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Effects of dietary intervention on human diseases:molecular mechanisms and therapeutic potential

Signal Transduction and Targeted Therapy 2024年第4期9卷 1389-1422页

作者： Yu-Ling Xiao yue Gong Ying-Jia Qi Zhi-Ming Shao Yi-Zhou jiang Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudanUniversityShanghai200032China

Diet,serving as a vital source of nutrients,exerts a profound influence on human health and disease ***,dietary interventions have emerged as promising adjunctive treatment strategies not only for cancer but also for neurodegenerative diseases,autoimmune diseases,cardiovascular diseases,and metabolic *** interventions have demonstrated substantial potential in modulating metabolism,disease trajectory,and therapeutic *** reprogramming is a hallmark of malignant progression,and a deeper understanding of this phenomenon in tumors and its effects on immune regulation is a significant challenge that impedes cancer *** intake,as a key environmental factor,can influence tumor *** evidence indicates that dietary interventions might affect the nutrient availability in tumors,thereby increasing the efficacy of cancer ***,the intricate interplay between dietary interventions and the pathogenesis of cancer and other diseases is *** encouraging results,the mechanisms underlying diet-based therapeutic strategies remain largely unexplored,often resulting in underutilization in disease *** this review,we aim to illuminate the potential effects of various dietary interventions,including calorie restriction,fasting-mimicking diet,ketogenic diet,protein restriction diet,high-salt diet,high-fat diet,and high-fiber diet,on cancer and the aforementioned *** explore the multifaceted impacts of these dietary interventions,encompassing their immunomodulatory effects,other biological impacts,and underlying molecular *** review offers valuable insights into the potential application of these dietary interventions as adjunctive therapies in disease management.

关键词： diseases metabolism potential

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黄芪-丹参药对改善高血压肾损害的研究进展

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中国实验方剂学杂志 2019年第12期25卷 214-220页

作者：韩聪姜月华李伟山东中医药大学第一临床医学院济南250014 山东中医药大学附属医院济南250014

高血压肾损害是高血压最严重的并发症之一,也是导致终末期肾脏病的主要原因,而肾损害又可进一步促进血压升高且难以控制,形成恶性循环的局面。中医认为本虚标实是其根本病机,而肾气不固、瘀血内阻是高血压肾损害的最常见证型之一。黄芪... 详细信息

高血压肾损害是高血压最严重的并发症之一,也是导致终末期肾脏病的主要原因,而肾损害又可进一步促进血压升高且难以控制,形成恶性循环的局面。中医认为本虚标实是其根本病机,而肾气不固、瘀血内阻是高血压肾损害的最常见证型之一。黄芪被誉为"补气诸药之最",丹参被比喻可"功同四物",基于补气活血理论的黄芪-丹参药对主要有黄芪总苷、黄芪多糖、毛蕊异黄酮、丹酚酸、丹参酮等有效成分,诸多研究表明,在高血压肾损害进程中,黄芪-丹参药对及其有效成分,不管是有效单体、单体配伍,亦或是药对直接配伍,均可通过调节与高血压肾损害相关的多个信号转导通路来调节血压、降低尿蛋白、保护肾小管、保护肾小球滤过屏障、改善肾脏血流动力学、改善肾功能,起到降压与改善肾功能双管齐下的作用。本文着眼于高血压肾损害气虚血瘀的病因病机,基于补气活血理论,综述黄芪-丹参药对及其有效成分在治疗高血压肾损害中的研究进展,以期为黄芪-丹参药对在高血压肾损害中的进一步研究以及临床应用提供科学依据。

关键词：黄芪-丹参药对高血压肾损害降血压改善肾功能

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Dietary fat and carbohydrate-balancing the lactation performance and methane emissions in the dairy cow industry: A meta-analysis

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Animal Nutrition 2024年第2期17卷 347-357页

作者： Chenguang Zhang Xingwei jiang Shengru Wu Jun Zhang yue Wang Zongjun Li Junhu Yao College of Animal Science and Technology Northwest A&F University

For the agroecosystems of the dairy cow industry, dietary carbohydrate（starch, neutral detergent fiber[NDF]） and fat could directly affect rumen methane emissions and host energy utilization. However, the relationships among diet, lactation performance, and methane emissions need to be further determined to assist dairy farms to adjust diet formulations and feeding strategies for environmental and production management. A meta-analysis was conducted in the current study to explore quantitative patterns of dietary fat and carbohydrate at different levels in balancing lactation performance and environment sustainability of dairy cows, and to establish a methane emission prediction model using the artificial neural network（ANN）model. The results showed that the regression relationship between dietary fat, carbohydrate and methane emissions could be shown by the following models: methane = 106.78 +（14.86 × DMI）, R2= 0.80;methane = 443.17-（46.41 × starch/NDF）, R2= 0.76; and methane = 388.91 +（31.40 × fat）-（5.42 × fat2）,R2= 0.80. The regression relationships between dietary fat, carbohydrate and lactation performance could be shown by the following models: milk fat yield = 1.08 +（0.43 × starch/NDF）-[0.34 ×（starch/NDF）2],R2= 0.79; milk protein yield = 0.68 +（0.15 × fat）-（0.016 × fat2）, R2= 0.82. In the structural equation model, we found that when formulating dietary carbohydrates and fats, it was necessary to balance the relationship between methane emissions and lactation performance. Specifically, dietary starch/NDF was lower than 0.63（extremum point） and dietary fat was between 2.89% and 4.69%（extremum point）, it could ensure that the aim of methane emission reduction（methane emissions decrease with increasing dietary starch/NDF and fat） was achieved without losing lactation performance of dairy cows（lactation performance increase with increasing dietary starch/NDF and fat）. Finally, we established the ANN model to predict methane emissions（training set: R2= 0.62; vali

关键词： Dietary fat and carbohydrate Environment sustainability Lactation performance Dairy cow Meta-analysis

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A novel transcription factor FnMYB4 regulates pigments metabolism of yellow leaf mutants in Fragaria nilgerrensis

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Horticultural Plant Journal 2024年第5期10卷 1134-1150页

作者： Shu jiang Yi Ji Jingyu yue Mingqian Wang Yumeifeng Jia Li Xue Jiajun Lei College of Horticulture Shenyang Agricultural UniversityShenyangLiaoning 110866China

The strawberry species Fragaria nilgerrensis Schlechtendal ex ***,renowned for its distinctive white,fragrant peach-like fruits and strong disease resistance,is an exceptional research *** a previous study,an ethyl methane sulfonate(EMS)mutant library was established for this species,resulting in various yellow leaf *** yellowing materials are not only the ideal materials for basic studies on photosynthesis mechanism,chloroplast development,and molecular regulation of various pigments,but also have important utilization value in ornamental plants *** present study focused on four distinct yellow leaf mutants:mottled yellow leaf(MO),yellow green leaf(YG),light green leaf(LG),and buddha light leaf(BU).The results revealed that the flavonoid content and carotenoid-to-chlorophyll ratio exhibited a significant increase among these mutants,while experiencing a significant decrease in chlorophyll and carotenoid contents compared to the wild type(WT).To clarify the regulatory mechanisms and network relationships underlying these mutants,the RNA-seq and weighted gene coexpression network(WGCNA)analyses were *** results showed flavonoid metabolism pathway was enriched both in MO and YG mutants,while the chlorophyll biosynthesis pathway and carotenoid degradation pathway were only enriched in MO and YG mutants,***,key structural genes and transcription factors were identified on metabolic pathways of three pigments through correlation analyses and quantitative ***,a R2R3-MYB transcription factor,FnMYB4,was confirmed to be positively correlated with flavonoid synthesis through transient overexpression,virus-induced gene silencing(VIGS),and RNA interference(RNAi),accompanying by reoccurrence and attenuation of mutant ***,dual-luciferase(LUC)and yeast one-hybrid assays confirmed the binding of FnMYB4 to the FnFLS and FnF3H promoters,indicating that FnMYB4 positively regulates flavonoid sy

关键词： Fragaria nilgerrensis Mutant Leaf yellowing RNA-seq Flavonoid MYB

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Numerical Investigation on the Harbour Resonance Inside A Harbour with Lateral Cavities

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China Ocean Engineering 2024年第5期38卷 838-844页

作者： YU yue-min huaNG Xiao-hua School of Marine Science and Engineering Hainan University Key Laboratory for Sustainable Utilization of Open-Sea Fishery Ministry of Agriculture and Rural Affairs South China Sea Fisheries Research Institute Chinese Academy of Fishery Sciences

Wave-induced harbour resonance is numerically investigated inside a harbour with lateral cavities. The theoretical solutions for the amplification parameter are compared with the simulated results under varying dimensionless wave numbers in order to verify the simulation model in a rectangular harbour at a constant depth. The results indicate that the numerical model can correctly calculate the natural frequency and the natural wave height. A range of calculations are performed for harbour resonance with one pair of lateral cavities, two pairs of lateral cavities and three pairs of lateral cavities, respectively. The simulated results indicate that the amplitude of the amplification parameter decreases both at the primary natural oscillation and the secondary natural oscillation, as the number of lateral cavities increases. The dimensionless wave number reduces as the number of lateral cavities increases both at the primary natural oscillation and the secondary natural oscillation as well.

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Evaluation of the efficacy and safety of endoscopic band ligation in the treatment of bleeding from mild to moderate gastric varices type 1

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World Journal of Gastroenterology 2024年第5期30卷 440-449页

作者： yue Deng Ya jiang Tong jiang Ling Chen Hai-Jun Mou Bi-Guang Tuo Guo-Qing Shi Department of Gastroenterology Digestive Disease HospitalThe Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Gastroenterology Guizhou Hospital of the First Affiliated HospitalSun Yat-sen UniversityGuiyang 550000Guizhou ProvinceChina Department of Gastroenterology Yinjiang Autonomous County People’s HospitalTongren 554300Guizhou ProvinceChina

BACKGROUND According to practice guidelines,endoscopic band ligation(EBL)and endoscopic tissue adhesive injection(TAI)are recommended for treating bleeding from esophagogastric ***,EBL and TAI are known to cause serious complications,such as hemorrhage from dislodged ligature rings caused by EBL and hemorrhage from operation-related ulcers resulting from ***,the optimal therapy for mild to moderate type 1 gastric variceal hemorrhage(GOV1)has not been ***,the aim of this study was to discover an individualized treatment for mild to moderate *** To compare the efficacy,safety and costs of EBL and TAI for the treatment of mild and moderate *** A clinical analysis of the data retrieved from patients with mild or moderate GOV1 gastric varices who were treated under endoscopy was also *** were allocated to an EBL group or an endoscopic TAI *** differences in the incidence of varicose relief,operative time,operation success rate,mortality rate within 6 wk,rebleeding rate,6-wk operation-related ulcer healing rate,complication rate and average operation cost were compared between the two groups of *** The total effective rate of the two treatments was similar,but the efficacy of EBL(66.7%)was markedly better than that of TAI(39.2%)(P<0.05).The operation success rate in both groups was 100%,and the 6-wk mortality rate in both groups was 0%.The average operative time(26 min)in the EBL group was significantly shorter than that in the TAI group(46 min)(P<0.01).The rate of delayed postoperative rebleeding in the EBL group was significantly lower than that in the TAI group(11.8%vs 45.1%)(P<0.01).At 6 wk after the operation,the healing rate of operation-related ulcers in the EBL group was 80.4%,which was significantly greater than that in the TAI group(35.3%)(P<0.01).The incidence of postoperative complications in the two groups was *** average cost and other related economic factors were g

关键词： Gastric varices Type 1 gastric variceal hemorrhage Endoscopic band ligation Tissue adhesive injection

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Thermoelectric transport properties of p-type Bi_(2)Se_(3)-Sb_(2)Se_(3)-In_(2)Se_(3) high entropy compounds

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Rare Metals 2024年第7期43卷 3415-3421页

作者： Feng jiang Cheng-Liang Xia Yong-Bin Zhu Jun Li yue Chen Wei-Shu Liu Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Mechanical Engineering The University of Hong KongHong Kong 999077China Guangdong Provincial Key Laboratory of Functional Oxide Materials and Devices Southern University of Science and TechnologyShenzhen 518055China

The introduction of entropy concept into thermoelectric materials recently has attracted broad ***,we showed the phase diagram of the ternary systems of Bi_(2)Se_(3)-Sb_(2)Se_(3)-In_(2)Se_(3).Among the high entropy compounds (HECs),we have identified an intrinsic p-type region near our previously reported Bi_(0.8)Sb_(0.8)In_(0.4)Se_(3) in the phase diagram.

关键词： entropy (3) compounds

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Adsorption behavior of CO2/H2S mixtures in calcite slit nanopores for CO2 storage:An insight from molecular perspective

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Petroleum Science 2024年第4期21卷 2444-2456页

作者： Cheng Qian Zhen-hua Rui yue-Liang Liu Kai Du Chen Liu Yang Zhao Xiao-Min Ma State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum College of Petroleum Engineering China University of Petroleum College of Carbon Neutrality Future Technology China University of Petroleum College of Petroleum China University of Petroleum-Beijing at Karamay College of Mining Engineering Taiyuan University of Technology

It is acknowledged that injecting CO2into oil reservoirs and saline aquifers for storage is a practical and affordable method for *** CO2produced from industrial exhaust contains impurity gases such as H2S that might impact CO2sequestration due to competitive *** study makes a commendable effort to explore the adsorption behavior of CO2/H2S mixtures in calcite slit *** Canonical Monte Carlo（GCMC） simulation is employed to reveal the adsorption of CO2,H2S as well as their binary mixtures in calcite *** show that the increase in pressure and temperature can promote and inhibit the adsorption capacity of CO2and H2S in calcite nanopores,***2exhibits stronger adsorption on calcite surface than *** energy plays the dominating role in the adsorption *** energy accounts for 97.11% of the CO2-calcite interaction energy and 56.33% of the H2S-calcite interaction energy at 10 MPa and 323.15 *** presence of H2S inhibits the CO2adsorption in calcite nanopores due to competitive adsorption,and a higher mole fraction of H2S leads to less *** quantity of CO2adsorbed is lessened by approximately 33% when the mole fraction of H2S reaches ***2molecules preferentially occupy the regions near the po re wall and H2S molecules tend to reside at the center of nanopore even when the molar ratio of CO2is low,indicating that CO2has an adsorption priority on the calcite surface over *** addition,moisture can weaken the adsorption of both CO2and H2S,while CO2is more *** interestingly,we find that pure CO2is more suitable to be sequestrated in the shallower formations,i.e.,500-1500 m,whereas CO2with H2S impurity should be settled in the deeper reservoirs.

关键词： Adsorption behavior CO 2 /H 2 S binary mixtures Molecular perspective Calcite slit nanopores CO 2 sequestration

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A Cascading Fault Path Prediction Method for Integrated Energy Distribution Networks Based on the Improved OPA Model under Typhoon Disasters

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Energy Engineering 2024年第10期121卷 2825-2849页

作者： yue He YaxiongYou ZhianHe Haiying Lu Lei Chen Yuqi jiang Hongkun Chen Guangzhou Power Supply Bureau Guangdong Power Grid Co.Ltd.CSGGuangzhou510000China School of Electrical Engineering and Automation Wuhan UniversityWuhan430072China

In recent times,the impact of typhoon disasters on integrated energy active distribution networks(IEADNs)has received increasing attention,particularly,in terms of effective cascading fault path prediction and enhanced fault recovery *** this study,we propose a modified ORNL-PSerc-Alaska(OPA)model based on optimal power flow(OPF)calculation to forecast IEADN cascading fault *** first established the topology and operational model of the IEADNs,and the typical fault scenario was chosen according to the component fault probability and information *** modified OPA model consisted of two layers:An upper-layer model to determine the cascading fault location and a lower-layer model to calculate the OPF by using Yalmip and CPLEX and provide the data to update the upper-layer *** approach was validated via the modified IEEE 33-node distribution system and two real *** results showed that the fault trend forecasted by the novel OPA model corresponded well with the development and movement of the typhoon above the *** proposed model also increased the load recovery rate by>24%compared to the traditional OPA model.

关键词： IEADNs OPA model cascading fault path prediction fault probability optimal power flow typical fault scenario

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BMP9 induces osteogenic differentiation through up-regulating LGR4 via the mTORC1/ Stat3 pathway in mesenchymal stem cells

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Genes & Diseases 2024年第3期11卷 468-483页

作者： Jie Zhang Jinhai jiang Hang Liu Shiyu Wang Kaixin Ke Siyuan Liu yue jiang Lu Liu Xiang Gao Baicheng He Yuxi Su Department of Pharmacology School of PharmacyChongqing Medical UniversityChongqing 400016China Key Laboratory of Biochemistry and Molecular Pharmacology of Chongqing Chongqing Medical UniversityChongqing 400016China Department of Orthopedics Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China orthopedics Department Children's Hospital of Chongqing Medical UniversityChongqing 400014China China International Science and Technology Cooperation Base of Child Development and Critical Disorders Jiangxi Hospital Affiliated Children's Hospital of Chongqing Medical UniversityJiangxi 330000China National Clinical Research Center for Child Health and Disorders China

Bone defects and non-union are prevalent in clinical orthopedy,and the outcomes of current treatments are often *** tissue engineering offers a promising approach to treating these conditions *** morphogenetic protein 9(BMP9)can commit mesenchymal stem cells to osteogenic lineage,and a knowledge of the underlying mechanisms may help advance the field of bone tissue ***-rich repeats con-taining G protein-coupled receptor 4(LGR4),a member of G protein-coupled receptors,is essential for modulating bone *** study is aimed at investigating the impact of LGR4 on BMP9-induced osteogenesis in mesenchymal stem cells as well as the underlying *** marrow stromal cells from BMp9-knockout mice exhibited diminished LGR4 expression,and exogenous LGR4 clearly restored the impaired osteogenic potency of the bone marrow stromal ***,LGR4 expression was increased by BMP9 in C3H10T1/2 ***4 augmented the benefits of BMP9-induced osteogenic markers and bone formation,whereas LGR4 inhibition restricted these ***,the BMP9-induced li-pogenic markers were increased by LGR4 *** protein levels of Raptor and p-Stat3 were elevated by *** knockdown or p-Stat3 suppression attenuated the osteoblastic markers and LGR4 expression brought on by ***4 significantly reversed the blocking ef-fect of Raptor knockdown or p-Stat3 suppression on the BMP9-induced osteoblastic *** interacts with p-Stat3,and p-Stat3 activates the LGR4 promoter *** conclusion,LGR4 boosts BMP9 osteoblastic potency in mesenchymal stem cells,and BMP9 may up-regulate LGR4 via the mTORC1/Stat3 signal activation.

关键词： BMP9 LGR4 mTORC1 Osteogenic differentiation Stat3

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