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Health diagnosis of ultrahigh arch dam performance using heterogeneous spatial panel vector model

Water Science and Engineering 2024年第2期17卷 177-186页

作者： Er-feng Zhao Xin Li chong-shi Gu The National Key Laboratory of Water Disaster Prevention Hohai UniversityNanjing 210098China NationalEngineering Research Centerof Water Resources Eficient Utilization and Engineering Safety Hohai UniversityNanjing 20098China

Currently,more than ten ultrahigh arch dams have been constructed or are being constructed in *** control is essential to long-term operation of these *** study employed the flexibility coefficient and plastic complementary energy norm to assess the structural safety of arch dams.A comprehensive analysis was conducted,focusing on differences among conventional methods in characterizing the structural behavior of the Xiaowan arch dam in ***,the spatiotemporal characteristics of the measured performance of the Xiaowan dam were explored,including periodicity,convergence,and time-effect *** findings revealed the governing mechanism of main ***,a heterogeneous spatial panel vector model was developed,considering both common factors and specific factors affecting the safety and performance of arch *** model aims to comprehensively illustrate spatial heterogeneity between the entire structure and local regions,introducing a specific effect quantity to characterize local deformation ***,the proposed model was applied to the Xiaowan arch dam,accurately quantifying the spatiotemporal heterogeneity of dam ***,the spatiotemporal distri-bution characteristics of environmental load effects on different parts of the dam were reasonably *** of the model prediction enhances its credibility,leading to the formulation of health diagnosis criteria for future long-term operation of the Xiaowan *** findings not only enhance the predictive ability and timely control of ultrahigh arch dams'performance but also provide a crucial basis for assessing the effectiveness of engineering treatment measures.

关键词： Ultrahigh arch dam Structural performance Deformation behavior Diagnosis criterion Panel data model

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Complications and comorbidities associated with antineoplastic chemotherapy:Rethinking drug design and delivery for anticancer therapy

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2901-2926页

作者： Xiaoman Mao Shuang Wu Dandan Huang chong Li College of Pharmaceutical Sciences Southwest UniversityChongqing 400715China Medical Research Institute Southwest UniversityChongqing 400715China School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou 510515China

Despite the considerable advancements in chemotherapy as a cornerstone modality in cancer treatment,the prevalence of complications and pre-existing diseases is on the rise among cancer patients along with prolonged survival and aging *** relationships between these disorders and cancer are intricate,bearing significant influence on the survival and quality of life of individuals with cancer and presenting challenges for the prognosis and outcomes of ***,we review the prevailing complications and comorbidities that often accompany chemotherapy and summarize the lessons to learn from inadequate research and management of this scenario,with an emphasis on possible strategies for reducing potential complications and alleviating comorbidities,as well as an overview of current preclinical cancer models and practical advice for establishing bio-faithful preclinical models in such complex context.

关键词： Complications Comorbidities Chemotherapy Preclinical cancer models Drug design Drug delivery

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One-Pot Synthesis of 5-Alkoxycarbonyl-4-aryl-3,4-dihydropyrimidin-2-ones Catalyzed by Phosphotungstic Acid

One-Pot Synthesis of 5-Alkoxycarbonyl-4-aryl-3,4-dihydropyri...

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第三届全国有机化学学术会议

作者： jin, Tong-Shou XIAO, jin-chong LI, Tong-Shuang (College of Chemistry and Environmental Science , Hebei University, Baoding 071002)

＜正＞ Many dihydropyrimidinones and their derivatives play an important role in medicine due to their therapeutic and pharmacological *** have emerged as the integral backbones of several calcium channel blockers, antihypertensive agents, alpha-1α-*** for the synthesis of dihydropyrimidinone nucleus have varied from one-pot to multistep approaches. Although high yields can be achieved by the following complex multi-step procedures, these methods lack the simplicity comparing with Biginelli protocol which firstly reported by Big-inelli by one-pot condensation of aryl aldehyde, β-ketoesters and urea with catalytic acid in 1993, and these multi-

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An effective catalyst carrier SiO_(2):Enhancing catalytic and combustion properties of CuFe_(2)O_(4)on energetic components

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Defence Technology（防务技术） 2024年第2期32卷 383-392页

作者： Li Ding chong Wan Suhang Chen Zhao Qin Kangzhen Xu School of Chemical Engineering/Xi'an Key Laboratory of Special Energy Materials Northwest UniversityXi'an710069China Xi’an Modern Chemistry Research Institute Xi'an710065China

To enhance the catalytic activity of copper ferrite(CuFe_(2)O_(4))nanoparticle and promote its application as combustion catalyst,a low-cost silicon dioxide(SiO_(2))carrier was employed to construct a novel CuFe_(2)O_(4)/SiO_(2)binary composites via solvothermal *** phase structure,morphology and catalytic activity of CuFe_(2)O_(4)/SiO_(2)composites were studied firstly,and thermal decomposition,combustion and safety performance of ammonium perchlorate(AP)and 1,3,5-trinitroperhydro-1,3,5-triazine(RDX)with it affecting were then systematically *** results show that CuFe_(2)O_(4)/SiO_(2)composite can remarkably either advance the decomposition peak temperature of AP and RDX,or reduce the apparent activation energy at their main decomposition ***,the flame propagation rate of RDX was promoted by about 2.73 times with SiO_(2)content of 3 wt%,and safety property of energetic component was also improved greatly,in which depressing the electrostatic discharge sensitivity of pure RDX by about 1.89 *** addition,the effective range of SiO_(2)carrier content in the binary catalyst is found to be 3 to 5 wt%.Therefore,SiO_(2)opens a new insight on the design of combustion catalyst carrier and will promote the application of CuFe_(2)O_(4)catalyst in solid propellant.

关键词： Copper ferrite Silicon dioxide Combustion catalyst Thermal decomposition Laser ignition

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Longitudinal vibration characteristics of a tapered pipe pile considering the vertical support of surrounding soil and construction disturbance

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 51-63页

作者： Li Zhenya Pan Yunchao He Xianbin Lv chong Mohammad Towhid Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai UniversityNanjing 210098China Geotechnical Research Institute Hohai UniversityNanjing 210098China MOE Key Laboratory of Soft Soils and Geoenvironmental Engineering Zhejiang UniversityHangzhou 310058China

This research is concentrated on the longitudinal vibration of a tapered pipe pile considering the vertical support of the surrounding soil and construction ***,the pile-soil system is partitioned into finite segments in the vertical direction and the Voigt model is applied to simulate the vertical support of the surrounding soil acting on the pile *** surrounding soil is divided into finite ring-shaped zones in the radial direction to consider the construction ***,the shear complex stiffness at the pile-soil interface is derived by solving the dynamic equilibrium equation for the soil from the outermost to innermost *** displacement impedance at the top of an arbitrary pile segment is obtained by solving the dynamic equilibrium equation for the pile and is combined with the vertical support of the surrounding soil to derive the displacement impedance at the bottom of the upper adjacent ***,the displacement impedance at the pile head is obtained based on the impedance function transfer ***,the reliability of the proposed solution is verified,followed by a sensitivity analysis concerning the coupling effect of the pile parameters,construction disturbance and the vertical support of the surrounding soil on the displacement impedance of the pile.

关键词： tapered pipe pile longitudinal vibration vertical support of the surrounding soil construction disturbance displacement impedance

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S-doped mesoporous graphene modified separator for high performance lithium-sulfur batteries

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Materials Reports(Energy) 2024年第3期4卷 60-68页

作者： Xinlong Ma Chenggen Xu Yin Yang Dong Sun Kai Zhao Changbo Lu Peng jin Yiting chong Sirawit Pruksawan Zhihua Xiao Fuke Wang State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijingChangping102249China State Key Laboratory of Coking Coal Exploitation and Comprehensive Utilization China Pingmei Shenma GroupPingdingshan 467000China Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)2 Fusionopolis WayInnovis#08-03138634Republic of Singapore

Due to their low cost,environmental friendliness and high energy density,the lithium-sulfur batteries(LSB)have been regarded as a promising alternative for the next generation of rechargeable battery ***,the practical application of LSB is seriously hampered by its short cycle life and high self-charge owing to the apparent shuttle effect of soluble lithium *** MgSO_(4)@MgO composite as both template and dopant,template-guided S-doped mesoporous graphene(SMG)is prepared via the fluidized-bed chemical vapor deposition *** the polypropylene(PP)modifier,SMG with high specific surface area,abundant mesoporous structures and moderate S doping content offers a wealth of physical and chemical adsorptive sites and reduced interfacial contact resistance,thereby restraining the serious shuttle effects of lithium ***,the LSB configured with mesoporous graphene(MG)as S host material and SMG as a separator modifier exhibits an enhanced electrochemical performance with a high average capacity of 955.64 mA h g^(-1) at 1C and a small capacity decay rate of 0.109%per ***,the density functional theory(DFT)calculation models have been rationally constructed and demonstrated that the doped S atoms in SMG possess higher binding energy to lithium polysulfides than that in MG,indicating that the SMG/PP separator can effectively capture soluble lithium polysulfides via chemical binding *** work would provide valuable insight into developing a versatile carbon-based separator modifier for LSB.

关键词： Fluidized-bed chemical vapor deposition Mesoporous graphene S doping Separator modification Lithium-sulfur battery

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早奥陶世Sinograptus typicalis Mu胞管形态研究补遗

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古生物学报 2018年第1期57卷 21-24页

作者：韩乃仁庞崇进桂林理工大学地球科学学院广西有色金属隐伏矿床勘查及材料开发协同创新中心广西桂林541004

早奥陶世Sinograptus typicalis Mu笔石胞管形态对于理解其生态具有重要意义。本文在原有研究基础上,重新解释Sinograptus笔石胞管形态特征及其生态。Sinograptus两个笔石枝均保存了一个完整的胞管,在一个胞管的长度内,共有三个胞管背... 详细信息

早奥陶世Sinograptus typicalis Mu笔石胞管形态对于理解其生态具有重要意义。本文在原有研究基础上,重新解释Sinograptus笔石胞管形态特征及其生态。Sinograptus两个笔石枝均保存了一个完整的胞管,在一个胞管的长度内,共有三个胞管背褶和三个腹褶。第一个背褶是该胞管(thn)的原胞管背褶,随后胞管延伸经过中间的背褶(胞管thn+1的原胞管背褶)下面,有一个曲尺式(L型)的弯曲,然后在延伸到胞管thn+2的生出位置(thn+2的原胞管褶)时向下延伸成一个与笔石枝呈近垂直的腹褶,胞管末端为胞管口部。左侧笔石枝胞管可见缝状的胞管口,而右侧笔石枝的胞管仅见胞管口部的背方,反映了Sinograptus两笔石枝胞管口的朝向方向是相反的,表明其悬浮于水中时很可能是缓慢旋转的,水动力较弱。Sinograptus发育明显的背褶刺和腹褶刺,表明其为热水型的、具刺的狭温型属。因此,Sinograptus基本上处于温暖的海水,在相对静水中呈悬浮状态。

关键词： Sinograptus typicalis Mu 胞管形态生态

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基于非极化分量的SAR图像海洋锋特征增强方法

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光学精密工程 2021年第6期29卷 1440-1447页

作者：赵亚威孙凯种劲松中国科学院空天信息创新研究院北京100094 微波成像技术国家级重点实验室北京100190 中国科学院大学北京100049

受到海面整体运动、海面后向散射系数相对低以及海况的影响,海洋锋特征在SAR图像中表现较弱,给后续的应用带来困难,亟需开展海洋锋特征增强方法的研究。SAR海面回波可以分解成Bragg散射分量和非极化分量,本文提出了一种基于非极化分量的... 详细信息

受到海面整体运动、海面后向散射系数相对低以及海况的影响,海洋锋特征在SAR图像中表现较弱,给后续的应用带来困难,亟需开展海洋锋特征增强方法的研究。SAR海面回波可以分解成Bragg散射分量和非极化分量,本文提出了一种基于非极化分量的SAR图像海洋锋特征增强方法。首先对双极化(VV和HH极化)数据进行辐射定标,为解决非极化分量提取过程中噪声增强的问题,对定标结果进行滤波;然后计算Bragg散射极化比;最后借助于极化差和极化比提取非极化分量,实现海洋锋特征增强。本文使用ALOSPALSAR数据进行处理验证,并通过计算峰值-背景比(PBR)和等效视数(ENL)进行定量分析。实验结果表明,经过本文方法处理后PBR较双极化图像可以提升15%以上,ENL较双极化图像可以提升30%以上。实验结果证明了方法的有效性,为后续的应用奠定基础。

关键词：海洋锋非极化分量特征增强

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基于学习的高分辨率掌纹细节点质量评价方法

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软件学报 2014年第9期25卷 2180-2186页

作者：王瀚刘重晋付翔封举富北京大学信息科学技术学院智能科学系北京100871 机器感知与智能教育部重点实验室(北京大学) 北京100871

细节点在高分辨率掌纹匹配中扮演了重要角色,然而掌纹图像受到主线、褶皱线等的影响,提取出的细节点质量参差不齐.所以,对细节点进行质量评价并去除伪细节点,成为一个研究课题.提出了一种基于学习的高分辨率掌纹细节点质量评价方法.首... 详细信息

细节点在高分辨率掌纹匹配中扮演了重要角色,然而掌纹图像受到主线、褶皱线等的影响,提取出的细节点质量参差不齐.所以,对细节点进行质量评价并去除伪细节点,成为一个研究课题.提出了一种基于学习的高分辨率掌纹细节点质量评价方法.首先使用了基于图像的Gabor卷积响应和复数滤波响应等的一系列特征,用来对细节点局部进行冗余描述;然后,把每个特征作为弱分类器,用AdaBoost算法进行多层训练,挑选出对真伪细节点判别效果最理想的特征;最后,把弱分类器加权线性组合的响应分数作为细节点质量的得分,筛选出得分在阈值以上的细节点作为真细节点.该方法的实验结果与基于傅里叶变换的方法相比,能够更好地区分真伪细节点,对细节点的质量做出了更好的评价.

关键词：掌纹识别细节点质量 Gabor卷积复数滤波 AdaBoost算法

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Evaluation of the value of combined detection of tumor markers CA724,carcinoembryonic antigen,CA242,and CA19-9 in gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1737-1744页

作者： chong-Mei Zhou Shao-Hua Zhao Department of Clinical Laboratory Henan Provincial People's HospitalZhengzhou 450003Henan ProvinceChina

BACKGROUND Gastric cancer is a global health concern that poses a significant threat to human *** To detecting serum changes in carcinoembryonic antigen(CEA),carbohydrate antigens(CA)724,CA242,and CA19-9 expression among patients with gastric *** Eighty patients diagnosed with gastric cancer between January 2020 and January 2023 were included in the observation group,while 80 patients with benign gastric diseases were included in the control *** groups were tested for tumor markers(CA724,CEA,CA242,and CA19-9].Tumor marker indicators(CA724,CEA,CA242,and CA19-9)were compared between the two groups,assessing positive rates of tumor markers across various stages in the observation ***,single and combined detection of various tumor markers were *** The sensitivity,specificity,accuracy,positive predictive value,and negative predictive value observed for the combined detection of CA724,CEA,CA242,and CA19-9 were higher than those of CA724,CEA,CA242,and CA19-9 ***,the combined detection of CA724,CEA,CA242,and CA19-9 has a high diagnostic accuracy and could reduce the occurrence of missed or misdiagnosed cases,facilitating the early diagnosis and treatment of *** CA724,CEA,CA242,and CA19-9 serum levels in gastric cancer patients significantly surpassed those in non-gastric cancer patients(P<0.05).Their combined detection can improve the diagnostic accuracy for gastric cancer,warranting clinical promotion.

关键词： Biomarkers Serum Gastric cancer Diagnostic value

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