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黄芪中有效成分的提取、生物活性功能及其在动物生产中的应用

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饲料研究 2024年第3期47卷 149-153页

作者：杨希文祁效林戴衍朋金国栋李爱堂张金霞冯坤蓉覃志江临夏州农业科学院甘肃临夏731100 山东省中医药研究院山东济南250103 甘肃润源农业科技发展有限公司甘肃临夏731801

黄芪有效成分主要包括黄芪多糖、皂苷、黄酮等,在药理上具有消炎、杀菌、抗氧化、提高免疫力等作用。黄芪有效成分的提取方法主要有溶剂萃取法、酶解法和超声波法等。黄芪有效成分可以有效调节动物的生长发育和免疫功能,现已广泛用作动... 详细信息

黄芪有效成分主要包括黄芪多糖、皂苷、黄酮等,在药理上具有消炎、杀菌、抗氧化、提高免疫力等作用。黄芪有效成分的提取方法主要有溶剂萃取法、酶解法和超声波法等。黄芪有效成分可以有效调节动物的生长发育和免疫功能,现已广泛用作动物饲料添加剂以及动物疾病防治药剂。文章主要介绍了黄芪有效成分组成、提取工艺、生物活性功能及其在动物生产中的应用情况,展望其在动物生产应用中的研究方向和前景,为黄芪有效成分在动物生产中的高效推广与应用提供参考。

关键词：黄芪多糖皂苷黄酮动物生产

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Fluoroscopic removal of fractured,retained,embedded Z self-expanding metal stent using a guidewire lasso technique:A case report

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World Journal of Clinical Cases 2022年第8期10卷 2516-2521页

作者： Yong-Hua Bi Jian-Zhuang Ren jin-dong Li Xin-Wei Han Department of Interventional Radiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Thoracic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

BACKGROUND There are few reports of a fractured esophageal self-expanding metallic stent(SEMS)and the lasso retrieval technique,forming a guidewire loop by directing the guidewire back up the external stent for *** SUMMARY A 74-year-old man complained of dysphagia approximately 6 mo after radical resection of esophageal *** anastomotic stenosis was diagnosed,and a 20 mm in diameter and 60 mm in length esophageal covered SEMS was inserted after repeated balloon *** 13.5 mo after stenting,dysphagia recurred and esophagography showed severe stenosis above the proximal stent and stent removal was ***-third of the stent was removed and the fractured stent remained in the proximal esophagus.A suction tube was introduced through the guidewire and then the guidewire was grabbed,acting like a“lasso”on *** remaining fractured stent was successfully removed by slowly pulling back the guidewire,with no fragments of stent wires *** The guidewire lasso technique is a simple,effective method of removing esophageal SEMS in rare cases of stent fracture.

关键词： Self-expanding metallic stent Stenosis Guidewire lasso technique Stent removal Esophagus Case report

A Review on Particle Reinforced Mg Matrix Composites Fabricated by Powder Metallurgy

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 391-400页

作者： Zhiyuan Liu Li jin Jian Zeng Fulin Wang Fenghua Wang Shuai dong Jie dong National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China

This paper provides a comprehensive review of research progress in particle-reinforced Mg matrix composites prepared via powder *** article discusses different strategies,such as micro-sized,nano-sized particles,and multi-particle hybridization,which has been employed to enhance the performance of the *** addition,a range of preparation techniques that optimize the dispersion of the reinforcing particles are *** paper also highlights how the different configurations between the reinforcements and matrix alloy impact the composites’***,the article outlines the prospects of particles reinforced Mg matrix composites fabricated via powder metallurgy and recommends modification methods that could be explored to further develop these materials for various applications.

关键词： Magnesium matrix composites Reinforcing particle Powder metallurgy Mechanical properties Configuration

Cancer cachexia:Focus on cachexia factors and inter-organ communication

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Chinese Medical Journal 2024年第1期137卷 44-62页

作者： Yongfei Wang Zikai dong Ziyi An Weilin jin The First Clinical Medical College of Lanzhou University LanzhouGansu 730000China Institute of Cancer Neuroscience Medical Frontier Innovation Research CenterThe First Hospital of Lanzhou UniversityThe First Clinical Medical College of Lanzhou UniversityLanzhouGansu 730000China

Cancer cachexia is a multi-organ syndrome and closely related to changes in signal communication between organs,which is mediated by cancer cachexia *** cachexia factors,being the general name of inflammatory factors,circulating proteins,metabolites,and microRNA secreted by tumor or host cells,play a role in secretory or other organs and mediate complex signal communication between organs during cancer *** cachexia factors are also a potential target for the diagnosis and *** pathogenesis of cachexia is unclear and no clear effective treatment is ***,the treatment of cancer cachexia from the perspective of the tumor ecosystem rather than from the perspective of a single molecule and a single organ is urgently *** the point of signal communication between organs mediated by cancer cachexia factors,finding a deeper understanding of the pathogenesis,diagnosis,and treatment of cancer cachexia is of great significance to improve the level of diagnosis and *** review begins with cancer cachexia factors released during the interaction between tumor and host cells,and provides a comprehensive summary of the pathogenesis,diagnosis,and treatment for cancer cachexia,along with a particular sight on multi-organ signal communication mediated by cancer cachexia *** summary aims to deepen medical community’s understanding of cancer cachexia and may conduce to the discovery of new diagnostic and therapeutic targets for cancer cachexia.

关键词： Cancer cachexia Cancer cachexia factors Inter-organ communication Tumor ecosystem Tumor microenvironment

桥梁桩基废弃泥浆制作地聚物胶凝材料试验研究

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建材技术与应用 2024年第4期 58-61页

作者：游彪邬俊峰董金中胡国祥武汉工程大学土木工程与建筑学院湖北武汉430074 湖北交投荆楚建设管理有限公司湖北荆州434100

为处理桥梁桩基废弃泥浆,采用工业固废协同泥浆制作地质聚合物胶凝材料,改良其工程性能。基于正交试验设计原理,参考水泥胶砂试验方法研究了泥浆掺量、水固比、养护龄期对地聚物胶凝材料强度的影响。试验结果表明:掺加泥浆的地聚物胶凝... 详细信息

为处理桥梁桩基废弃泥浆,采用工业固废协同泥浆制作地质聚合物胶凝材料,改良其工程性能。基于正交试验设计原理,参考水泥胶砂试验方法研究了泥浆掺量、水固比、养护龄期对地聚物胶凝材料强度的影响。试验结果表明:掺加泥浆的地聚物胶凝材料28 d抗压强度可达21.65 MPa,抗折强度可达4.11 MPa。在泥浆掺量为30%~50%、水固比为0.35~0.55及养护龄期28 d范围内,地聚物胶凝材料的抗压、抗折强度与泥浆掺量、水固比呈负相关,与养护龄期呈正相关。

关键词：桥梁桩基废弃泥浆地聚物胶凝材料粉煤灰矿渣粉脱硫石膏

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Observation of gapless corner modes of photonic crystal slabs in synthetic translation dimensions

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Photonics Research 2024年第3期12卷 444-455页

作者： WEN-jin ZHANG HAO-CHANG MO WEN-JIE CHEN XIAO-dong CHEN JIAN-WEN dong School of Physics&State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen UniversityGuangzhou 510275China

Second-order topological photonic crystals support localized corner modes that deviate from the conventional bulk-edge ***,the frequency shift of corner modes spanning the photonic band gap has not been experimentally ***,we observe the gapless corner modes of photonic crystal slabs within a parameter space by considering translation as an additional synthetic *** corner modes,protected by topological pumping in synthetic translation dimensions,are found to exist independently of the specific corner *** gapless corner modes are experimentally imaged via the near-field scanning measurement and validated numerically by full-wave *** propose a topological rainbow with gradient translation,demonstrating the ability to extract and separate specific frequency components of light into different spatial *** work contributes to the advancement of topological photonics and provides valuable insights into the exploration of gapless corner modes in synthetic dimensions.

关键词： translation dimensions corner

Time-domain dynamic constitutive model suitable for mucky soil site seismic response

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 1-13页

作者： dong Qing Chen Su jin Liguo Zhou Zhenghua Li Xiaojun Architectural Engineering Institute Huaiyin Institute of TechnologyHuai’an 223600China Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of TechnologyBeijing 100020China Institute of Geophysics China Earthquake AdministrationBeijing 100089China College of Transportation Science and Engineering Nanjing Tech UniversityNanjing 211816China

Soil nonlinear behavior displays noticeable effects on the site seismic *** study proposes a new functional expression of the skeleton curve to replace the hyperbolic skeleton *** integrating shear modulus and combining the dynamic skeleton curve and the damping degradation coefficient,the constitutive equation of the logarithmic dynamic skeleton can be obtained,which considers the damping effect in a soil dynamics *** on the finite difference method and the multi-transmitting boundary condition,a 1D site seismic response analysis program called Soilresp1D has been developed herein and used to analyze the time-domain seismic response in three types of *** the same time,this study also provides numerical simulation results based on the hyperbolic constitutive model and the equivalent linear *** results verify the rationality of the new soil dynamic constitutive *** can analyze the mucky soil site nonlinear seismic response,reflecting the deformation characteristics and damping effect of the silty *** hysteresis loop area is more extensive,and the residual strain is evident.

关键词： seismic response time-domain dynamic constitutive model logarithmic dynamic skeleton dampening effect mucky soil

台风“烟花”(2106)期间江苏南通地区降水稳定同位素组成变化特征及影响因素

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地球科学与环境学报 2024年第2期46卷 169-179页

作者：陈思帆刘张齐毕丽丽丁文娜姜修洋董进国福建师范大学福建省亚热带资源与环境重点实验室福建福州350117 福建师范大学地理研究所福建福州350117 南通大学地理科学学院江苏南通226019

2021年第6号(2106)台风“烟花”是我国有监测记录以来对大陆影响时间最长的台风,为华东地区带来了暴雨级的降水。基于台风“烟花”(2106)影响江苏南通地区期间小时尺度高分辨率的降水稳定同位素数据,分析了降水稳定同位素组成变化特征... 详细信息

2021年第6号(2106)台风“烟花”是我国有监测记录以来对大陆影响时间最长的台风,为华东地区带来了暴雨级的降水。基于台风“烟花”(2106)影响江苏南通地区期间小时尺度高分辨率的降水稳定同位素数据,分析了降水稳定同位素组成变化特征及影响因素。结果表明:降水δ^(18)O值为-11.7‰~-2.3‰,加权平均值为-7.4‰。台风影响前期,采样点水汽主要来源于附近海域,受云下蒸发效应的影响,降水δ^(18)O值相对偏正;台风影响中期,受相对湿度与上游累积对流强度的共同控制,降水δ^(18)O值逐渐偏负。但相较于已发表的我国台风降水δ^(18)O极端偏负值(-20.1‰~-12.6‰),台风“烟花”(2106)降水δ^(18)O极值并未显著偏负,主要是由于上游累积对流降水历时较短以及台风登陆后水汽缺乏大规模有组织性的对流活动。

关键词：降水稳定同位素台风“烟花”(2106) 云下蒸发效应对流强度上游降水华东地区

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狭缝引导配体13′UTR通过miR-34a-5p/SIRT1轴调节内皮细胞表型

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中国生物化学与分子生物学报 2024年第3期40卷 362-372页

作者：欧涛胡志琴高原伍华燕陈凯茵徐金东方咸宏单志新华南理工大学医学院广州510006 广州医科大学附属第五医院药学部广州510799 南方医科大学附属广东省人民医院(广东省医学科学院)医学研究部广州510080 南方医科大学附属广东省人民医院(广东省医学科学院)麻醉科广州510080 南方医科大学附属广东省人民医院(广东省医学科学院)心内科广州510080

在高等生物的进化过程中,mRNA的3′非翻译区(3′untranslated region,3′UTR)序列显著增加,提示3′UTR在生物功能调节中可能发挥重要作用。我们发现狭缝引导配体1(slit guidance ligand 1,SLIT1)3′UTR在肥厚型心肌病(HCM)患者心肌中水... 详细信息

在高等生物的进化过程中,mRNA的3′非翻译区(3′untranslated region,3′UTR)序列显著增加,提示3′UTR在生物功能调节中可能发挥重要作用。我们发现狭缝引导配体1(slit guidance ligand 1,SLIT1)3′UTR在肥厚型心肌病(HCM)患者心肌中水平降低,但其对肥厚心肌中血管功能调节的作用机制不清楚。利用腺病毒介导在主动脉内皮细胞(human aortic endothelial cells,HAECs)中过表达SLIT13′UTR,检测HAECs中一氧化氮合酶(endothelial nitric oxide synthases,eNOS)和血管内皮生长因子A(vascular endothelial growth factor,VEGFA)表达。分别采用划痕实验和基于Matrigel胶的管腔形成实验检测HAECs的迁移和成管腔能力。结果发现,过表达SLIT13′UTR会升高HAECs中p-eNOS、eNOS和VEGFA水平(P<0.01),并促进HAECs迁移和成管腔能力(P<0.01)。生物信息学预测提示,SLIT13′UTR上有多个微RNA(miRNA)的潜在结合位点,反义RNA纯化技术(RNA antisense purification,RAP)筛选和利用Ago2抗体进行RNA结合蛋白质免疫沉淀(RNA binding protein immunoprecipitation,RIP)结果显示,SLIT13′UTR与miR-34a-5p存在结合作用,而过表达SLIT13′UTR的HAECs中miR-34a-5p水平显著降低(P<0.05)。Western印迹结果证实,miR-34a-5p可逆转过表达SLIT13′UTR对去乙酰化酶SIRT1的上调作用(P<0.05)。在HAECs中转染miR-34a-5p和si-SIRT1,可一致地抑制过表达SLIT13′UTR引起的p-eNOS、eNOS和VEGFA增加(P<0.05,P<0.01),及促进HAECs迁移和成管腔的能力(P<0.01,P<0.001)。因此,SLIT13′UTR可以特异性吸附miR-34a-5p,通过miR-34a-5p/SIRT1轴发挥促进内皮细胞迁移和管腔生成的作用。

关键词：狭缝引导配体1,3′非翻译区血管内皮细胞微RNA

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