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THREE-DIMENSIONAL PAIRING OF COHERENT STRUCTURES IN A PLANE MIXING LAYER

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Journal of Hydrodynamics 2002年第2期14卷 1-6页

作者： Lin, jian-Zhong shi, Xing yu, Zhao-Sheng Shao, Xue-Ming Dept. of Mech. Lab. of Fluid Power Trans. Zhejiang Univ. Hangzhou 310027 China

The three-dimensional (3D) pairing process of coherent structures in a plane mixing layer was simulated numerically with the pseudo-spectral method. The behaviors of spanwise cup-shaped vortices, streamwise rib-shaped vortices and quadrupoles were obtained in terms of their iso-surfaces. The results show that three-dimensional structures are strongly influenced by the initial amplitude of the 3D disturbance, and that in most cases the local pairing finishes in a roughly two-dimensional manner. In pairing region, the streamwise vortices are chaotic after pairing due to the breakdown of the engulfed ribs and especially the subsequent breakdown of the quadrupoles. The surviving ribs extend to the top (or bottom) of the paired vortices under the stretch of them. In addition, it is revealed that three dimensional vortices pairing can enhance the mixing of fluid. Finally, some patterns of numerical flow visualization are presented by computing the passive scalar.

关键词： Flow of fluids Flow visualization Mixing Numerical analysis Three dimensional

Interpretable prediction of drug-cell line response by triple matrix factorization

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Quantitative Biology 2021年第4期9卷 426-439页

作者： Xiao-Ying Yan Shao-Wu Zhang Siu-Ming Yiu jian-yu shi Key Laboratory of Information Fusion Technology of Ministry of Education School of AutomationNorthwestern Polytechnical UniversityXi'an 710072China College of Computer Science Xi’an Shiyou UniversityXi’an 710065China Department of Computer Science The University of Hong KongHong Kong 999077China School of Life Sciences Northwestern Polytechnical UniversityXi’an 710072China

Background:One of the challenges in personalized medicine is to determine specific drugs and their dosages for patient individuals who are undergoing a common *** technique of cell lines provides a safe approach to capture the drug responses of patient individuals when given specific drugs with varied ***,it is still costly to determine drug responses in cells w.r.t dosages by biological *** methods provide a promising screening to infer possible drug responses in the cells of patient individuals on a large ***,existing computational approaches are insufficient to interpret the underlying reason for drug ***:In this work,we propose an interpretable model for analyzing and predicting drug responses across cell *** proposed model bridges drug features(e.g.f chemical structure fingerprints),cell features(e.g.f gene expression profiles),and drug responses across cells(measured by IC50)by a triple matrix factorization(TMF),such that the underlying reason for drug responses in specific cells is possibly ***'.The comparison with state-of-the-art computational approaches demonstrates the superiority of our *** importantly,a case study of drug responses in lung-related cell lines shows its interpretable ability to find out highly occurring drug substructures,crucial mutated genes,as well as significant pairs between substructures and mutated genes in terms of drug sensitivity and ***:TMF is an effective and interpretable approach for predicting cell lines responses to drugs,and can dig out crucial pairs of chemical substructures and genes,which uncovers the underlying reason for drug responses in specific cells.

关键词： drug response drug sensitivity drug resistance triple matrix factorization

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盾构土与沙漠砂制备再生砖的性能研究

砖瓦 2024年第7期 18-20页

作者：石健宇李景康安斌于淇李国祥丛干文保定理工学院资源与工程技术学院河北保定071000

研究了不同含水率下不同取代率的沙漠砂对再生砖制坯、烧结、微观形貌、力学性能及含水率等因素的影响规律。研究结果表明:沙漠砂可有效补充再生砖中SiO2等必要的化学成分,提供稳定充分的烧结环境,满足烧结要求;陈化时间需稳定在20h左右... 详细信息

研究了不同含水率下不同取代率的沙漠砂对再生砖制坯、烧结、微观形貌、力学性能及含水率等因素的影响规律。研究结果表明:沙漠砂可有效补充再生砖中SiO2等必要的化学成分,提供稳定充分的烧结环境,满足烧结要求;陈化时间需稳定在20h左右,测得陈化料含水率20%、25%、30%时的干燥敏感性系数分别为0.69、0.72、1.04;含水率为25%~28%时,再生砖成型效果最佳;沙漠砂取代率为27%~30%时可有效承担砖体骨架作用,再生砖抗压强度及吸水率分别稳定在15.5MPa~17.3MPa、9.5%~10.04%之间;盾构土和沙漠砂混合制备再生砖,性能优异,综合效益显著,可拓宽建筑垃圾资源化利用途径,满足市场需求,具有一定的实际应用价值。

关键词：盾构土沙漠砂再生砖抗压强度吸水率

A direct electrochemical biosensor for rapid glucose detection based on nitrogen-doped carbon nanocages

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Rare Metals 2024年第5期43卷 2184-2192页

作者： Lan-Lan Li yu Zhao Li-Jia Pan jian-Bin Xu Yi shi College of Mechanical and Electrical Engineering Henan Agricultural UniversityZhengzhou 450002China School of Electronic Science and Engineering Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing210093China Department of Electronic Engineering The Chinese University of HongKongHongkong 999077China

Given the increasing number of diabetic patients,rapid and accurate detection of glucose in body fluids is *** study developed a direct electrochemical biosensor for glucose based on nitrogen-doped carbon nanocages(NCNCs).NCNCs possess a large specific surface area of 1395 m^(2)·g^(-1),a high N atomic content of 9.37%and good biocompatibility,which is favorable for enzyme loading and electron *** surface average concentration of electroactive glucose oxidase on NCNCs was 2.82×10^(-10)mol·cm^(-2).The NCNC-based direct electrochemical biosensor exhibited a high sensitivity of 13.7μA·(mmol·L^(-1))^(-1)·cm^(-2),rapid response time of 5 s and an impressive electron-transferrate constant(ks)of 1.87 s^(-1).Furthermore,we investigated an NCNC-based direct electron transfer(DET)biosensor for sweat glucose detection,which demonstrated tremendous promise for non-invasive wearable diabetes diagnosis.

关键词： Direct electron transfer(DET) Nitrogen-doped carbon nanocages(NCNCs) Glucose oxidase Biosensor

Intelligent geochemical interpretation of mass chromatograms:Based on convolution neural network

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Petroleum Science 2024年第2期21卷 752-764页

作者： Kai-Ming Su Jun-Gang Lu jian yu Zi-Xing Lu shi-Jia Chen Hubei Key Laboratory of Petroleum Geochemistry and Environment Wuhan430100HubeiChina College of Resources and Environment Yangtze UniversityWuhan430100HubeiChina School of Geoscience and Technology Southwest Petroleum UniversityChengdu610500SichuanChina Changqing Oilfield Company PetroChinaXi'an710021ShaanxiChina

Gas chromatography-mass spectrometry(GC-MS)is an extremely important analytical technique that is widely used in organic *** is the only approach to capture biomarker features of organic matter and provides the key evidence for oil-source correlation and thermal maturity ***,the conventional way of processing and interpreting the mass chromatogram is both timeconsuming and labor-intensive,which increases the research cost and restrains extensive applications of this *** overcome this limitation,a correlation model is developed based on the convolution neural network(CNN)to link the mass chromatogram and biomarker features of samples from the Triassic Yanchang Formation,Ordos Basin,*** this way,the mass chromatogram can be automatically *** research first performs dimensionality reduction for 15 biomarker parameters via the factor analysis and then quantifies the biomarker features using two indexes(*** and PMI)that represent the organic matter thermal maturity and parent material type,***,training,interpretation,and validation are performed multiple times using different CNN models to optimize the model structure and hyper-parameter setting,with the mass chromatogram used as the input and the obtained MI and PMI values for supervision(label).The optimized model presents high accuracy in automatically interpreting the mass chromatogram,with R2values typically above 0.85 and0.80 for the thermal maturity and parent material interpretation results,*** significance of this research is twofold:(i)developing an efficient technique for geochemical research;(ii)more importantly,demonstrating the potential of artificial intelligence in organic geochemistry and providing vital references for future related studies.

关键词： Organic geochemistry Biomarker Mass chromatographic analysis Automated interpretation Convolution neural network Machine learning

The influence of yttrium and manganese additions on the degradation and biocompatibility of magnesium-zinc-based alloys:In vitro and in vivo studies

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Journal of Magnesium and Alloys 2024年第2期12卷 608-624页

作者： Lei shi Yang Yan Chun-sheng Shao Kun yu Bo Zhang Liang-jian Chen Third Xiangya Hospital Central South UniversityChangsha 410013China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China School of Materials Science and Engineering Central South UniversityChangsha 410083China Department of Mechanical Engineering City University of Hong KongHong KongChina

The repair and regeneration of bone defects are highly challenging orthopedic ***,Mg-based implants have gained popularity due to their unique biodegradation and elastic modulus similar to that of human *** aim of our study is to develop a magnesium alloy with a controllable degradation that can closely match bone tissue to help injuries heal in vivo and avoid cytotoxicity caused by a sudden increase in ion *** this study,we prepared and modified Mg-3Zn,Mg-3Zn-1Y,and Mg-2Zn-1Mn by hot extrusion,and used Mg-2.5Y-2.5Nd was as a *** then investigated the effect of additions of Y and Mn on alloys'*** results show that Mn and Y can improve not only compression strength but also corrosion *** alloy Mg-2Zn-1Mn demonstrated good cytocompatibility in vitro,and for this reason we selected it for implantation in *** degraded Mg-2Zn-1Mn implanted a bone defect area did not cause obvious rejection and inflammatory reaction,and the degradation products left no signs of damage to the heart,liver,kidney,or ***,we find that Mg-2Zn-1Mn can promote an osteoinductive response in vivo and the formation of bone regeneration.

关键词： Magnesium alloy Biodegradation Biocompatibility Bone regeneration Bone defect repair

A case report of neck, chest and upper limb cutaneous metastasis from synchronous colorectal cancer

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Chinese Medical Journal 2009年第14期122卷 1716-1717页

作者： WANG jian shi yu-qian WU Zhi-yong Division of General Surgery Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200001 China

Cutaneous metastasis from colorectal carcinoma is uncommon, occurring in less than 4% of the whole patients. The most frequently involved are incision scar or abdominal skin, while cutaneous metastasis to neck and chest is very rare. We hereby report a case of synchronous, postoperative cutaneous metastasis from colorectal carcinoma to neck, upper limb and chest skin, which were confirmed by biopsy.

关键词： colorectal cancer cutaneous metastasis

The Enhanced Period Map and Equivariant Deformation Quantizations of Nilpotent Orbits

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Acta Mathematica Sinica,English Series 2024年第3期40卷 885-934页

作者： shi Lin yu Department of Mathematics School of Mathematical SciencesXiamen UniversityXiamen 361005P.R.China

In a previous paper,the author and his collaborator studied the problem of lifting Hamil-tonian group actions on symplectic varieties and Lagrangian subvarieties to their graded deformation quantizations and apply the general results to coadjoint orbit method for semisimple Lie *** even quantizations were considered *** this paper,these results are generalized to the case of general quantizations with arbitrary *** key step is to introduce an enhanced version of the(truncated)period map defined by Bezrukavnikov and Kaledin for quantizations of any smooth sym-plectic variety X,with values in the space of Picard Lie algebroid over *** an application,we study quantizations of nilpotent orbits of real semisimple groups satisfying certain codimension condition.

关键词： Coadjoint orbit method deformation quantization Harish-Chandra modules semisimple Liegroups

Solvent-Resistant Wearable Triboelectric Nanogenerator for Energy-Harvesting and Self-Powered Sensors

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Energy & Environmental Materials 2024年第5期7卷 380-390页

作者： Yongtao yu yuelin yu Hongyi Wu Tianshuo Gao Yi Zhang Jiajia Wu Jiawei Yan jian shi Hideaki Morikawa Chunhong Zhu Graduate School of Medicine Science and Technology Shinshu University Institute for Fiber Engineering (IFES) Interdisciplinary Cluster for Cutting Edge Research (ICCER) Shinshu University Faculty of Textile Science and Technology Shinshu University

Wearable triboelectric nanogenerators （TENGs） have attracted attention owing to their ability to harvest energy from the surrounding environment without maintenance. Herein, polyetherimide–Al2O3（PAl） and polyvinylidene fluoride-co-hexafluoropropylene （PVDF-HFP, PH） nanofiber membranes were used as tribo-positive and tribo-negative materials, respectively. Phytic aciddoped polyaniline （PANI）/cotton fabric （PPCF） and ethylenediamine （EDA）-crosslinked PAl （EPAl） nanofiber membranes were used as triboelectrode and triboencapsulation materials, respectively. The result showed that when the PAl–PH-based TENG was shaped as a circle with a radius of 1 cm, under the pressure of 50 N, and the frequency of 0.5 Hz, the open-circuit voltage (Voc)and short-circuit current (Isc) reached the highest value of 66.6 V and-93.4to 110.1 nA, respectively. Moreover, the PH-based TENG could be used as a fabric sensor to detect fabric composition and as a sensor-inductive switch for light bulbs or beeping warning devices. When the PAl–PH-based TENG was shaped as a 5×5 cm2rectangle, a 33μF capacitor could be charged to15 V in 28 s. Interestingly, compared to PAl nanofiber membranes, EPAl nanofiber membranes exhibited good dyeing properties and excellent solvent resistance. The PPCF exhibited shing,bending, and stretching.

关键词： energy-harvesting power supply sensors solvent-resistant wearable triboelectric nanogenerator