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Shift Strategy Development for Electric Bus

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Shift Strategy Development for Electric Bus

Artificial Nucleic Acid Tractor-Directed Simultaneous Depletion of Oncogenic Membrane Proteins Without Hijacking Proteolysis-Specific Actuator

2022中国汽车工程学会年会暨展览会

作者： Wang Yonghui Yang Disha Li Heyan Qu erhu College of Urban Transportation and Logistics Shenzhen Technology University

This paper studies the shifting strategy based on an electric *** to the development performance requirements of the bus,a dynamic shifting strategy and an economical shifting strategy are formulated *** them,the dynamic shifting strategy is mainly based on the principle of maximum acceleration to formulate corresponding shifting strategy,and the economical shifting strategy is mainly formulated based on the test data of the motor bench and the characteristics of the vehicle speed and efficiency curve under different accelerator pedal ***,build an AVL CRUISE vehicle simulation model to simulate and analyze the shifting strategy of the electric bus and a test platform for *** and test results show that the proposed shifting strategy is feasible.

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CCS Chemistry 2024年第2期6卷 439-449页

作者： Zhen Zou Songlan Pan Qian Xue Ting Chen Ziyun Huang Bei Qing Pengfei Liu Conghui Zhao Yunlin Sun erhu Xiong Ronghua Yang Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research Ministry of EducationCollege of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081 School of Chemistry and Chemical Engineering Hunan Provincial Key Laboratory of CytochemistryChangsha University of Science and TechnologyChangsha 410114 The Second Xiangya Hospital Central South UniversityChangsha 410011

Targeted protein degradation(TPD)is an emerging tool for degrading proteins of interest,which affords an attractive modality for cancer ***,the present TPD technologies must engage a proteolysis-specific actuator to initiate degradation of targeted proteins in the proteasome or ***,we report an artificial tractor that can induce endocytosis-mediated protein depletion without hijacking a proteolysis-specific *** this design,bispecific aptamer chimeras(BSACs)are established,which can bridge human epidermal growth factor receptor 2(ErbB-2),an important biomarker in a common important biomarker in cancer,with membrane proteins of *** advantage of the property of aptamer-induced endocytosis and digestion of ErbB-2,another membrane protein is translocated into the lysosome in a hitchhike-like manner,resulting in lysosomal proteolysis along with *** strategy frees the TPD from the fundamental limitation of proteolysis-specific actuator and allows simultaneous regulation of the quantity and function of two oncogenic receptors in a cell-type-specific manner,expanding the application scope of TPD-based therapeutics.

关键词： targeted protein degradation aptamer epidermal growth factor receptor 2 lysosome membrane proteins cancer therapy

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我国发射射电卫星的作用及关键技术研究

武汉大学学报（信息科学版） 2005年第10期30卷 847-852页

作者：刘经南魏二虎武汉大学校长办公室武汉市珞珈山430072 武汉大学测绘学院武汉市珞喻路129号430079

论述了我国发射射电卫星对于天文学和射电天文方法的发展、我国月球及深空探测计划、大地测量和天文地球动力学的研究和发展等方面的意义;根据VLBI卫星的技术和应用特点,分析了射电望远镜及相关设施的技术要求和指标,比较全面地分析和... 详细信息

论述了我国发射射电卫星对于天文学和射电天文方法的发展、我国月球及深空探测计划、大地测量和天文地球动力学的研究和发展等方面的意义;根据VLBI卫星的技术和应用特点,分析了射电望远镜及相关设施的技术要求和指标,比较全面地分析和总结了VLBI卫星及相关设施的关键技术和方法。

关键词：射电卫星射电卫星空间组网地面服务站定轨时间同步深空探测

Roles of endoplasmic reticulum stress and apoptosis signaling pathways in gynecologic tumor cells：A systematic review

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Oncology and Translational Medicine 2017年第3期3卷 131-135页

作者： Kangsheng Liu Weimin Fang erhu Sun Yajun Chen Department of Clinical Laboratory Nanjing Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University Nanjing 210029 China Department of Obstetrics and Gynecology Nanjing Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University Nanjing 210029 China

Efficient functioning of the endoplasmic reticulum(ER) is very important for most cellular activities, such as protein folding and modification. The ER closely interacts with other organelles, including the Golgi body, endosome, membrane, and mitochondria, providing lipids and proteins for the repair of these organelles. ER stress can be induced by various abnormal materials in the cell. ER stress is a compensatory intracellular environment disorder that occurs during areaction. ER can sense the stress and respond to it through translational attenuation, upregulation of the genes for ER chaperones and related proteins, and degradation of unfolded proteins by a quality-control system, but excessive ER activation can cause cell death. The Pubmed and Web of Science databases were searched for full-text articles, and the terms "endoplasmic reticulum stress/unfolded protein response/gynecologic tumor cell apoptosis" were used as key words. Thirty-five studies of ER stress and unfolded protein response published from 2000 to 2016 were analyzed. Stress triggers apoptosis through a variety of signaling pathways. Increasing evidence has shown that the ER plays an important role in tumor cell diseases. The present review discusses the molecular mechanisms underlying unfolded protein response and its ability to promote survival and proliferation in gynecologic tumor cells.

关键词： endoplasmic reticulum(ER) unfolded protein response(UPR) inositol-requiring-JNK(IRE1-JNK) caspase CCAAT-enhancer-binding protein homologous protein(CHOP) gynecologic tumor cell

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东汉画像中所见的早期民间道教

文艺研究 2007年第2期 121-129页

作者：罗二虎上海大学艺术研究院美术考古研究中心

本文认为在东汉后期画像出现的新因素中,有相当部分与当时出现的早期民间道教有关,并从画像符号化与道符、画像中所见的特殊人物与道士、丹鼎与仙丹画像的象征意义、秘戏与房中图的象征意义等几个方面进行具体论述。

关键词：画像东汉后期早期民间道教

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试论卡莎湖文化

华夏考古 2008年第4期 97-106页

作者：罗二虎四川大学中国藏学研究所四川成都市610065 上海大学艺术研究院上海市200444

该文首次提出在川滇青藏民族走廊地区的古代石棺葬中存在着一种新的文化——卡莎湖文化,并对卡莎湖文化的主要特征、分期、年代、与其他文化的关系、族属等问题都进行了初步的讨论。

关键词：卡莎湖文化川西高原石棺葬周代

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重庆忠县邓家沱汉代石阙再讨论

四川大学学报（哲学社会科学版） 2016年第4期 5-14页

作者：罗二虎四川大学历史文化学院

虽然已有学者对重庆忠县邓家沱石阙进行了研究,但在石阙出土地层、形制结构、铭文书体与文字释读、图像内容、雕刻技法、复原方案、年代、总体特点等方面都需要再讨论,前人的某些观点也值得商榷。该阙形制较为简单,部分特点不同于本地... 详细信息

虽然已有学者对重庆忠县邓家沱石阙进行了研究,但在石阙出土地层、形制结构、铭文书体与文字释读、图像内容、雕刻技法、复原方案、年代、总体特点等方面都需要再讨论,前人的某些观点也值得商榷。该阙形制较为简单,部分特点不同于本地区其他石阙,却与同时期北方的石阙相似,其建造年代可追溯到东汉中期前段,是迄今为止川渝地区发现的年代最早的石阙。此外,该阙还有部分特点在川渝地区和北方地区的石阙中都不曾见到,展现出汉代石阙形态的多样性。

关键词：邓家沱石阙复原年代主要特点