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中国现代医学杂志 2005年第6期15卷 943-944页

作者：李金成吕冬湖南省邵阳市医学高等专科学校湖南邵阳422000

目的观察多巴胺、酚妥拉明联用治疗肾综合征出血热肾衰的疗效。方法将100例患者随机分为两组,主要观察尿量及肾功能变化。结果及结论多巴胺、酚妥拉明联用治疗肾综合征出血热肾衰疗效明显,并可减少各药单用时对机体的不良反应。

关键词：多巴胺与酚妥拉明联用肾综合征出血热肾衰

Identification of bioactive anti-angiogenic constitutes targeting tumor endothelial cells in Shenmai Injection using multidimensional pharmacokinetics

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中国药理学与毒理学杂志 2019年第9期33卷 681-682页

作者： ZHONG chong-jin JIANG Chao NI Sui-ying WANG Qi-zhi CHENG Ling-ge WANG Huan ZHANG Qi-xiang LIU Wen-yue ZHANG jing-wei LIU Jia-li WANG Mu-lan jin Min SHEN Pei-qiang YAO Xue-quan WANG Guang-ji ZHOU Fang Key Laboratory of Drug Metabolism and Pharmacokinetics State Key Laboratory of Natural MedicinesChina Pharmaceutical UniversityNanjing 210009China Department of Digestive Tumor Surgery Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029China Chiatai QingChunbao Pharmaceutical Co.Ltd. Hangzhou 310023China

OBJECTIVE To identify the bioactive anti-angiogenic constitutes targeting tumor endothelial cells(TECs)in Shenmai Injection(SMI).METHEODS For pharmacokinetic(PK)studies,Balb/c mice harboring human colorectal cancer(LoVo)xenografts were treated with SMI 10 mL·kg^-1 daily for 1 or 8 *** PK profiles of ginsenosides in plasma,subcutaneous tumors,and TECs were *** PD studies,the tumor-bearing mice Intravital multi-photon imaging and CD31 immunofluorescence staining were used to evaluate the number of microves⁃sels and *** staining of CD31 and α-SMA was performed to evaluate pericytes coverage ratios around *** was performed to determine the concentrations of VEGF and FGF in tumor *** synergistic anti-tumor study,the tumor-bearing mice were treated with SMI 10 mL·kg^-1 daily,Rd 5 mg·kg^-1 daily with or without 5-FU 15 mg·kg^-1 every 3 d for 20 ***-MS/MS was used to determine the concentrations of 5-FU in plasma and tumor *** SMI decreased the number of microvessels(P<0.05)and vessel branches(P<0.05)and improved vascular pericytes coverage(P<0.05).PK studies showed that the concentrations of protopanaxadiol-type(PPD)ginsenosides(Rb1,Rb2/Rb3,Rc,and Rd)in both,plasma and tumors,were higher than those of protopanaxatriol-type(Rg1 and Re)and oleanane-type(Ro)*** PPD ginsenosides,Rd exhibited the greatest concentrations in tumors and TECs after repeated *** fact,the proportion of Rd in the detectable components of SMI gradually increased in the following order:SMI formula(2.8%),plasma(16.0%),tumor tissues(34.3%),and TECs(40.3%).In vivo bioactivity results showed that Rd 5 mg·kg^-1 daily significantly decreased the number of microvessels(P<0.05)and vessel branches(P<0.05)and increased pericytes coverage(P<0.05)while Rd 0.5 mg·kg^-1 daily,Rb1 and Rg1 had no significant effect on *** 5 mg·kg^-1 suppressed the expression of VEGF and FGF *** 5 mg·kg^-1 enhanced the antit

关键词： Shenmai Injection multidimensional pharmacokinetics ginsenoside Rd anti-angiogenic tumor endo⁃thelial cell

Triggering triplet excitons of carbon nanodots through nanospace domain confinement for multicolor phosphorescence in aqueous solution

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Nano Research 2024年第7期17卷 6534-6543页

作者： Ya-Chuan Liang Qing Cao Yuan Deng Yong Wang Kai-Kai Liu chong-Xin Shan School of Electronics and Information Zhengzhou University of Light IndustryZhengzhou 450002China Henan Key Laboratory of Diamond Optoelectronic Material and Devices Key Laboratory of Material PhysicsMinistry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450001China Academy for Quantum Science and Technology Zhengzhou University of Light IndustryZhengzhou 450002China Institute of Quantum Materials and Physics Henan Academy of SciencesZhengzhou 450046China

Easy non-radiative decay property of long-lived triplet excitons in aqueous solution obstructs their applications in aquatic *** reported phosphorescence phenomena in aqueous solution have excited researchers enormously but achieving full-color water-soluble phosphorescent carbon nanodots(CNDs)is still a challenging ***,full-color phosphorescence of water-soluble CNDs has been demonstrated by triggering their triplet excitons through nanospace domain confinement,and Förster energy resonance transfer is used for further tuning phosphorescence *** phosphorescence spans across most of the visible spectrum,ranging from 400 to 700 *** an aqueous solution,the CNDs exhibits blue,green,and red phosphorescence,lasting for approximately 6,10,and 7 s,***,the phosphorescence quantum yields are 11.85%,8.6%and 3.56%,making them readily discernible to the naked eyes and laying a solid foundation for practical ***,phosphorescence flexible optical display and bioimaging have been demonstrated by using the multicolor CNDs-based nanomaterials,showing distinct superiority for accuracy and complete display and imaging in complex emission background.

关键词： carbon nanodots triplet excitons multicolor aqueous solution

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右室双出口：7例尸检临床病理分析

中华胸心血管外科杂志 1992年第4期8卷 236-239,T009页

作者：吴波李凤山南京军区总医院南京市妇产医院

摘要右室双出口是一种少见的先天性心脏畸形。我们收集7例尸检标本，应用心脏节段分析法进行较为详细的解剖形态学观察描述，着重观察：大动脉排列与室缺类型的关系；隔缘肉柱与室缺的关系及心室漏斗皱折与漏斗间隔的关系。结合文献复... 详细信息

摘要右室双出口是一种少见的先天性心脏畸形。我们收集7例尸检标本，应用心脏节段分析法进行较为详细的解剖形态学观察描述，着重观察：大动脉排列与室缺类型的关系；隔缘肉柱与室缺的关系及心室漏斗皱折与漏斗间隔的关系。结合文献复习，提出右室双出口的室间隔仅由窦部及肉柱部二部分组成。对目前右室双出口存在的争议提出我们自己的看法，并就解剖学特征对右室双出口的自然生存期及手术预后进行初步讨论。

关键词：右室双出口漏斗间隔先天性心脏病

Facile preparation of ZIF-8/ZIF-67-derived biomass carbon composites for highly efficient electromagnetic wave absorption

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Chinese Chemical Letters 2024年第9期35卷 376-381页

作者： Xuexia Lin Yihui Zhou Jiafu Hong Xiaofeng Wei Bin Liu chong-Chen Wang College of Chemical Engineering Huaqiao UniversityXiamen 361021China Beijing Key Laboratory of Functional Materials for Building Structure and Environment Remediation Beijing University of Civil Engineering and ArchitectureBeijing 100044China College of Materials Science and Engineering Huaqiao UniversityXiamen 361021China

Biomass absorbing materials have received increasing attention for electromagnetic wave(EMW)absorption field absorbing materials due to its low density and high dielectric ***,the biomass EMW absorbing materials often suffer from the insufficient magnetic loss and impedance *** this work,a facile ZIF-8/ZIF-67-derived biomass composites(CoZnO@BPC)was prepared for high-performance EMW absorption based on multi-component micro,nano structures metal particles and xanthoce sorbifolia bunge shells-derived biomass porous carbon(BPC).The dielectric loss and/or magnetic loss abilities of CoZnO@BPC composites were adjusted by changing the mass ratio of Zn^(2+)to Co^(2+)*** the filled amount of 20 wt%,Co Zn O@BPC exhibited excellent EMW absorption with the minimum reflection loss(RL)at 15.84 GHz is-50.2 dB,and the matching thickness is only 1.7 *** adjusting the ZIFs mass ratio,the effective absorption bandwidth(EAB)can be up to 5.92 GHz(from 12.08 GHz to 18 GHz),and the matching thickness is only 1.9 *** results provide a new insight for the economical and efficient preparation of lightweight and advanced microwave absorbing materials.

关键词： Biomass Metal organic framework EMW absorption Dielectric loss Magnetic loss

The principle and amelioration of lithium plating in fast-charging lithium-ion batteries

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Journal of Energy Chemistry 2024年第10期97卷 453-459,I0009页

作者： Yi Yang Xia-Lin Zhong Lei Xu Zhuo-Lin Yang chong Yan Jia-Qi Huang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Yangtze River Delta Graduate School of Beijing Institute of Technology Jiaxing 314003ZhejiangChina

Fast charging is restricted primarily by the risk of lithium(Li)plating,a side reaction that can lead to the rapid capacity decay and dendrite-induced thermal runaway of lithium-ion batteries(LIBs).Investigation on the intrinsic mechanism and the position of Li plating is crucial to improving the fast rechargeability and safety of ***,we investigate the Li plating behavior in porous electrodes under the restricted transport of Li^(+).Based on the theoretical model,it can be concluded that the Li plating on the anodeseparator interface(ASI)is thermodynamically feasible and kinetically ***,the prior deposition of metal Li on the ASI rather than the anode-current collector interface(ACI)is verified *** order to facilitate the transfer of Li^(+)among the electrode and improve the utilization of active materials without Li plating,a bilayer asymmetric anode composed of graphite and hard carbon(GH)is *** and simulation results suggest that the GH hybrid electrode homogenizes the lithiated-rate throughout the electrode and outperforms the pure graphite electrode in terms of the rate performance and inhibition of Li *** work provides new insights into the behavior of Li plating and the rational design of electrode structure.

关键词： Graphite Hard carbon Fast charging Lithium plating Lithium-ion batteries

Nanoindentation responses of NiCoFe medium-entropy alloys from cryogenic to elevated temperatures

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Journal of Iron and Steel Research International 2024年第8期31卷 2068-2077页

作者： Qin-qin Xu Kamran Karimi Amirhossein H.Naghdi Wen-yi Huo chong Wei Stefanos Papanikolaou NOMATEN Centre of Excellence National Centre for Nuclear ResearchOtwock 05-400MazowszePoland College of Mechanical and Electrical Engineering Nanjing Forestry UniversityNanjing 210037JiangsuChina Science and Technology on Thermo Structural Composite Materials Laboratory Northwestern Polytechnical UniversityXi'an 710072ShaanxiChina School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710072ShaanxiChina

NiCoFe alloy,a medium-entropy alloy,shows potential for applications in extreme ***,there is a theoretical barrier concerning the unclear understanding of its high-temperature dislocation motion *** load response exhibits distinct signatures relevant to thermal activation,most notably a decrease in critical force(i.e,softening)from cryogenic to elevated temperatures,e.g.,from 200 to 1000 *** onset of plasticity is characterized by the nucleation of stacking faults and prismatic loops at low temperatures,whereas the surface nucleation of Shockley partial dislocations dominates plasticity at elevated *** show that thermal effects lead to non-uniform atom pile-ups and control the rate of phase transformation with increasing indentation *** findings in this work extend the understanding of the mechanical response of NiCoFe alloys under indentation at different temperatures,shedding light on the underlying dislocation motion mechanisms and surface deformation *** observed transformation-induced plasticity mechanism has implications for the properties of medium-entropy alloys and their potential applications in extreme environments.

关键词： Orientation Dislocations Mechanical behaviors Phase transition

Risk assessment,fitness cost,cross-resistance,and mechanism of tetraniliprole resistance in the rice stem borer,Chilo suppressalis

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Insect Science 2024年第3期31卷 835-846页

作者： Hao Sun Shuai Wang chong Liu Wen-Kai Hu jin-Wei Liu Ling-Jun Zheng Meng-Yue Gao Fang-Rui Guo Song-Tao Qiao Jun-Li Liu Bo Sun Cong-Fen Gao Shun-Fan Wu College of Plant Protection Nanjing Agricultural UniversityState&Local Joint Engineering Research Center of Green Pesticide Invention and ApplicationNanjingChina Bayer Cropscience(China)Co. Ltd.HangzhouChina

The rice stem borer(RSB),Chilo suppressalis,a notorious rice pest in China,has evolved a high resistance level to commonly used ***,a new anthranilic diamide insecticide,effectively controls multiple pests,including ***,the potential resistance risk of RSB to tetraniliprole is still *** this study,the tetraniliprole-selection(Tet-R)strain was obtained through 10 continuous generations of selection with tetraniliprole 30%lethal concentration(LC_(30)).The realized heritability(h^(2))of the Tet-R strain was 0.387,indicating that resistance of RSB to tetraniliprole developed rapidly under the continuous selection of *** Tet-R strain had a high fitness cost(relative fitness=0.53).We established the susceptibility baseline of RSB to tetraniliprole(lethal concentration at LC_(50)=0.727 mg/L)and investigated the resistance level of 6 field populations to *** tested strains that had resistance to chlorantraniliprole exhibited moderate-to high-level resistance to tetraniliprole(resistance ratio=27.7-806.8).Detection of ryanodine receptor(RyR)mutations showed that the Y4667C,Y4667D,I4758M,and Y4891F mutations were present in tested RSB field *** mutations were responsible for the cross-resistance between tetraniliprole and ***,the clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9-mediated genome-modified flies were used to study the contribution of RyR mutations to tetraniliprole *** order of contribution of a single RyR mutation to tetraniliprole resistance was Y4667D>G4915E>Y4667C~~I4758M>*** addition,the I4758M and Y4667C double mutations conferred higher tetraniliprole resistance than single Y4667C *** results can guide resistance management practices for diamides in RSB and other arthropods.

关键词： Chilo suppressalis diamide resistance fitness cost cross-resistance RyR target-site mutations

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一类三次Bent函数的二阶非线性度

计算机应用研究 2011年第7期28卷 2687-2689,2718页

作者：徐媛崇金凤卓泽朋淮北师范大学数学科学学院安徽淮北235000 西安电子科技大学综合业务网国家重点实验室西安710071

研究了形如yTr(x5)+Tr(x3)的三次Bent函数,通过研究其导数的非线性度的下界,得到了该函数的二阶非线性度的下界,将所得结果与Carlet的结果进行了比较,结果表明,该函数的二阶非线性度大于Carlet给出的下界。

关键词：布尔函数 Bent函数二阶非线性度导数

Clinical significance of platelet mononuclear cell aggregates in patients with sepsis and acute respiratory distress syndrome

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World Journal of Clinical Cases 2024年第5期12卷 966-972页

作者： chong-Min Huang Juan-Juan Li Wei-Ke Wei Department of Intensive Medicine The Second People's Hospital of Haining CityHaining 314419Zhejiang ProvinceChina Department of Integrated Traditional Chinese and Western Medicine Qingyang HospitalHangzhou 310023Zhejiang ProvinceChina

BACKGROUND The diagnosis of sepsis combined with acute respiratory distress syndrome(ARDS)has increased owing to the enhanced awareness among medical profes-sionals and the continuous development of modern medical technologies,while early diagnosis of ARDS still lacks specific *** of the main patho-genic mechanisms of sepsis-associated ARDS involves the actions of various pathological injuries and inflammatory factors,such as platelet and white blood cells activation,leading to an increase of surface adhesion *** adhesion molecules further form platelet-white blood cell aggregates,including platelet-mononuclear cell aggregates(PMAs).PMAs has been identified as one of the markers of platelet activation,here we hypothesize that PMAs might play a potential biomarker for the early diagnosis of this *** We selected 72 hospitalized patients diagnosed with sepsis as the study population between March 2019 and March *** them,30 patients with sepsis and ARDS formed the study group,while 42 sepsis patients without ARDS comprised the control *** diagnosis,venous blood samples were imme-diately collected from all *** cytometry was employed to analyze the expression of PMAs,platelet neutrophil aggregates(PNAs),and platelet aggregates(PLyAs)in the ***,the Acute Physiology and Chronic Health Evaluation(APACHE)II score was calculated for each patient,and receiver operating characteristic curves were generated to assess diagnostic *** The study found that the levels of PNAs and PLyAs in the serum of the study group were higher than those in the control group,but the difference was not statistically significant(P>0.05).However,the expression of PMAs in the serum of the study group was significantly upregulated(P<0.05)and positively correlated with the APACHE II score(r=0.671,P<0.05).When using PMAs as a diagnostic indicator,the area under the curve value was 0.957,indicating a high diagnostic va

关键词： Sepsis Acute respiratory distress syndrome Platelet leukocyte aggregates Platelet mononuclear cell aggregates,Biomarker