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The remodeling roles of lipid metabolism in colorectal cancer cells and immune microenvironment

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Oncology Research 2022年第5期30卷 231-242页

作者： jiateng zhong JINGYU GUO XINYU ZHANG SHUANG FENG WENYU DI YANLING WANG HUIFANG ZHU Department of Pathology School of Basic Medical SciencesXinxiang Medical UniversityXinxiang453003China Department of Pathology The First Affiliated Hospital of Xinxiang Medical UniversityXinxiang453100China Department of Anesthesiology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510630China

Lipid is a key component of plasma membrane,which plays an important role in the regulation of various cell biological behaviors,including cell proliferation,growth,differentiation and intracellular signal transduction.Studies have shown that abnormal lipid metabolism is involved in many malignant processes,including colorectal cancer(CRC).Lipid metabolism in CRC cells can be regulated not only by intracellular signals,but also by various components in the tumor microenvironment,including various cells,cytokines,DNA,RNA,and nutrients including lipids.In contrast,abnormal lipid metabolism provides energy and nutrition support for abnormal malignant growth and distal metastasis of CRC cells.In this review,we highlight the remodeling roles of lipid metabolism crosstalk between the CRC cells and the components of tumor microenvironment.

关键词： Lipid metabolism Colorectal cancer Tumor microenvironment(TME)

Hsa_Circ_0000826 inhibits the proliferation of colorectal cancer by targeting AUF1

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Journal of Genetics and Genomics 2023年第3期50卷 192-203页

作者： Zheying Zhang Wenyan Fan Qingzu Gao Yifei Han Jingyu Ma Wuji Gao Yuhan Hu Huifang Zhu Rui Yang Haijun Wang Baoshun Du Zuoyang Zhang jiateng zhong Department of Pathology School of Basic Medical SciencesXinxiang Medical UniversityXinxiangHenan 453003China Department of Microscopic Morphology Laboratory School of Basic Medical SciencesXinxiang Medical UniversityXinxiangHenan 453003China Department of Pathology The First Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan 453003China School of Life Science and Technology Xinxiang Medical UniversityXinxiangHenan 453003China Second Department of Neurosurgery Xinxiang Central HospitalXinxiangHenan 453003China Department of Pathology Anhui Medical UniversityHefeiAnhui 230032China

Many circular RNAs(circRNAs)are reported to be abnormally expressed during the progression of various tumors,and these circRNAs can be used as anti-tumor targets.Therefore,it is important to identify circRNAs that can be used effectively for the clinical diagnosis and treatment of colorectal cancer(CRC).Here,we report that hsa_Circ_0000826(Circ_0000826),a circ RNA with significantly reduced expression level in CRC tissues,is associated with a poor prognosis in patients.The silencing of Circ_0000826 promotes the proliferation of CRC cells.Conversely,the overexpression of Circ_0000826 restricted CRC cell proliferation both in vitro and in vivo.Furthermore,Circ_0000826 could target AU-rich element RNA-binding protein 1(AUF1).AUF1,known as heterogeneous nuclear ribonucleoprotein D(hnRNP D),could bind to the c-MYC 3’-UTR and promote c-MYC expression.When Circ_0000826 binds to AUF1,it competitively inhibits the binding of AUF1 to the c-MYC 3’-UTR,which inhibits the c-MYC expression and cell proliferation.These results provide novel insights into the functional mechanism of Circ_0000826 action in CRC progression and indicate its potential use as a therapeutic target in CRC.

关键词： Colorectal cancer Hsa_Circ_0000826 AUF1 Proliferation CircRNA

SCFβ-TRCP E3 ubiquitin ligase targets the tumor suppressor ZNRF3 for ubiquitination and degradation

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Protein & Cell 2018年第10期9卷 879-889页

作者： Yanpeng Ci Xiaoning Li Maorong Chen jiateng zhong Brian J. North Hiroyuki Inuzuka Xi He Yu Li Jianping Guo Xiangpeng Dai School of Life Science and Technology Harbin Institute of Technology Harbin 150001 China Department of Pathology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA Department of Biochemistry and Molecular Biology Shanxi Medical University Taiyuan 030001 China The FM Kirby Neurobiology Center Children's Hospital Boston Harvard Medical School Boston MA 02115 USA Department of Oncology The First Affiliated Hospital of Xinxiang Medical University Xinxiang 453100 China Center for Advanced Stem Cell and Regenerative Research Tohoku University Graduate School of DentistrySendai 980-8575 Japan

Wnt signaling has emerged as a major regulator of tissue development by governing the self-renewal and maintenance of stem cells in most tissue types. As a key upstream regulator of the Wnt pathway, the transmem- brane E3 ligase ZNRF3 has recently been established to play a role in negative regulation of Wnt signaling by targeting Frizzled （FZD） receptor for ubiquitination and degradation. However, the upstream regulation of ZNRF3, in particular the turnover of ZNRF3, is still unclear. Here we report that ZNRF3 is accumulated in the presence of proteasome inhibitor treatment independent of its E3-ubiquitin ligase activity. Furthermore, the Cullin f-specific SCF complex containing β-TRCP has been identified to directly interact with and ubiqui- tinate ZNRF3 thereby regulating its protein stability. Similar with the degradation of β-catenin by β-TRCP, ZNRF3 is ubiquitinated by β-TRCP in both CKI-phos- phorylation- and degron-dependent manners. Thus, our findings not only identify a novel substrate for β-TRCP oncogenic regulation, but also highlight the dual regu- lation of Wnt signaling by β-TRCP in a context-dependent manner where β-TRCP negatively regulates Wnt signaling by targeting β-catenin, and positively regulates Wnt signaling by targeting ZNRF3.

关键词： ZNRF3 β-TRCP Wnt ubiquitination CKI

Summer extreme precipitation patterns and synoptic-scale circulation precursors over the Tibetan Plateau

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Science China Earth Sciences 2024年第5期67卷 1625-1638页

作者： Zhiyuan DING Yao HA zhong zhong College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China Key Laboratory for Virtual Geographic Environment School of Geography ScienceNanjing Normal UniversityNanjing 210023China Jiangsu Collaborative Innovation Center for Climate Change School of Atmospheric SciencesNanjing UniversityNanjing 210023China

In the context of global warming,the extreme summer precipitation over the Tibetan Plateau(TP)has changed significantly.In this study,the summer(June–August)extreme precipitation on the TP was classified into three spatial types by applying the K-means clustering method to the Third Pole Region long time-series high-resolution(1/30°)precipitation dataset(TPHi Pr,1979–2020).The characteristics of the circulation anomalies and precursors corresponding to the extreme precipitation on the TP in summer during 1979–2020 were investigated.The results showed that the summer extreme precipitation of the TP can be categorized into northwestern(NW),southeastern(SE),and southern Himalayan(HS)types based on extreme precipitation thresholds.The NW and SE types are mainly influenced by anomalous signals in the mid-to-high latitude regions upstream of them,whereas the HS type is controlled by the localized subtropical anomalous circulation.On the 8th day before the onset of the NW type,an anomalous cyclone was observed in the western Atlantic Ocean(60°W,50°N),which triggered the west-to-east quasi-latitudinal propagation of Rossby waves.On the onset day of the NW type,the upper troposphere showed positive-negative-positive geopotential height anomalies along the latitudinal 40°N from the Caspian Sea,the western part of Xinjiang,to the northeastern TP.Moisture entered from the Arabian Sea along the southeastern edge of the anomalous cyclone on the southwestern TP and converged in the northwestern TP.Compared to the NW type,the precursors of the SE type appeared at higher latitudes and were more intense.On the 8th day before the onset of the SE type,an anomalous cyclone occurred near Greenland(60°W,70°N)and excited Rossby waves propagating southeastward.On the onset day of the SE type,the upper troposphere showed negative-positive-negative geopotential height anomalies across Eurasia from the Ural Mountains and the Iranian Plateau to the northern TP in the northwest-southeast direction and entered the southeastern TP from the Bay

关键词： Tibetan Plateau Summer extreme precipitation Atmospheric circulation anomaly Precursor Teleconnection wave train

Analysis of photocatalytic degradation of polyamide microplastics in metal salt solution by high resolution mass spectrometry

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Journal of Environmental Sciences 2024年第5期139卷 473-482页

作者： Yunjin zhong Lebing Zhuo Wangyang Lu National Engineering Lab for Textile Fiber Materials&Processing Technology(Zhejiang) School of Materials Science&EngineeringZhejiang Sci-Tech UniversityHangzhou 310018China

Microplastic pollution has become one of the most concerned focuses in the world.Among many treatment methods,photocatalysis is considered to be one of the most environmentally friendly methods.In this work,the photodegradation behavior of polyamide microplastics is studied by using polyamide 6(PA6)as model microplastics and FeCl_(3) as catalyst.It is hoped that the PA6 fiber can be effectively degraded by utilizing the strong oxidizing active species that can be produced after FeCl_(3) is irradiated in water.The results shows that PA6 fiber can be almost completely degraded after 10 days of irradiation in FeCl_(3) aqueous solution,indicating that it is promising to use this new method to solve the problem of PA6type microplastics.In addition,the chain scission mechanism and degradation process of PA6 are analyzed in detail by ultra-high performance liquid chromatography-tandem mass spectrometry(UPLC-MS),which provides a new insight for the study of polymer degradation mechanism.

关键词： FeCl_(3) Photocatalysis Polyamide 6 Chain scission

Hot versus cold subduction initiation

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National Science Review 2024年第2期11卷 101-102页

作者： zhong-Hai Li Key Laboratory of Computational Geodynamics College of Earth and Planetary SciencesUniversity of Chinese Academy of Sciences

In the framework of plate tectonics, subduction initiation(SI) indicates the birth of a plate convergent boundary, which is a key point of plate tectonics and Wilson's cycle; however, its dynamic process is not well c... 详细信息

关键词： DRIVEN CRUST

Early diagnosis and management of neonatal sepsis:a perspective

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World Journal of Pediatrics 2024年第4期20卷 303-306页

作者： Li‑zhong Du Neonatal Intensive Care Unit Children’s Hospital Zhejiang University School of MedicineNational Clinical Research Center for Child Health3333 Binsheng RoadHangzhou 310052China

Neonatal sepsis is an illness caused by bloodstream bacteria or fungal infections that affect newborn infants under 28 days of age.It stands as a significant contributor to morbidity and mortality in neonatal intensive care units(NICUs).With the improved survival rates of very low-birth-weight or extremely premature infants,a growing number of these vulnerable infants are receiving intensive care and undergoing invasive procedures,making nosocomial infections a persistent challenge in NICUs.The mortality rate associated with neonatal sepsis varies depending on factors such as birth weight,gestational age,and other co-morbidities.It can also lead to a range of long-term health consequences,including neurodevelopmental disabilities like cerebral palsy,visual or hearing impairments,and cognitive problems.Furthermore,neonatal sepsis is linked to various adverse outcomes,including respiratory complications,bronchopulmonary dysplasia,nutritional and growth issues,and immunological dysfunction[1].Due to its atypical clinical presentation and the low rate of specific diagnostic indicators,such as a positive blood culture,accurately diagnosing neonatal sepsis is challenging.Consequently,the appropriateness of antibiotic treatment is often a matter of controversy.

关键词： neonatal mortality diagnosis

Design and simulation investigations on charge transport layers‑free in lead‑free three absorber layer all‑perovskite solar cells

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Frontiers of Optoelectronics 2024年第2期17卷 69-85页

作者： Guangdong Li Mingxiang Xu zhong Chen School of Physics Southeast UniversityNanjing 211189China

The multiple absorber layer perovskite solar cells(PSCs)with charge transport layers-free(CTLs-free)have drawn widespread research interest due to their simplified architecture and promising photoelectric characteristics.Under the circumstances,the novel design of CTLs-free inversion PSCs with stable and nontoxic three absorber layers(triple Cs_(3)Bi_(2)I_(9),single MASnI_(3),double Cs_(2)TiBr_(6))as optical-harvester has been numerically simulated by utilizing wxAMPS simulation software and achieved high power conversion efficiency(PCE)of 14.8834%.This is owing to the innovative architecture of PSCs favors efficient transport and extraction of more holes and the slender band gap MASnI_(3)extends the absorption spectrum to the near-infrared periphery compared with the two absorber layers architecture of PSCs.Moreover,the performance of the device with p-type-Cs_(3)Bi_(2)I_(9)/p-type-MASnI_(3)/n-type-Cs_(2)TiBr_(6)architecture is superior to the one with the p-type-Cs_(3)Bi_(2)I_(9)/ntype-MASnI_(3)/n-type-Cs_(2)TiBr_(6)architecture due to less carrier recombination and higher carrier life time inside the absorber layers.The simulation results reveal that Cs_(2)TiF_(6)double perovskite material stands out as the best alternative.Additionally,an excellent PCE of 21.4530%can be obtained with the thicker MASnI_(3)absorber layer thickness(0.4μm).Lastly,the highestperformance photovoltaic devices(28.6193%)can be created with the optimized perovskite doping density of around E15 cm^(3)(Cs_(3)Bi_(2)I_(9)),E18 cm^(3)(MASnI_(3)),and 1.5E19 cm^(3)(Cs_(2)TiBr_(6)).This work manifests that the proposed CTLs-free PSCs with multi-absorber layers shall be a relevant reference for forward applications in electro-optical and optoelectronic devices.

关键词： Multiple absorber layer PSCs CTLS-free·Inverted Narrow-band gap Simulation

Modeling and Simulation of Lithium Vacuum Evaporation Process Using COMSOL Multiphysics

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Journal of Thermal Science 2024年第1期33卷 86-100页

作者： LIAN Xuexin zhong Dawen Beijing Key Laboratory of Passive Nuclear Power Safety and Technology North China Electric Power UniversityBeijing 102206China

Based on the COMSOL Multiphysics simulation software,this study carried out modeling and numerical simulation for the evaporation process of liquid metal lithium in the vacuum free molecular flow state.The motion of lithium atoms in the evaporation process was analyzed through a succession of studies.Based on the available experimental values of the saturated vapor pressure of liquid metal lithium,the relationship between saturated vapor pressure and temperature of liquid lithium in the range of 600 K-900 K was obtained.A two-dimensional symmetric model(3.5 mm×20 mm) was established to simulate the transient evaporation process of liquid lithium at wall temperatures of 750 K,780 K,800 K,810 K,825 K,and 850 K,respectively.The effects of temperature,the evaporation coefficient,back pressure,and length-to-diameter ratio on the evaporation process were studied;the variation trends and reasons of the molecular flux and the pressure during the evaporation process were analyzed.At the same time,the evaporation process under variable wall temperature conditions was simulated.This research made the evaporation process of liquid lithium in vacuum molecular flow clearer,and provided theoretical support for the space reactor and nuclear fusion related fields.

关键词： free molecular flow saturated vapor pressure vacuum evaporation liquid lithium metal