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ginsenoside Rd Induces Differentiation of Myeloid Leukemia Cells via Regulating ERK/gSK-3βSignaling Pathway

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Chinese Journal of Integrative Medicine 2024年第7期30卷 588-599页

作者： jiang yu-xia ZHAO Yan-na yu xiao-ling YIN Li-ming Department of Hematology Tongde Hospital of Zhejiang ProvinceHangzhou310012China Institute of Hematology Research the First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou310006China

Objective To investigate the role of ginsenoside Rd(gRd)in acute myeloid leukemia(AML)cell *** AML cells were treated with gRd(25,50,100 and 200µg/mL),retinoic acid(RA,0.1g/L)and PD98059(20 mg/mL)for 72 h,cell survival was detected by methylthiazolyldiphenyl-tetrazolium bromide and colony formation assays,and cell cycle was detected by flow *** morphology and differentiation were observed by Wright-giemsa staining,peroxidase chemical staining and cellular immunochemistry assay,*** protein expression levels of gATA binding protein 1(gATA-1),purine rich Box-1(PU.1),phosphorylated-extracellular signal-related kinase(p-ERK),ERK,phosphorylated-glycogen synthase kinase-3β(p-gSK3β),gSK3βand signal transducer and activator of transcription 1(STAT1)were detected by Western ***-six mice were randomly divided into 3 groups using a random number table:model control group(non-treated),gRd group[treated with 200 mg/(kg·d)gRd]and homoharringtonine(HTT)group[treated with 1 mg/(kg·d)HTT].A tumor-bearing nude mouse model was established,and tumor weight and volume were *** of subcutaneous tumor tissue were observed after hematoxylin and eosin ***1 and gATA-1 expressions were detected by immunohistochemical *** The cell survival was inhibited by gRd in a dose-dependent manner and gRd caused g0/g1 cell arrest(pgRd treatment induced leukemia cell differentiation,showing increased expressions of peroxidase and specific proteins concerning erythrogenic or granulocytic differentiation(pgRd treatment elicited upregulation of p-ERK,p-gSK-3βand STAT1 expressions in cells,and reversed the effects of PD98059 on inhibiting the expressions of peroxidase,gATA-1 and PU.1(PgRd treatment,tumor weight and volume of mice were decreased,and tumor cells underwent massive apoptosis and necrosis(PgATA-1 level was significantly increased in subcutaneous tumor ti

关键词： ginsenoside Rd myeloid leukemia survival differentiation extracellular signal-related kinase signaling pathway

Morphological Classification of Infrared galaxies Based on WISE

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Research in Astronomy and Astrophysics 2024年第4期24卷 222-236页

作者： Zhi-Ren Pan Bo Qiu Cui-xia.g Liu A-Li Luo xia jiang xiao-yu guo School of Electronic and Information Engineering Hebei University of TechnologyTianjin 300401China Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China

This study introduces a novel convolutional neural network,the WISE galaxy Classification Network(WgC),for classifying spiral and elliptical galaxies using Wide-field Infrared Survey Explorer(WISE)*** attains an accuracy of 89.03%,surpassing the combined use of K-means or SVM with the Color-Color method in more accurately identifying galaxy *** enhanced variant,WgC_mag,integrates magnitude parameters with image features,further boosting the accuracy to 89.89%.The research also delves into the criteria for galaxy classification,discovering that WgC primarily categorizes dust-rich images as elliptical galaxies,corresponding to their lower star formation rates,and classifies less dusty images as spiral *** paper explores the consistency and complementarity of WISE infrared images with SDSS optical images in galaxy morphology *** SDSS galaxy Classification Network(SgC),trained on SDSS images,achieved an accuracy of 94.64%.The accuracy reached 99.30% when predictions from SgC and WgC were *** the complementarity of features in WISE and SDSS images,a novel variant of a classifier,namely the Multi-band galaxy Morphology Integrated Classifier,has been *** classifier elevates the overall prediction accuracy to 95.39%.Lastly,the versatility of WgC was validated in other data *** the HyperLEDA data set,the distinction between elliptical galaxies and Sc,Scd and Sd spiral galaxies was most pronounced,achieving an accuracy of 90%,surpassing the classification results of the galaxy Zoo 2 labeled WISE data *** research not only demonstrates the effectiveness of WISE images in galaxy morphology classification but also represents an attempt to integrate multi-band astronomical data to enhance understanding of galaxy structures and evolution.

关键词： methods:data analysis infrared:galaxies galaxies:spiral galaxies:elliptical and lenticular cD

A Nonparametric Model Checking Test for Functional Linear Composite Quantile Regression Models

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Journal of Systems Science & Complexity 2024年第4期37卷 1714-1737页

作者： xia Lili DU jiang ZHANg Zhongzhan Faculty of Science Beijing University of TechnologyBeijing 100124China

This paper is focused on the goodness-of-fit test of the functional linear composite quantile regression model.A nonparametric test is proposed by using the orthogonality of the residual and its conditional expectation under the null *** proposed test statistic has an asymptotic standard normal distribution under the null hypothesis,and tends to infinity in probability under the alternative hypothesis,which implies the consistency of the ***,it is proved that the test statistic converges to a normal distribution with nonzero mean under a local alternative *** simulations are reported,and the results show that the proposed test has proper sizes and is sensitive to the considered model *** proposed methods are also applied to two real datasets.

关键词： Composite quantile regression consistent test functional data nonparametric test quadratic form

Numerical insight into heat transfer enhancement by granules inner-migration in a moving bed:A performance comparison between slanted-stick and plow-shaped agitator

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Particuology 2024年第6期89卷 109-116页

作者： Binfan jiang Hao Pei Dehong xia Haiyang Wang School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China Shunde graduate School of University of Science and Technology Beijing Guangdong 528399China Jianlong group&USTB Joint Laboratory Beijing 100083China

Waste heat recovery of high-temperature granules is one of the most promising sustainable energy supply and carbon reduction ways for industry.A moving bed indirect heat exchanger(MBIHE)with inner-migration was proposed for granular heat *** migration and the enhanced heat transfer induced by two types of agitators(i.e.,agitator with slanted stick A_(s)and with plow-shaped surface A_(p))in the MBIHE are analyzed based on DEM coupled with *** to the effective agitation,the average heat transfer coefficient in the granule side is enhanced to∼3 times compared to that without *** heat recovery efficiency in the moving bed reached more than 70%with the agitations of either A_(s)or A_(p).The heat efficiency of A_(s)is∼7%higher than that of A_(p),but with at least 60%greater rotational *** ensure reliable agitation,the A_(p)is suggested to be adopted in the MBIHE to induce granule migration.

关键词： Waste heat recovery High-temperature granule granule migration Heat transfer enhancement Industry energy saving

Low Concentration of Wenyang Tonglin Decoction Promotes Conjugation and Transfer of Drug-Resistant Plasmids among Heterologous Strains

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Chinese Journal of Integrative Medicine 2024年第8期30卷 721-728页

作者： WANg Bi-yan BU Hong-shi xia Li-bo jiang xia.g-yu TONg Yan-qing Department of Traditional Chinese Medicine Changchun University of Traditional Chinese MedicineChangchun130000China

Objective To investigate the effect of low concentration of Wenyang Tonglin Decoction(WTD)on the binding conditions of R45 plasmid conjugative transfer under liquid phase conjugation and its *** Escherichia coli CP9(R45)and Staphylococcus aureus RN450RF were cultured in medium containing WTD,and their minimum inhibitory concentration(MIC)values were *** promoter fusion technology,*** CP9(R45)containing a promoter fusion was obtained.β-galactosidase activity of TrfAp and TrbBp was tested,and the mRNA expression of regulatory factors(TrbA,KorA,and KorB)was detected by real-time fluorescent quantitative polymerase chain *** The MIC of *** CP9(R45)was 400 g/L and that of *** RN450RF was 200 g/*** the drug concentration in the culture medium was 200 g/L,the highest number of conjugants was(3.47±0.20)×10^(7) CFU/mL At 90 h of conjugation,the maximum number of conjugants was(1.15±0.06)×10^(8) CFU/mL When the initial bacterial concentration was 10^(8) CFU/mL,the maximum number of conjugants was(3.47±0.20)×10^(7) CFU/*** the drug concentration was 200 g/L,theβ-galactosidase activity of TrfAp and TrbBp significantly increased;the relative quantification of TrbA,KorA and KorB were significantly *** Low concentration of WTD promoted the development of bacterial resistance by affecting promoters and inhibiting the expression of regulatory factors.

关键词： urinary tract infection Chinese medicine drug-resistant plasmid heterozygous strains conjugation transfer

Robust boundary-induced bulk propagations in elastic waveguides with nonplanar surfaces

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 88-96页

作者： Baizhan xia Jielong Zhang Zihan jiang Jianting Liu State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan UniversityChangsha 410082China College of Mechanical and Vehicle Engineering Hunan UniversityChangsha 410082China

Trivial elastic waveguides induced by line defects and nontrivial elastic waveguides protected by topological edge states have been extensively examined in planar waveguide *** these investigations,little is known about topologically protected bulk states and their resulting robust transmission properties,especially in nonplanar elastic waveguides with folded,curved,and twisted *** Dirac waveguides with robust boundary-induced bulk states are *** states arise from the truncated boundaries of bulks with linear Dirac conical dispersions,differing from topologically protected edge states ensured by the bulk-edge *** proof is provided,in which boundary-induced bulk states show robustly high-throughput transmissions along the waveguides,even with folded,curved,and twisted *** results not only open up new avenues for examining novel topological phenomena about bulk but also offer new platforms for developing topological devices with nonplanar surfaces.

关键词： elastic waveguides boundary-induced bulk propagations Dirac conical dispersions nonplanar surfaces

CONVERgENCE OF MODIFIED TRUNCATED EULER-MARUYAMA METHOD FOR STOCHASTIC DIFFERENTIAL EQUATIONS WITH HOLDER DIFFUSION COEFFICIENTS

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Journal of Computational Mathematics 2024年第4期42卷 1109-1123页

作者： guangqiang Lan yu jiang College of Mathematics and Physics Beijing University of Chemical TechnologyBeijing 100029China

Convergence of modified truncated Euler-Maruyama(MTEM)method for stochastic differential equations(SDEs)with(1/2+α)-Holder continuous diffusion coefficients are investigated in this *** prove that the MTEM method for... 详细信息

关键词： Stochastic differential equations Modified truncated Euler-Maruyama method Strong convergence One-sided Lipschitz Holder continuous

Photocatalytic vinyl radical-mediated multicomponent 1,4-/1,8-carboimination across alkynes and olefins/(hetero)arenes

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Science China Chemistry 2024年第2期67卷 558-567页

作者： Shan-Shan Li yu-Shi jiang Xue-Ling Luo Xuming Ran yuqiang Li Dong Wu Cheng-Xue Pan Peng-Ju xia School of Chemistry and Pharmaceutical Sciences Guangxi Normal UniversityGuilin541004China Shanghai Artificial Intelligence Laboratory Shanghai200433China The Institute for Advanced Studies Wuhan UniversityWuhan430064China

We developed a highly selective and efficient multicomponent transformation by utilizing alkynes and olefins/(hetero)arenes through photoinduced energy-transfer *** reaction involves the formation of three distinct chemical bonds,namely C(sp~3)–C(sp~2),C(sp~2)–C(sp~3),and C(sp~3)–N,in a single coordinated *** strategy used a vinyl radical-mediated radical relay approach under mild conditions,exhibiting a broad substrate scope(>70 examples),excellent functional-group tolerance,and remarkable regio-and *** the utilization of a combination of experimental techniques and density functional theory(DFT),we delved deeper into the mechanistic intricacies of this distinctive *** revealed that the selective radical addition to electron-deficient alkynes,rather than olefins,was governed by the inherent reactivity of alkyl *** discovery presented a highly effective approach for the synthesis of stereodefined multisubstituted alkenes.

关键词： alkyne-olefin coupling DFT studies regio-and anti-stereoselectivity multisubstituted alkenes

Resveratrol combats chronic diseases through enhancing mitochondrial quality

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Food Science and Human Wellness 2024年第2期13卷 597-610页

作者： Weichu Tao Hu Zhang xia jiang Ning Chen Tianjiu Research and Development Center for Exercise Nutrition and Foods Hubei Key Laboratory of Exercise Training and MonitoringCollege of Sports MedicineWuhan Sports UniversityWuhan 430079China The University Hospital of Wuhan Sports University Wuhan 430079China

Resveratrol(RSV),as a functional food component extracted from natural plants,has been widely studied and recognized in preventing and treating various diseases,with major mechanisms including executing anti-inflammation and anti-oxidation functions,and improving mitochondrial *** diseases as non-communicable diseases are mainly caused by multiple factors,such as physiological decline and dysfunction in the body,and have become a significant challenge on public health *** is worth noting that chronic diseases such as Alzheimer's disease(AD),Parkinson's disease(PD),muscle atrophy,cardiovascular disease,obesity,and cancer are accompanied by abnormal mitochondrial ***,targeted regulation of mitochondria may be a meaningful way to prevent and treat chronic *** evidence has confirmed that RSV is actively involved in regulating mitochondria,and it has become an essential consideration to prevent and treat chronic diseases through targeting mitochondria and improving corresponding *** this article,current studies on RSV to optimize mitochondrial quality for preventing and alleviating chronic disease are systematically summarized,which can provide a theoretical reference for the development of functional foods or drugs to combat chronic diseases.

关键词： Resveratrol Functional food Mitochondrial quality Chronic disease Anti-inflammation Anti-oxidation