds identified as quality standard of CCAE to be used in the investigate of hypoglycemic ***,in this study,the quality standard and the hypoglycemic effect of CCAE were *** and coumarin as the quality control in CCAE were analyzed by high performance liquid chromatography(HPLC)*** results showed that the average yield of extraction was 10.06%.The concentration of coumarin was linear with peak area ranging from 0.02–1.00μg/mL(r=0.9996,n=6)and that of cinnamaldehyde also demonstrated a good linear relationship with peak area in the range of 1.05–52.50μg/mL(r=0.9997,n=6).The average recovery rate of coumarin and cinnamaldehyde was 99.42%and 100.11%,*** investigation of hypoglycemic effect revealed that CCAE could improve weight loss,lower liver and pancreas indices,improve organ damage caused by diabetes,and lower fasting blood glucose,glycosylated serum protein(GSP)and total cholesterol(TC)*** results showed that CCAE can reduce fasting blood glucose and blood lipid levels in diabetic mice.

关键词： Cinnamomi Cortex Cinnamaldehyde Coumarin Hypoglycemic effect

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采用SIFT特征的空基动态视频稳定技术

红外与激光工程 2011年第12期40卷 2552-2557页

作者：林锦梅周付根金挺北京航空航天大学宇航学院图像处理中心北京100191

当采用空基平台对道路进行交通检测时,平台沿道路飞行,空基平台姿态不易控制且控制精度较低,此外,由于风速影响和平台自身振动等因素,检测获取的视频图像存在不必要的随机摇摆和抖动,为了去除抖动,改善观测效果,需进行动态观测模式下的... 详细信息

当采用空基平台对道路进行交通检测时,平台沿道路飞行,空基平台姿态不易控制且控制精度较低,此外,由于风速影响和平台自身振动等因素,检测获取的视频图像存在不必要的随机摇摆和抖动,为了去除抖动,改善观测效果,需进行动态观测模式下的视频稳定处理以实现稳定观测。采用改进的SIFT算法进行特征提取,提高了SIFT特征提取的效率,并根据动态视频相邻帧匹配的实际应用,采用邻域搜索方法进行特征匹配,提高了匹配的精度。得到精确匹配的特征点对进行运动参数估计,并采用Kalman滤波对运动参数平滑后进行视频图像的校正补偿,得到稳定的视频输出。该算法精度较高,稳定效果较好,能有效地实现空基平台动态视频稳定处理,便于交通监控,为后续的目标检测与跟踪提供了便利。

关键词：视频稳定 SIFT特征运动估计 Kalman滤波