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Recent progress in understanding mitokines as diagnostic and therapeutic targets in hepatocellular carcinoma

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World Journal of Clinical Cases 2023年第23期11卷 5416-5429页

作者： Jiang Wang lan-Zhu Luo Dao-Miao Liang Chao Guo Zhi-Hong Huang Xiao-Hong Jian Jie Wen Children Medical Center Hunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410013Hunan ProvinceChina Department of Hepatobiliary Surgery Hunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410013Hunan ProvinceChina Department of Anatomy Hunan Normal University School of MedicineChangsha 410013Hunan ProvinceChina Department of Pediatric Orthopedics Hunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410013Hunan ProvinceChina

Hepatocellular carcinoma(HCC)is one of the most prevalent tumors worldwide and the leading contributor to cancer-related *** progression and metastasis of HCC are closely associated with altered mitochondrial metabolism,including mitochondrial stress ***,soluble proteins produced and secreted in response to mitochondrial stress,play an essential immunomodulatory *** has emerged as a crucial treatment option for ***,a positive response to therapy is typically dependent on the interaction of tumor cells with immune regulation within the tumor ***,exploring the specific immunomodulatory mechanisms of mitokines in HCC is essential for improving the efficacy of *** study provides a comprehensive overview of the association between HCC and the immune microenvironment and highlights recent progress in understanding the involvement of mitochondrial function in preserving liver *** addition,a systematic review of mitokines-mediated immunomodulation in HCC is ***,the potential diagnostic and therapeutic roles of mitokines in HCC are prospected and *** progress in mitokine research represents a new prospect for mitochondrial *** the potential of mitokines to regulate immune function,investigating them as a relevant mole cular target holds great promise for the diagnosis and treatment of HCC.

关键词： Hepatocellular carcinoma Mitochondria Mitokine Immune escape Autophagy

Ge Film Contacts to Radio Frequency Sputtered Y-Ba-Cu-O Superconductor Film

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Chinese Physics Letters 1991年第9期8卷 487-490页

作者： ZHANG Bei QIAN Yi TONG Litai CHEN Haiying WANG Guizhi QIAO Yongping XING Miaoxiang FENG Qingrong LIU Zunxiao lan Jian DAI Yuandong Department of Physics Peking UniversityBeijing 100871

The semiconductor-superconductor con tact system of Ge/Y-Ba-Cu-O(YBCO)/SrTiO_(3) has been successfully fabricated by two steps of *** YBCO film in the contact of Ge/YBCO did not lose its superconductivity and its T_(c)(on set)did not degrade as *** top layer of Ge was polycrystalline with preferred orientation corresponding to the epitaxial structure of the underlayer of YBCO.

关键词： deposition steps superconductor

Synthesis and Crystal Structure of tert-Butyl(((2R,3R,6R)-3-hydroxy-6-(nitromethyl)-3,6-dihydro-2H-pyran-2-yl)methyl)carbonate

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Chinese Journal of Structural Chemistry 2021年第9期40卷 1205-1212,1110页

作者： FENG Yong-Kui SU Hua-lan MUKULA OTUKOL Billy Joel ZHANG Xue-Qing YAO Hui HUANG Nian-Yu Hubei Key Laboratory of Natural Products Research and Development Key Laboratory of Functional Yeast(China National Light Industry)College of Biological and Pharmaceutical SciencesChina Three Gorges UniversityTichangHubei 443002China

In this paper,aβ-C-pyranogalactoside(Ⅸ)was synthesized from D-galactose through a nine-step reaction with a total yield of 32%under the palladium catalyst,and its structure was characterized by nuclear magnetic resonance(NMR)and high-resolution electrospray ionization mass spectrometry(HR-ESI-MS).The absolute configuration of this pyranogalactoside was confirmed with a Flack parameter of–0.01(6)by X-ray crystallography using a Cu radiation ***(Ⅸ),C_(12)H_(19)NO_(7),crystal data:monoclinic system,space group P2_(1)2_(1)2_(1),a=8.53480(10),b=9.4207(2),c=18.1308(3)A,V=1457.79(4)A^(3),Z=4,F(000)=616,Dc=1.318 g/cm^(3),μ=0.931 mm^(-1),R=0.0294 and wR=0.0752 for 2875 independent reflections(R_(int)=0.0163)and 2857 observed ones(I>2σ(I)).

关键词： X-ray diffraction crystal structure absolute configuration β-C-pyranogalactoside α-glucosidase inhibitory activity

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Generation and application of two monoclonal antibodies targeting conserved linear epitopes in the NP protein of influenza A virus

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Journal of Integrative Agriculture 2022年第7期21卷 2095-2105页

作者： ZHAO Yu-hui WEN Xia LI Qi-bing JIANG Li WANG Guang-wen LIANG Li-bin WANG Xiu-rong CHEN Hua-lan LI Cheng-jun State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069P.R.China

Monoclonal antibodies(mAbs) are widely used in virus research and disease diagnosis. The nucleoprotein(NP) of influenza A virus(IAV) plays important roles in multiple stages of the virus life cycle. Therefore, generating conserved mAbs against NP and characterizing their properties will provide useful tools for IAV research. In this study, two mAbs against the NP protein, 10 E9 and 3 F3, were generated with recombinant truncated NP proteins(NP-1 and NP-2) as immunogens. The heavy-chain subclass of both 10 E9 and 3 F3 was determined to be IgG2α, and the light-chain type was κ. Truncation and site-specific mutation analyses showed that the epitopes of mAbs 10 E9 and 3 F3 were located in the N terminal 84–89 amino acids and the C terminal 320–324 amino acids of the NP protein, respectively. We found that mAbs 10 E9 and 3 F3 reacted well with the NP protein of H1–H15 subtypes of IAV. Both 10 E9 and 3 F3 can be used in immunoprecipitation assay, and 10 E9 was also successfully applied in confocal microscopy. Furthermore, we found that the 10 E9-recognized _(84) SAGKDP_(89) epitope and 3 F3-recognized 320 ENPAH324 epitope were highly conserved in NP among all avian and human IAVs. Thus, the two mAbs we developed could be used as powerful tools in the development of diagnostic methods of IAV, and also surely promote the basic research in understanding the replication mechanisms of IAV.

关键词： influenza A virus nucleoprotein monoclonal antibody application

Design of High-Utilization Current-Sharing Controller for Battery-Ultracapacitor Hybrid Energy Storage System

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Circuits and Systems 2018年第9期9卷 125-132页

作者： lan-Rong Dung Zhe-Yi Lin Institute of Electrical and Computer Engineering National Chiao-Tung University Hsinchu Taiwan

In this paper, a new control strategy of battery-ultracapacitor hybrid energy storage system (HESS) is proposed for hybrid electric drive vehicles (HEVs). Compared to the stand, alone battery system may not be sufficient to satisfy peak demand periods during transients in HEVs, the ultracapacitor pack can supply or recover the peak power and it can be used in high C-rates. However, the problem of battery-ultracapacitor hybrid energy storage system (HESS) is how to interconnect the battery and ultracapacitor and how to control the power distribution. This paper reviewed some battery-ultracapacitor hybrid energy storage system topology and investigated the advantages and disadvantages, then proposed a new control strategy. The proposed control strategy can improve the system performance and ultracapacitor utilization, while also decreasing the battery pack size to avoid the thermal runaway problems and increase the life of the battery. The experiment results showed the proposed control strategy can improve 3% - 4% ultracapacitor utilization.

关键词： Ultracapacitor DC/DC Converter Energy Storage System Battery

Synthesis and biological evaluation of indole-3-carboxamide derivatives as antioxidant agents

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Chinese Chemical Letters 2019年第12期30卷 2157-2159页

作者： Erfang Huang lan Zhang Chuying Xiao Guangpeng Meng Bingqi Zhang Jianshu Hu David Chi-Cheong Wan Qingguo Meng Zhe Jin Chun Hu Key Laboratory of Structure-based Drug Design&Discovery Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Pharmacy Yantai UniveristyYantai 264005China

Oxidative stress results in various pathologies and as consequence antioxidant agents have attracted uninterrupted *** this paper,a novel series of indole-3-carboxamide derivatives(6 a-61) were designed and synthesized based on the melatonin structure as novel *** of them were evaluated for the antioxidant activities in vitro against human neuroblastoma SH-SY5 Y cell line using H2 O2 radical scavenging *** target compounds 6 a,6 f and 6 i indicated better activities than the positive control,ascorbic acid,and 6 a exhibited the best antioxidant *** addition,the structureactivity relationships of the target compounds were also preliminarily summarized based on the obtained experimental data.

关键词： Heterocycle Melatonin Indole-3-carboxamide derivatives Synthesis Antioxidant activity Structure-activity relationship

Trans-acting factors from the human fetal liver bindingto the human ε-globin gene silencer

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Cell Research 1997年第2期7卷 151-159页

作者： YAN ZHI JIANG CHU JIANG RUO lan QIAN(Shanghai Institute of Cell Biology, Chinese Academy ofSciences, Shanghai 200031, China) Shanghai Institute of Cell Biology Chinese Academy of Sciences Shanghai 200031 China

The developmental stage-specific silencing of the human ε-globin gene during embryonic life is controlled, inpart, by the silencer (-392bp～-177bp) upstream of thisgene. In order to elucidate its role, the nuclear extractfrom the human fetal liver has been prepared and the interactions between trans-acting factors and this silencerelement have been examined. By using DNasel footprinting assay, a major protected region from -278bp to -235bpwithin this silencer element was identified. Furthermore,we found in gel mobility shift assay and Southwestern blotting assay that there were at least four trans-acting factors (MW ≈ 32, 28, 26 and 22kD) in the nuclear extractisolated from the human fetal liver, which could specifically bind to this region. Our results suggested that thesetrans-acting factors might play an important role in silencing the human embryonic ε-globin gene expression at thefetal stage through the interactions with this silencer.

关键词： Human ε-globin gene silencer transacting factor

BOUNDEDNESS OF FRACTIONAL INTEGRAL OPERATORS IN HERZ-TYPE SPACES ON LOCALLY COMPACT VILENKIN GROUPS

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Approximation Theory and Its Applications 2002年第3期18卷 15-25页

作者： lan Senhua (Lishui Teachers College, China) 1. Department of Mathematics Lishui Teachers’ College 323000 Lishui Zhejiang P R China

Let G be a locally compact Vilenkin group. In this paper toe first establish the Hardy-Littlewood-Sobolev theorem on G. Then some boundedness theorems of fractional integral operators in Herz-type spaces on G are obta... 详细信息

关键词：局部紧 Hardy-littlewood-Sobolev定理 Vilenkin群有界性分数次积分算子 Herz空间

Misdiagnosis of scalp angiosarcoma: A case report

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World Journal of Clinical Cases 2023年第13期11卷 3099-3104页

作者： Zhao-Hong Yan Zhen-lan li Xiao-Wei Chen Ya-Wen Lian Li-Xin Liu Hao-Yang Duan Department of Rehabilitation Medicine The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Plastic and Aesthetic Surgery The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND Angiosarcoma is a rare malignant *** to the lack of specific clinical manifestations of this disease,it is difficult to achieve early diagnosis and start early *** SUMMARY A 78-year-old male patient was admitted to the hospital because of a bump on his head that did not heal for 4 *** patient was diagnosed with a refractory head *** patient underwent neoplasm resection and skin grafting surgery in the Plastic *** neoplasm was sent for pathological examination during the *** final pathological results were confirmed scalp *** Our research suggests that pathological examination should be performed for refractory ulcers of the scalp,and physical factor therapy should be used with caution before the diagnosis is clear.

关键词： Scalp angiosarcoma Refractory head wound Pathological examination Case report