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Yinhuang granule alleviates carbon tetrachloride-induced liver fibrosis in mice and its mechanism

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World Journal of Hepatology 2024年第2期16卷 264-278页

作者： Hao Ouyang Hui Miao Zhen Li Duan Wu Si-Cheng Gao Yao-Yao Dai Xiao-Di Gao hai-Sheng Chai Wei-Ye Hu Jun-feng Zhu Department of Liver Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 201203China State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 201203China

BACKGROUND Liver fibrosis is a formidable global medical challenge,with no effective clinical treatment currently *** granule(YHG)is a proprietary Chinese medicine comprising Scutellariae Radix and Lonicerae Japonicae *** is frequently used for upper respiratory tract infections,pharyngitis,as well as acute and chronic *** To investigate the potential of YHG in alleviating carbon tetrachloride(CCl4)-induced liver fibrosis in *** To induce a hepatic fibrosis model in mice,this study involved intraperitoneal injections of 2 mL/kg of CCl4 twice a week for 4 ***,liver fibrosis mice in the low dose of YHG(0.4 g/kg)and high dose of YHG(0.8 g/kg)groups were orally administered YHG once a day for 4 *** alanine/aspartate aminotransferase(ALT/AST)activity and liver hydroxyproline content were *** red and Masson's trichrome staining assay were *** polymerase chain reaction,western-blot and enzyme-linked immunosorbent assay were *** glutathione content,superoxide dismutase activity level,reactive oxygen species and protein carbonylation amount were *** The administration of YHG ameliorated hepatocellular injury in CCl4-treated mice,as reflected by decreased serum ALT/AST activity and improved liver histological *** also attenuated liver fibrosis,evident through reduced liver hydroxyproline content,improvements in Sirius red and Masson's trichrome staining,and lowered serum hyaluronic acid ***,YHG hindered the activation of hepatic stellate cells(HSCs)and ameliorated oxidative stress injury and inflammation in liver from CCl4-treated *** prompted the nuclear accumulation of nuclear factor erythroid 2-related factor 2(Nrf2)and upregulated the expression of Nrf2-dependent downstream antioxidant *** addition,YHG promoted mitochondrial biogenesis in liver from CCl4-treated mice,as demonstrated by increased liver adenosine triphosphate content,

关键词： Yinhuang granule Liver fibrosis Hepatic stellate cells Oxidative injury Nuclear factor erythroid 2-related factor 2 Inflammation

基于符号回归方法探索磁性斯格明子结构近似解析式

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动态公交专用道分区控制方法设计及适用性分析

物理学报 2024年第1期73卷 43-50页

作者：史猛王伟伟杜海峰中国科学院合肥物质科学研究院强磁场科学中心合肥 230031 中国科学技术大学合肥 230026 安徽大学物质科学与信息技术研究院合肥 230601 中国科学院合肥物质科学研究院强磁场科学中心合肥 230031

磁性斯格明子是一种非平庸的拓扑磁结构,它能够在具有Dzyaloshinskii-Moriya(DM)相互作用的手性磁体中稳定存在,其静态以及动态特性与其结构特征息息相关.然而,一般情况下斯格明子结构解析式并不存在.因此,许多研究者给出了近似解析式.... 详细信息

磁性斯格明子是一种非平庸的拓扑磁结构,它能够在具有Dzyaloshinskii-Moriya(DM)相互作用的手性磁体中稳定存在,其静态以及动态特性与其结构特征息息相关.然而,一般情况下斯格明子结构解析式并不存在.因此,许多研究者给出了近似解析式.本文介绍了使用符号回归算法探索磁性斯格明子结构解析式的新方法,在考虑DM相互作用和外部磁场对磁性斯格明子结构的影响下,使用符号回归算法得到了两个较为合适的近似解析式,其适用范围与占主导地位的相互作用有关.研究结果验证了符号回归算法在探索磁性斯格明子结构解析式的强大能力,为磁结构的解析式探索提供了新思路.

关键词：磁性斯格明子符号回归磁性斯格明子结构 Dzyaloshinskii-Moriya相互作用

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公路交通科技 2024年第2期41卷 166-172页

作者：周锦强王海林杨雄曹峰湖南省交通规划勘察设计院有限公司湖南长沙410008

针对公交专用道利用率较低的问题,提出了一种公交专用道路权动态分配策略,实现公交专用道精细化管理,提升道路通行效率。在公交优先的基础上,基于道路分区控制思想,将公交停靠站间道路划分成一定数量的清空区域,通过检测器获取当前通过... 详细信息

针对公交专用道利用率较低的问题,提出了一种公交专用道路权动态分配策略,实现公交专用道精细化管理,提升道路通行效率。在公交优先的基础上,基于道路分区控制思想,将公交停靠站间道路划分成一定数量的清空区域,通过检测器获取当前通过车辆的类型,利用可变情报板提示公交专用道的使用状态,当检测到公交车时,可变情报板提示公交专用道对外关闭。反之,当公交车未使用专用道时,可变情报板将提示其对外开放。进一步通过数值仿真与模拟对不同清空区域长度、车辆饱和度及公交发车间隔组合条件下公交车辆和其他车辆运营效果进行对比分析,最终得到能取得最佳运营效果的清空区域长度、车辆饱和度及公交发车间隔组合条件。最后以兰州市BRT为例,采用C++与Vissim-COM进行了联合仿真试验,验证分区控制方法的有效性。结果表明:车辆饱和度大于0.4时,清空区域长度在50~200 m时,其他车辆车均明显降低,动态公交专用道分区控制运营效果良好;饱和度在0.4~0.6,清空间距100 m时,其他车辆受益较大,公交车所受影响较小,实行动态公交专用道分区控制策略综合运营效益最佳。该结论对于公交专用道分时段灵活使用具有一定的现实意义,为优化道路资源利用提供了重要的理论支撑与实践参考。

关键词：交通工程动态公交专用道联合仿真分区控制清空区域

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使用丙烷模拟航空煤油燃烧特性

船海工程 2017年第3期46卷 50-52,56页

作者：金海峰宋子刚董辉李志奎中国船舶重工集团公司第七〇三研究所哈尔滨150078

针对航空器火灾模拟训练,分析航空煤油和丙烷的燃烧特性,提出使用丙烷在可控条件下模拟航空煤油燃烧状态的方法,基于此方法设计一套使用丙烷模拟航空煤油燃烧的系统,效果理想。

关键词：航空煤油丙烷热释放速率燃烧速率火焰高度

Rare primary squamous cell carcinoma of the intrahepatic bile duct: A case report and review of literature

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World Journal of Clinical Oncology 2024年第7期15卷 936-944页

作者： Qing-Jun Ma Fu-hai Wang Ning-Ning Yang Hong-Long Wei feng Liu Department of General Surgery The First Affiliated Hospital of Shandong First Medical UniversityJinan 250014Shandong ProvinceChina Department of Respiratory and Critical Care Medicine Shandong Provincial Chest Hospital Affiliated to Shandong UniversityJinan 250013Shandong ProvinceChina

BACKGROUND Cholangiocarcinoma is the most common malignancy of the biliary tree and has a poor *** is the most common pathological type of cho-langiocarcinomas,but rare squamous,adenosquamous,and mucinous variants have been reported without adequate clinical *** SUMMARY This report describes a rare case of primary squamous cell carcinoma(SCC)of the intrahepatic bile *** patient was admitted with a tumor in the hepatic caudate lobe with no obvious clinical *** revealed hepatitis B surface antigen positivity,a slight increase in alfa-fetoprotein to 16.34 ng/mL,and an irregular slightly heterogeneous enhancing lesion in the hepatic caudate lobe,which was initially thought to be hepatocellular *** re-section was performed,and the final pathology suggested a rare primary SCC of the intrahepatic bile *** indicated positivity for villin,partial positivity for p63,and negativity for hepatocyte,CK7,CK8,CK19,and *** Ki-67 index was approximately 60%.The patient received six cycles of Tegio chemotherapy.A new lesion was detected in the liver after 15 *** surgery was performed,and the patient was followed-up at a local *** date,no new lesions have been *** Surgery is the first choice for resectable lesions,and combined chemotherapy based on pathology is essential for increasing overall survival.

关键词： Squamous cell carcinoma Bile duct Cholangiocarcinoma Clinical characteristics Treatment Case report

Clinical characteristics of triple negative breast cancer in northeast Chinese patients

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Clinical characteristics of triple negative breast cancer in...

A universal strategy for the refined frameworks and improved performance of distinct commercial polyacrylonitriles in sulfur cathodes

国际药理学术研讨会暨第三届两岸三地药理学学术会议

作者： Jie Ren,Zhao-jin Yu,Lin Zhao,feng jin,hai-Shan Zhao 1,Wei-Fan Yao, Min-Jie Wei~* Department of Pharmacology,Pharmaceutical College of China Medical University, First Affiliated Hospital of China Medical University,Shenyang 1100011, China Shenyang 110001 China

＜正＞Aim:Triple-negative breast cancer（TNBC）is defined by a lack of expression of estrogen receptor, progesterone receptor,and human epidermal growth factor receptor2（HER2）,which has a relatively aggressive clini... 详细信息

关键词： Triple -Negative Breast Cancer Clinical characteristics BRCA1

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Science China Materials 2024年第9期67卷 2915-2924页

作者： Yikun Yi feng hai Wenting Chen Xin Gao jingyu Guo Weicheng Xue Mingtao Li Shaanxi Key Laboratory of Energy Chemical Process Intensification School of Chemical Engineering and TechnologyXi’an Jiaotong UniversityXi’an710049China

Sulfurized polyacrylonitrile(SPAN)with the exceptional stability,safety,low cost,and high capacity have been positioned as a highly promising cathode material for next-generation lithium-ion ***,in the market,polyacrylonitrile(PAN)sourced from different suppliers and available at varying prices exhibits significant variations in physical and chemical properties,resulting in diverse behaviors in Li-SPAN *** studying the mechanism,we found that the PAN copolymerization structure leads to the stacking of chain segments which obstructs the embedding of sulfur and lithium ***,we propose a universal strategy for the refined frameworks by an exogenous additive to modify various PAN raw materials,and the battery capacity and cycling performance are obviously *** a result,the copolymerized SPAN with a poor original capacity is nearly doubled to over 500 mAh g^(-1),almost comparable to high-quality yet expensively imported products;for the sample with a high initial capacity but fading in ether-based electrolytes,it can be modified to maintain stability over 400 *** strategy offers an alternative approach for SPAN modification that is characterized by its simplicity and low cost,thereby facilitating the large-scale development of Li-SPAN batteries.

关键词： copolymerization structure universal strategy exogenous additive SPAN modification

陆军某部官兵创伤后应激障碍患病情况及其与功能性胃肠病的关系

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解放军医学杂志 2018年第2期43卷 172-180页

作者：王倩姚欣靳海峰孙蓉于佳智佳王春华郭丽丽承德医学院研究生学院河北承德067000 首都医科大学附属北京友谊医院新华医院消化内科北京101100 解放军白求恩国际和平医院消化内科石家庄050082

目的探讨陆军某部官兵创伤后应激障碍(PTSD)患病情况及其与功能性胃肠病(FGIDs)的关系。方法应用创伤后应激障碍症状自评量表(PCL-C)诊断PTSD,应用罗马ⅢFGIDs调查问卷进行FGIDs的分类和诊断。采用创伤史筛查问卷及压力性事件调查问卷研... 详细信息

目的探讨陆军某部官兵创伤后应激障碍(PTSD)患病情况及其与功能性胃肠病(FGIDs)的关系。方法应用创伤后应激障碍症状自评量表(PCL-C)诊断PTSD,应用罗马ⅢFGIDs调查问卷进行FGIDs的分类和诊断。采用创伤史筛查问卷及压力性事件调查问卷研究PTSD与创伤性及压力性事件的关系。分析PTSD与FGIDs的重叠情况及二者的相关性。结果 927例调查对象中,诊断为PTSD者33例,总体患病率3.56%;诊断为FGIDs者435例,总体患病率为46.93%。诊断为PTSD的33例中28例合并FGIDs,FGIDs患病率为84.85%(28/33),明显高于非PTSD组(45.53%,P<0.05)。同时,FGIDs组PTSD患病率高于非FGIDs组(6.43%vs.1.02%,P<0.05)。PTSD官兵最常见的FGIDs是周期性呕吐综合征(CVS,33.33%)、非特异性功能性肠病(24.24%)、功能性腹胀(18.18%)和功能性直肠肛门痛(18.18%)。多因素分析发现,PTSD是CVS(OR=9.118)、功能性直肠肛门痛(OR=3.373)、功能性腹胀(OR=4.772)、肠易激综合征(OR=3.438)、反刍综合征(OR=16.033)、功能性呕吐(OR=10.329)和功能性吞咽困难(OR=9.891)的危险因素(P<0.05)。多因素logistic回归分析显示,CVS(OR=4.063)、创伤性事件个数(OR=1.159)和压力性事件个数(OR=1.401)是军人PTSD患病的危险因素(P<0.05)。结论 PTSD与FGIDs互为患病的危险因素,PTSD在多种FGIDs中的患病率存在较大差异。CVS是PTSD官兵最常见的FGIDs,也是PTSD患病的危险因素,其原因及机制值得深入研究。

关键词：创伤后应激障碍功能性胃肠病军人创伤性事件压力性事件

天津北郊500kV变电站无功补偿方案的比较

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华北电力技术 2007年第8期 53-54页

作者：刘亚成金海峰安徽省皖能股份公司安徽合肥230011 华北电力科学研究院有限责任公司北京100045

首先对比了几种静止电容器、同步调相机和SVC等无功补偿装置的性能,然后针对天津北郊变电站中现有的160 Mvar同步调相机老化并且需要更换的情况,分别使用同容量的同步调相机、电容器以及SVC进行邻近线路"N-1"和"N-2"故障时的时域仿真,3... 详细信息

首先对比了几种静止电容器、同步调相机和SVC等无功补偿装置的性能,然后针对天津北郊变电站中现有的160 Mvar同步调相机老化并且需要更换的情况,分别使用同容量的同步调相机、电容器以及SVC进行邻近线路"N-1"和"N-2"故障时的时域仿真,3种方案下的仿真结果对天津北郊无功补偿方案的确定具有重要的指导意义。

关键词：同步调相机电容器 SVC 时域仿真