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上海金属 2004年第2期26卷 29-31,20页

作者：焦海燕洪新王华兵潘路影吴国庆上海大学上海200072 上海三钢有限责任公司

从理论上阐述冶炼不锈钢时熔渣的发泡机理。并根据上海三钢公司的情况,在2500Hz的中频感应炉上对熔渣进行发泡高度的实验,找出发泡性能较好的渣系,研究渣中各成分对发泡性能的影响。

关键词：泡沫渣不锈钢电弧炉发泡机理炼钢发泡高度

Injectable bioactive polymethyl methacrylate-hydrogel hybrid bone cement loaded with BMP-2 to improve osteogenesis for percutaneous vertebroplasty and kyphoplasty

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Bio-Design and Manufacturing 2022年第2期5卷 318-332页

作者： xin Sun xin Zhang xin jiao Jie Ma xingzhen Liu Han Yang Kangping Shen Yaokai Gan Jinwu Wang haiyan Li Wenjie Jin Shanghai Key Laboratory of Orthopaedic Implants Department of Orthopaedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200001China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200030China Chemical and Environmental Engineering School of EngineeringRMIT University124 La Trobe St.MelbourneVIC 3000Australia

Poly methyl methacrylate(PMMA)bone cement is used in augmenting and stabilizing fractured vertebral bodies through percutaneous vertebroplasty(PVP)and percutaneous kyphoplasty(PKP).However,applications of PMMA bone cement are limited by the high elasticity modulus of PMMA,its low biodegradability,and its limited ability to regenerate *** improve PMMA bio activity and biodegradability and to modify its elasticity modulus,we mixed PMMA bone cement with oxidized hyaluronic acid and carboxymethyl chitosan in situ cross-linking hydrogel loaded with bone morphogenetic protein-2(BMP-2)to achieve novel hybrid *** fabric ated PMMA-hydrogel hybrid cements exhibited lower setting temperatures,a lower elasticity modulus,and better biodegradability and biocompatibility than that of pure PMMA cement,while retaining acceptable setting times,mechanical strength,and inj *** addition,we detected release of BMP-2 from the PMMA-hydrogel hybrid cements,significantly enhancing in vitro osteogenesis of bone marrow mesenchymal stem cells by up-regulating the gene expression of Runx2,Coll,and *** of PMMA-hydrogel hybrid cements loaded with BMP-2 on rabbit femoral condyle bone-defect models revealed their biodegradability and enhanced bone *** study demonstrated the favorable mechanical properties,biocompatibility,and biodegradability of fabricated PMMA-hydrogel hybrid cements loaded with BMP-2,as well as their ability to improve osteogenesis,making them a promising material for use in PKP and PVP.

关键词： Polymethyl methacrylate bone cement Hydrogel Bone morphogenetic protein-2 Osteogenesis Percutaneous vertebroplasty

Metabolic pathway modulation by olanzapine:Multitarget approach for treating violent aggression in patients with schizophrenia

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World Journal of Psychiatry 2025年第1期15卷 37-53页

作者： Yan-Ning Song Shuang Xia Zhi Sun Yong-Chao Chen Lu jiao Wen-Hua Wan hong-Wei Zhang Xiao Guo Hua Guo Shou-Feng Jia Xiao-xin Li Shi-Xian Cao Li-Bin Fu Meng-Meng Liu Tian Zhou Lv-Feng Zhang Qing-Quan Jia Department of Pharmacy The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pharmacy Zhumadian First People's HospitalZhumadian 463000Henan ProvinceChina Scientific Education Section The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Psychiatry The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Clinical Laboratory The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Publicity Division The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina

BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment *** To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent *** Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were *** pharmacology was used to establish protein-protein interaction networks of the core targets of *** Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were subsequently *** Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis *** treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with *** effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis *** core targets of olanzapine were involved in several key *** The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia.

关键词： Schizophrenia Violent aggression Olanzapine Metabolomics Network pharmacology

Spanning tree trajectory optimization in the galaxy space

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Astrodynamics 2021年第1期5卷 27-37页

作者： Tian-jiao Zhang Dietmar Wolz hong-xin Shen Ya-Zhong Luo State Key Laboratory of Astronautic Dynamics Xi’an Satellite Control CenterXi’an 710043China University of Jena Jena 07737Germany National University of Defense Technology Changsha 410073China

The 10th edition of the Global Trajectory Optimization Competition considered the problem of the galaxy settlement wherein competitors from all over the world were expected to design the trajectories of different settler vessels to maximize the given multi-faceted merit *** synthesis methods used by the winning team,led jointly by the National University of Defense Technology(NUDT)and Xi’an Satellite Control Center(XSCC),are described along with a greedy search method and the improved solution obtained by University of ***,we presented a layout-first topology-second approach that allows an efficient settlement tree search guided by the pre-specified ideal spatial *** also explained how the problem of constructing settlement trees can be modeled as the widely studied minimum spanning tree ***,University of Jena explored the possibility that a greedy search can generate even better settlement trees,based on the same initial conditions,when compared to that of the winning solution.

关键词： trajectory optimization Settlers of the Galaxy minimum spanning tree ant colony optimization greedy search

Hydrothermal-sedimentary dolomite—A case from the Middle Permian in eastern Junggar Basin,China

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Journal of Palaeogeography 2020年第4期9卷 415-437页

作者： Shuai Zhang Yi-Qun Liu hong Li xin jiao Ding-Wu Zhou State Key Laboratory of Continental Dynamics Northwest UniversityXi'an 710069Shaanxi ProvinceChina Department of Geology Northwest UniversityXi'an 710069Shaanxi ProvinceChina Key Laboratory of Alpine Ecology Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

The Middle Permian Lucaogou Formation in the Jimusar Sag,eastern Junggar Basin,NW China,was deposited in a salt lake within an intracontinental rift basin with intense hydrothermal ***-sedimentary dolomite in the form of three types of dolostones,namely,analcime-feldspar dolostone(AFD),silicic dolostone(SD)and buddingtonite-albite dolostone(BAD),related to syn-sedimentary hydrothermal activity at lake bottom was *** characteristics and formation mechanism of the dolomite were studied based on micron-scale petrographic and isotopic geochemical *** syn-depositional formation of these dolostones was indicated by their rock-mineral features and syn-sedimentary deformation *** dolomite was composed of relatively poorly ordered proto-dolomite crystals with micron-sized spherical or sub-spherical morphology and coexisted with hydrothermal minerals,including analcime,buddingtonite,albite and *** clasts were replaced by the dolomite,indicating high-temperature conditions during *** remarkably low strontium isotopic compositions of the dolostones(87Sr/86Sr with an average of 0.705687)indicated that mantle-derived materials might have involved in the ore-forming *** dolostones had positiveδ13CPDB values(with an average of 6.94‰)and negativeδ18OPDB values(with an average of-8.12‰).Based on theδ18OPDB values,the formation temperatures of the dolomite were at least^25ºC higher than those of the penecontemporaneous dolomite in the Lucaogou Formation in the study *** is concluded that the dolomite precipitated from hydrothermal fluid erupting at the lake *** possible genetic models are *** suggest that the hydrothermal-sedimentary dolomite is an important genetic type,and this study may help increase the awareness of this understudied type of dolomite.

关键词： Dolomite genesis Hydrothermal sedimentary dolomite Permian Lucaogou Formation Jimusar Sag Junggar Basin

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu xin Shao Qinqin Wang xin Dong Bin Duan Feiyang xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

Analysis of Organic Acids Accumulated in Kochia Scoparia Shoots and Roots by Reverse-phase High Performance Liquid Chromatography Under Salt and Alkali Stress

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Chemical Research in Chinese Universities 2006年第3期22卷 315-318页

作者： YAN hong ZHAO Wei jiao xin-qian YAN Bing-jun ZHOU Dao-wei School of Life Sciences Northeast Normal University Changchun 130024 P.R. China Department of Avigation Lifesaving Avigation University of Air Force Changchun 130022 P. R. China College of Environment and Resources Jilin University Changchun 130012 P. R. China

Several organic acids accumulated in Kochia Scoparia shoots and roots were studied by means of reverse-phase high performance liquid chromatography with a C18 column. Five types of binary organic acids were separated. The organic acid concentrations were determined in K. Scoparia seedlings stressed by saline （NaCI） and alkaline （NaHCO3） at the same Na^＋ concentration. Concentrations of organic acids are stimulated by alkaline because the cells will adjust their pH values through the accumulation of organic acids, when the environment is basic. The concentrations of oxalic acid and succinic acid are higher than those of other organic acids, including tartaric acid and malic acid, and the concentration of citric acid is the lowest. The concentrations of the organic acids in the roots are higher than those in the shoots under salt（NaCI） stress, but the results are opposite while the roots are under alkali （ NaHCO3 ） stress. This indicates that there are different adaptive strategies for K. Scopar/a seedlings in organic acid metabolism under salt and alkali stress.

关键词： Kochia Scoparia(L. ) Sehrad Salt stress Alkaline stress Organic acid HPLC

Characterization and expression of sweetfish （Plecoglossus altivelis） cathepsin D

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Zoological Research 2014年第4期35卷 294-299页

作者： Yu jiao Chang-hong LI xin-Jiang LU Jiong CHEN Key Laboratory of Applied Marine Biotechnology Ministry of Education Ningbo University

Cathepsin D （CTSD） is a lysosomal acidic endoproteinase that plays an important role in immune response, In this study, we obtained sweetfish （Plecoglossus altivelis） CTSD （PaCTSD） via de-novo transcriptome sequencing of sweetfish macrophages. The full length cDNA sequence of PaCTSD was 1955 bp encoding a propeptide of 397 amino acids. The deduced protein had a calculated molecular weight of 43.17x 103. Multiple alignment with other known CTSD amino acid sequences revealed amino acid conservation through the teleosts. Phylogenetic tree analysis showed that PaCTSD grouped tightly with other fish CTSD, and was close to that of Atlantic salmon and rainbow trout. Subsequently, PaCTSD was prokaryotically expressed and refolded by the urea gradient method on a nickel-nitrilotriacetic acid column. Enzyme activity analysis showed that PaCTSD exhibited pH-dependent proteolytic activity. Quantitative real-time PCR showed that PaCTSD mRNA was expressed in all detected tissues in healthy sweetfish. The highest expression was observed in the spleen and white blood cells, followed by liver, head-kidney, kidney, intestine, gill, and muscle. After Listonella anguillarum infection, PaCTSD transcripts were up-regulated significantly in liver, spleen, white blood cells, and head-kidney of sweetfish. In summary, PaCTSD has proteolytic activity and is closely involved in the immune response of sweetfish.

关键词： Cathepsin D Plecolossus altivelis Bacterial infection Prokaryotic expression qRT-PCR

Defect Engineering:Can it Mitigate Strong Coulomb Effect of Mg^(2+)in Cathode Materials for Rechargeable Magnesium Batteries?

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Nano-Micro Letters 2025年第1期17卷 135-159页

作者： Zhengqing Fan Ruimin Li xin Zhang Wanyu Zhao Zhenghui Pan Xiaowei Yang School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024People’s Republic of China School of Materials Science and Engineering Tongji UniversityShanghai 201804People’s Republic of China

Rechargeable magnesium batteries(RMBs)have been considered a promising“post lithium-ion battery”system to meet the rapidly increasing demand of the emerging electric vehicle and grid energy storage ***,the sluggish diffusion kinetics of bivalent Mg^(2+)in the host material,related to the strong Coulomb effect between Mg^(2+)and host anion lattices,hinders their further development toward practical *** engineering,regarded as an effective strategy to break through the slow migration puzzle,has been validated in various cathode materials for *** this review,we first thoroughly understand the intrinsic mechanism of Mg^(2+)diffusion in cathode materials,from which the key factors affecting ion diffusion are further ***,the positive effects of purposely introduced defects,including vacancy and doping,and the corresponding strategies for introducing various defects are *** applications of defect engineering in cathode materials for RMBs with advanced electrochemical properties are also ***,the existing challenges and future perspectives of defect engineering in cathode materials for the overall high-performance RMBs are described.

关键词： Rechargeable magnesium battery Sluggish diffusion kinetic Defect engineering Cathode materials Ion migration