检索结果-南通市图书馆

World Journal of Gastrointestinal Oncology 2024年第3期16卷 787-797页

作者： Peng-Yang Zhou De-Xiang Zhu Yi-jiao Chen Qing-Yang Feng Yi-Hao Mao Ao-Bo Zhuang Jian-Min xu Department of General Surgery Zhongshan Hospital Fudan UniversityShanghai 200032China

BACKGROUND Patatin like phospholipase domain containing 8(PNPLA8)has been shown to play a significant role in various cancer *** studies have focused on its roles as an antioxidant and in lipid ***,the role of PNPLA8 in colorectal cancer(CRC)progression is *** To explore the prognostic effects of PNPLA8 expression in *** A retrospective cohort containing 751 consecutive CRC patients was ***8 expression in tumor samples was evaluated by immunohistochemistry staining and semi-quantitated with immunoreactive *** patients were divided into high and low PNPLA8 expression groups based on the cut-off va-lues,which were calculated by X-tile *** prognostic value of PNPLA8 was identified using univariate and multivariate Cox regression *** over-all survival(OS)rates of CRC patients in the study cohort were compared with Kaplan-Meier analysis and Log-rank *** PNPLA8 expression was significantly associated with distant metastases in our cohort(P=0.048).CRC patients with high PNPLA8 expression indicated poor OS(median OS=35.3,P=0.005).CRC patients with a higher PNPLA8 expression at either stage I and II or stage III and IV had statistically significant shorter *** patients with left-sided colon and rectal cancer,the survival curves of two PN-PLA8-expression groups showed statistically significant *** analysis also confirmed that high PNPLA8 expression was an independent prog-nostic factor for overall survival(hazard ratio HR=1.328,95%CI:1.016-1.734,P=0.038).

关键词： Biomarker Colorectal cancer Expression level Overall survival Patatin like phospholipase domain containing 8 Prognosis

Emergency management capacity assessment for urban rail transit-an example of Beijing Metro Line 13

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transportation Safety and Environment 2024年第1期6卷 109-115页

作者： jiao Liu Yun Qi Wei Wang School of Emergency Management and Safety Engineering China University of Mining&Technology(Beijing)Beijing 100083China China Safety Science Journal Editorial Department China Occupational Safety and Health AssociationBeijing 100011China College of mechanical engineering and automation Liaoning University of TechnologyJinzhou 121001LiaoningChina

In order to improve the emergency management capability of urban rail transit system and reduce accidents during metro operation,an emergency management capability evaluation method combining analytic hierarchy process(AHP)and technique for order preference by similarity to ideal solution(TOPSIS)is *** on the Prevention Preparation Response Recovery(PPRR)model,factors influencing the emergency management capability of the urban rail transit system are summarized from the perspective of‘human,machine,environment and management’.Then,an emergency management capability evaluation index system containing of 20 secondary indicators is constructed in four stages:emergency prevention,emergency preparation,emergency response and emergency *** weights of indicators are calculated using the AHP method,and the closeness of each indicator to the optimal solution is analysed with the TOPSIS ***,take the Beijing Metro Line 13 as an example to investigate the level of emergency management capability of urban rail *** results show that the emergency management capability of Beijing’s urban rail transit system is‘well’,among which hazard prevention measures(0.31)and emergency response team(0.34)have a greater weight on the emergency management capability of rail *** model can more accurately assess the emergency management capability of urban rail transit and provide a basis for emergency management.

关键词： urban rail transit emergency management capability analytic hierarchy process(AHP) technique for order preference by similarity to ideal solution(TOPSIS) prevention preparation response recovery(PPRR)model

Structural and biochemical basis of FLS2-mediated signal activation and transduction in rice

在线全文

学校读者我要写书评

暂无评论

Plant Communications 2024年第3期5卷 216-231页

作者： Qiaoqiao Zhao Jinlin Bao Huailong Li Wei Hu Yanqiong Kong Yifeng Zhong Qiang Fu Guolyu xu Fenmei Liu Xi jiao Jian Jin Zhenhua Ming State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi Key Laboratory for Sugarcane BiologyGuangxi UniversityNanning 530004P.R.China

The receptor-like kinase FLAGELLIN-SENSITIVE 2(FLS2)functions as a bacterialflagellin receptor local-ized on the cell membrane of *** Arabidopsis,the co-receptor BRI1-ASSOCIATED RECEPTOR KI-NASE 1(BAK1)cooperates with FLS2 to detect theflagellin epitopeflg22,resulting in formation of a signaling complex that triggers plant defense ***,the co-receptor responsible for recog-nizing and signaling theflg22 epitope in rice remains to be determined,and the precise structural mecha-nism underlying FLS2-mediated signal activation and transduction has not been *** study pre-sents the structural characterization of a kinase-dead mutant of the intracellular kinase domain of OsFLS2(OsFLS2-KDD1013A)in complex with ATP or ADP,resolved at resolutions of 1.98 A˚and 2.09 A˚,*** analysis revealed that OsFLS2 can adopt an active conformation in the absence of phosphorylation,although it exhibits only weak basal catalytic activity for ***-quent investigations demonstrated that OsSERK2 effectively phosphorylates OsFLS2,which reciprocally phosphorylates OsSERK2,leading to complete activation of OsSERK2 and rapid phosphorylation of the downstream substrate receptor-like cytoplasmic kinases OsRLCK176 and *** mass spectrometry experiments,we successfully identied critical autophosphorylation sites on OsSERK2,as well as sites transphosphorylated by ***,we demonstrated the interaction between OsSERK2 and OsFLS2,which is enhanced in the presence *** evidence suggests that OsRLCK176 and OsRLCK185 may function downstream of the OsFLS2-mediated signaling *** study reveals the molecular mechanism by which OsFLS2 mediates signal transduction pathways in rice and provides a valuable example for understanding RLK-mediated signaling pathways in plants.

关键词： FLS2 active conformation kinase activation transphosphorylation signal transduction

An active learning workflow for predicting hydrogen atom adsorption energies on binary oxides based on local electronic transfer features

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Energy & Environment 2024年第10期9卷 1489-1496页

作者： Wenhao Jing Zihao jiao Mengmeng Song Ya Liu Liejin Guo International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong University Department of Energy and Power Engineering Shandong University of Technology

Machine learning combined with density functional theory（DFT） enables rapid exploration of catalyst descriptors space such as adsorption energy, facilitating rapid and effective catalyst screening. However, there is still a lack of models for predicting adsorption energies on oxides,due to the complexity of elemental species and the ambiguous coordination environment. This work proposes an active learning workflow（Le NN） founded on local electronic transfer features（e） and the principle of coordinate rotation invariance. By accurately characterizing the electron transfer to adsorption site atoms and their surrounding geometric structures, Le NN mitigates abrupt feature changes due to different element types and clarifies coordination environments. As a result, it enables the prediction of *H adsorption energy on binary oxide surfaces with a mean absolute error（MAE） below 0.18 e V. Moreover, we incorporate local coverage（θl） and leverage neutral network ensemble to establish an active learning workflow, attaining a prediction MAE below 0.2 e V for 5419 multi-*H adsorption structures. These findings validate the universality and capability of the proposed features in predicting *H adsorption energy on binary oxide surfaces.

关键词： Machine learning Adsorption energy Binary oxide Electron transfer Active learning

Two-layer Lagrange-based relay network topology and trajectory design for solar system explorations

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第6期67卷 342-358页

作者： Jun CAO Jian jiao Hao LIU Rongxing LU Qinyu ZHANG Guangdong Provincial Key Laboratory of Aerospace Communication and Networking Technology Harbin Institute of Technology (Shenzhen) Faculty of Computer Science (FCS) University of New Brunswick

Exploration targeting outer planets and even the edge of the solar system is an emerging direction for the deep-space exploration in the next decades. To address this challenge, a novel two-layer Lagrangebased relay network topology is proposed in this study. Specifically, we utilize the Sun-Mars and Sun-Saturn Lagrange points(LPs) L4 and L5 to build a two-layer backbone relay network, which ensures continuous and high-efficiency communication capability for the exploration of the solar system. Furthermore, we utilize the planetary gravity assist and design the transfer trajectory of backbone relays with the help of planetary celestial body motion equations and Kepler's laws. Moreover, we conduct link budget analysis for multihop relay transmission under Gamma-Gamma distribution, shadowed Rician fading, and additive white Gaussian noise channels in several typical exploration scenarios and validate that the LP relays can effectively support future deep-space exploration missions.

关键词： deep-space communication Lagrangian points backbone relay network transfer trajectory relay selection

Microwave-assisted exploration of the electron configuration-dependent electrocatalytic urea oxidation activity of 2D porous NiCo_(2)O_(4) spinel

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第4期91卷 226-235页

作者： Jun Wan Zhiao Wu Guangyu Fang Jinglin Xian jiao Dai Jiayue Guo Qingxiang Li Yongfei You Kaisi Liu Huimin Yu Weilin xu Huiyu Jiang Minggui Xia Huanyu Jin State Key Laboratory of New Textile Materials and Advanced Processing Technologies Hubei Key Laboratory of Biomass Fibers and Eco-Dyeing&FinishingWuhan Textile UniversityWuhan 430200HubeiChina Institute for Sustainability Energy and ResourcesThe University of AdelaideAdelaideSA 5005Australia Future Industries Institute University of South AustraliaMawson Lakes CampusAdelaideSA 5095Australia

Urea holds promise as an alternative water-oxidation substrate in electrolytic ***-valence nickelbased spinel,especially after heteroatom doping,excels in urea oxidation reactions(UOR).However,traditional spinel synthesis methods with prolonged high-temperature reactions lack kinetic precision,hindering the balance between controlled doping and highly active two-dimensional(2D)porous structures *** significantly impedes the identification of electron configuration-dependent active sites in doped 2D nickel-based ***,we present a microwave shock method for the preparation of 2D porous NiCo_(2)O_(4)*** the transient on-off property of microwave pulses for precise heteroatom doping and 2D porous structural design,non-metal doping(boron,phosphorus,and sulfur)with distinct extranuclear electron disparities serves as straightforward examples for *** tuning of lattice parameter reveals the impact of covalent bond strength on NiCo_(2)O_(4)structural *** introduced defect levels induce unpaired d-electrons in transition metals,enhancing the adsorption of electron-donating amino groups in urea ***,Bode plots confirm the impact mechanism of rapid electron migration caused by reduced band gaps on UOR *** prepared phosphorus-doped 2D porous NiCo_(2)O_(4),with optimal electron configuration control,outperforms most reported *** controlled modification strategy advances understanding theoretical structure-activity mechanisms of high-performance 2D spinels in UOR.

关键词： 2D materials Spinel Microwave Electrocatalysis Urea oxidation reaction

Solar-and/or Radiative Cooling-Driven Thermoelectric Generators:A Critical Review

在线全文

学校读者我要写书评

暂无评论

Energy Engineering 2024年第10期121卷 2681-2718页

作者： Jinglong Wang Lin Lu Kai jiao Department of Building Environment and Energy Engineering The Hong Kong Polytechnic UniversityHong Kong999077China

Thermoelectric generators(TEGs)play a critical role in collecting renewable energy fromthe sun and deep space to generate clean *** their environmentally friendly,reliable,and noise-free operation,TEGs offer diverse applications,including areas with limited power infrastructure,microelectronic devices,and wearable *** review thoroughly analyses TEG system configurations,performance,and applications driven by solar and/or radiative cooling,covering non-concentrating,concentrating,radiative cooling-driven,and dual-mode *** for solar absorbers and radiative coolers,simulation techniques,energy storage management,and thermal management strategies are *** integration of TEGs with combined heat and power systems is identified as a promising ***,TEGs hold potential as charging sources for electronic *** comprehensive review provides valuable insights into this energy collection approach,facilitating improved efficiency,reduced costs,and expanded *** also highlights current limitations and knowledge gaps,emphasizing the importance of further research and development in unlocking the full potential of TEGs for a sustainable and efficient energy future.

关键词： Thermoelectric generators solar energy radiative sky cooling applications

Relationship between Phenotypic Changes of Dendritic Cell Subsets and the Onset of Plateau Phase during Intermittent Interferon Therapy in Patients with CHB

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2024年第3期37卷 303-314页

作者： YANG Liu WANG Shi Yu JIANG Ting Ting DENG Wen CHANG Min WU Shu Ling CAO Wei Hua LU Yao SHEN Ge LIU Ru Yu GAO Yuan jiao xu Meng jiao HU Lei Ping ZHANG Lu XIE Yao LI Ming Hui Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Center for Infectious Diseases Second Affiliated Hospital of Air Force Medical UniversityXi'an 710038ShaanxiChina Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China

Objective This study aimed to evaluate whether the onset of the plateau phase of slow hepatitis B surface antigen decline in patients with chronic hepatitis B treated with intermittent interferon therapy is related to the frequency of dendritic cell subsets and expression of the costimulatory molecules CD40,CD80,CD83,and *** This was a cross-sectional study in which patients were divided into a natural history group(namely NH group),a long-term oral nucleoside analogs treatment group(namely NA group),and a plateau-arriving group(namely P group).The percentage of plasmacytoid dendritic cell and myeloid dendritic cell subsets in peripheral blood lymphocytes and monocytes and the mean fluorescence intensity of their surface costimulatory molecules were detected using a flow *** In total,143 patients were enrolled(NH group,n=49;NA group,n=47;P group,n=47).The results demonstrated that CD141/CD1c double negative myeloid dendritic cell(DNmDC)/lymphocytes and monocytes(%)in P group(0.041[0.024,0.069])was significantly lower than that in NH group(0.270[0.135,0.407])and NA group(0.273[0.150,0.443]),and CD86 mean fluorescence intensity of DNmDCs in P group(1832.0[1484.0,2793.0])was significantly lower than that in NH group(4316.0[2958.0,5169.0])and NA group(3299.0[2534.0,4371.0]),Adjusted P all<*** Reduced DNmDCs and impaired maturation may be associated with the onset of the plateau phase during intermittent interferon therapy in patients with chronic hepatitis B.

关键词： CHB Dendritic Cells Intermittent Interferon Therapy Plateau Phase

Identification of TMEM217 as a novel prognostic biomarker and potential therapeutic target in acute myeloid leukemia

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第4期11卷 90-93页

作者： Yunying Yao Zhizhou Xi Min Wu Bo jiao Jiaming Gao Donghe Li Xi Xie Pengfei xu jiaoyang Li Lei Yan Ruibao Ren Ping Liu Shanghai Institute of Hematology State Key Laboratory for Medical GenomicsNational Research Center for Translational MedicineCollaborative Innovation Center of HematologyRuijin Hospital affiliated with Shanghai Jiao Tong University School of MedicineShanghai 200025China International Center for Aging and Cancer Hainan Medical UniversityHaikouHainan 570102China

Despite remarkable advances in molecular and cell biology of acute myeloid leukemia(AML),AML patients still frequently relapse and have low 5-year overall survival(OS)rates.1 It is worth noting that a recent study from the registry or clinical trial compilation has reported an improvement in the OS of adult AML patients,especially those under 60 years of age.

关键词： acute myeloid leukemia

The CLAVATA signaling:a roadmap to optimize grain shape in rice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第7期51卷 677-679页

作者： Shaoyan Shen Bingyang jiao Yunhai Li Key Laboratory of Seed Innovation Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China College of Advanced Agriculture University of Chinese Academy of SciencesBeijing 100039China

The shoot apical meristem(SAM)is the source of all postembryonic cells in aerial parts of a plant,and large shoot meristems with an increased stem cell population hold promise for enhancing yield(Li et al.,2022).

关键词： grain shape shoot