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Numerical analysis of the three-dimensional aerodynamics of a hovering rufous hummingbird(Selasphorus rufus)

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Acta Mechanica Sinica 2015年第6期31卷 931-943页

作者： Songyuan Yang weiping Zhang National Key Laboratory of Nano/Micro Fabrication Technology Key Laboratory for Thin Film and Microfabrication of Ministry of Education Shanghai Key Lab of Navigation and Location-based Services Department of Micro-Nano Electronics School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University School of Mechanical and Aerospace Engineering Nanyang Technological University

Hummingbirds have a unique way of hover- ing. However, only a few published papers have gone into details of the corresponding three-dimensional vortex struc- tures and transient aerodynamic forces. In order to deepen the understanding in these two realms, this article presents an integrated computational fluid dynamics study on the hovering aerodynamics of a rufous hummingbird. The original morphological and kinematic data came from a former researcher＇s experiments. We found that conical and sta- ble leading-edge vortices （LEVs） with spanwise flow inside their cores existed on the hovering hummingbird＇s wing surfaces. When the LEVs and other near-field vortices were all shed into the wake after stroke reversals, periodically shed bilateral vortex rings were formed. In addition, a strong downwash was present throughout the flapping cycle. Time histories of lift and drag were also obtained. Combining the three-dimensional flow field and time history of lift, we believe that high lift mechanisms （i.e., rotational circulation and wake capture） which take place at stroke reversals in insect flight was not evident here. For mean lift throughout a whole cycle, it is calculated to be 3.60 g （104.0 % of the weight support）. The downstroke and upstroke provide 64.2 % and 35.8 % of the weight support, respectively.

关键词： Rufous hummingbird · Selasphorus rufus·Hovering · Aerodynamics · Computational fluid dynamics(CFD)

New discoveries in obesity and related metabolic diseases:from bench to bed

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Journal of Molecular Cell Biology 2021年第8期13卷 541-542页

作者： weiping Jia Department of Endocrinology and Metabolism Shanghai Diabetes InstituteShanghai Key Laboratory of Diabetes MellitusShanghai Clinical Center for DiabetesShanghai Key Clinical Center for Metabolic DiseaseShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China

Obesity,and other metabolic diseases including non-alcoholic fatty liver disease(NAFLD),metabolic syndrome(MetS),type 2 diabetes mellitus(T2DM)and its related complications like chronic kidney disease(CKD),and hepatocellular carcinoma(HCC)have led to alarming health and social burdens globally and in China as *** strong links exist among those multifactorial metabolic disorders,there are limited researches on better understanding of their pathogenesis and the provision of effective interventional measures in *** this special issue,we have five researches including three research articles providing new insights into potential mechanisms in the development and possible prevention and treatment therapies of NAFLD,HCC,and CKD,as well as two review articles summarizing multi-omics profiling and future strategies for precision medicine in T2DM,NAFLD,and MetS,and the rapid advances in the field of metabolic surgery in China.

关键词： diseases prevention obesity

Personalized medicine of type 2 diabetes

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Frontiers of Medicine 2013年第1期7卷 1-3页

作者： weiping Jia Shanghai Diabetes Institute Department of Endocrinology and MetabolismShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Key Laboratory of Diabetes MellitusShanghai Clinical Center for DiabetesShanghai 200233China

Type 2 diabetes is characterized by impaired insulin secretion and decreased insulin *** has reached epidemic proportions worldwide and poses a considerable concern for public *** management of this disease is hence strongly emphasized for the aim of controlling the *** and injectable pharmacologic agents are currently both available for glycemic *** anti-diabetic drugs are among the most widely prescribed,including metformin,sulfonylureas,glinides,α-glucosidase inhibitors,thiazolidinediones and DPP-IV inhibitors[1].Despite the rapid progress in drug development,it is still challenging to achieve good glycemic control in a substantial population even when multiple anti-diabetic treatments are applied.

关键词： impaired diabetes drugs

红曲霉发酵龙虾壳产酸性蛋白酶分离纯化及酶学性质研究

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湖北工业大学学报 2024年第5期39卷 55-59,107页

作者：李莹莹刘枣李娇蒋潇吴滢滢王伟平湖北工业大学生物工程与食品学院湖北武汉430068

小龙虾虾壳废弃物排放造成环境污染和资源浪费,而红曲霉可以转化利用虾壳蛋白质。以小龙虾虾壳为唯一氮源,烟灰色红曲霉BQ2液态发酵诱导其产胞外酸性蛋白酶。该酸性蛋白酶经硫酸铵盐析沉淀和DEAE-Sepharose CL-6B阴离子交换柱层析分离纯... 详细信息

小龙虾虾壳废弃物排放造成环境污染和资源浪费,而红曲霉可以转化利用虾壳蛋白质。以小龙虾虾壳为唯一氮源,烟灰色红曲霉BQ2液态发酵诱导其产胞外酸性蛋白酶。该酸性蛋白酶经硫酸铵盐析沉淀和DEAE-Sepharose CL-6B阴离子交换柱层析分离纯化,酶活为29.10 U/mL,纯化倍数为11.42,相对分子质量为65000。对其酶学性质进行研究,结果表明该酸性蛋白酶的最适反应pH为4.0,最适反应温度为40℃。该酶属于天冬氨酸蛋白酶,Pepstatin A能强烈抑制其活性,Cu^(2+)和Ca^(2+)能抑制该蛋白酶活性,而Mg^(+)、Zn^(2+)和Fe^(3+)对该蛋白酶的活性具有促进作用。

关键词：红曲霉小龙虾壳酸性蛋白酶酶学性质

Obesity in China： its characteristics, diagnostic criteria, and implications

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Frontiers of Medicine 2015年第2期9卷 129-133页

作者： weiping Jia Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai Clinical Centerfor Diabetes Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes Mellitus Shanghai Key Clinical Center for MetabolicDisease Shanghai 200233 China

The rising prevalence of overweight and obesity in several countries has been described as a global pandemic. Obesity and obesity-related diseases are increasing dramatically and have become a massive burden on world economy and global health. In 2010, overweight and obesity were estimated to cause 3.4 million deaths, with 4% of years of life lost and 4% of disability-adjusted life-years worldwide [1]. Abdominal obesity, also known as central obesity, refers to the presence of excess fat in the abdominal area. Epidemiological studies have demonstrated that obesity, especially central obesity,

关键词： INTIMA-MEDIA THICKNESS BODY-MASS INDEX WAIST CIRCUMFERENCE CUTOFFS CORONARY-ARTERY-DISEASE METABOLIC RISK-FACTORS ABDOMINAL OBESITY VISCERAL FAT CARDIOVASCULAR-DISEASE ADULT OVERWEIGHT ADIPOSE-TISSUE

Early-onset diabetes:an epidemic in China

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Frontiers of Medicine 2018年第6期12卷 624-633页

作者： Jiemin Pan weiping Jia Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai Clinical Center for DiabetesShanghai Diabetes InstituteShanghai 200233China

Although type 2 diabetes is a disease often associated with aging, the global prevalence of early-onset diabetes has been increasing due to man’s sedentary lifestyle, low-physical activity, obesity, and some non-modifiable risk factors. Many studies have found that individuals with early-onset type 2 diabetes were at higher risk of developing vascular complications than those with late-onset diabetes. Individuals with early-onset diabetes are usually unwilling to visit hospital and have more confidence in their health, which results in poor glycemic control and the delayed detection of diabetes-related complications. Few studies have focused on the treatment and prevention of complications in specific population of individuals with early-onset type 2 diabetes. Therefore, focusing on this particular population is critical for the government and academic societies. Screening for T2DM is imminent for young adults with a family history of diabetes, obesity, markers of insulin resistance, or alcohol consumption. More data are definitely required to establish a reasonable risk model to screen for early-onset diabetes.

关键词： diabetes early-onset diabetes complications

Multi-omics profiling:the way toward precision medicine in metabolic diseases

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Journal of Molecular Cell Biology 2021年第8期13卷 576-593页

作者： Cheng Hu weiping jia Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes MellitusShanghai Clinical Center for DiabetesShanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China Institute for Metabolic Disease Fengxian Central HospitalThe Third School of Clinical MedicineSouthern Medical UniversityShanghai 201499China

Metabolic diseases including type 2 diabetes mellitus(T2DM),non-alcoholic fatty liver disease(NAFLD),and metabolic syndrome(MetS)are alarming health burdens around the world,while therapies for these diseases are far from satisfying as their etiologies are not completely dear yet.T2DM,NAFLD,and MetS are all complex and multifactorial metabolic disorders based on the interactions between genetics and *** studies such as genetics,transcriptomics,epigenetics,proteomics,and metabolomics are all promising approaches in accurately characterizing these *** the most effective treatments for individuals can be achieved via omics pathways,which is the theme of precision *** this review,we summarized the multi-omics studies of T2DM,NAFLD,and MetS in recent years,provided a theoretical basis for their pathogenesis and the effective prevention and treatment,and highlighted the biomarkers and future strategies for precision medicine.

关键词： type 2 diabetes mellitus non-alcoholic fatty liver disease metabolic syndrome biomarkers multi-omics profiling precision medicine

Photonics-aided THz-wireless transmission over 400 m at 335 GHz

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Science China(Technological Sciences) 2022年第12期65卷 3082-3084页

作者： LI weiping YU JianJun ZHU BoWen WANG Feng TAN YuXuan WANG YanYi ZHU Min ZHANG jiao ZHOU Wen ZHAO Feng YU JianGuo Key Laboratory for Information Science of Electromagnetic Waves(MoE) Fudan UniversityShanghai 200433China Purple Mountain Laboratories Nanjing 211111China School of Electronic Engineering Xi’an University of Posts and TelecommunicationsXi’an 710121China School of Electronic Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

The terahertz(THz)band(0.3–10 THz),with abundant bandwidth,can satisfy the need for large-capacity transmission of fiber-wireless integration communication systems,which has attracted more and more attention[1–3].

关键词： wireless fiber communication

Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

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Frontiers of Medicine 2015年第2期9卷 146-161页

作者： Tao Wang weiping Jia Cheng Hu Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes Mellitus Shanghai Clinical Center for Diabetes Shanghai Jiao TongUniversity Affiliated Sixth People's Hospital Shanghai 200233 China

Obesity prevalence has increased in recent years. Lifestyle change fuels obesity, but genetic factors cause more than 50% of average variations in obesity. The advent of genome-wide association studies （GWAS） has hastened the progress of polygenic obesity research. As of this writing, more than 73 obesity susceptibility loci have been identified in ethnic groups through GWAS. The identified loci explain only 2% to 4% of obesity heritability, thereby indicating that a large proportion of loci remain undiscovered. Thus, the next step is to identify and confirm novel loci, which may exhibit smaller effects and lower allele frequencies than established loci. However, achieving these tasks has been difficult for researchers. GWAS help researchers discover the causal loci. Moreover, numerous biological studies have been performed on the polygenic effects on obesity, such as studies on fat mass- and obesity-associated gene （FTO）, but the role of these polygenic effects in the mechanism of obesity remains unclear. Thus, obesity-causing variations should be identified, and insights into the biology of polygenic effects on obesity are needed.

关键词： obesity genetics genome-wide association studies body mass index fat mass- and obesity-associated gene