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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu qian-qian jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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On the Approximation of the Derivatives of Spline Quasi-Interpolation in Cubic Spline Space S_(3)^(1,2)(∆_(mn)^((2)))

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Numerical Mathematics(Theory,Methods and Applications) 2014年第1期7卷 1-22页

作者： jiang qian Fan Wang College of Sciences Hohai UniversityNanjing 210098China Center for Numerical Simulation Software in Engineering and Sciences Department of Engineering MechanicsHohai UniversityNanjing 210098China College of Engineering Nanjing Agricultural UniversityNanjing 210031China

In this paper,based on the basis composed of two sets of splines with distinct local supports,cubic spline quasi-interpolating operators are reviewed on nonuniform type-2 *** variation diminishing operator is defined by discrete linear functionals based on a fixed number of triangular mesh-points,which can reproduce any polynomial of nearly best *** by means of the modulus of continuity,the estimation of the operator approximating a real sufficiently smooth function is reviewed as ***,the derivatives of the nearly optimal variation diminishing operator can approximate that of the real sufficiently smooth function uniformly over quasi-uniform type-2 *** then the convergence results are worked out.

关键词： Bivariate splines conformality of smoothing cofactor method nonuniform type-2 triangulation quasi-interpolation modulus of continuity

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Ergodic stationary distribution of two stochastic tuberculosis models with imperfect vaccination and early and late latency

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International Journal of Biomathematics 2023年第6期16卷 27-56页

作者： qian jiang Zhijun Liu School of Mathematics and Statistics Hubei Minzu University Enshi Hubei445000P.R.China

This contribution probes into ergodic stationary distribution for two stochastic SVELIT(susceptible-vaccinated-early latent-late latent-infective-treated)tuberculosis(TB)models to observe the impact of white noises and color noises on TB control in random *** first investigate the existence and uniqueness of ergodic stationary distribution(EUESD)for the autonomous SVELIT model subject to white noises via the proper Lyapunov functions,and suficient conditions on the extinction of disease are ***,sufficient conditions for the EUESD and the extinction of disease for the SVELIT model with Markov switching are also ***,some numerical examples validate the theoretical ***'s more,it has been observed that higher amplitude noises may lead to the eradication of TB,which is conducive to TB control.

关键词： TB models random perturbations Markov switching ergodic stationary distribution extinction

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Design and Implementation of Secure and Reliable Information Interaction Architecture for Digital Twins

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China Communications 2023年第2期20卷 79-93页

作者： qian Wang Wanwan Wu Liping qian Yiming Cai jiang qian Limin Meng College of Information Engineering Zhejiang University of TechnologyHangzhou 310023China

In order to improve the comprehensive defense capability of data security in digital twins(DTs),an information security interaction architecture is proposed in this paper to solve the inadequacy of data protection and transmission mechanism at ***,based on the advanced encryption standard(AES)encryption,we use the keystore to expand the traditional key,and use the digital pointer to avoid the key transmission in a wireless ***,the identity authentication technology is adopted to ensure the data integrity,and an automatic retransmission mechanism is added for the endogenous properties of the wireless ***,the software defined radio(SDR)platform composed of universal software radio peripheral(USRP)and GNU radio is used to simulate the data interaction between the physical entity and the virtual *** numerical results show that the DTs architecture can guarantee the encrypted data transmitted completely and decrypted accurately with high efficiency and reliability,thus providing a basis for intelligent and secure information interaction for DTs in the future.

关键词： digital twins AES encryption digital pointer identity authentication automatic retransmission SDR

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Empirical Likelihood Confidence Intervals for the Differences of Quantiles with Missing Data

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Acta Mathematicae Applicatae Sinica 2009年第1期25卷 105-116页

作者： Yong-song Qin Yong-jiang qian School of Mathematical Sciences Guangxi Normal University Guilin Guangxi 541004 China

Suppose that there are two nonparametric populations x and y with missing data on both of them. We are interested in constructing confidence intervals on the quantile differences of x and y. Random imputation is used.... 详细信息

关键词： Empirical likelihood confidence Interval quantile missing data imputation

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A new algorithm for pole assignment of single-input linear systems using state feedback

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Science China Mathematics 2005年第3期48卷 307-321页

作者： qian jiang CHENG Mingsong XU Shufang LMAM School of Mathematical Sciences Peking University Beijing 100871 China LMAM School of Mathematical Sciences Peking University Beijing 100871 China LMAM School of Mathematical Sciences Peking University Beijing 100871 China

In this paper we present a new algorithm for the single-input pole assignment problem using state feedback. This algorithm is based on the Schur decomposition of the closed-loop system matrix, and the numerically stable unitary transformations are used whenever possible, and hence it is numerically *** good numerical behavior of this algorithm is also illustrated by numerical examples.

关键词： pole assignment problem, numerical method, Schur decomposition.

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CONSTRUCTION OF CUBATURE FORMULAS VIA BIVARIATE QUADRATIC SPLINE SPACES OVER NON-UNIFORM TYPE-2 TRIANGULATION

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Journal of Computational Mathematics 2022年第2期40卷 205-230页

作者： jiang qian Xiquan Shi Jinming Wu Dianxuan Gong College of Science Hohai UniversityNanjing 211100China Key Laboratory of Coastal Disaster and Defence(Hohai University) Ministry of EducationNanjing 210098China Division of Physics EngineeringMathematicsand Computer ScienceDelaware State UniversityDoverDE 19901USA Statistics and Mathematics Institute Zhejiang Gongshang UniversityHangzhou 310018China College of Science North China University of Science and TechnologyTangshan 063210China

In this paper,matrix representations of the best spline quasi-interpolating operator over triangular sub-domains in S_(2)^(1)(△_(mn)^(2),and coefficients of splines in terms of B-net are calculated ***,by means of coefficients in terms of B-net,computation of bivariate numerical cubature over triangular sub-domains with respect to variables x and y is transferred into summation of coefficients of splines in terms of *** concise bivariate cubature formulas are constructed over rectangular ***,by means of module of continuity and max-norms,error estimates for cubature formulas are derived over both sub-domains and the domain.

关键词： Multivariate spline Bivariate cubature Conformality of Smoothing Cofactor Method B-net Non-uniform Type-2 Triangulation

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Effects of the original state of sodium-based additives on microstructure,surface characteristics and filtration performance of SiC membranes

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Chinese Journal of Chemical Engineering 2023年第11期63卷 1-11页

作者： Yuling Xie Qilin Gu qian jiang Zhaoxiang Zhong Weihong Xing National Engineering Research Center for Special Separation Membrane State Key Laboratory of Materials-Oriented Chemical EngineeringCollege of Chemical EngineeringNanjing Tech UniversityNanjing 210009China School of Environmental Science and Engineering Nanjing Tech UniversityNanjing 211816China

Sodium-contained compounds are promising sintering additives for the low-temperature preparation of reaction bonded SiC *** sodium-based sintering additives in various original states were attempted,their effects on microstructure and surface properties have rarely been *** this work,three types of sodium-based additives,including solid-state NaA zeolite residue(NaA)and liquidstate dodecylbenzene sulfonate(SDBS)and water glass(WG),were separately adopted to prepare SiC membranes,and the microstructure,surface characteristics and filtration performance of these SiC membranes were comparatively *** showed that the SiC membranes prepared with liquid-state SDBS and WG(S-SDBS and S-WG)showed lower open porosity yet higher bending strength compared to those prepared with solid-state NaA(S-NaA).The observed differences in bending strength were further interpreted by analyzing the reaction process of each sintering additive and the composition of the bonding phase in the reaction bonded SiC ***,the microstructural differentiation was correlated to the original state of the *** addition,their surface characteristics and filtration performance for oil-in-water emulsion were examined and correlated to the membrane *** S-NaA samples showed higher hydrophilicity,lower surface roughness(1.80μm)and higher rejection ratio(99.99%)in O/W emulsion separation than those of S-WG and *** can be attributed to the smaller mean pore size and higher open porosity,resulting from the originally solid-state NaA ***,this work revealed the comprehensive effects of original state of sintering additives on the prepared SiC membranes,which could be helpful for the application-oriented fabrication by choosing additives in suitable state.

关键词： SiC membrane Sintering additive Reaction sintering Microstructure Oil-in-water emulsions

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The Bases of the Non-Uniform Cubic Spline Space S_(3)^(1,2)(Δ_(mn)^((2))

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Numerical Mathematics(Theory,Methods and Applications) 2012年第4期5卷 635-652页

作者： jiang qian Renhong Wang Chongjun Li College of Sciences Hohai UniversityNanjing 210098China School of Mathematical Sciences Dalian University of TechnologyDalian 116024China

In this paper,the dimension of the nonuniform bivariate spline space S_(3)^(1,2)(Δ_(mn)^((2))is discussed based on the theory of multivariate spline ***,by means of the Conformality of Smoothing Cofactor Method,the basis ofS_(3)^(1,2)(Δ_(mn)^((2))composed of two sets of splines are worked out in the form of the values at ten domain points in each triangular cell,both of which possess distinct local ***,the explicit coefficients in terms of B-net are obtained for the two sets of splines respectively.

关键词： Bivariate spline conformality of smoothing cofactor method B-net nonuniform type-2 triangulation

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Effects of arbuscular mycorrhizal fungi inoculation on arsenic accumulation by tobacco (Nicotiana tabacum L.)

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Journal of Environmental Sciences 2009年第9期21卷 1214-1220页

作者： HUA Jianfeng LIN Xiangui YIN Rui jiang qian SHAO Yufang State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 China. Institute of Botany Jiangsu Province and the Chinese Academy of Sciences Nanjing 210014 China Soil and Environment Analysis Center Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 China Graduate University of the Chinese Academy of Sciences Beijing 100049 China Bioengineering College of lnner Mongolia Agricultural University Huhhot 010019 China

A pot experiment was conducted to study the effects of arbuscular mycorrhizal （AM） fungi （from contaminated or uncontaminated soils） on arsenic （As） uptake of tobacco （Nicotiana tabacurn L.） in As-contaminated soil. Mycorrhizal colonization rate, dry weight, As and P uptake by plants, concentrations of water-extractable As and As fractions were determined. A low mycorrhizal colonization rate （〈 25%） was detected. Our research indicated that AM fungi isolated from polluted soils were no more effective than those from unpolluted soils when grown in symbiosis with tobacco. No significant differences were observed in roots and stalks dry weights among all treatments. Leaves and total plant dry weights were much higher in Glomus versiforme treatment than that in control treatment. As contents in roots and stalks from mycorrhizal treatments were much lower than that from control treatment. Total plant As content exhibited the same trend. P concentrations in tobacco were not affected by colonization, nor were stalks, leaves and total plant P contents. Roots P contents were remarkably lower in HN treatments than in other treatments. Meanwhile, decreased soil pH and lower water-extractable As concentrations and higher levels of As fraction bound to well-crystallized hydrous oxides of Fe and AI were found in mycorrhizal treatments than in controls. The protective effect of mycorrhiza against plant As uptake may be associated with changes in As solubility mediated by changing soil pH. These results indicated that under As stress, proper mechanisms employed by AM fungi can protect tobacco against As uptake. Results confirmed that AM fungi can play an important role in food quality and safety.

关键词： arbuscular mycorrhizal fungi arsenic tobacco soil pH

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