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Five-year in-orbit background of Insight-HXMT

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Radiation Detection Technology and Methods 2023年第1期7卷 34-47页

作者： jin-Yuan Liao Shu Zhang Juan Zhang Gang Li Zhi Chang Yu-Peng Chen Ming-Yu Ge jing jin xue-Feng Lu Yuan You xue-Lei Cao Yong Chen Yue Huang Wei-Chun jiang Xiao-Bo Li xu-fang Li zheng-Wei Li Cong-Zhan Liu ying Tan yan-Ji yang yi-Fei Zhang Hai-Sheng zhao fang-Jun Lu Yu-Peng xu jin-Lu Qu Li-Ming Song Shuang-Nan Zhang Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences19B Yuquan RoadShijingshan DistrictBeijing 100049China Key Laboratory of Stellar and Interstellar Physics and School of Physics and Optoelectronics Xiangtan UniversityYuhu DistrictXiangtan 411105China University of Chinese Academy of Sciences 19A Yuquan RoadShijingshan DistrictBeijing 100049China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of Sciences20A Datun RoadChaoyang DistrictBeijing 100012China

Purpose We present the five-year in-orbit background evolution of Insight-HXMT since the launch,as well as the effects of the background model in data *** The backgrounds of the three main payloads,i.e.,low-energy telescope,medium-energy telescope,and high-energy telescope,are *** evolution of the background over time is obtained by simply comparing the background in every year during the in-orbit operation of *** The major observational characteristics of the Insight-HXMT in-orbit background are presented,including the light curve,spectrum,geographical distribution,and long-term *** systematic error in background estimation is investigated for every *** The observational characteristics of the five-year in-orbit background are consistent with our knowledge of the satellite design and the space environment,and the background model is still valid for the latest observations of Insight-HXMT.

关键词： Instrumentation:detectors Space vehicles:instruments Methods:data analysis X-rays:general

The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-Li Luo Yong-Heng zhao Gang zhao Li-Cai Deng Xiao-Wei Liu yi-Peng jing Gang wang Hao-Tong Zhang Jian-rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping Li Zhong-Rui Bai Yue Wu yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen Li Chen xue-Lei Chen Xiao-yan Chen ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng Jian-Ning Fu Peng Gao xue-Fei Gong Bo-Zhong Gu yan-Xin Guo Zhan-Wen Han Bo-Liang He jin-Liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-ying Huo Lei Jia fang-Hua jiang Xiang jiang Zhi-Bo jiang Ge jin Xiao Kong xu Kong Ya-Juan Lei Ai-Hua Li Chang-Hua Li Guang-Wei Li Hai-Ning Li Jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li yan Li yin-Bi Li Ye-Ping Li Yuan Liang Chien-Cheng Lin Chao Liu Gen-rong Liu Guan-Qun Liu Zhi-Gang Liu Wen-Zhi Lu Yu Luo yin-Dun Mao Heidi Newberg Ji-Jun Ni zhao-Xiang Qi Yong-Jun Qi Shi-yin Shen Huo-Ming Shi jing Song yi-Han Song Ding-Qiang Su Hong-Jun Su zheng-Hong Tang Qing-Sheng Tao Yuan Tian Dan wang Da-Qi wang Feng-Fei wang Guo-Min wang Hai wang Hong-Chi wang Jian wang Jia-Ning wang Jian-Ling wang Jian-Ping wang Jun-Xian wang Lei wang Meng-Xin wang shou-Guan wang Shu-Qing wang Xia wang Ya-Nan wang You wang Yue-Fei wang You-Fen wang Peng Wei Ming-Zhi Wei Hong Wu Ke-Fei Wu xue-Bing Wu Yu-Zhong Wu Xiao-zheng Xing Ling-Zhe xu Xin-Qi xu yan xu Tai-Sheng yan De-Hua yang Hai-Feng yang Hui-Qin yang Ming yang zheng-Qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng Zhang Hua-Wei Zhang Jian-Nan Zhang Li-Pin Zhang Wei Zhang Yong Zhang yan-Xia Zhang zheng-Chao Zhang Ming zhao fang Zhou xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

Chinese expert consensus on the non-invasive imaging examination pathways of stable coronary artery disease

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Journal of Geriatric Cardiology 2018年第1期15卷 30-40页

作者： Yun-Dai CHEN Wei-yi fang Ji-yan CHEN Zhan-Ming FAN Chuan-Yu GAO Jun-Bo GE Zuo-Xiang HE Yong HUO Lang LI Si-jin LI Xi-Lie LU Bin LV Ju-ying QIAN Ya-Jun SHI Zhu-Jun SHEN jing wang yi-Ning wang Lei xu Li yanG Bo YU Mei ZHANG Jun-Jie yanG Shu-yang ZHANG Xiao-Li ZHANG Shi-Hua zhao yang zheng Yu-Chi HAN Guang ZHI Chinese PLA General Hospital Beijing China Shanghai Chest Hospital Shanghai Jiaotong University Shanghai China Guangdong General Hospital Guangzhou China Beijing Anzhen Hospital Capital Medical University Beijing China Henan Provincial People's Hospital zhengzhou China Zhongshan Hospital Fudan University Shanghai China Fuwai Hospital Chinese Academy of Medical Sciences Beijing China The First Hospital of Peking University Beijing China The First Affiliated Hospital of Guangxi Medical University Nanning China The First Affiliated Hospital of Shanxi Medical University Taiyuan China Peking Union Medical College Hospital Beijing China The 2^nd Affiliated Hospital of Harbin Medical University Harbin China Qilu Hospital of Shandong University Jinan China The First Bethune Hospital of Jilin University Changchun China University of Pennsylvania United States

1 Introduction Early detection and diagnosis of stable coronary artery disease （SCAD） is essential for proactive secondary prevention of myocardial infarction （MI）, control of disease progress, and reduction of mortality. Clinical decision-making in modem medicine is increasingly dependent on cardiovascular imaging techniques. 2012 ACCF/AHA/ACP/AATS/ PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease has been issued by American Heart Association （AHA）. European Society of Cardiology （ESC） has issued 2013 ESC guidelines on the management of stable coronary artery disease.

关键词： Expert consensus Clinical pathway Coronary artery disease Non-invasive imaging examination Pre-test probabilities

CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumorassociated macrophage polarization via FBXW7-N0TCHCCL2/ CSF1 axis

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Signal Transduction and Targeted Therapy 2021年第2期6卷 482-495页

作者： Yao-Hui Huang Kun Cai Peng-Peng xu Li wang Chuan-Xin Huang ying fang Shu Cheng Xiao Jian Sun Feng Liu jin-yan Huang Meng-Meng Ji Wei-Li zhao Shanghai Istitute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRulin Hospital Afliated to Shanghai Jiao Tong University School of MedicineShanghaiChina School of Life Sciences and Biotechnology.Shanghai Jiao Tong Universiy ShanghalChina Department of Immunobiology and Microbiology Shanghai Istitute of ImmunologyShanghai Jiao Tong University School of MedicineShanghaiChina Pole de Recherches Sino Francais en Science du Vivant et Genomique Laboratory of Molecular PathologyShanghalChina

Epigenetic alterations play an important role in tumor progression of diffuse large B-cell lymphoma(DL BCL).However,the biological relevance of epigenetic gene mutations on tumor microenvironment remains to be *** core set of genes relating to histone methylation(KMT2D,KMT2C,EZH2),histone acetylation(CREBBP,EP300),DNA methylation(TET2),and chromatin remodeling(ARID1A)were detected in the training cohort of 316 patients by whole-genome/exome sequencing(WGS/WES)and in the validation cohort of 303 patients with newly diagnosed DL BCL by targeted *** correlation with peripheral blood immune cells and clinical outcomes were *** mechanisms on tumor microenvironment were investigated both in vitro and in *** all 619 DLBCL patients,somatic mutations in KMT2D(19.5%)were most frequently observed,followed by mutations in ARID1A(8.7%),CREBBP(8.4%),KMT2C(8.2%),TET2(7.8%),EP300(6.8%),and EZH2(2.9%).Among them,CREBBP/EP300 mutations were signifcantly associated with decreased peripheral blood absolute lymphocyte-to-monocyte ratios,as well as inferior progression-free and overall *** B-lymphoma cells,the mutation or knockdown of CREBBP or EP300 inhibited H3K27 acetylation,downregulated FBXW7 expression,activated the NOTCH pathway,and downstream CCL2/CSF1 expression,resulting in tumor-associated macrophage polarization to M2 phenotype and tumor cell *** B-lymphoma murine models,xenografted tumors bearing CREBBP/EP300 mutation presented lower H3K27 acetylation,higher M2 macrophage recruitment,and more rapid tumor growth than those with CREBBP/EP300 wild-type control via FBXW7-NOTCH-CCL2/CSF1 *** work thus contributed to the understanding of aberrant histone acetylation regulation on tumor microenvironment as an alternative mechanism of tumor progression in DLBCL.

关键词： FBXW7 P300 macrophage

Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China

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Biomedical and Environmental Sciences 2020年第12期33卷 893-905页

作者： MA yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN yi Pin WU Gui Hui yanG Pu Ye BAI jiang Feng CHEN Hong CHEN Li ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG jin HUANG Qiu Hua HUANG Shao Zhen JI Liang jin Hai Hao LEI Xiao LI Chun yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui wang jing Wei SONG fang Li SUN Sheng wang Dong Ting wang Ming xuan wang Xiao yan wang yin Zhen wang Yu Dong WU Wei WU Lan Ping XIAO yan Hua XIE Hai Jun xu Hong Ming xu shou fang xuE Rui Xia yanG Chun yanG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG jin Bo ZHANG Lin Song zhao Shu Sen zhao Wan ying zheng Kai ZHOU ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min wang yan Ping wang Yong yan 无 Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Centre for Health Management and Policy Research School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Department of Tuberculosis The Public Health Clinical Center of ChengduChengdu 610066SichuanChina Department of Infectious Disease Shaanxi Infectious Disease HospitalXi'an 610113ShaanxiChina Department of Infectious Disease Yulin Chinese Medicine HospitalYulin 719000ShaanxiChina President's Office The First Hospital of QiqiharQiqihar 161005HeilongjiangChina Department of Traditional Chinese Medicine Shangluo Central HospitalShangluo 726000ShaanxiChina Department of Traditional Chinese Medicine The People's Hospital of QitaiheQitaihe 154603HeilongjiangChina Department of Scientific Research Xianyang Central HospitalXianyang 712000ShaanxiChina Department of traditional Chinese medicine The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230012AnhuiChina Department of Infectious Disease Heping Hospital Affiliated to Changzhi Medical CollegeChangzhi 046000ShanxiChina Department of Traditional Chinese Medicine Langfang Hospital of Chinese MedicineLangfang 065000HeibeiChina Department of Traditional Chinese Medicine Xingtai Hospital of Chinese MedicineXingtai 054001HeibeiChina Department of Traditional Chinese Medicine The People's Hospital of Guangxi Zhuang Autonomous RegionNanning 168600GuangxiChina Department of Traditional Chinese Medicine The First People'sHospital of FangchenggangFangchenggang 538001GuangxiChina Department of Traditional Chinese Medicine Mianyang Hospital of Traditional Chinese MedicineMianyang 621000SichuanChina Department of Traditional Chinese Medicine Liuzhou People's HospitalLiuzhou 545006GansuChina Department of Traditional Chinese Medici

Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains *** A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of *** Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two *** Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes.

关键词： Comorbidities COVID-19 Severity Gender Age Treatment outcome

Specific pupylation as IDEntity reporter(SPIDER)for the identification of protein-biomolecule interactions

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Science China(Life Sciences) 2023年第8期66卷 1869-1887页

作者： He-Wei jiang Hong Chen Yun-Xiao zheng xue-Ning wang Qingfeng Meng jin Xie Jiong Zhang ChangSheng Zhang zhao-Wei xu Zi-Qing Chen Lei wang Wei-Sha Kong Kuan Zhou Ming-Liang Ma Hai-Nan Zhang Shu-Juan Guo Jun-Biao xue jing-Li Hou Zhe-yi Liu Wen-xue Niu fang-Jun wang Tao wang Wei Li Rui-Na wang Yong-Jun Dang Daniel MCzajkowsky JianFeng Pei Jia-Jia Dong Sheng-Ce Tao Shanghai Center for Systems Biomedicine Key Laboratory of Systems Biomedicine(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200240China Center for Quantitative Biology Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province School of PharmacyAnhui Medical UniversityHefei 230032China Key Laboratory of Organofluorine Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of the Chinese Academy of SciencesChinese Academy of SciencesShanghai 200240China College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China Key Laboratory of Gastrointestinal Cancer(Fujian Medical University) Ministry of EducationFuzhou 350122China Department of Molecular Biology Princeton UniversityNew Jersey 08540USA Instrumental Analysis Center Shanghai Jiao Tong UniversityShanghai 200240China CAS Key Laboratory of Separation Sciences for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Institute of Systems Biology Shenzhen Bay LaboratoryPeking University Shenzhen Graduate SchoolShenzhen 518055China Department of Medicinal Chemistry School of PharmacyChina Pharmaceutical UniversityNanjing 211198China Key Laboratory of Metabolism and Molecular Medicine the Ministry of EducationDepartment of Biochemistry and Molecular BiologySchool of Basic Medical SciencesFudan UniversityShanghai 200240China Center for Novel Target and Therapeutic Intervention Chongqing Medical UniversityChongqing 400016China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Protein-biomolecule interactions play pivotal roles in almost all biological *** a biomolecule of interest,the identification of the interacting protein(s)is *** this need,although many assays are available,highly robust and reliable methods are always *** combining a substrate-based proximity labeling activity from the pupylation pathway of Mycobacterium tuberculosis and the streptavidin(SA)-biotin system,we developed the Specific Pupylation as IDEntity Reporter(SPIDER)method for identifying protein-biomolecule *** SPIDER,we validated the interactions between the known binding proteins of protein,DNA,RNA,and small *** successfully applied SPIDER to construct the global protein interactome for m^(6)A and m RNA,identified a variety of uncharacterized m^(6)A binding proteins,and validated SRSF7 as a potential m^(6)A *** globally identified the binding proteins for lenalidomide and Cob ***,we identified SARS-CoV-2-specific receptors on the cell ***,SPIDER is powerful and highly accessible for the study of proteinbiomolecule interactions.

关键词： proximity labeling protein-biomolecule interaction proteomics pupylation

Data processing and data products from 2017 to 2019 campaign of astronomical site testing at Ali,Daocheng and Muztagh-ata

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Research in Astronomy and Astrophysics 2020年第6期20卷 109-130页

作者： Zi-Huang Cao jin-Xin Hao Lu Feng Hugh RAJones Jian Li jing xu Li-Yong Liu Teng-Fei Song Jian-Feng wang Hua-Lin Chen yan-Jie xue Huang Shen Yong-Heng zhao zhao-Xiang Qi Jian-rong Shi Yuan Tian zheng wang Xia wang jin-Liang Hou jin-Ming Bai Ji yang xu Zhou Yong-Qiang Yao Jia yin Ali Esamdin Guang-Xin Pu Peng Wei Chun-Hai Bai Guo-Jie Feng Lu Ma xuan Zhang Yu Liu Chong Pei Zhi-Xia Shen Yun-ying jiang Jian-Feng Tian Xian-Qun Zeng Zhi-Gang Hou xu yang Jun-Bo Zhang Shi-Long Liao Dong-Wei Fan Yun-Fei xu Jian-Ping Xiong Tai-Sheng yan Xi Zhang Chang-Hua Li yi-Han Tao Si-Cheng Yu Zhi-Song Cao Hong-Shuai wang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Centre for Astrophysics University of HertfordshireHatfieldUK School of Journalism Communication University of ChinaBeijing 100024China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Yunnan Observatories Chinese Academy of SciencesKunming 650216China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210033China Beijing Kaiyang Space Technology Co. LtdBeijing 100085China

Based on previous site testing and satellite cloud data,Ali,Daocheng and Muztagh-ata have been selected as candidate sites for the Large Optical/Infrared Telescope(LOT) in *** present the data collection,processing,management and quality analysis for our site testing based on using similar *** analyze meteorological data,seeing,background light,cloud and precipitable water vapor data from 2017 March 10 to 2019 March *** also investigated the relative usefulness of our all-sky camera data in comparison to that from the meteorological TERRA satellite data based on a night-by-night comparison of the correlation and consistency between *** find a 6% discrepancy arising from a wide range of factors.

关键词： LOT Site-selection-data processing

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu yang Guo-Wen yin Bin-yan Zhong Jun-Hui Sun Zhi-Cheng jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui zhao Shu-Wei Wen yan-Ming Lei Yu-Sheng Song Chun-wang Yuan Wei-Dong wang Ming Huang Wei zhao Jian-Bing Wu Song wang xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui xu Wen-Hao Hu Qiang Tu Hong-ying Su Chuan-Sheng zheng Yong Chen xu-Ya zhao Zhu-Ting fang Qi wang jin-Wei zhao Ai-Bing xu Jian xu Qing-Hua Wu Huan-Zhang Niu Jian wang Feng Dai Dui-Ping Feng Qing-Dong Li rong-Shu Shi Jia-Rui Li Guang yang Hai-Bin Shi Jian-Song Ji Yu-E Liu zheng Cai Po yang yang zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of Interventional Radiology Nantong First People’s HospitalNantong 226001China Department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,228 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,*** results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching

Long-term analysis of clear nights using satellite data considering astronomical sites in western China

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Research in Astronomy and Astrophysics 2020年第6期20卷 96-108页

作者： Zi-Huang Cao Li-Yong Liu Yong-Heng zhao Lu Feng Hugh RAJones Huang Shen jin-Xin Hao yan-Jie xue Yong-Qiang Yao jing xu Ali Esamdin zhao-Xiang Qi Jian-rong Shi Jian Li Yuan Tian zheng wang Tai-Sheng yan Xia wang Jian-Ping Xiong Si-Cheng Yu Jun-Bo Zhang Zhi-Xia Shen Yun-ying jiang Jia yin Guang-Xin Pu Peng Wei Chun-Hai Bai Guo-Jie Feng Lu Ma Teng-Fei Song Jian-Feng wang Jian-Feng Tian Xian-Qun Zeng Zhi-Gang Hou Shi-Long Liao Zhi-Song Cao Dong-Wei Fan Yun-Fei xu Chang-Hua Li yi-Han Tao National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Centre for Astrophysics University of HertfordshireHatfieldUK School of Journalism.Communication University of China Beijing 100024China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Yunnan Observatories Chinese Academy of SciencesKunming 650216China

A large ground-based optical/infrared telescope is being planned for a world-class astronomical site in *** cloud-free night percentage is the primary meteorological consideration for evaluating candidate *** data from GMS and NOAA satellites and the MODIS instrument were utilized in this research,covering the period from 1996 to *** data analysis benefits from overlapping results from different independent teams as well as a uniform analysis of selected sites using GMS+NOAA *** significant ground-based monitoring is needed to validate these findings,we identify three different geographical regions with a high percentage of cloud-free conditions(~83%on average),which is slightly lower than at Mauna Kea and Cerro Armazones(~85%on average)and were chosen for the large international projects TMT and ELT *** study finds evidence that cloud distributions and the seasonal changes affected by the prevailing westerly winds and summer monsoons reduce the cloud cover in areas influenced by the *** is consistent with the expectations from climate change models and is suggestive that most of the identified sites will have reduced cloud cover in the future.

关键词： methods statistical-site testing-atmospheric effects-MODIS