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From ancient wisdom to modern science:Gut microbiota sheds light on property theory of traditional Chinese medicine

Journal of Integrative Medicine 2024年第4期22卷 413-444页

作者： Ya-nan Yang Jia-guo Zhan Ying Cao chong-ming Wu School of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 301617China Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine Tianjin 301617China

The property theory of traditional Chinese medicine(TCM) has been practiced for thousands of years,playing a pivotal role in the clinical application of TCM. While advancements in energy metabolism,chemical composition analysis, machine learning, ion current modeling, and supercritical fluid technology have provided valuable insight into how aspects of TCM property theory may be measured, these studies only capture specific aspects of TCM property theory in isolation, overlooking the holistic perspective inherent in TCM. To systematically investigate the modern interpretation of the TCM property theory from multidimensional perspectives, we consulted the Chinese Pharmacopoeia(2020 edition) to compile a list of Chinese materia medica(CMM). Then, using the Latin names of each CMM and gut microbiota as keywords, we searched the PubMed database for relevant research on gut microbiota and CMM. The regulatory patterns of different herbs on gut microbiota were then summarized from the perspectives of the four natures, the five flavors and the meridian tropism. In terms of the four natures, we found that warm-natured medicines promoted the colonization of specific beneficial bacteria,while cold-natured medicines boosted populations of some beneficial bacteria while suppressing pathogenic bacteria. Analysis of the five flavors revealed that sweet-flavored and bitter-flavored CMMs positively influenced beneficial bacteria while inhibiting harmful bacteria. CMMs with different meridian tropism exhibited complex modulative patterns on gut microbiota, with Jueyin(Liver) and Taiyin(Lung) meridian CMMs generally exerting a stronger effect. The gut microbiota may be a biological indicator for characterizing the TCM property theory, which not only enhances our understanding of classic TCM theory but also contributes to its scientific advancement and application in healthcare.

关键词： Traditional Chinese medicine Property theory Gut microbiota Four natures Five flavors Meridian tropism

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Multi-Strategy Assisted Multi-Objective Whale Optimization Algorithm for Feature Selection

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1563-1593页

作者： Deng Yang chong Zhou Xuemeng Wei Zhikun Chen Zheng Zhang School of Information Engineering Hebei GEO UniversityShijiazhuang050031China Faculty of Science University of AlbertaEdmontonT2N1N4Canada College of Resources and Environment Beibu Gulf UniversityQinzhou535011China Clinical Laboratory The Frist Hospital of Hebei Medical UniversityShijiazhuang050000China

In classification problems,datasets often contain a large amount of features,but not all of them are relevant for accurate *** fact,irrelevant features may even hinder classification *** selection aims to alleviate this issue by minimizing the number of features in the subset while simultaneously minimizing the classification error ***-objective optimization approaches employ an evaluation function designed as an aggregate function with a parameter,but the results obtained depend on the value of the *** eliminate this parameter’s influence,the problem can be reformulated as a multi-objective optimization *** Whale Optimization Algorithm(WOA)is widely used in optimization problems because of its simplicity and easy *** this paper,we propose a multi-strategy assisted multi-objective WOA(MSMOWOA)to address feature *** enhance the algorithm’s search ability,we integrate multiple strategies such as Levy flight,Grey Wolf Optimizer,and adaptive mutation into ***,we utilize an external repository to store non-dominant solution sets and grid technology is used to maintain *** on fourteen University of California Irvine(UCI)datasets demonstrate that our proposed method effectively removes redundant features and improves classification *** source code can be accessed from the website:https://***/zc0315/MSMOWOA.

关键词： Multi-objective optimization whale optimization algorithm multi-strategy feature selection

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Numerical and experimental study on the falling film flow characteristics with the effect of co-current gas flow in hydrogen liquefaction process

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Petroleum Science 2024年第2期21卷 1369-1384页

作者： chong-Zheng Sun Yu-Xing Li Hui Han Xiao-Yi Geng Xiao Lu College of Energy Storage Technology Shandong University of Science and TechnologyQingdao 266590ShandongChina College of Pipeline and Civil Engineering/Shandong Provincial Key Laboratory of Oil&Gas Storage and Transportation Safety China University of PetroleumQingdao 266580ShandongChina

Liquid hydrogen storage and transportation is an effective method for large-scale transportation and utilization of hydrogen energy. Revealing the flow mechanism of cryogenic working fluid is the key to optimize heat exchanger structure and hydrogen liquefaction process(LH2). The methods of cryogenic visualization experiment, theoretical analysis and numerical simulation are conducted to study the falling film flow characteristics with the effect of co-current gas flow in LH2spiral wound heat *** results show that the flow rate of mixed refrigerant has a great influence on liquid film spreading process, falling film flow pattern and heat transfer performance. The liquid film of LH2mixed refrigerant with column flow pattern can not uniformly and completely cover the tube wall surface. As liquid flow rate increases, the falling film flow pattern evolves into sheet-column flow and sheet flow, and liquid film completely covers the surface of tube wall. With the increase of shear effect of gas-phase mixed refrigerant in the same direction, the liquid film gradually becomes unstable, and the flow pattern eventually evolves into a mist flow.

关键词： Hydrogen liquefaction Spiral wound heat exchanger Flow pattern transition Falling film flow

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热电池硫化物正极材料放电机理研究进展

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电源技术 2009年第3期33卷 227-230页

作者：种晋高文明中国电子科技集团公司第十八研究所天津300381

论述了热电池硫化物正极材料的放电机理研究进展。大部分的文献都是根据电池的电压平台与对应的放电容量推理出反应机理,并无物相检测结果或其他分析手段来佐证。有部分研究者利用XRD物相分析、SEM形貌分析、原位X射线吸收结构精修技术(... 详细信息

论述了热电池硫化物正极材料的放电机理研究进展。大部分的文献都是根据电池的电压平台与对应的放电容量推理出反应机理,并无物相检测结果或其他分析手段来佐证。有部分研究者利用XRD物相分析、SEM形貌分析、原位X射线吸收结构精修技术(in situ X-ray absorption fine structure,缩写为insituXAFS)、穆斯堡尔谱等手段确定出了部分中间产物和反应机理,其结果和根据电池的电压平台与对应的放电容量推理出的反应机理吻合。由于原位反应检测分析技术的不断创新应用和发展,对于硫化物正极材料还未确定的放电机理分析带来了希望。

关键词： FeS2 CoS2 热电池放电机理

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海南岛晚二叠世大岭岩体岩石成因:锆石原位Hf同位素制约

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桂林理工大学学报 2018年第4期38卷 654-662页

作者：温淑女庞崇进桂林理工大学广西隐伏金属矿产勘查重点实验室广西桂林541004 桂林理工大学广西有色金属隐伏矿床勘查及材料开发协同创新中心广西桂林541004 中国科学院广州地球化学研究所同位素国家重点实验室广州510640

LA-ICP-MS锆石U-Pb年代学研究表明,海南岛大岭闪长质岩体形成于255. 7±1. 9 Ma,锆石的εHf(256 Ma)值为-4. 7～-0. 2,变化范围较大。计算结果表明,低εHf(256 Ma)值锆石的εNd(256 Ma)值为-5. 6,这与岩体全岩εNd(256 Ma)值(-5. 8)以... 详细信息

LA-ICP-MS锆石U-Pb年代学研究表明,海南岛大岭闪长质岩体形成于255. 7±1. 9 Ma,锆石的εHf(256 Ma)值为-4. 7～-0. 2,变化范围较大。计算结果表明,低εHf(256 Ma)值锆石的εNd(256 Ma)值为-5. 6,这与岩体全岩εNd(256 Ma)值(-5. 8)以及海南岛中-新元古代结晶基底火成岩的εNd(256 Ma)值(-7. 42～-4. 19)范围相一致;但高εHf(256 Ma)值锆石的εNd(256 Ma)值为-4. 19～-2. 25,明显高于岩体和结晶基底火成岩的εNd(256 Ma)值,暗示存在一个来自相对亏损(εHf(t)> 0)地幔源区的端元组分的贡献。结合全岩主微量元素特征,大岭闪长质岩浆很可能是相对年轻的富集交代岩石圈地幔来源的基性岩浆与中-新元古代结晶基底火成岩来源的酸性岩浆发生混合的产物。因此,壳-幔岩浆混合成因模式可以很好地解释海南岛大岭闪长岩元素地球化学特征以及锆石微区Hf同位素组成变化。

关键词：二叠纪侵入岩年代学锆石Hf同位素壳-幔岩浆混合作用海南岛

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Structural Regulations of Layered Borates:From Centric Layers to Chiral Porous Layers

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Precision Chemistry 2024年第6期2卷 256-262页

作者： chong-An Chen Guo-Yu Yang MOE Key Laboratory of Cluster Science School of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 102488China

Three pentaborates were made by precise structural regulations under hydrothermal conditions,namely,K_(2)Cs-[B_(5)O_(8)(OH)]·0.5CO_(3)(1),KNa_(4)Cs[B_(5)O_(8)(OH)]_(2)·2OH(2),and NaBa[B_(5)O_(8.5)(OH)](3).Compound 1 features the typical 2D layers constructed from the four-connected B_(5)O_(10)(OH)*** adjustment of the reactants and pH values of the systems to remove interlayered CO_(3)^(2−)groups,the centric layers in 1 were transformed to the chiral layers of *** further adjusting cationic templates based on host−guest charge matching,the B_(5)O_(10)(OH)cluster unit was transformed to B_(5)O_(11)(OH),which built the chiral porous layers of *** chiral compounds 2 and 3 exhibit moderate second harmonic generation(SHG)responses of 1.1 and 1.7 times that of KDP(KH_(2)PO_(4)).The structural regulations actualize the evolutions on both structural symmetries and dimensions.

关键词： oxoboron cluster hydrothermal syntheses layers structural regulation nonlinear optical property

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ENVISAT ASAR交替极化模式目标检测性能分析

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电子与信息学报 2007年第10期29卷 2359-2362页

作者：种劲松李晓玮韩昭颖中国科学院电子学研究所微波成像技术国家重点实验室北京100080

ENVISAT ASAR具有交替极化模式,可以提供3种双极化组合。该文针对3种双极化组合分别推导了几种目标检测器,包括最优极化检测器、白化滤波检测器、张量检测器、单通道检测器等,并使用ROC曲线对它们分别进行了性能比较。结果表明极化白化... 详细信息

ENVISAT ASAR具有交替极化模式,可以提供3种双极化组合。该文针对3种双极化组合分别推导了几种目标检测器,包括最优极化检测器、白化滤波检测器、张量检测器、单通道检测器等,并使用ROC曲线对它们分别进行了性能比较。结果表明极化白化滤波检测器的性能最接近于理想的最优极化检测器,极大地提高了检测性能。

关键词：合成孔径雷达交替极化目标检测

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Loss of LBP triggers lipid metabolic disorder through H3K27 acetylation-mediated C/EBPβ-SCD activation in non-alcoholic fatty liver disease

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Zoological Research 2024年第1期45卷 79-94页

作者： Ya-Ling Zhu Lei-Lei Meng jin-Hu Ma Xin Yuan Shu-Wen Chen Xin-Rui Yi Xin-Yu Li Yi Wang Yun-Shu Tang Min Xue Mei-Zi Zhu jin Peng Xue-jin Lu Jian-Zhen Huang Zi-Chen Song chong Wu Ke-Zhong Zheng Qing-Qing Dai Fan Huang Hao-Shu Fang Department of Pathophysiology Anhui Medical UniversityHefeiAnhui 230032China Laboratory Animal Research Center School of Basic Medical SciencesAnhui Medical UniversityHefeiAnhui 230032China Department of Hepatobiliary Surgery First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China College of Animal Science and Technology Jiangxi Agricultural UniversityNanchangJiangxi 330045China

Non-alcoholic fatty liver disease(NAFLD)is associated with mutations in lipopolysaccharide-binding protein(LBP),but the underlying epigenetic mechanisms remain ***,LBP^(-/-)rats with NAFLD were established and used to conduct integrative targetingactive enhancer histone H3 lysine 27 acetylation(H3K27ac)chromatin immunoprecipitation coupled with high-throughput and transcriptomic sequencing analysis to explore the potential epigenetic pathomechanisms of active enhancers of NAFLD exacerbation upon LBP ***,LBP^(-/-)reduced the inflammatory response but markedly aggravated high-fat diet(HFD)-induced NAFLD in rats,with pronounced alterations in the histone acetylome and regulatory *** total,1128 differential enhancer-target genes significantly enriched in cholesterol and fatty acid metabolism were identified between wild-type(WT)and LBP^(-/-)NAFLD *** on integrative analysis,CCAAT/enhancer-binding proteinβ(C/EBPβ)was identified as a pivotal transcription factor(TF)and contributor to dysregulated histone acetylome H3K27ac,and the lipid metabolism gene SCD was identified as a downstream effector exacerbating *** study not only broadens our understanding of the essential role of LBP in the pathogenesis of NAFLD from an epigenetics perspective but also identifies key TF C/EBPβand functional gene SCD as potential regulators and therapeutic targets.

关键词： Non-alcoholic fatty liver disease C/EBPβ Lipopolysaccharide-binding protein H3K27ac Integrative analysis Enhancer

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煤矿冒顶原因及预防措施

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煤炭工程 2009年第8期41卷 74-75页

作者：靳爱江乔崇金鸡西矿业集团黑龙江鸡西158100

冒顶是煤矿中最常见的事故,经常会影响到煤矿的正常生产。论文阐述了冒顶原因,分析了在正常情况下,顶板冒落之前出现的各种各样的预兆。及时发现和掌握预兆,对预防重大冒顶事故的发生极为重要。因此加强顶板管理,预防冒顶事故发生是实... 详细信息

冒顶是煤矿中最常见的事故,经常会影响到煤矿的正常生产。论文阐述了冒顶原因,分析了在正常情况下,顶板冒落之前出现的各种各样的预兆。及时发现和掌握预兆,对预防重大冒顶事故的发生极为重要。因此加强顶板管理,预防冒顶事故发生是实现煤矿安全生产的重要手段。

关键词：冒顶预兆顶板管理预防措施

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DNS缓存投毒攻击原理与防御策略

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China Communications 2009年第4期6卷 17-22页

作者：靳冲郝志宇吴志刚中国科学院计算技术研究所北京100190 中国科学院研究生院北京100190

DNS是Internet最重要的基础设施之一,若遭受攻击将影响Internet的正常运转,因而其安全性备受关注。本文分析了传统以及新型(Kaminsky)DNS缓存投毒(Cache Poisoning)攻击的原理,给出攻击实例,详细描述了攻击流程,验证了DNS缓存投毒攻击... 详细信息

DNS是Internet最重要的基础设施之一,若遭受攻击将影响Internet的正常运转,因而其安全性备受关注。本文分析了传统以及新型(Kaminsky)DNS缓存投毒(Cache Poisoning)攻击的原理,给出攻击实例,详细描述了攻击流程,验证了DNS缓存投毒攻击潜在的危害性,并提出若干防御策略。

关键词： DNS 缓存投毒 Kaminsky攻击

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