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Effects of red Palm Oil on Serum Lipids and Plasma Carotenoids Level in chinese Male Adults

Biomedical and Environmental Sciences 2003年第4期16卷 348-354页

作者： jian zhang , chun-r.ng wang,{2., AND {3.-you gein.t.tute of Nutrition and food Safety, chinese center for disease control and prevention, beijing 100050, china Institute of Nutrition and food Safety Chinese Center for Disease Control and Prevention Beijing 100050 Chin

Objective Effects of red palm oil on major plasma carotenoids, tocopherol, retinol and serum lipids were evaluated when used in chinese diet. Methods red palm oil group (rPO) composed of 2. male subjects(aged 18-3.1} and soybean oil group (SBO) composed of 2. male subjects (aged 18-3.1}. Dietary fat provided about 2.% of total calories, and the test oil accounted for about 60% of total dietary fat. In the 3.weeks of pretest period, diets were prepared with soybean oil, and then in the next 6 weeks subjects in each group consumed the diet prepared by test oil. results Plasma α-carotene, β-carotene and lycopene concentration of rPO group significantly increased at the time of interim (2. days) and of the end (42.days) (Ptocopherol concentration significantly increased at the time of the end (42.days) in this study. though chinese plasma retinol level was relatively low when compared with that of Westerners, red palm oil diet showed no significant effect on adult chinese plasma retinol level. Serum concentration of total cholesterol, triglyceride, high density lipoprotein cholesterol, apolipoprotein AI and apolipoprotein B of all subjects showed no significant changes in rPO group dur.ng the study. Conclusions the data in our study suggest that red palm oil is a good source of carotenoids and vitamin E when used in chinese diet preparation, and it can significantly increase plasma concentration of a-carotene, α-carotene, lycopene and β-tocopherol.

关键词： red palm oil retinal α-carotene β-carotene α-tocopherol Serum cholesterol Serum triglyeride Apolipoprotein AI Apolipoprotein B

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Association Between Serum Uric Acid and Prevalence of type 2.Diabetes Diagnosed using HbA1c Criteria Among {2. Adults in Qingdao,china

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Biomedical and Environmental Sciences 2015年第12期28卷 884-893页

作者： xue Bai tAN Ji Bin NIng Feng SUN {3. Ping zhang ke Yi LIU Li wang Shao Jie zhang Dong Feng QIAO Qing PAng Zeng Chang Department of Nutrition and food Hygiene Medical College of Qingdao University center for disease {2. and {3. School of Public Health Jilin University chinese center for {2. {3. and prevention Department of Public Health University of Helsinki

Objective to determine whether elevated serum uric acid(UA)levels are associated with type 2.diabetes diagnosed using Hb A1 c levels among {2. *** We conducted two population-based cross-sectional studies in Qingdao in china in 2.06 and 2.09.A total of 6894(3..4% men)subjects aged 3.-74 years were included in the data *** diagnosed diabetes was defined as Hb A1 c level of ≥6.5%,and prediabetes was classified as Hb A1 c level between 5.7% and 6.4% according to the International Diabetes Federation *** logistic regression was employed to assess the association between UA and prevalence of type 2.diabetes defined using Glycated hemoglobin A1c(Hb A1 c *** Subjects with prediabetes had higher UA levels than those with normal glucose tolerance,newly diagnosed diabetes,and known diabetes,with corresponding values of 3.0}.1(82.5)μmol/L,3.0.9(84.2.μmol/L,2.1.3.81.7)μmol/L,3.5.2.83.6)μmol/L,respectively(Pr all comparisons).Binary logistic regression analysis showed that UA was a possible predictor for the prevalence of type 2.diabetes diagnosed using Hb A1 c levels,and the second quartile of UA levels had a higher odds ratio(Or:4.088;95% CI:2.900-5.765)for Hb A1 c than the other quartiles after adjusting for age,body mass index,sex,marital status,education,income,alcohol consumption,smoking,and cardiometabolic *** Serum UA is significantly associated with type 2.diabetes diagnosed using Hb A1 c levels,independent of other cardiometabolic parameters.

关键词： Uric acid type 2.diabetes Hemoglobin A1c Cardiometabolic parameters

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HLA-Dr expression on regulatory t cells is closely associated with the global immune activation in HIV-1 infected subjects naive to antiretroviral therapy

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chinese Medical Journal 2011年第15期124卷 2340-2346页

作者： XIAO jian QIAN ke-lei CAO Qi{2.-hua QIU Chen-li QIU Cao {3. Yi-le zhang Xiao-yan ZHO{2. Pi{2. XU jian-qi{2. LI Mi{2.-yuan wang Yi{2. Department of Microbiology West China School of preclimcal and Forensic Medicine Sichuan University Chengdu Sichuan 610041 China Department of AIDS/StD Shanghai Municipal Center for Disease Control and Prevention Shanghai 200336 China Shanghai Public Health Clinical center Institutes of Biomedical Sciences key Laboratory of Medical Molecular Virology of Ministry of Education/Health Shanghai Medical College Fudan University Shanghai 201508 China

Background the frequencies of regulatory t cells （tregs） increased over the HIV infection but its counts actually decreased. We proposed that the decrease of treg counts may cause the reduction of inhibitory effect and thereby account for the over-activation of tregs dur.ng HIV infection. However, it remains unknown whether tregs are also over-activated and thereafter the activation induced death may lead to the decrease of tregs. Methods tregs were defined as CD4＋CD2.＋CD12.lo/-t cells. Eighty-one HIV-1 infected patients were enrolled in our study, and twenty-two HIV-1 seronegative donors were recruited as the {3.. the levels of HLA-Dr on tregs were determined by FACSAria flow cytometer. results Compared to HIV-1 seronegative donors, the levels of HLA-Dr on CD4＋CD2.＋CD12.lo/- tregs were significantly increased in HIV-1 infected patients, and its increase was positively associated with viral loads （r=0.3.63. P=-0.004） and negatively with CD4 t-cell counts （r=-0.4153. P 〈0.0001）. In addition, significant associations between HLA-Dr expression on CD4＋CD2.＋CD12.lo/- tregs and the percentages of HLA-Dr, CD3., Ki67 expressi{2. CD4＋ and CD8＋ t cells were also identified. Conclusion HLA-Dr on tregs is a good marker for viral replication and disease progression. the over-activation of tregs might result in the decrease of tregs.

关键词： human immunodeficiency virus type 1 t-lymphocytes, regulatory HLA-Dr antigens immune activation

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micrornas在自身免疫性疾病中的研究进展

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中国新药杂志 2020年第14期29卷 1596-1601页

作者：任禹珂王超吕建军屈哲霍桂桃张頔杨艳伟王雪李波林志中国食品药品检定研究院国家药物安全评价监测中心药物非临床研究北京市重点实验室北京100176

micrornas(mirnas)是一类单链内源性非编码小rnas,长度约为18~{3.个核苷酸,在调控基因表达、细胞生长、分化及凋亡、生物的生长发育和疾病中发挥重要作用。自身免疫性疾病是以自身免疫反应导致组织器官损伤和相应功能障碍为主要发病机制... 详细信息

micrornas(mirnas)是一类单链内源性非编码小rnas,长度约为18~{3.个核苷酸,在调控基因表达、细胞生长、分化及凋亡、生物的生长发育和疾病中发挥重要作用。自身免疫性疾病是以自身免疫反应导致组织器官损伤和相应功能障碍为主要发病机制的一类疾病。研究发现多种mirnas的异常表达有可能成为这类疾病早期诊断的生物标志物或临床治疗的靶标。本文对mirnas的生物学特点以及mirnas在自身免疫性疾病中的研究进展进行综述。

关键词： micrornas 自身免疫作用机制生物标志物

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中草药添加剂对肉羊血常规和免疫功能影响的研究

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畜牧兽医杂志 2018年第2期37卷 6-9页

作者：刘瑞生王珂徐建峰张新报师希雄薛春胜甘肃省畜牧兽医研究所甘肃平凉744000 平凉市崆峒区畜牧技术服务中心甘肃农业大学食品科学与工程学院平凉职业技术学院

试验旨在研究中草药添加剂对肉羊血常规和免疫功能的影响。将10只3.龄左右萨福克与小尾寒羊杂交一代公羔,随机均分为2.,对照组饲喂精料,试验组在精料中添加1.5%中草药添加剂饲喂,试验期90d。分别在试验前后不同阶段采血测定血常规指... 详细信息

试验旨在研究中草药添加剂对肉羊血常规和免疫功能的影响。将10只3.龄左右萨福克与小尾寒羊杂交一代公羔,随机均分为2.,对照组饲喂精料,试验组在精料中添加1.5%中草药添加剂饲喂,试验期90d。分别在试验前后不同阶段采血测定血常规指标和免疫功能参数。结果试验组肉羊血液中红细胞、白细胞、血红蛋白、淋巴细胞百分率、淋巴细胞绝对值和血小板计数及血清中总蛋白、白蛋白、球蛋白、白/球比、免疫球蛋白G、免疫球蛋白A和白细胞介素1含量均不同程度高于对照组。表明中草药添加剂能够提高肉羊免疫功能,增强抗病力。

关键词：中草药添加剂肉羊血常规免疫功能

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89株纹带棒状杆菌耐药性及其耐药基因特征分析

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中国抗生素杂志 2023年第5期48卷 579-585页

作者：薛佳琦王雪冰崔尧马小涵邢欢王娜刘泽梁段立科施淇源周君辰李娟周海健董爱英华北理工大学附属医院唐山063000 中国疾病预防控制中心传染病预防控制所传染病预防控制国家重点实验室北京102206

目的通过分析河北省华北理工大学附属医院临床分离的纹带棒状杆菌的耐药性和基因组特征,为临床鉴别、治疗和防控提供参考。方法收集并鉴定临床分离非重复纹带棒状杆菌89株。经VItEK2.Compact全自动细菌仪联合16S rrna鉴定为纹带棒状杆菌... 详细信息

目的通过分析河北省华北理工大学附属医院临床分离的纹带棒状杆菌的耐药性和基因组特征,为临床鉴别、治疗和防控提供参考。方法收集并鉴定临床分离非重复纹带棒状杆菌89株。经VItEK2.Compact全自动细菌仪联合16S rrna鉴定为纹带棒状杆菌,采用微量肉汤稀释法进行体外药敏试验,使用全基因组测序技术进行测序。结果药敏结果显示所有菌株对利奈唑胺及万古霉素都表现为敏感,对环丙沙星(89,100.0%)全部耐药;全基因组测序共检出identity在90%以上耐药基因16种,大环内酯类和氨基糖苷类耐药基因和耐药表型匹配度较高;在基因组水平上,纹带棒状杆菌的传播具有优势克隆群。结论该院分离的纹带棒状杆菌同时携带多种抗菌药物的耐药基因,其某些耐药表型和耐药基因型具有一致性。该院纹带棒状杆菌院内传播由于优势克隆群的存在,菌株在进化过程中能通过耐药基因的获得及累积而产生不同的克隆群。

关键词：纹带棒状杆菌耐药性耐药基因全基因组

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