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真实分岔静脉下多种血液流变模型的溶栓治疗差异数值研究

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力学学报 2024年第5期56卷 1328-1341页

作者：程鸿宇林博远姜胜晖张祥雷周宏明温州大学机电工程学院浙江温州325035 温州职业技术学院浙江温州325035

静脉血栓栓塞(VTE)是一种常见的心血管疾病,建立基于计算流体力学(CFD)的数值模型是开展血栓治疗研究的重要手段.然而,血液的流变模型众多,多种血液流变模型之间存在显著的差异.目前,针对不同血液流变模型间的差异表现尚未得到充分研究... 详细信息

静脉血栓栓塞(VTE)是一种常见的心血管疾病,建立基于计算流体力学(CFD)的数值模型是开展血栓治疗研究的重要手段.然而,血液的流变模型众多,多种血液流变模型之间存在显著的差异.目前,针对不同血液流变模型间的差异表现尚未得到充分研究.本研究提出一种生物流体力学模型以用于静脉血栓治疗数值研究,研究考虑静脉血流、血管结构以及药物传质间的作用耦合,并将血液视为不同流变特性的7种流体、静脉瓣膜视为超弹性固体、血栓块视为多孔材料.针对患者理想化和特异性的血管模型进行数值模拟,综合分析静脉血栓的溶栓治疗数值结果.结果表明,患者特异性血管模型更接近实际血管情况,其受分岔、弯曲等局部特征的影响,流速变化明显、涡流强度和Pe较高、瓣膜位移值较大.同时,不同血液流变学模型的研究结果不同.在患者特异性模型下,牛顿模型的血液黏度较小,流速和Pe较大,物质传质更快,溶栓表现较优;非牛顿模型中Bingham流体表现差异最显著,其血液黏度值较高,Pe较小,溶栓表现较差.本研究提倡采用患者实际血管模型、考虑血液实际流变特性进行静脉血栓数值研究,以推动血栓治疗领域的数字医疗、智慧医疗技术进步.

关键词：静脉血栓血液流变特性生物流体力学溶栓治疗数值模拟

Study on the Sediment Transport Flux and Mechanism in the Bohai Strait at the Tidal and Monthly Scales in Summer

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Journal of Ocean University of China 2023年第1期22卷 75-87页

作者： YUAN Xiaodong FENG Xiuli HU Rijun jiang shenghui ZHONG Wei College of Marine Geoscience Ocean University of ChinaQingdao 266100China Key Laboratory of Submarine Geosciences and Prospecting Techniques MOEOcean University of ChinaQingdao 266100China

Based on the data of tidal currents and suspended sediment concentrations observed synchronously at 11 stations in the Bohai Strait lasting for 25 hours,the temporal and spatial variations of currents and suspended sediment concentrations in the Bohai Strait in summer were *** Study preliminarily discussed the transport mechanism,transport trend and transport flux of suspended sediments in summer,using flux-mechanism decomposition method and numerical *** suspended sediment transport was mainly controlled by advection and next influenced by vertical net circulation,while resuspension is relatively weak in Bohai *** single-width fluxes of investigation stations varied from 3.8 to 89.1 gm^(−1) s^(−1),with the maximum value in Miaodao *** suspended sediment transport trends in Laotieshan channel along the vertical section are obviously *** waters mainly flow out of the Bohai Sea in surface layer,while into the Bohai Sea in bottom ***,the transport trends of other channels in the centre and south are consistent *** sediments in the Bohai Strait follows the transport pattern of moving outward from the south and inward from the north in summer,i.e.,the sediments are carried out of the Bohai Sea through the Laotieshan channel,while into the Bohai Sea through other *** the outflow flux exceeds the inflow flux in August with the net water flux of 1.4×10^(10)m^(3),basically same as the deliveries of the rivers into the Bohai ***,the suspended sediment flux is 0.33 Mt under the action of tidal residual currents in the Yellow Sea in August.

关键词： Bohai Strait suspended sediment transport numerical simulation summer

Beach Morphology and Coastline Evolution in the Southern Bohai Strait

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Journal of Ocean University of China 2015年第5期14卷 803-815页

作者： ZHANG Wei WU Jianzheng LI Weiran ZHU Longhai HU Rijun jiang shenghui SUN Yonggen WANG Huijuan College of Marine Geoscience Ocean University of China Qingdao Marine Geological Engineering Investigation Institute Key Laboratory of Submarine Geosciences and Prospecting Techniques Ministry of EducationOcean University of China First Institute of Oceanography SOA Qingdao Boyan Marine Environment Science & Technology Co.Ltd.

The beach studied in this paper spans a length of 51 km and is one of several long sandy beaches in the southern Bohai Strait. Due to the obstruction of islands in the northeast and the influence of the underwater topography, the wave environment in the offshore area is complex; beach types and sediment transport characteristics vary along different coasts. The coastlines extracted from six aerial photographs in different years were compared to demonstrate the evolving features. Seven typical beach profiles were selected to study the lateral beach variation characteristics. Continuous wind and wave observation data from Beihuangcheng ocean station during 2009 were employed for the hindcast of the local wave environment using a regional spectral wave model. Then the results of the wave hindcast were incorporated into the LITDRIFT model to compute the sediment transport rates and directions along the coasts and analyze the longshore sand movement. The results show that the coastline evolution of sand beaches in the southern Bohai Strait has spatial and temporal variations and the coast can be divided into four typical regions. Region （1）, the north coast of Qimudao, is a slightly eroded and dissipative beach with a large sediment transport rate; Region （II）, the southwest coast of Gangluan Port, is a slightly deposited and dissipative beach with moderate sediment transport rate; Region （III）, in the central area, is a beach that is gradually transformed from a slightly eroded dissipative beach to a moderately or slightly strong eroded bar-trough beach from west to east with a relatively moderate sediment transport rate. Region （IV）, on the east coast, is a strongly eroded and reflective beach with a weak sediment transport rate. The wave conditions exhibit an increasing trend from west to east in the off- shore area. The distribution of the wave-induced current inside the wave breaking region and the littoral sediment transport in the nearshore region exhibit a gradua

关键词： sand beach coastline evolution profile feature wave hind-casting wave-induced current littoral sediment transport

Sediment Transport in the Nearshore Area of Phoenix Island

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Journal of Ocean University of China 2016年第5期15卷 767-782页

作者： HU Rijun MA Fang WU Jianzheng ZHANG Wei jiang shenghui XU Yongchen ZHU Longhai WANG Nan LIU Aijiang College of Marine Geoscience Ocean University of China Qingdao 266100 P. R. China Key Laboratory of Submarine Geosciences and Prospecting Techniques Ministry of Education Ocean University of ChinaQingdao 266100 P. R. China North China Sea Branch of the State Oceanic Administration Qingdao 266033 P. R. China Qingdao Institute of Marine Geology Qingdao 266071 P. R. China

Based on the measured data, suspended sediment concentration, surface sediment grain size, current and waves, the sediment transport mechanisms and pathways in the Phoenix Island area were analyzed using methods of flux decomposition and Grain Size Trend Analysis(GSTA). The results show that net suspended sediment is mainly transported by average current, Stokes drift, and gravitational circulation. The transport direction of suspended sediment is varying and basically following the direction of residual tidal currents. Surface sediment transport pathways are primarily parallel to the coastline along with two convergent centers. Waves and longshore currents have a significant influence on sediment transport, but the influence is limited due to a steep and deep underwater bank. Tidal current is the main controlling factor for sediment transport, especially in the deep water area. Neither suspended nor surface sediment is transported towards the southwest. The South Shandong Coastal Current(SSCC) has little effect on sediment transport processes in the nearshore area of Phoenix Island.

关键词： suspended Phoenix Island tidal currents Sediment convergent primarily Shandong underwater

以学生为中心的地质学专业制图课程构建与教学模式探索

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中国地质教育 2024年第1期33卷 87-93页

作者：朱龙海韩宗珠姜胜辉胡日军尹砚军冷星中国海洋大学海洋地球科学学院山东青岛266100 中国海洋大学海底科学与探测技术教育部重点实验室山东青岛266100

“AutoCAD制图”是一门技能型课程,针对传统教学中存在的问题,本研究在教学设计、理论教学、上机实践和考核方式上进行了创新实践探索。授课前,进行精心的教学设计,自行编制命令口诀89条、录制演示视频451个,全方位展示软件操作和案例... 详细信息

“AutoCAD制图”是一门技能型课程,针对传统教学中存在的问题,本研究在教学设计、理论教学、上机实践和考核方式上进行了创新实践探索。授课前,进行精心的教学设计,自行编制命令口诀89条、录制演示视频451个,全方位展示软件操作和案例演示的各环节;授课过程采用启发式教学法、动画演示法、列举法、多媒体教学、归纳法等,让学生深入理解和掌握命令操作和制图过程。把握AutoCAD“精准制图”的特点,将工匠精神、规则意识和创新精神等课程思政元素融入课程中。精心设计上机指导书,将工程地质剖面图、表层沉积物类型图等专业图件的绘制及校园图的绘制等融入课程中,提高学生的学习兴趣和制图能力。综合更加多样的考核方式,采用图件绘制、批改和修改的三步骤模式,引导学生逐步规范图件绘制。

关键词： AutoCAD制图地质学类专业教学模式创新实践

MdMYB6 regulates anthocyanin formation in apple both through direct inhibition of the biosynthesis pathway and through substrate removal

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Horticulture Research 2020年第1期7卷 1835-1851页

作者： Haifeng Xu Qi Zou Guanxian Yang shenghui jiang Hongcheng Fang Yicheng Wang Jing Zhang Zongying Zhang Nan Wang Xuesen Chen College of Horticulture Science and Engineering Shandong Agricultural University61 Daizong RoadTai’an 271018China State Key Laboratory of Crop Biology Shandong Agricultural University61 Daizong RoadTai’an 271018China

Anthocyanin biosynthesis and sugar metabolism are important processes during plant growth,but the molecular interactions underlying these pathways are still *** this work,we analyzed the anthocyanin and soluble sugar contents,as well as the transcript levels of transcription factors that are known to be related to the biosynthesis of anthocyanin in‘Hongcui 1’apple flesh during fruit *** of MdMYB6 in red-fleshed calli was found to reduce anthocyanin content and result in downregulated expression of the MdANS and MdGSTF12 *** one-hybrid and electrophoretic mobility shift analyses showed that MdMYB6 could directly bind to the promoters of MdANS and MdGSTF12,indicating that MdMYB6 could inhibit anthocyanin biosynthesis by regulating MdANS and *** of MdTMT1 in the Arabidopsis tmt1 mutant restored the glucose and fructose contents to the wild-type levels,while overexpression of MdTMT1 in red-fleshed calli increased the contents of glucose and fructose but reduced the contents of UDP-glucose,UDP-galactose,and *** a GUS reporter system,yeast one-hybrid,chromatin immunoprecipitation-PCR and electrophoretic mobility shift analyses,we found that MdMYB6 could bind to the promoter of MdTMT1,resulting in increased promoter *** of MdMYB6 in calli overexpressing MdTMT1 increased the expression of MdTMT1,which led to reduced contents of UDP-glucose and UDP-galactose and decreased anthocyanin content compared to those of the calli that overexpressed *** finding suggested that MdMYB6 could also inhibit anthocyanin biosynthesis by regulating MdTMT1 to decrease the contents of UDP-glucose and *** together,these results showed that MdMYB6 and MdTMT1 play key roles in both anthocyanin biosynthesis and sugar transport.

关键词： sugar Yeast metabolism

CALORIMETRY OF PARTIAL MARTENSITIC TRANSFORMATIONS

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Acta Metallurgica Sinica(English Letters) 1996年第3期9卷 193-198页

作者： LI Jianchen, NAN shenghui and jiang Qing.(Department of Materials Science and Engineering, Jilin University of Technology, Changchun 130025, China)

Partial thermoelastic martensitic transformations have been studied by calorimetry on CuAlNi single crystals with special methods. The chemical enthalpy change, the elastic energy stored at the interfaces or inside of the martensite and the energy dissipated in acoustic emission were calculated for a partial transformation; the relationship among them was studied based on measured latent heat and transformation temperatures. The influence of specimen shape on the stored elastic energy was evaluated and discussed.

关键词： partial martensitic transformation CuAlNi single crystal elastic energy latent heat

Mechanism and genesis of Sanmen Bay as a sink of Holocene Yangtze River sediment,Zhejiang Province,China

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Mechanism and genesis of Sanmen Bay as a sink of Holocene Ya...

Finite-time fault tolerant control for spacecraft attitude systems based adding a power integrator approach

第十七届全国古地理学及沉积学学术会议

作者： Jiandong Qiu shenghui jiang Jing Feng Qingdao Institute of Marine Geology China Geological Survey

The Holocene mud deposits that extend from the Yangtze River mouth to the Taiwan Strait along the Zhejiang–Fujian coast,East China Sea（ECS）,have attracted onsiderable research attention. However,there is a lack of consensus regarding the redistribution flux of Yangtze River sediment after it enters the sea. There are many bays along the Zhejiang and Fujian coasts,but their role in the source–sink process of Yangtze River sediment is not well-documented owing to limited data. In this study,data from shallow seismic profiles,core samples,and surface sediment samples were analysed to assess the role of Sanmen Bay,the second largest bay in Zhejiang Province,in the source–sink process of Yangtze River sediments. The results showed that Sanmen Bay is an important sink for Yangtze River sediments. The characteristics of the clay minerals indicate that the fine-grained sediments in Sanmen Bay are mainly derived from Yangtze River sediments. The thickness of Holocene deposits in Sanmen Bay ranges from 8.2 to 32.0 m,with an average of 23.4 m and a total sediment volume of 5.06 × 10～4 Mt,accounting for 1% of Yangtze River sediment in this time period. The Bayesian age-depth model based on borehole accelerator mass spectrometry（AMS） C dating shows that a high sedimentation rate occurred in the early and late Holocene but decreased significantly in the mid-Holocene,which is similar to that of the inner shelf of the East China Sea（ECS）. The variation in the Holocene sedimentation rate in Sanmen Bay is related to the southward transport process and mechanism of Yangtze River sediments. The results of this study provide a basis for understanding the source–sink process of sediment in large rivers.

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Finite-time fault tolerant control for spacecraft attitude s...