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Influence of Acupuncture on Microcirculation Perfusion of Pericardium Meridian and Heart in Acute Myocardial Ischemia Model Rats

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Chinese Journal of Integrative Medicine 2022年第1期28卷 69-75页

作者： ZHUANG Yi ZHOU Jie ZHOU yu-mei CHEN Jiao WU Ping Lyu Pei-ran WAN Min LUO Liao-jun CAI Ding-jun LIANG Fan-rong College of Acupuncture Moxibustion and TuinaChengdu University of Traditional Chinese MedicineChengdu(610075)China College of Acupuncture Moxibustion and TuinaNanjing University of Chinese MedicineNanjing(210023)China Department of Acupuncture and Moxibustion Xin Du Hospital of Traditional Chinese MedicineChengdu(610599)China The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine ShenzhenGuangdong Province(518005)China

Objective: To observe the influence of acupuncture on microcirculation perfusion of the pericardium meridian and heart in acute myocardial ischemia(AMI) rats and evaluate whether acupuncture can simultaneously affect the meridians and corresponding viscera. Additionally, acupoints at different meridians were compared and whether they exert the same effects was discussed. Methods: Totally 32 Sprague-Dawley rats were subjected to left anterior descending(LAD) ligation to develop an AMI *** were divided into 4 groups, including AMI, acupuncture Neiguan(PC 6), Lieque(LU 7) and Qiansanli(LI 10) groups(n=8). Eight rats received only thoracotomy(sham-operated group). The rats in the acupuncture groups received manual acupuncture at PC 6, LU 7 and LI 10 acupoints for 15 min, respectively. The microcirculation perfusion of pericardium meridian and heart was monitored by laser speckle perfusion imager(LSPI) before, during and after acupuncture manipulation for 15 min. Subsequently, the perfusion unit(PU)was calculated and analyzed by PSI System. Results: After LAD, compared to pre-acupuncture stage, the heart microcirculation perfusion(HMP) in the AMI group decreased continuously at during-acupuncture(P>0.05) and post-acupuncture stages(P0.05). Compared to pre-acupuncture stage, the PMP and HMP in PC 6 group significantly increased during acupuncture manipulation(both P0.05);however, they were significantly reduced after acupuncture manipulation(both P<0.05). Additionally, HMP of LI 10 group was decreased significantly during acupuncture, especially compared to pre-acupuncture stage(P<0.05). Conclusions: Acupuncture at PC 6 obviously increased the PMP and HMP in AMI rats, and the effects were superior to at LU 7 and LI 10 acup

关键词： microcirculation perfusion acupuncture pericardium meridian heart acute myocardial ischemia

Two-photon Up-conversion Luminescent Properties of HMASPS and HEASPS in Three Different Polymer Matrices

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Chinese Chemical Letters 2002年第5期13卷 452-455页

作者： Yan REN Xiao Qiang yu Dong WANG Guang Yong ZHOU Zhi Qiang LIU yu Fang ZHOU Xian ZHAO Zong Shu SHAO Ji Yang WANG Min Hua jiang State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100

Three dye-doped polymer rods in different matrices were synthesized in which weak hydrogen bond, strong hydrogen bond and covalent bond existed between the dye and the polymer chain. And the two-photon up-conversion... 详细信息

关键词： Two-photon up-conversion lasing solid-state laser dye.

Nonlinear Dynamics of International Gold Prices:Conditional Heteroskedasticity or Chaos?

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Journal of Systems Science and Information 2014年第5期2卷 411-427页

作者： Xiaowei HUANG mei yu Chengwei BAN Guanghua School of Management Peking University University of International Business and Economics The School of Banking and Finance

Taking the special nonlinear characteristics of the domestic and international gold price into account, this paper systematically analyzed its nonlinearity by the methods of BDS test, R/S analysis and improved largest Lyapunov exponent. We find three main results:(1) ARMA-GARCH model could adequately explain the linear and nonlinear dependence of gold price series;(2) long-memory does not exist anymore in price series explained by ARMA-GARCH model;(3) chaos phenomenon which is sensitive to the initial value does not exist either in the residuals of regression model. Therefore, we believe that the nonlinearity of gold price is mainly characterized in conditional heteroscedasticity rather than chaos.

关键词： heteroscedasticity chaos BDS test R/S analysis Lyapunov exponent

Optimization of Urban Land Use Structure Based on the Perspective of GMOP-GA——A Case Study of the Urban Districts of Hohhot

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Asian Agricultural Research 2018年第11期10卷 52-57页

作者： Tongyu TIAN mei yu Hong SU College of Geographical Science Inner Mongolia Normal University

Taking the urban districts of Hohhot as the study area,using the classification data of land use change and relevant socio-economic statistical yearbook data in 2001-2016,taking the dual targets of economic-ecological and related constraint factors as the optimal decision of optimization of land use structure,using the Grey Multi-objective Programming( GMOP) and Genetic Algorithm( GA) to estimate the intervals of predictive threshold value of the factors and inequality constraint equations,and on the basis of it to designed two schemes for optimization of land use structure for the study area in 2030 and made them in comparison and optimization. The results show that in contrast to the primitive land use structure,the optimized scheme based on the economic-ecological comprehensive benefit is better than the current land use structure as the two aspects of the overall land output benefit and the scale combination of single type land use and the current land use structure.

关键词：呼和浩特市土地利用发展现状农业

光学玻璃超声振动维氏压痕中位裂纹的实验研究

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光子学报 2019年第7期48卷 1-8页

作者：姜晨高睿姜臻禹郝宇上海理工大学机械工程学院

为了进一步掌握光学玻璃材料超声振动辅助磨削亚表面损伤机理,设计常规和超声振动条件下维氏压痕实验,调查两种情况下K9光学玻璃压痕形貌特征;采用磁性复合流体抛光方法检测K9光学玻璃压痕区域的中位裂纹深度,对常规压痕系统中位裂纹模... 详细信息

为了进一步掌握光学玻璃材料超声振动辅助磨削亚表面损伤机理,设计常规和超声振动条件下维氏压痕实验,调查两种情况下K9光学玻璃压痕形貌特征;采用磁性复合流体抛光方法检测K9光学玻璃压痕区域的中位裂纹深度,对常规压痕系统中位裂纹模型进行两次系数修正,获得超声振动条件下的维氏压痕系统中位裂纹深度模型.通过超声振动维氏压痕实验计算静态和动态断裂韧性,得到两种加载条件的一次修正系数分别为0.08和0.06;结合检测中位裂纹深度实验结果拟合获得的两种条件下二次修正系数数值接近,分别为94.75和94.50.结果表明该模型对超声振动和加工条件具有良好的识别度.

关键词：光学玻璃中位裂纹超声振动维氏压痕磁性复合流体抛光

Genome-wide map of N6-methyladenosine circular RNAs identified in mice model of severe acute pancreatitis

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World Journal of Gastroenterology 2021年第43期27卷 7530-7545页

作者： Jun Wu Xiao-Hui yuan Wen jiang Yi-Chen Lu Qi-Lin Huang Yi Yang Hua-Ji Qie jiang-Tao Liu Hong-yu Sun Li-Jun Tang Department of General Surgery and Pancreatic Injury and Repair Key Laboratory of Sichuan Province The General Hospital of Western Theater CommandChengdu 610036Sichuan ProvinceChina College of Medicine Southwest Jiaotong UniversityChengdu 610036Sichuan ProvinceChina Laboratory of Basic Medicine The General Hospital of Western Theater CommandChengdu 610036Sichuan ProvinceChina

BACKGROUND Severe acute pancreatitis(SAP)is a deadly inflammatory disease with complex pathogenesis and lack of effective therapeutic options.N6-methyladenosine(m6A)modification of circRNAs plays important roles in physiological and pathological ***,the roles of m6A circRNA in the pathological process of SAP remains *** To identify transcriptome-wide map of m6A circRNAs and to determine their biological significance and potential mechanisms in *** The SAP in C57BL/6 mice was induced using 4%sodium taurocholate *** transcriptome-wide map of m6A circRNAs was identified by m6A-modified RNA immunoprecipitation *** biological significance of circRNAs with differentially expressed m6A peaks was evaluated through gene ontology and Kyoto Encyclopedia of Genes and Genomes *** underlying mechanism of m6A circRNAs in SAP was analyzed by constructing of m6A circRNAmicroRNA *** expression of demethylases was determined by quantitative polymerase chain reaction and western blot to deduce the possible mechanism of reversible m6A process in *** Fifty-seven circRNAs with differentially expressed m6A peaks were identified by m6A-modified RNA immunoprecipitation sequencing,of which 32 were upregulated and 25 *** analysis of these m6A circRNAs in SAP found some important pathways involved in the pathogenesis of SAP,such as regulation of autophagy and protein *** m6A circRNA–miRNA networks,several important miRNAs participated in the occurrence and progression of SAP were found to bind to these m6A circRNAs,such as miR-24-3p,miR-26a,miR-92b,miR-216b,miR-324-5p and ***,the total m6A level of circRNAs was reduced,while the demethylase alkylation repair homolog 5 was upregulated in *** m6A modification of circRNAs may be involved in the pathogenesis of *** findings may provide novel insights to explore the possible pathogenetic mechanism of SAP and seek new poten

关键词： Severe acute pancreatitis Circular RNAs N6-methyladenosine MeRIP-seq Epigenetic analysis

Role of p300 in the pathogenesis of Henoch-Schonlein purpura nephritis and as a new target of glucocorticoid therapy in mice

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Chinese Medical Journal 2019年第16期132卷 1942-1950页

作者： Ming-yu jiang Wei Li Xiang-Ping Xu Jie-Qing Zhou Hong jiang Department of Pediatrics The First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Pediatrics The First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150001China

Background: Henoch-Schonlein purpura nephritis (HSPN) is a very common secondary kidney disease of childhood. Its pathogenesis and the treatment mechanism of glucocorticoid have not been fully elucidated. The aim of this study was to determine the relationship between p300 and the pathogenesis, glucocorticoid therapy in mice with HSPN, respectively. Methods: Forty-eight C57BL/6N male mice, weighing 18 to 20 g, were selected (3–4 weeks old, n = 8 per group). The mice in the normal control group (Group I) were given normal solvent and the HSPN model group (Group II) were given sensitizing drugs. The mice in Group III were injected intraperitoneally with dexamethasone after being given sensitizing drugs. Meanwhile, mice in Groups IV, V and VI with conditional knockout of p300 were also given normal solvent, sensitizing drugs and dexamethasone. The levels of serum IgA, creatinine, and circulating immune complex (CIC) concentrations, 24 h urinary protein and urinary erythrocyte in C57 wild mice, and p300 conditional knockout mice in each group were measured. The expression of p300 in renal tissues and the expression of glucocorticoid receptor (GR)α and β, transforming growth factor (TGF)-β1, and activator protein (AP)-1 after dexamethasone treatment were determined by real-time polymerase chain reaction and Western blotting. Results: Compared with the normal solvent control group (Group I), the expression of p300 mRNA in the model group (Group II) was significantly up-regulated. Western blotting further confirmed the result. Urinary erythrocyte count, 24 h urinary protein quantification, serum IgA, CIC, and renal pathologic score in Group V were distinctly decreased compared with non-knockout mice in Group II (9.7 ± 3.8 per high-power field [/HP] vs. 18.7 ± 6.2/HP, t = 1.828, P = 0.043;0.18 ± 0.06 g/24 h vs. 0.36 ± 0.08 g/24 h, t = 1.837, P = 0.042;18.78 ± 0.85 mg/mL vs. 38.46 ± 0.46 mg/mL, t = 1.925, P = 0.038;0.80 ± 0.27 μg/mL vs. 1.64 ± 0.47 μg/mL, t = 1.892, P = 0.04

关键词： p300 Henoch-Schonlein purpura nephritis Pathogenesis Glucocorticoid treatment

基于支持向量回归的立体图像客观质量评价模型

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电子与信息学报 2012年第2期34卷 368-374页

作者：顾珊波邵枫蒋刚毅郁梅宁波大学信息科学与工程学院宁波315211

立体图像质量评价是评价立体视频系统性能的有效途径,而如何利用人类视觉特性对立体图像质量进行有效评价是目前的研究难点。该文根据图像奇异值有较强稳定性的特点,结合立体图像的主观视觉特性,提出了一种基于支持向量回归(Support Vec... 详细信息

立体图像质量评价是评价立体视频系统性能的有效途径,而如何利用人类视觉特性对立体图像质量进行有效评价是目前的研究难点。该文根据图像奇异值有较强稳定性的特点,结合立体图像的主观视觉特性,提出了一种基于支持向量回归(Support Vector Regression,SVR)的立体图像客观质量评价模型。该模型通过分析立体图像的视觉特性,提取左右图像的奇异值作为立体图像的特征信息,然后根据立体图像的不同失真类型情况对其特征进行融合,通过SVR预测得到立体图像质量的客观评价值。实验结果表明,采用该文提出的客观评价模型对立体数据测试库进行评价,Pearson线性相关系数值在0.93以上,Spearman等级相关系数值在0.94以上,均方根误差值接近6,异常值比率值为0.00%,符合人眼视觉特性,能够很好地预测人眼对立体图像的主观感知。

关键词：立体图像质量评价人类视觉特性支持向量回归奇异值分解特征融合

The essential role of N6-methyladenosine RNA methylation in complex eye diseases

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Genes & Diseases 2023年第2期10卷 505-520页

作者： Xiaohua Li Binyun Ma Wenfang Zhang Zongming Song Xiaodan Zhang Mengyu Liao Xue Li Xueru Zhao mei Du Jinguo yu Shikun He Hua Yan Henan Provincial People’s Hospital Henan Eye HospitalHenan Eye InstituteHenan Key Laboratory of Ophthalmology and Visual SciencePeople’s Hospital of Zhengzhou UniversityPeople’s Hospital of Henan UniversityZhengzhouHenan 450003China Department of Medicine/Hematology Keck School of Medicine of the University of Southern CaliforniaLos AngelesCA 90033USA Department of Ophthalmology Lanzhou University Second HospitalLanzhouGansu 730030China Department of Ophthalmology Tianjin Medical University General HospitalLaboratory of Molecular OphthalmologyTianjin Medical University. Department of Pharmacology and Tianjin Key Laboratory of Inflammation BiologySchool of Basic Medical SciencesTianjin Medical UniversityTianjin 300052China Department of Pathology and Ophthalmology USC Roski Eye InstituteKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA

There are many complex eye diseases which are the leading causes of blindness,however,the pathogenesis of the complex eye diseases is not fully understood,especially the underlying molecular mechanisms of N6-methyladenosine(m6A)RNA methylation in the eye diseases have not been extensive *** review summarizes the latest advances in the studies of m6A modification in the pathogenesis of the complex eye diseases,including cornea disease,cataract,diabetic retinopathy,age-related macular degeneration,proliferative vitreoretinopathy,Graves’disease,uveal melanoma,retinoblastoma,and traumatic optic *** further discuss the possibility of developing m6A modification signatures as biomarkers for the diagnosis of the eye diseases,as well as potential therapeutic approaches.

关键词： Degeneration Eye diseases Fibrosis Inflammation m6A RNA methylation Tumor