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基于IRF+MDC技术的高性能校园网络系统设计探究

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软件 2020年第8期41卷 125-128页

作者：金海峰坎香江阴职业技术学院江苏江阴214405

安全、通畅、稳定、可靠是大型园区网络建设始终追求的目标,而传统网络采用单链路架构方式,极易出现因为链路故障而造成网络不稳定,甚至网络瘫痪的现象。文章基于虚拟化技术MDC、路由策略、冗余技术IRF,提出一种全新的校园网络架构解决... 详细信息

安全、通畅、稳定、可靠是大型园区网络建设始终追求的目标,而传统网络采用单链路架构方式,极易出现因为链路故障而造成网络不稳定,甚至网络瘫痪的现象。文章基于虚拟化技术MDC、路由策略、冗余技术IRF,提出一种全新的校园网络架构解决方案,在保障校园网络的可靠性、稳定性的同时,通过部署校园网络资源分配策略,优先保障教育教学的需求,提升了出口带宽资源的有效利用率。

关键词：虚拟化 MDC IRF 路由策略

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监检衔接下政务处分的检察监督

南京大学学报（哲学．人文科学．社会科学） 2024年第4期61卷 139-146,159,160页

作者：陈海锋上海社会科学院法学研究所上海市200020

处置是国家监察权的重要职能之一。在当下的国家监察权运行中,政务处分与移送审查起诉的标准存在模糊空间、监察权的运行程序具有封闭性,造成监察处置中以政务处分替代移送审查起诉的问题。《监察法》并未赋予监察机关针对职务犯罪案件... 详细信息

处置是国家监察权的重要职能之一。在当下的国家监察权运行中,政务处分与移送审查起诉的标准存在模糊空间、监察权的运行程序具有封闭性,造成监察处置中以政务处分替代移送审查起诉的问题。《监察法》并未赋予监察机关针对职务犯罪案件处理的裁量权,替代移送审查起诉的不当政务处分僭越检察权。为促进监察法治目标的实现,检察机关应当根据宪法定位,建立政务处分检察监督制度,强化对监察处置权的监督与制约。具体包括,以选择性不起诉制度为基础,建构检察机关的预先核准制;结合检察权对监察调查的介入,建立依申请介入的事后监督机制,同时以监检职能管辖完善、监检衔接平台建立、职务犯罪定罪量刑标准细化与政务处分的公开说理等作为监督的保障。

关键词：监检衔接政务处分检察监督预先核准检察介入

血管紧张素Ⅱ及其受体在慢性环孢素A肾毒性大鼠肾组织中的表达

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第二军医大学学报 2010年第12期31卷 1286-1290页

作者：金英顺洪英礼崔镇花刘雨田金海峰金华陈瑛李灿延边大学附属医院肾内科延吉133000

目的观察血管紧张素Ⅱ(AngⅡ)及其受体在慢性环孢素A(CsA)肾毒性中的表达。方法 Sprague-Daw-ley大鼠皮下注射CsA(15mg·kg-1.d-1)4周,建立慢性CsA肾毒性模型;正常对照组皮下注射橄榄油。检测各组大鼠的体重、收缩期血压、血CsA浓度、... 详细信息

目的观察血管紧张素Ⅱ(AngⅡ)及其受体在慢性环孢素A(CsA)肾毒性中的表达。方法 Sprague-Daw-ley大鼠皮下注射CsA(15mg·kg-1.d-1)4周,建立慢性CsA肾毒性模型;正常对照组皮下注射橄榄油。检测各组大鼠的体重、收缩期血压、血CsA浓度、血清肌酐、肌酐清除率;三色染色观察肾小管间质纤维化;免疫组织化学染色和蛋白质免疫印迹法分别检测AngⅡ及其受体AT1和AT2的表达。结果慢性CsA肾毒性组表现为体重减少、血肌酐上升、肌酐清除率下降、肾小管间质带状纤维化(P<0.01)。与对照组相比,毒性组大鼠AngⅡ的免疫活性明显增加(47±7vs13±4,P<0.01),主要分布于入球动脉的肾小球旁器,与肾小管间质纤维化程度紧密相关(r=0.769,P<0.001)。免疫印迹显示毒性组AngⅡ受体AT1的表达明显减少[(114±14)%vs(42±6)%,P<0.01],而AT2的表达增加[(129±23)%vs(469±43)%,P<0.01]。结论在慢性CsA肾毒性中,肾内肾素血管紧张素被激活,表现为AngⅡ免疫活性增加,这种AngⅡ免疫活性与肾小管间质纤维化紧密相关。

关键词：慢性环孢素A肾毒性间质性肾炎血管紧张素Ⅱ 血管紧张素受体

Elimination of GGTA1,CMAH,β4GalNT2 and CIITA genes in pigs compromises human versus pig xenogeneic immune reactions

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Animal Models and Experimental Medicine 2024年第4期7卷 584-590页

作者： jing Xu Jilong Ren Kai Xu Minghui Fang Meina Ka Fei Xu Xin Wang jing Wang Zhiqiang Han Guihai feng Ying Zhang Tang hai Wei Li Zheng Hu State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Key Laboratory of Organ Regeneration and Reconstruction Chinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education The First HospitalJilin UniversityChangchunChina Beijing Farm Animal Research Center Institute of ZoologyChinese Academy of SciencesBeijingChina

Background:Pig organ xenotransplantation is a potential solution for the severe organ shortage in clinic,while immunogenic genes need to be eliminated to improve the immune compatibility between humans and *** knockout strategies are mainly aimed at the genes causing hyperacute immune rejection(HAR)that occurs in the first few hours while adaptive immune reactions orchestrated by CD4 T cell thereafter also cause graft failure,in which process the MHCⅡmolecule plays critical ***:Thus,we generate a 4-gene(GGTA1,CMAH,β4GalNT2,and CIITA)knockout pig by CRISPR/Cas9 and somatic cell nuclear transfer to compromise HAR and CD4 T cell reactions ***:We successfully obtained 4KO piglets with deficiency in all alleles of genes,and at cellular and tissue ***,the safety of our animals after gene editing was verified by using whole-genome sequencing and *** have survived for more than one year in the barrier,and also survived for more than 3 months in the conventional environment,suggesting that the piglets without MHCⅡcan be raised in the barrier and then gradually mated in the conventional ***:4KO piglets have lower immunogenicity,are safe in genomic level,and are easier to breed than the model with both MHCⅠandⅡdeletion.

关键词： CD4 T cell genetically edited pig immune rejection major histocompatibility complex II xenotransplantation

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摩擦焊机监控系统的设计与应用

电焊机 2007年第10期37卷 43-45页

作者：冯金海陈秀香长春数控机床有限公司吉林长春130012

介绍了一套摩擦焊机监控系统,该系统采用VB开发,实现了摩擦焊机各参数的自动测量,完成数据采集、焊接的控制与实时显示、曲线生成、数据存储、分析处理以及所生成报表的浏览与打印等功能,提高了摩擦焊机的焊接质量。系统操作简单、数据... 详细信息

介绍了一套摩擦焊机监控系统,该系统采用VB开发,实现了摩擦焊机各参数的自动测量,完成数据采集、焊接的控制与实时显示、曲线生成、数据存储、分析处理以及所生成报表的浏览与打印等功能,提高了摩擦焊机的焊接质量。系统操作简单、数据精度高、准备工作时间短、有良好的重复性、实时性强,充分满足了对摩擦焊机的监控要求。

关键词：数据采集工作方式控制数据存储与回放摩擦焊缩短量

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乳化液-含油废水处理工程实例

能源环境保护 2016年第1期30卷 48-50页

作者：毛荣水金海峰海天塑机集团有限公司浙江宁波315821 浙江海元环境科技有限公司浙江杭州310051

对海亮铜加工乳化液/含油废水进行了污水站设计,并根据实际水质进行了工艺调整,采用隔油-破乳-气浮-沉淀工艺进行处理,取得了较好效果,污水站出水达标排放。

关键词：乳化液含油废水破乳混凝沉淀

High-efficiency gene editing in Anopheles sinensis using ReMOT control

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Insect Science 2024年第1期31卷 307-312页

作者： Xiao-lin Yang Xia Ling Quan Sun Pin-pin Qiu Kai Xiang Jun-feng Hong Shu-lin He Jie Chen Xin Ding hai Hu Zheng-bo He Cao Zhou Bin Chen Liang Qiao Chongqing Key Laboratory of Vector Insects Institute of Entomology and Molecular BiologyCollege of Life SciencesChongqing Normal UniversityChongqingChina Xunjian Life Science&Technology Co.Ltd. ChongqingChina State Key Laboratory of Resource Insects Southwest UniversityChongqingChina

Dear editor,Functional genomics studies of mosquito vectors are crucial for understanding their physiological behavior,pathogen transmission,and evolution,and for providing essential molecular targets for genetic control(Severson&Behura,201l;Alphey,2014;Ruzzante et al.,2019;Hong et al.,2022).The main methods involve clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)gene editing via embryo microinjection(Criscione et al.,2015;Kistler et al.,2015).

关键词： editor editing injection

Chromosome-level genome assembly of the Asian citrus psyllid,Diaphorina citri

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Insect Science 2024年第1期31卷 13-27页

作者： Shuang Lei Shi-Jiang Yu Qi Pan Li-Li Ding Si-Chen Li Lu-Yan Cheng Shu-Qi Wang Bing-hai Lou Jun He Cui-Yun Lei Lin Cong Hao-Qiang Liu Xue-feng Wang Chun Ran Citrus Research Institute Southwest University/Chinese Academy of Agricultural SciencesNational Engineering Research Center for CitrusChongqingChina

Diaphorina citri is a global citrus *** a vector insect,it can transmit the causative agents of citrus huanglongbing,causing irreversible losses to the citrus *** acquisition of genomic information can provide a molecular genetic basis for effective control of ***,the DNBSEQ™,Oxford Nanopore Technologies,and Hi-C technologies are applied to generate a high-quality chromosome-level genome of *** genome size of *** was 523.78 Mb with a scaffold N50 of 47.05 Mb distributed on 13 chromosomes.A total of 250.64 Mb(47.85%)repeat sequences and 24048 protein-coding genes were *** resequencing of female and male individuals indicated that the sex chromosome system of *** is *** analysis demonstrated that *** and Pachypsylla venusta,which separated from their most recent common ancestor about 336.62 million years ago,were the most closely ***,we identified genes potentially involved in detoxification metabolism,pathogen transmission,and honeydew secretion for further *** high-quality genome provides an important reference for developing effective management strategies of ***.

关键词： Asian citrus psyllid chromosome-level genome comparative genomics cytochrome P450 detoxification Huanglongbing

Cadherin-18 loss in prospermatogonia and spermatogonial stem cells enhances cell adhesion through a compensatory mechanism

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Zoological Research 2024年第5期45卷 1048-1060页

作者： Xiao-Xiao Li Dan-Chen Zhang Yan Wang Jian Wen Xing-Ju Wang Yu-Lu Cao Ru Jiang Jia-Rui Li Yi-Nuo Li He-He Liu Wen-hai Xie Zheng-feng Xu Ping Hu Kang Zou Germline Stem Cells and Microenvironment Lab College of Animal Science and TechnologyNanjing Agricultural UniversityNanjingJiangsu 210095China Stem Cell Research and Translation Center Nanjing Agricultural UniversityNanjingJiangsu 210095China School of Life Sciences and Medicine Shandong University of TechnologyZiboShandong 255000China Department of Prenatal Diagnosis Women’s Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China

Extracellular membrane proteins are crucial for mediating cell attachment,recognition,and signal transduction in the testicular microenvironment,particularly germline stem *** 18(CDH18),a type Ⅱ classical cadherin,is primarily expressed in the nervous and reproductive ***,we investigated the expression of CDH18in neonatal porcine prospermatogonia(ProSGs)and murine spermatogonial stem cells(SSCs).Disruption of CDH18 expression did not adversely affect cell morphology,proliferation,self-renewal,or differentiation in cultured porcine ProSGs,but enhanced cell adhesion and prolonged cell *** analysis indicated that the down-regulation of CDH18 in ProSGs significantly up-regulated genes and signaling pathways associated with cell *** further elucidate the function of CDH18 in germ cells,Cdh18 knockout mice were generated,which exhibited normal testicular morphology,histology,*** analysis showed increased expression of genes associated with adhesion,consistent with the observations in porcine *** interaction of CDH18withβ-catenin and JAK2 in both porcine ProSGs and murine SSCs suggested an inhibitory effect on the canonical Wnt and JAK-STAT signaling pathways during CDH18 ***,these findings highlight the crucial role of CDH18 in regulating cell adhesion in porcine ProSGs and mouse *** this regulatory mechanism provides significant insights into the testicular niche.

关键词： Extracellular signal Fertility Quiescency Wnt signaling pathway