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Effects of adenoviral-mediated gene transduction of NK4 on proliferation, movement, and invasion of human colonic LS174T cancer cells in vitro

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World Journal of Gastroenterology 2006年第25期12卷 3983-3988页

作者： Jian-zheng jie Jian-Wei Wang Jian-Guo Qu Wei Wang Tao Hung National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100052 China Department of General Surgery China-Japan Union Hospital Jilin University Changchun 130031 Jilin Province China

AIM： To investigate the inhibitory effects of a recombinant adenovirus vector that expresses NK4, a truncated form of human hepatocyte growth factor （HGF）, on human colonic adenocarcinoma cells in vitro to establish a basis for future NK4 gene cancer therapy. METHODS： Cells from the LS174T human colonic adenocarcinoma cell line were infected with recombinant adenovirus rvAdCMV/NK4 and the effects of the manipulation on tumor cell proliferation, scatter, migration, and basement membrane invasion were assessed. Cells infected with a recombinant adenovirus vector （Ad-LacZ） expressing β-galactosidase served as the controls. RESULTS： We found that rvAdCMV/NK4 expression attenuated HGF-induced tumor cell scatter, migration, and basement membrane invasion （P 〈 0.05）, but did not inhibit tumor cell proliferation. CONCLUSION： HGF-induced LS174T tumor cell scatter, migration, and invasion can be antagonized by the recombinant NK4-expressing adenovirus.

关键词： Human colonic adenocarcinoma NK4 Hepatocyte growth factor Adenoviral vector

Bimetallic Ru-Ni/TiO2 catalysts for hydrogenation of N-ethylcarbazole:Role of TiO2 crystal structure

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Journal of Energy Chemistry 2020年第1期29卷 188-195,I0007页

作者： Hongen Yu Xue Yang Yong Wu Yanru Guo Shuan Li Wei Lin Xingguo Li jie zheng Beijing National Laboratory for Molecular Sciences(BNLMS) College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Sinopec Research Institute of Petroleum Processing Beijing 100083China

Hydrogenation of N-ethylcarbazole(NEC),the hydrogen lean form of a liquid organic hydrogen carrier,on TiO2 supported Ru-Ni bimetallic catalysts is *** structure of TiO2 plays a critical role on the hydrogenation activity and selectivity towards fully hydrogenated ***/anatase catalyst exhibits higher selectivity but lower reactivity compared to Ru/rutile *** addition significantly promotes the performance of Ru/anatase catalyst while causes severe performance deterioration of Ru/rutile *** P25,a mixture of anatase and rutile phases in approximate ratio A/R1/4,is found to be the best TiO2 support for NEC ***/P25 catalyst outperforms both Ru/rutile and Ru/anatase and its activity can be further slightly improved by Ni *** unexpected synergism between the two different TiO2 phases for Ru based NEC hydrogenation catalysts is related to metal-support interaction and Ru-Ni interaction.

关键词： Liquid organic hydrogen carriers N-ethylcarbazole Hydrogenation Ru-Ni

One-step growth of the interconnected carbon nanotubes/graphene hybrids from cuttlebone-derived bi-functional catalyst for lithium-ion batteries

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Journal of Materials Science & Technology 2023年第18期149卷 205-213页

作者： Yan Zhong Kuan Deng jie zheng Tingting Zhang Peng Liu Xingbin Lv Wen Tian Junyi Ji School of Chemical Engineering Sichuan UniversityChengdu 610065China College of Chemistry and Environment Southwest Minzu UniversityChengdu 610041China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065China

Carbon nanotubes/graphene hybrid materials with excellent physicochemical properties can be widely ap-plied in the fields of energy storage,electrocatalysis,sensing,*** the self-stacking and achiev-ing covalent interaction between carbon nanotubes and graphene are important to ensure a stable hi-erarchical architecture and effective mass ***,we propose a one-step strategy to synthesize 3D interconnected carbon nanotubes/graphene hybrids on the easy-to-remove biomass-derived *** calcined natural cuttlebone as bi-functional catalyst precursor can simultaneously grow carbon nan-otubes and graphene by one-step chemical vapor deposition without the addition of extra metal catalysts,while the interconnected structure can act as the porous template for graphene *** simultane-ous growth process can obtain covalent bonding between carbon nanotubes and graphene,while the crystalline quality and interlayer space can be adjusted by different carbon sources and growth parame-ters(e.g.,temperature).The one-step grown carbon nanotubes/graphene hybrids with seamless interfaces and hierarchical interconnected 3D structure can effectively enhance the electron transfer as well as the electrolyte infiltration *** utilized as lithium-ion batteries(LIBs)anode,a high specific ca-pacity(544 mAh g^(-1) at 0.1 A g^(-1)),good rate capability(200 mAh g^(-1) at 6.4 A g^(-1) with an ultrashort charge time of 113 s),and excellent cyclic stability can be *** simple and one-step carbon nanotubes/graphene hybrids fabrication strategy can be easily scale-up and applied in various fields.

关键词： Cuttlebone biomass Carbon nanotube/graphene hetero-junction Bi-functional catalyst Chemical vapor deposition Lithium-ion batteries

Current Research Trends and Perspectives on Solid-State Nanomaterials in Hydrogen Storage

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Research 2021年第1期2021卷 125-163页

作者： jie zheng Chen-Gang Wang Hui Zhou Enyi Ye Jianwei Xu Zibiao Li Xian Jun Loh Institute of Materials Research and Engineering A^(∗)STAR(Agency for Science Technology and Research)2 Fusionopolis WayInnovis#08-03SingaporeSingapore 138634

Hydrogen energy,with environment amicable,renewable,efficiency,and cost-effective advantages,is the future mainstream substitution of fossil-based ***,the extremely low volumetric density gives rise to the main challenge in hydrogen storage,and therefore,exploring effective storage techniques is key hurdles that need to be crossed to accomplish the sustainable hydrogen *** physically or chemically stored into nanomaterials in the solid-state is a desirable prospect for effective large-scale hydrogen storage,which has exhibited great potentials for applications in both reversible onboard storage and regenerable off-board storage *** attractive points include safe,compact,light,reversibility,and efficiently produce sufficient pure hydrogen fuel under the mild *** review comprehensively gathers the state-of-art solid-state hydrogen storage technologies using nanostructured materials,involving nanoporous carbon materials,metal-organic frameworks,covalent organic frameworks,porous aromatic frameworks,nanoporous organic polymers,and nanoscale *** describes significant advances achieved so far,and main barriers need to be surmounted to approach practical applications,as well as offers a perspective for sustainable energy research.

关键词： mounted attractive substitution

Carbohydrate antigen 19-9 — tumor marker: Past, present, andfuture

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World Journal of Gastrointestinal Surgery 2020年第12期12卷 468-490页

作者： Tsinrong Lee Thomas zheng jie Teng Vishal G Shelat Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore Department of General Surgery Tan Tock Seng HospitalSingapore 308433Singapore

Carbohydrate antigen 19-9 (CA 19-9) is a cell surface glycoprotein complex mostcommonly associated with pancreatic ductal adenocarcinoma (PDAC). Koprowskifirst described it in 1979 using a mouse monoclonal antibody in a colorectalcarcinoma cell line. Historically, it is one of the most commonly used tumormarkers for diagnosing, managing, and prognosticating PDAC. Additionally,elevated CA 19-9 levels are used as an indication for surgery in suspected benignpancreatic conditions. Another common application of CA 19-9 in the biliary tractincludes its use as an adjunct in diagnosing cholangiocarcinoma. However, itsclinical value is not limited to the hepatopancreatobiliary system. The reality isthat the advancing literature has broadened the clinical value of CA 19-9. Thepotential value of CA 19-9 in patients' workup extends its reach to gastrointestinalcancers – such as colorectal and oesophageal cancer – and further beyond thegastrointestinal tract - including urological, gynecological, pulmonary, andthyroid pathologies. Apart from its role in investigations, CA 19-9 presents apotential therapeutic target in PDAC and acute pancreatitis. In a bid toconsolidate its broad utility, we appraised and reviewed the biomarker’s currentutility and limitations in investigations and management, while discussing thepotential applications for CA 19-9 in the works for the future.

关键词： Carbohydrate antigen 19-9 antigen Pancreatic diseases Liver diseases Biliary tract diseases Gastrointestinal diseases Pancreatic neoplasms

Leveraging the Public Health Emergency Operation Center (PHEOC)for pandemic response: opportunities and challenges

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Global Health Journal 2020年第4期4卷 118-120页

作者： Jiyan Ma Yangmu Huang Zhi-jie zheng Department of Global Health School of Public HealthPeking University38 Xueyuan RoadHaidian DistrictBeijing 100191China Institute for Global Health Peking University38 Xueyuan RoadHaidian DistrictBeijing 100191China

Public Health Emergency Operation Center (PHEOC) was conceptualized and established for coordinatinginformation and resources towards goal-oriented response in large scale public health emergency. Yet, theactivities undertaken by PHEOCs and their intended goals have not been fully optimized in current *** paper revisited the collective efforts invested in PHEOC conceptualization and development, identified theopportunities and challenges in compliance with standards and framework, demonstrated the accountabilityof PHEOC network, thereby promoted best practice guidance for global public health emergency preparednessand response. This review will help navigate emergency response complexities leveraging PHEOC partnershipsand advance the ability to detect and respond to public health emergencies in low resource settings. The reviewshows that the information on how to adapt best practice guidance to local circumstances could incentivizethe full implementation of prevention, early detection and response to outbreaks. Identifying and correctingdeficiencies in effectiveness evaluation will provide the basis for continuous PHEOC improvement. With thegradually reopening economies and public services in some countries, there is an urgent need to emphasize andvalidate the collective efforts undertaken by PHEOCs for tackling the COVID-19 pandemic.

关键词： Public Health Emergency Operation Center PHEOC Preparedness Response COVID-19 Coronavirus disease 2019

Ruthenium(Ⅱ)-catalyzed para-selective C—H difluoroalkylation of aromatic aldehydes and ketones using transient directing groups

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Chinese Chemical Letters 2021年第4期32卷 1437-1441页

作者： Yaohang Cheng Yuhang He jie zheng Hui Yang Jun Liu Guanghui An Guangming Li Key Laboratory of Functional Inorganic Material Chemistry(MOE) School of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080China College of Materials Science and Chemical Engineering Harbin Engineering UniversityHarbin 150001China

A Ru(Ⅱ)-catalyzed para-difluoroalkylation of aro matic alde hydes and ketones with a tra nsient directing group has been *** utilizes less expensive ruthenium catalysts and allows facile access to challenging difluoroalkylated *** mechanism studies suggest that the distinct coordination mode of ruthenium complex with imine moieties is responsible for para-selectivity.

关键词： para-Selectivity C-H activation Difluoroalkylation Ruthenium catalysis

MAVS-loaded unanchored Lys63-linked polyubiquitin chains activate the RIG-I-MAVS signaling cascade

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Cellular & Molecular Immunology 2023年第10期20卷 1186-1202页

作者： Feng Liu Wanxin Zhuang Bin Song Yuan Yang Junqi Liu Yi zheng Bingyu Liu jie zheng Wei Zhao Chengjiang Gao Key Laboratory of Infection and Immunity of Shandong Province&Key Laboratory for Experimental Teratology of Ministry of Education Shandong UniversityJinan250012ShandongP.R.China Department of Immunology School of Biomedical SciencesShandong UniversityJinan250012ShandongP.R.China Shanghai Institute of Materia Medica Chinese Academy of Sciences201203ShanghaiP.R.China Department of Pathogenic Biology School of Biomedical SciencesShandong UniversityJinan250012ShandongP.R.China

The adaptor molecule MAVS forms prion-like aggregates to govern the RIG-I-like receptor(RLR)signaling ***63(K63)-linked polyubiquitination is critical for MAVS aggregation,yet the underlying mechanism and the corresponding E3 ligases and deubiquitinating enzymes(DUBs)remain ***,we found that the K63-linked polyubiquitin chains loaded on MAVS can be directly recognized by RIG-I to initiate RIG-I-mediated MAVS aggregation with the prerequisite of the CARDRIG-I-CARDMAVS ***,many K63-linked polyubiquitin chains attach to MAVS via an unanchored *** identified Ube2N as a major ubiquitin-conjugating enzyme for MAVS and revealed that Ube2N cooperates with the E3 ligase Riplet and TRIM31 to promote the unanchored K63-linked polyubiquitination of *** addition,we identified USP10 as a direct DUB that removes unanchored K63-linked polyubiquitin chains from ***,USP10 attenuates RIG-I-mediated MAVS aggregation and the production of type I *** with a deficiency in USP10 show more potent resistance to RNA virus *** work proposes a previously unknown mechanism for the activation of the RLR signaling cascade triggered by MAVS-attached unanchored K63-linked polyubiquitin chains and establishes the DUB USP10 and the E2:E3 pair Ube2N-Riplet/TRIM31 as a specific regulatory system for the unanchored K63-linked ubiquitination and aggregation of MAVS upon viral infection.

关键词： MAVS Aggregation Unanchored K63-linked polyubiquitin chains RIG-l USP10

Profiles of muscular amino acids,fatty acids,and metabolites in Shaziling pigs of different ages and relation to meat quality

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Science China(Life Sciences) 2023年第6期66卷 1323-1339页

作者： Yehui Duan Changbing zheng jie zheng Lu Ma Xinran Ma Yinzhao Zhong Xichen Zhao Fengna Li Qiuping Guo Yulong Yin CAS Key Laboratory of Agro-ecological Processes in Subtropical Region Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic ProcessNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha410125China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing100049China Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai200241China

Pork meat is closely related to physicochemical alterations during growth and development,resulting in differences in nutritional value and meat *** study aimed to evaluate the composition of amino acids,fatty acids,and metabolic profiles in the longissimus thoracis muscle(LM)of Shaziling pigs aged 30,90,150,210,and 300 *** results showed that the predominant fatty acids identified in the LM of Shaziling pigs were C16:0,C16:1,C18:0,C18:1n9c,and C18:*** opposite correlation was observed for C18:2n6c and n6/n3 polyunsaturated fatty acids(P<0.05).Alanine,aspartate,glutamate,Dglutamine,and D-glutamate metabolism were the main metabolic pathways for the Shaziling pig meat flavor(P<0.05).Moreover,the correlation coefficients revealed that the contents of anserine,C16:0,C16:1,and C18:1n9c were positively correlated with intramuscular fat and/or p H24hand were negatively correlated with the values of L^(*)(lightness)and b^(*)(yellowness)(P<0.05).In conclusion,age greatly affected the meat quality of Shaziling pigs,and the contents of muscular anserine,C16:0,C16:1,and C18:1n9c might be promising indicators for better meat quality.

关键词： Shaziling pigs meat quality amino acids fatty acids metabolites