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Suppression of human colon tumor growth by adenoviral vector-mediated NK4 expression in an athymic mouse model

World Journal of Gastroenterology 2007年第13期13卷 1938-1946页

作者： Jian-zheng jie State Key Laboratory ofMolecular Virology and Genetic Engineering Beijing 100730China Natinoal Institute for Viral Disease Control and Prevention ChinaCDC Beijing 100052 China Department of General Surgery China-JapanFriendship Hospital Beijing 100029 China

AIM： To investigate the suppressive effects of adenoviral vector-mediated expression of NK4, an antagonist of hepatocyte growth factor （HGF）, on human colon cancer in an athymic mouse model to explore the possibility of applying NK4 to cancer gene therapy. METHODS： A human colon tumor model was developed by subcutaneous implantation of tumor tissue formed by LS174T cells grown in athymic mice. Fifteen tumorbearing mice were randomized into three groups （n= 5 in each group） at d 3 after tumor implantation and mice were injected intratumorally with phosphate-buffered saline （PBS） or with recombinant adenovirus expressing 13-galactosidase （Ad-LacZ） or NK4 （rvAdCMV/NK4） at a 6-d interval for total 5 injections in each mouse. Tumor sizes were measured during treatment to draw a tumor growth curve. At d 26 after the first treatment, all animals were sacrificed and the tumors were removed to immunohistochemically examine proliferating cell nuclear antigen （PCNA）, microvessel density （represented by CD31）, and apoptotic cells. In a separate experiment, 15 additional athymic mice were employed to develop a tumor metastasis model by intraperitoneal injection （ip） of LS174T cells. These mice were randomized into 3 groups （n = 5 in each group） at d 1 after injection and were treated by ip injection of PBS, or Ad-LacZ, or rvAdCMV/NK4 at a 6-d interval for total two injections in each mouse. All animals were sacrificed at d 14 and the numbers and weights of disseminated tumors within the abdominal cavity were measured. RESULTS： Growth of significantly suppressed human colon tumors were in the athymic mice treatedwith rvAdCMV/NK4 （2537.4± 892.3 mm^3） compared to those treated by either PBS （5175.2 ± 1228.6 mm^3） or Ad-LacZ （5578.8± 1955.7 mm^3）（P 〈 0.05）. The tumor growth inhibition rate was as high as 51%. Immunohistochemical staining revealed a similar PCNA labeling index （75.1% ± 11.2% in PBS group vs 72.8% ± 7.6% in Ad-LacZ group vs 69.3% ± 9.4% in rvAdCMV/ NK4 group） in all

关键词： Human colon cancer NK4 Hepatocytegrowth factor Adenoviral vector Gene therapy

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Compensation for Neurodegeneration by Hippocampal Neurogenesis in Alzheimer’s Disease: Where is the way?

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Neuroscience Bulletin 2021年第6期37卷 885-888页

作者： jie zheng Yawen Li Department of Pharmacology Key Laboratory of Basic Pharmacology of Ministry of EducationJoint International Research Laboratory of Ethnomedicine of Ministry of EducationKey Laboratory of Basic Pharmacology of Guizhou ProvinceZunyi Medical UniversityZunyi 563000China Digestive Disease Institute of Guizhou Province Clinical Medical Research Center of Digestive Diseases of Guizhou ProvinceDepartment of GastroenterologyAffiliated Hospital of Zunyi Medical UniversityZunyi 563000China

Neurodegeneration,a defining hallmark of Alzheimer's disease(AD),features the progressive loss of neuronal structure and *** approaches to AD show limited efficiency in halting the neurodegeneration to *** the lack of neuronal renewability in most subareas of the adult brain,symptomatic drugs or treatments cannot repopulate neurons and rewire the degenerated neuronal circuits in AD.

关键词： degeneration Alzheimer drugs

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Understand spiciness： mechanism of TRPV1 channel activation by capsaicin

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Protein & Cell 2017年第3期8卷 169-177页

作者： Fan Yang jie zheng Department of Physiology and Membrane Biology University of California Davis CA 95616 USA

Capsaicin in chili peppers bestows the sensation of spiciness. Since the discovery of its receptor, transient receptor potential vanilloid 1 （TRPV1） ion channel, how capsaicin activates this channel has been under extensive investigation using a variety of experimental techniques including mutagenesis, patch-clamp recording, crystallography, cryo-electron microscopy, computational docking and molecular dynamic simu- lation. A framework of how capsaicin binds and acti- vates TRPV1 has started to merge： capsaicin binds to a pocket formed by the channel＇s transmembrane seg- ments, where it takes a ＂tail-up, head-down＂ configu- ration. Binding is mediated by both hydrogen bonds and van der Waals interactions. Upon binding, cap- saicin stabilizes the open state of TRPV1 by ＂pull-and- contact＂ with the $4-$5 linker. Understanding the ligand-host interaction will greatly facilitate pharma- ceutical efforts to develop novel analgesics targeting TRPV1.

关键词： capsaicin TRPV1 ligand gating cryo-EM,computation spiciness

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Hippocampal neurogenesis and pro-neurogenic therapies for Alzheimer's disease

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Animal Models and Experimental Medicine 2022年第1期5卷 3-14页

作者： jie zheng Department of Pharmacology Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of EducationKey Laboratory of Basic Pharmacology of Guizhou ProvinceZunyi Medical UniversityZunyiChina

Adult hippocampal neurogenesis(AHN)facilitates hippocampal circuits plasticity and regulates hippocampus-dependent cognition and ***,AHN malfunction has been widely reported in both human and animal models of Alzheimer's disease(AD),the most common form of dementia in the *** therapies including rescuing innate AHN,cell engraftment and glianeuron reprogramming hold great potential for compensating the neuronal loss and rewiring the degenerated neuronal network in AD,but there are still great challenges to be *** review covers recent advances in unraveling the involvement of AHN in AD and highlights the prospect of emerging proneurogenic remedies.

关键词： Alzheimer's disease cognitive deficit hippocampus neurogenesis pro-neurogenic therapy

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Analytical and experimental study on mild steel dampers with non-uniform vertical slits

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Earthquake Engineering and Engineering Vibration 2015年第1期14卷 111-123页

作者： zheng jie Li Aiqun Guo Tong School of Civil Engineering Southeast University Key Laboratory of Concrete and Prestressed Concrete Structure of China Ministry of Education Southeast University

This study proposes a novel mild steel damper with non-uniform vertical slits. The influence of different shapes of vertical slits of the core energy plate on the energy dissipation and buckling resistance capacities is analyzed. Based on the theoretical analysis, formulas of key parameters of the dampers, including the elastic lateral stiffness, shear bearing capacity and yield displacement, are derived. The effectiveness of the proposed damper is demonstrated through pseudo static tests on four 0.25-scale specimens. Performance of these dampers, i.e. cyclic deformation, stress distribution, energy dissipation capacity, etc., are presented and discussed. Using the numerical models of dampers calibrated through test data, earthquake time-history analyses were conducted, and it is observed that the dampers significantly reduce the seismic responses of the prototype frame and have a desirable energy dissipation capacity.

关键词： mild steel damper vertical slit pseudo static test energy dissipation

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Synthesis and characterization of Li Fe(PO_4)_(3-x)/3Br_x/C as a cathode material for lithium-ion battery

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Science China(Technological Sciences) 2015年第7期58卷 1294-1298页

作者： zheng jie YONG HouHui YANG WenZhong College of Science Nanjing Tech University

The olivine-typed cathode material of Li Fe PO4 was prepared via sol-gel method,and the bromine was doped into Li Fe *** crystal structure,morphology,and electrochemical properties of the samples were investigated by X-ray diffraction,scanning electron microscopy and charge–discharge cycle *** results showed that the electrochemical performance of Li Fe PO4 had been improved by bromine doping,and the best doping amount of bromine is 2%.The discharge capacity of this sample can reach 152 m Ah/g at 0.2 C.

关键词： lithium ion battery LiFePO4 bromine doping

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Application of an immune algorithm to settlement prediction

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第1期10卷 93-100页

作者： Jia GUO Jun-jie zheng Yong LIU Institute of Geotechnieal and Underground Engineering Huazhong University of Science and Technology Wuhan 430074 China

The settlement curve of the foundation endured the ramp load is an S-type curve,which is usually simulated via Poisson *** at the difficulty of preferences in Poisson curve,an immune algorithm (IA) is *** is able to obtain a multiple quasi-optimum solution while maintaining the population *** this paper,IA is used in an attempt to obtain accurate settlement *** predicted settlements obtained by IA are compared with those predicted by the least squares fitting method (LSM),the Asaoka method and the genetic algorithm (GA).The results show that IA is a useful technique for predicting the settlement of foundations with an acceptable degree of accuracy and has much better performance than GA and the Asaoka methods.

关键词： Settlement Prediction Foundation Immune algorithm (IA)

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Long Period Grating Imprinted on a Flat-Shaped Plastic Optical Fiber for Refractive Index Sensing

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Photonic Sensors 2023年第4期13卷 39-49页

作者： Yuan LIU Yanfei ZHOU Haiyang BAO jie zheng State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012China Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130012China

A corrugated surface long period grating(LPG)was fabricated on a flat-shaped plastic optical fiber(POF)as a refractive index(RI)sensor by a simple pressing with the heat pressure and mechanical die press print *** light propagation characteristics of an LPG imprinted on a multi-mode POF were analyzed by the method of geometrical *** and experimental results showed that the structural parameters of the sensor affected the RI sensing performance,and the sensor with a thinner flat thickness,a deeper groove depth of the corrugated surface LPG,and a longer LPG exhibited better RI sensing *** the POF with a diameter of 1 mm was pressed with the heat pressure to a flat shape with a thickness of 600μm,an LPG with a period of 300μm,a groove depth of 200μm,and a length of 6 cm was fabricated on it,and the RI sensitivity of 1447%/RIU was obtained with a resolution of 5.494×10^(−6) *** addition,the influences of the POF cladding,tilting of LPG,and bending of the sensing structure were *** results demonstrated that after removing the cladding and tilting or bending the LPG,the RI sensing performance was *** the LPG imprinted on the flat-shaped POF was bent with a curvature radius of 6/πcm,the highest sensitivity of 6563%/RIU was achieved with a resolution of 2.487×10^(−9) RIU in the RI range of 1.3330–*** proposed sensor is a low-cost solution for RI measurement with the features of easy fabrication,high sensitivity,and intensity modulation at the visible wavelengths.

关键词： Plastic optical fiber fiber optic sensor flat-shaped optical fiber long period grating refractive index sensing

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Mechanism of CeO_(2) synthesized by thermal decomposition of Ce-MOF and its performance of benzene catalytic combustion

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Journal of Rare Earths 2021年第7期39卷 790-796,I0002页

作者： jie zheng Zhuo Wang Zhu Chen Shufeng Zuo Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process Shaoxing UniversityShaoxing 312000China

In this paper,the formation mechanism of mesoporous CeO_(2) synthesized by thermal decomposition of Ce-MOF and its performance of benzene catalytic combustion,as well as the structure-activity relationship between them were studied in *** self-assembly process and physicochemical properties of CeO_(2) were characterized by thermogravimetry analysis,powder X-ray diffraction,N2 adsorption/desorption,high-resolution transmission electron microscopy and X-ray photoelectron spectroscopy *** results show that Ce-MOF is completely decomposed into pure mesoporous CeO_(2) when the decomposition temperature is higher than 400℃.At this threshold temperature,CeO_(2)(400) has the largest specific surface area and pore volume of 114 m^(2)/g and 0.152 cm^(3)/g,***_(2)(400) exhibits very high catalytic activity for benzene combustion,which can completely catalyze the degradation of benzene at 260℃.Meanwhile,the mesoporous CeO_(2)(400) supported Pt nanocrystalline catalysts were prepared by high temperature solution-phase reduction ***/CeO_(2)(400)can completely degrade benzene at about 200℃ and represents high durability and good waterresistance for benzene combustion during 100 h of continuous reaction.

关键词： Thermal decomposition Ce-MOF Mechanism Structure-effect relationship Benzene Catalytic combustion

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Radially loading rotary extrusion for manufacturing large-size conical cylinders with inner transverse high ribs

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Chinese Journal of Aeronautics 2023年第5期36卷 582-594页

作者： Zhe CHEN Zhimin ZHANG jie zheng Yong XUE School of Material Science and Engineering North University of ChinaTaiyuan 030051China

The Large-size Conical Cylinders with Inner Transverse High Ribs(LCCWITHR) can reduce the weight of the parts while maintaining high rigidity and strength. Radially Loading Rotary Extrusion(RLRE) forming technology can achieve integral forming of LCCWITHR through the synergy of radial and rotary movements of dies. The flow law of the material during the forming process is the key to forming large-size inner ribs. At present, there is no unified understanding of the metal flow law of RLRE forming technology. An analytical expression was derived to predict the Radial Direction(RD) deformation loads. The FE simulation and process experiment were carried out to investigate the effects of the inclination angle, thickness factor and transition arc radius of the split top dies on the spacing of the metal diversion plane, the metal flow velocity of the rib area and the final radius of the inner rib. The influence of the split top dies loading distance and the bottom die rotation angle of each pass on the inner radius of the inner rib was verified. And the optimal combination of dies shape parameters and loading paths which can make the metal flow orderly was obtained: the inclination angle is 140°, the thickness factor is 3.64, the transition arc radius is 16 mm;the top dies loading distance is 15 mm, the bottom die rotation angle is 45°.The FE simulation results have been found to be in close agreement with physics *** research results reveal the metal flow law of rib growth in the RLRE of LCCWITHR, which lays a theoretical foundation for subsequent thorough research and process optimization.

关键词： Extrusion molding Rotary extrusion Radially loading Inner transverse rib Metal flow law Conical cylinder

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