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World Journal of Gastrointestinal Oncology 2024年第3期16卷 787-797页

作者： Peng-Yang Zhou De-xiang Zhu Yi-jiao Chen Qing-Yang Feng Yi-Hao Mao Ao-Bo Zhuang Jian-Min Xu Department of General Surgery Zhongshan Hospital Fudan UniversityShanghai 200032China

BACKGROUND Patatin like phospholipase domain containing 8(PNPLA8)has been shown to play a significant role in various cancer *** studies have focused on its roles as an antioxidant and in lipid ***,the role of PNPLA8 in colorectal cancer(CRC)progression is *** To explore the prognostic effects of PNPLA8 expression in *** A retrospective cohort containing 751 consecutive CRC patients was ***8 expression in tumor samples was evaluated by immunohistochemistry staining and semi-quantitated with immunoreactive *** patients were divided into high and low PNPLA8 expression groups based on the cut-off va-lues,which were calculated by X-tile *** prognostic value of PNPLA8 was identified using univariate and multivariate Cox regression *** over-all survival(OS)rates of CRC patients in the study cohort were compared with Kaplan-Meier analysis and Log-rank *** PNPLA8 expression was significantly associated with distant metastases in our cohort(P=0.048).CRC patients with high PNPLA8 expression indicated poor OS(median OS=35.3,P=0.005).CRC patients with a higher PNPLA8 expression at either stage I and II or stage III and IV had statistically significant shorter *** patients with left-sided colon and rectal cancer,the survival curves of two PN-PLA8-expression groups showed statistically significant *** analysis also confirmed that high PNPLA8 expression was an independent prog-nostic factor for overall survival(hazard ratio HR=1.328,95%CI:1.016-1.734,P=0.038).

关键词： Biomarker Colorectal cancer Expression level Overall survival Patatin like phospholipase domain containing 8 Prognosis

Credible and Facile Fluorometric Detection of Soybean Trypsin Inhibitor Activity with a Water-Soluble Poly(diphenylacetylene) Derivative

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Transactions of Tianjin University 2024年第4期30卷 305-313页

作者： jiao Tang Xiao Tang Jiaxiang Tang Wei Qi Qianwei Pan Jinhong zeng Housheng Xia Jianping Zhou Zhongyi Sheng Junfeng Niu Zhejiang Tiantai xianghe Industrial Co. Ltd.Taizhou 317200China Zhejiang xianghe Track Fastener Research Institute Taizhou 317200China Shaoxing Institute for Food and Drug Control Shaoxing 312000China Key Laboratory of Chemical and Biological Processing Technology for Farm Products of Zhejiang Province School of Biological and Chemical EngineeringZhejiang University of Science and TechnologyHangzhou 310023China

Herein,a novel method for fl uorometric detection of soybean trypsin inhibitor(SBTI)activity based on a water-soluble poly(diphenylacetylene)derivative was *** quenching of the polymer via p-nitroaniline,produced from the trypsin-catalyzed decomposition of N-benzoyl-DL-arginine-4-nitroanilide hydrochloride(L-BAPA),was well described using the Stern-Volmer *** activity was quantitatively assessed based on changes in the fl uorescence intensity of the *** strategy has several advantages,such as high sensitivity and ease of ***,its applicability to other biochemical analyses is promising.

关键词： Fluorometric detection Soybean trypsin inhibitor Inhibition activity Fluorescence quenching

Highly efficient 1D p-Te/2D n-Bi_(2)Te_(3) heterojunction self-driven broadband photodetector

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Nano Research 2024年第3期17卷 1864-1874页

作者： Chenchen Zhao Dongbo Wang Jiamu Cao Zhi zeng Bingke Zhang Jingwen Pan Donghao Liu Sihang Liu Shujie jiao Tianyuan Chen Gang Liu Xuan Fang Liancheng Zhao Jinzhong Wang School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China School of Astronautics Harbin Institute of TechnologyHarbin 150001China Center for High Pressure Science and Technology Advanced Research Shanghai 201203China State Key Laboratory of High Power Semiconductor Lasers Changchun University of Science and TechnologyChangchun 130022China

Broadband photodetectors with self-driven functions have attracted intensive scientific interest due to their low energy consumption and high optical ***,high-performance broadband self-driven photodetectors are still a significant challenge due to the complex fabrication processes,environmental toxicity,high production costs of traditional 3D semiconductor materials and sharply raised contact resistance,severe interfacial recombination of 2D materials and 2D/3D mixed dimension ***,1D p-Te/2D n-Bi_(2)Te_(3) heterojunctions are constructed by the simple and low-cost hydrothermal method.1D p-Te/2D n-Bi_(2)Te_(3) devices are applied in photoelectrochemical(PEC)photodetectors,with their high performance attributed to the good interfacial contacts reducing interface *** device demonstrated a broad wavelength range(365–850 nm)with an Iph/Idark as high as *** R_(i),D^(*),and external quantum efficiency(EQE)values of the device were as high as 12.07 mA/W,5.87×10^(10) Jones,and 41.05%,respectively,which were significantly better than the performance of the prepared Bi_(2)Te_(3) and Te devices.A comparison of the freshly fabricated device and the device after 30 days showed that 1D p-Te/2D n-Bi_(2)Te_(3) had excellent stability with only 18.08%decay of *** is anticipated that this work will provide new emerging material for future design and preparation of a high-performance self-driven broadband photodetector.

关键词： topological insulating states interfacial recombination self-driven 1D p-Te/2D n-Bi_(2)Te_(3) photodetector

Control of defensive behavior by the nucleus of Darkschewitsch GABAergic neurons

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National Science Review 2024年第4期11卷 70-83页

作者： Huiying Zhao Jinrong Liu Yujin Shao xiang Feng Binhan Zhao Li Sun Yijun Liu Linghui zeng Xiao-ming Li Hongbin Yang Shumin Duan Yan-qin Yu Department of Neurology of Second Affiliated Hospital and School of Brain Science and Brain Medicine Zhejiang University School of Medicine Nanhu Brain-Computer Interface Institute Liangzhu Laboratory MOE Frontier Science Center for Brain Science and Brain-Machine Integration State Key Laboratory of Brain-Machine Intelligence Zhejiang University NHC and CAMS Key Laboratory of Medical Neurobiology Zhejiang University Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of Medicine Hangzhou City University

The nucleus of Darkschewitsch(ND), mainly composed of GABAergic neurons, is widely recognized as a component of the eye-movement controlling system. However, the functional contribution of ND GABAergic neurons(NDGABA) in animal behavior is largely unknown. Here, we show that NDGABA neurons were selectively activated by different types of fear stimuli, such as predator odor and foot *** and chemogenetic manipulations revealed that NDGABA neurons mediate freezing ***, using circuit-based optogenetic and neuroanatomical tracing methods, we identified an excitatory pathway from the lateral periaqueductal gray(l PAG) to the ND that induces freezing by exciting ND inhibitory outputs to the motor-related gigantocellular reticular nucleus, ventral part(Gi V). Together,these findings indicate the NDGABA population as a novel hub for controlling defensive response by relaying fearful information from the l PAG to Gi V, a mechanism critical for understanding how the freezing behavior is encoded in the mammalian brain.

关键词： nucleus of Darkschewitsch GABAergic population defensive behavior freezing neural circuitry

Orientation controlled photogenerated carriers on selfsupporting CdS/Ni_(3)S_(2) paper toward photocatalytic hydrogen evolution and biomass upgrading

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Rare Metals 2024年第5期43卷 2015-2025页

作者： Xiao-Yan Liu Qing Cao Gui-xiang Li Hui Liu Li-Li zeng Li-Li Zhao Bin Chang Xi-Wen Wang Hong Liu Wei-Jia Zhou Institute for Advanced Interdisciplinary Research School of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China Institute of Chemical Sciences and Engineering Ecole Polytechnique Federale de Lausanne1015LausanneSwitzerland KAUST Catalysis Center King Abdullah University of Science and TechnologyThuwal 23955-6900Kingdom of Saudi Arabia School of Environment and Energy South China University of TechnologyGuangzhou Higher Education Mega CenterGuangzhou 510006China State Key Laboratory of Crystal Materials Shandong UniversityJinan250100China School of Mechanical Engineering Xi'an Jiaotong UniversityXi'an 710054China

The appropriate regulation of band structure is an effective strategy in constructing efficient photocatalytic *** photocatalytic system mainly employs powder photocatalysts,which makes their recovery reliant on expensive separation processes and severely limits their industrial ***,we constructed a novel CdS/Ni_(3)S_(2)heterostructure using free-standing and flexible nickel fiber paper as the *** regulated energy band structure achieves effective electron–hole *** as-synthesized flexible photocatalyst exhibits considerable photocatalytic activity toward the H_(2)evolution reaction under visible-light irradiation,with an H_(2)production rate of5.63μmol·cm^(-2)·h^(-1)(14.1 mmol·g^(-1)cat·h^(-1)according to the catalyst loading content).Additionally,the otherwisewasted excited holes simultaneously drive organic transformations to yield value-added organic products,thus markedly improving the photocatalytic H_(2)evolution *** a photocatalytic system is scaled up further,where a self-supported 20 cm×25 cm sample achieves a champion H_(2)production rate of 60-80μmol·h^(-1)under practical sun *** newly developed self-supported photocatalyst produces opportunities for practical solar H2production with biomass upgrading.

关键词： Self-supporting photocatalyst CdS/Ni_(3)S_(2) heterojunction Hydrogen evolution Biomass upgrading Large-scaleapplication

Boost VS_(2) electrochemical reactive kinetics by regulating crystallographic planes and coupling carbon matrix for high performance sodium-ion storage

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Rare Metals 2024年第1期43卷 98-112页

作者： Min zeng Ming-Shan Wang Lin Chen En-Zhi Li Zhen-Liang Yang Dan Zhou Hai-jiao Xie Jun-Chen Chen Zhi-Yuan Ma Bing-Shu Guo Bo Yu Xing Li School of New Energy and Materials Southwest Petroleum UniversityChengdu 610500China Energy Storage Research Institute Southwest Petroleum UniversityChengdu 610500China Institute of Materials China Academy of Engineering PhysicsMianyang 621908China Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and TechnologyBeijingBeijing 100083China Hangzhou Yanqu Information Technology Co. Ltd.Hangzhou 310003China

Vanadium disulfide(VS_(2)) as a typical two-dimensional transition metal chalcogenide has excellent competitiveness for sodium-ion storage due to its wide layer spacing(0.575 nm),high theoretical capacity of 932mAh·g^(-1) originating from multi-electron electrochemical ***,continuous sodiation process accompanied by crystal structural evolution and collapse cause rapid capacity ***,novel few-layer VS_(2)nanosheets with open(001) crystal planes are in-situ constructed on reduced graphene oxide to solve these issues mentioned *** indicates that few-layer VS_(2)provides more Na^(+) storage activity due to the low Na^(+)surface migration energy barrier on exposed crystal(001)*** flexible and high electronic conductivity of carbon matrix also effectively builds multi-level buffer structure and electron transport kinetics to boost the Na^(+)insertion/conversion reactive activity on VS_(2) as well as Na^(+) pseudocapacitance storage kinetics on edges and defects of nano *** coupling effects result in high rate capability and long cycling stability as a battery/capacitor *** delivers conspicuous high energy density of 81 and 40 Wh·kg^(-1) at power density of 118 and 10,286W·kg^(-1),as well as 80% energy retention rate after 5000cycles,confirming its great application potential in sodiumbased storage devices.

关键词： Vanadium disulfide Reduced graphene oxide Anode Sodium-ion battery Sodium-ion capacitor

Implementation of sub-100 nm vertical channel-all-around(CAA) thin-film transistor using thermal atomic layer deposited IGZO channel

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Journal of Semiconductors 2024年第7期45卷 40-44页

作者： Yuting Chen Xinlv Duan Xueli Ma Peng Yuan Zhengying jiao Yongqing Shen Liguo Chai Qingjie Luan Jinjuan xiang Di Geng Guilei Wang Chao Zhao Beijing Superstring Academy of Memory Technology Beijing 100176China State Key Laboratory of Fabrication Technologies for Integrated Circuits Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029China

In-Ga-Zn-O(IGZO) channel based thin-film transistors(TFT), which exhibit high on-off current ratio and relatively high mobility, has been widely researched due to its back end of line(BEOL)-compatible potential for the next generation dynamic random access memory(DRAM) application. In this work, thermal atomic layer deposition(TALD) indium gallium zinc oxide(IGZO) technology was explored. It was found that the atomic composition and the physical properties of the IGZO films can be modulated by changing the sub-cycles number during atomic layer deposition(ALD) process. In addition, thin-film transistors(TFTs) with vertical channel-all-around(CAA) structure were realized to explore the influence of different IGZO films as channel layers on the performance of transistors. Our research demonstrates that TALD is crucial for high density integration technology, and the proposed vertical IGZO CAA-TFT provides a feasible path to break through the technical problems for the continuous scale of electronic equipment.

关键词： In-Ga-Zn-O(IGZO) thermal atomic layer deposition vertical channel thin-film transistor

Developing and validating a predictive model of delivering large-forgestational-age infants among women with gestational diabetes mellitus

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World Journal of Diabetes 2024年第6期15卷 1242-1253页

作者： Yi-Tian Zhu Lan-Lan xiang Ya-Jun Chen Tian-Ying Zhong Jun-Jun Wang Yu zeng Department of Clinical Laboratory Jinling Clinical Medical College of Nanjing Medical UniversityNanjing 210002Jiangsu ProvinceChina Department of Clinical Laboratory Women’s Hospital of Nanjing Medical UniversityNanjing Women and Children’s Healthcare HospitalNanjing 210003Jiangsu ProvinceChina

BACKGROUND The birth of large-for-gestational-age(LGA)infants is associated with many shortterm adverse pregnancy *** has been observed that the proportion of LGA infants born to pregnant women with gestational diabetes mellitus(GDM)is significantly higher than that born to healthy pregnant ***,traditional methods for the diagnosis of LGA have ***,this study aims to establish a predictive model that can effectively identify women with GDM who are at risk of delivering LGA *** To develop and validate a nomogram prediction model of delivering LGA infants among pregnant women with GDM,and provide strategies for the effective prevention and timely intervention of *** The multivariable prediction model was developed by carrying out the following ***,the variables that were associated with LGA risk in pregnant women with GDM were screened by univariate analyses,for which the P value was<***,Least Absolute Shrinkage and Selection Operator regression was fit using ten cross-validations,and the optimal combination factors were se-lected by choosing lambda 1se as the *** final predictors were deter-mined by multiple backward stepwise logistic regression analysis,in which only the independent variables were associated with LGA risk,with a P value<***,a risk prediction model was established and subsequently evaluated by using area under the receiver operating characteristic curve,calibration curve and decision curve *** After using a multistep screening method,we establish a predictive *** risk factors for delivering an LGA infant were identified(P<0.01),including weight gain during pregnancy,parity,triglyceride-glucose index,free tetraiodothyronine level,abdominal circumference,alanine transaminase-aspartate aminotransferase ratio and weight at 24 gestational *** nomogram’s prediction ability was supported by the area under the curve(0.703,0.709,and 0.699 f

关键词： Large-for-gestational-age Gestational diabetes mellitus Predictive model Nomogram Triglyceride-glucose index

Phosphorylation of PB2 at serine 181 restricts viral replication and virulence of the highly pathogenic H5N1 avian influenza virus in mice

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Virologica Sinica 2024年第1期39卷 97-112页

作者： jiao Hu Zixiong zeng Xia Chen Manyu Zhang zenglei Hu Min Gu Xiaoquan Wang Ruyi Gao Shunlin Hu Yu Chen Xiaowen Liu Daxin Peng Xiufan Liu Animal Infectious Disease Laboratory School of Veterinary MedicineYangzhou UniversityYangzhou225009China Joint International Research Laboratory of Agriculture and Agri-Product Safety The Ministry of Education of ChinaYangzhou University225009China Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis Yangzhou UniversityYangzhou225009China Key Laboratory of Prevention and Control of Biological Hazard Factors(Animal Origin)for Agri-food Safety and Quality Ministry of Agriculture of China(26116120)Yangzhou UniversityYangzhou225009China

Influenza A virus(IAV)continues to pose a pandemic threat to public health,resulting a high mortality rate annually and during pandemic *** modification of viral protein plays a substantial role in regulating IAV ***,based on immunoprecipitation(IP)-based mass spectrometry(MS)and purified virus-coupled MS,a total of 89 phosphorylation sites distributed among 10 encoded viral proteins of IAV were identified,including 60 novel phosphorylation ***,for the first time,we provide evidence that PB2 can also be acetylated at site ***,the PB2 S181 phosphorylation site was consistently identified in both IP-based MS and purified virus-based *** S181 and K187 are exposed on the surface of the PB2 protein and are highly conserved in various IAV strains,suggesting their fundamental importance in the IAV life *** analysis results demonstrated that S181E/A and K187Q/R mimic mutations do not significantly alter the PB2 protein *** continuous phosphorylation mimicked by the PB2 S181E mutation substantially decreases viral fitness in mice,PB2 K187Q mimetic acetylation slightly enhances viral virulence in ***,PB2 S181E substantially impairs viral polymerase activity and viral replication,remarkably dampens protein stability and nuclear accumulation of PB2,and significantly weakens IAV-induced inflammatory ***,our study further enriches the database of phosphorylation and acetylation sites of influenza viral proteins,laying a foundation for subsequent mechanistic ***,the unraveled antiviral effect of PB2 S181E mimetic phosphorylation may provide a new target for the subsequent study of antiviral drugs.

关键词： H5N1 influenza virus PB2 Phosphorylation Acetylation Viral fitness Mice

The Optical Variability Properties of TeV Blazars

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Research in Astronomy and Astrophysics 2024年第9期24卷 66-75页

作者： Zi-An Su Wen-Xin Yang xiang-Tao zeng Le-Jian Ou Ze-Lin Li Jiang-He Yang Jun-Hui Fan Department of Physics School of Physics and ElectronicsHunan Normal UniversityChangsha 410081China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Greater Bay Brand Center of the National Astronomical Data Center Guangzhou 510006China Astronomy Science and Technology Research Laboratory of Department of Education of Guangdong Province Guangzhou 510006China College of Microelectronics Feicuihu Campus of Hefei University of TechnologyHefei 230601China College of Mathematics and Physics Science Hunan University of Arts and ScienceChangde 415000China

Variability is one of the typical observational properties of blazars and the spectral changes are usually associated with variability,although this kind of association is unclear *** this work,we used data from the Steward Observatory blazar monitoring program to investigate the optical variability properties including the short-term timescale,the brightness-dependent spectral property,the correlation between the the brightness variation and the polarization,and then estimate the Doppler factors based on the obtained short timescale to study the polarization property for a sample of 20 TeV *** analyses arrive at the following results:(1)The largest variation amplitude in R-band,ΔR_(M),covers a range from ΔR_(M)=0.29 mag(1ES 2344+514)to ΔR_(M)=4.66 mag(3C 279).(2)Intra-day variability was found from five sources with timescales from 0.14 day for S50716+714 to 0.98 day for PKS *** sources show spectra that are bluer when they become brighter,suggesting a common bluer-when-brighter property.(3)The plot of the polarization versus estimated Doppler factor is consistent with the Doppler factor dependent formula of polarization.(4)The largest polarization is correlated with the largest optical variation,suggesting that the high polarization and high amplitude variation are both the indicator of beaming effect.

关键词： galaxies:active galaxies:jets radiation mechanisms:non-thermal