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The Mining of Citrus EST-SNP and Its Application in Cultivar Discrimination

Agricultural Sciences in China 2010年第2期9卷 179-190页

作者： jiang dong ye qing-liang wang fu-sheng cao li Citrus Research Institute Chinese Academy of Agricultural Sciences Chongqing 400712 P.R.China

Single nucleotide polymorphisms （SNPs） are the most abundant sequence variations found in plant genomes and are widely used as molecular genetic markers in cultivar identification and genetic diversity studies. The objective of this study was to identify SNP markers useful for discrimination of citrus cultivars, since large numbers of expressed sequence tags （ESTs） of sweet orange are available from the National Center for Biotechnology Information （NCBI）. We now have the opportunity to discover SNP markers suitable for determining the haplotypes with which to distinguish very closely related cultivars and to assess genetic diversity within or between related species of citrus. SNPs and small insertions/deletions （Indels） from ESTs of sweet orange and satsuma were identified by the in silico SNP discovery strategy. 55 296 EST sequences of sweet orange and 2 575 of satsuma retrieved from the NCBI repository were mined for potential SNPs. Cleaved amplified polymorphic sequences （CAPS） and sequencing approaches were used to validate putative SNPs in a sample of 30 citrus accessions. A total of 3 348 putative SNPs were identified based on the abundance of sequences and haplotype cosegregation. Of these 3 348 SNPs, the transitions, transversions and Indels ratios were 47.9, 36.1 and 16.0%, respectively. The SNPs occurred on average at a frequency of 1 per 164 bp in the coding region of citrus. 14 SNPs were randomly selected and genotyped according to 30 citrus accessions including 23 accessions of sweet orange; 11 SNPs displayed polymorphism with an average polymorphism information content （PIC） of 0.20 among 30 citrus accessions. The genetic diversity present in sweet orange was low, so the 14 SNP markers failed to discriminate different cultivars of sweet orange, but they did succeed in distinguishing accessions of inter-species of citrus. In this study, SNPs were mined from EST sequences of sweet orange and satsuma, which displayed potential capability as molecular ma

关键词： citrus single nucleotide polymorphisms (SNPs) EST-SNP cleaved amplified polymorphic sequences (CAPS)

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Risk assessment of fault reactivation considering the heterogeneity of friction strength in the BZ34-2 Oilfield,Huanghekou Sag,Bohai Bay Basin,China

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Petroleum Science 2023年第5期20卷 2695-2708页

作者： ye-Jun Jin ling-dong Meng Ding-You Lyu Xiao-Fei fu jiang-Bo Huang Si-Jia cao Jian-Da li School of Earth Sciences Northeast Petroleum UniversityDaqing 163318HeilongjiangChina Key Laboratory of Oil&Gas Reservoir and Underground Gas Storage Integrity Evaluation of Heilongjiang Province Northeast Petroleum UniversityDaqing 163318HeilongjiangChina Bohai Rim Energy Research Institute Northeast Petroleum UniversityQinhuangdao066004HebeiChina CNOOC Tianjin Company Tianjin 300459China

The hazards of fault reactivation caused by fluid injection are a growing ***,traditional evaluation methods of fault stability are likely to underestimate the risk in fault segments with a high clay ***,an extended evaluation method of fault stability(ECPP)incorporating the heterogeneity in friction strength caused by variation in the clay content within the fault zone is established in this *** characterizing the current stress field of the BZ34-2 Oilfield in the Huanghekou Sag,Bohai Bay Basin,the reactivation potential of faults is evaluated using both traditional and ECPP *** evaluation of fault stability shows that all faults are stable in the present stress *** oriented ENE have a relatively high *** maximum sustainable fluid pressure Δp is approximately 8.8-8.9 MPa and 9.3-9.9 *** considering the heterogeneity in fault friction strength,the fault stability is clearly controlled by the clay content of the *** high-risk fault segments assessed using traditional methods are no longer obvious,which reflects the importance of incorporating friction strength heterogeneity in the process of fault ***,the results also show that most fault segments are activated when the fault zone is dominated by montmorillonite,reflecting the strong influence of clay mineral types on fault *** factors influencing the heterogeneity of fault friction strength are very complicated in actual ***,future work should focus on establishing a database through a large number of experiments and investigating the relationship between the friction coefficient and the main controlling factors.

关键词： Faultreactivation In-situ stress Strength heterogeneity of fault friction Huanghekou Sag

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Targeted metabolomics study of fatty-acid metabolism in lean metabolic-associated fatty liver disease patients

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World Journal of Gastroenterology 2024年第27期30卷 3290-3303页

作者： Pei-Qi Sun Yi-fu Yuan Qin cao Xiao-Yan Chen Yuan-ye jiang Wen-Min dong li-li Guo Department of Gastroenterology Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai 200062China Department of Pharmacy Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghai 201399China Central Laboratory Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China

BACKGROUND The annual incidence of metabolic-associated fatty liver disease(MAFLD)in China has been increasing and is often overlooked owing to its insidious *** 50%of the patients have a normal weight or are not *** are said to have lean-type MAFLD,and few studies of such patients are *** MAFLD is associated with abnormal lipid metabolism,lipid-targeted metabolomics was used in this study to provide experimental evidence for early diagnosis and *** and analyze metabolic ***-Q-Orbitrap/MS content determination was used to determine serum palmitic acid(PA),oleic acid(OA),linoleic acid(LA),and arachidonic acid(AA)levels in lean-type MAFLD *** Urea nitrogen and uric acid levels were higher in lean-type MAFLD patients than in healthy individuals(Plinesterase levels were higher in lean-type MAFLD patients than in healthy indi-viduals(Plipoprotein and apolipoprotein A-1 were lower in lean-type MAFLD patients than in healthy individuals(Plism of fatty acids were found with P*** levels of PA,OA,LA,and AA were significantly increased compared with healthy *** The metabolic profiles of lean-type MAFLD patients and healthy participants differed significantly,yielding 65 identified ***,OA,LA,and AA exhibited the most significant changes,offering valuable clinical guidance for prevention and treatment of lean-type MAFLD.

关键词： Lean-type metabolic-associated fatty liver disease Targeted serum metabolomics Fatty acids Principal component analysis Orthogonal partial least squares-discriminant analysis

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Chromosome-scale genome sequence of Suaeda glauca sheds light on salt stress tolerance in halophytes

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Horticulture Research 2023年第9期10卷 233-246页

作者： Yan Cheng Jin Sun Mengwei jiang Ziqiang Luo Yu wang Yanhui liu Weiming li Bing Hu Chunxing dong Kangzhuo ye Zixian li Fang Deng Lulu wang ling cao Shijiang cao Chenglang Pan Ping Zheng sheng wang Mohammad Aslam Hong wang Yuan Qin State Key Laboratory of Ecological Pest Control for fujian and Taiwan Crops College of Plant ProtectionFujian Provincial Key Laboratory of Haixia Applied Plant Systems BiologyCenter for Genomics and BiotechnologyCollege of Life ScienceFujian Agriculture and Forestry UniversityFuzhou 350002China Pingtan Institute of Science and Technology Fujian Agriculture and Forestry UniversityFuzhou 350400China Department of Biochemistry Microbiology and ImmunologyUniversity of SaskatchewanSaskatoonSK S7N 5E5Canada College of Agriculture Fujian Agriculture and Forestry UniversityFuzhou 350002China College of Forestry Fujian Agriculture and Forestry UniversityFuzhou 350002China fujian Key Laboratory on Conservation and Sustainable Utilization of Marine Biodiversity Fuzhou Institute of OceanographyMinjiang UniversityFuzhou 350108China

Soil salinity is a growing concern for global crop production and the sustainable development of ***,it is crucial to comprehend salt tolerance mechanisms and identify salt-tolerance genes to enhance crop tolerance to salt *** glauca,a halophyte species well adapted to the seawater environment,possesses a unique ability to absorb and retain high salt concentrations within its cells,particularly in its leaves,suggesting the presence of a distinct mechanism for salt *** this study,we performed de novo sequencing of the *** *** genome has a size of 1.02 Gb(consisting of two sets of haplotypes)and contains 54761 annotated genes,including alleles and *** genomic analysis revealed a strong synteny between the genomes of *** and Beta *** the *** genome,70.56%comprises repeat sequences,with retroelements being the most *** the allele-aware assembly of the *** genome,we investigated genome-wide allele-specific expression in the analyzed *** results indicated that the diversity in promoter sequences might contribute to consistent allele-specific ***,a systematic analysis of the ABCE gene families shed light on the formation of ***’s flower morphology,suggesting that dysfunction of A-class genes is responsible for the absence of petals in *** family expansion analysis demonstrated significant enrichment of Gene Ontology(GO)terms associated with DNA repair,chromosome stability,DNA demethylation,cation binding,and red/far-red light signaling pathways in the co-expanded gene families of *** and ***,in comparison with glycophytic species within the chenopodium ***-course transcriptome analysis under salt treatments revealed detailed responses of *** to salt tolerance,and the enrichment of the transition-upregulated genes in the leaves associated with DNA repair and chromosome stability,lipid biosynthetic process,an

关键词： light expanded tolerance

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Using preoperative N-terminal pro-B-type natriuretic peptide levels for predicting major adverse cardiovascular events and myocardial injury after noncardiac surgery in Chinese advanced-age patients

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Journal of Geriatric Cardiology 2022年第10期19卷 768-779页

作者： Kai ZHANG Chang liU Jian TAN Yu-Hai XU jiang-Bei cao Yan-Hong liU Qiang fu Jing-sheng LOU Wei-dong MI Hao li Department of Anesthesiology the First Medical CentreChinese PLA General HospitalBeijingChina Medical School of Chinese PLA BeijingChina Department of Thoracic Surgery the Seventh Medical CentreChinese PLA General HospitalBeijingChina Department of Anesthesiology Air Force Medical CenterBeijingChina

BACKGROUND N-terminal pro-B-type natriuretic peptide(NT-proBNP)is often viewed as an indicator for heart ***,the prognostic association and the predictive utility of NT-proBNP for postoperative major adverse cardiovascular events(MACEs)and myocardial injury after noncardiac surgery(MINS)among older patients are *** In this study,we included 5033 patients aged 65 years or older who underwent noncardiac surgery with preoperative NT-proBNP *** regression was adopted to model the associations between preoperative NT-proBNP and the risk of MACEs and *** receiver operating characteristic curve was used to determine the predictive value of *** A total of 5033 patients were enrolled,63 patients(1.25%)and 525 patients(10.43%)had incident postoperative MACEs and MINS,*** of the receiver operating characteristic curve indicated that the cutoff values of ln(NT-proBNP)for MACEs and MINS were 5.16(174 pg/mL)and 5.30(200 pg/mL),*** preoperative ln(NT-proBNP)to the Revised Cardiac Risk Index score and the Cardiac and Stroke Risk Model boosted the area under the receiver operating characteristic curves from 0.682 to 0.726 and 0.787 to 0.804,*** inclusion of preoperative NT-proBNP in the prediction models significantly increased the reclassification and *** Increased preoperative NT-proBNP was associated with a higher risk of postoperative MACEs and *** inclusion of NT-proBNP enhances the predictive ability of the preexisting models.

关键词： patients preoperative surgery

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His bundle pacing versus left bundle branch pacing on ventricular function in atrial fibrillation patients referred for pacing:a prospective crossover comparison

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Journal of Geriatric Cardiology 2023年第1期20卷 51-60页

作者： Yang ye Bo GAO Yuan LV Tian-Tian XU Si-Si ZHANG Xiao-li LU Ying YANG dong-Mei jiang Yi-Wen PAN Xia sheng Bei wang Yan-Kai MAO Zu-Wen ZHANG Shi-Quan CHEN Jie-Fang ZHANG li wang jiang-Fen jiang Ya-Xun SUN Yan MA Fei-ling wang Min wang Hong HE Chen-Yang jiang Guo-sheng fu Department of Cardiology Sir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Cardiology Zhejiang Rongjun HospitalJiaxingZhejiang ProvinceChina Department of Cardiology Lishui People’s HospitalLishuiZhejiang ProvinceChina Department of Cardiology Ningbo Ninth HospitalNingboZhejiang ProvinceChina Department of Cardiology Anji people’s HospitalNingboZhejiang ProvinceChina Department of Diagnostic Ultrasound and Echocardiography Sir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina

BACKGROUND His bundle pacing(HBP)and left bundle branch pacing(LBBP)both provide physiologic pacing which maintain left ventricular *** both improve heart failure(HF)symptoms in atrial fibrillation(AF)*** aimed to assess the intra-patient comparison of ventricular function and remodeling as well as leads parameters corresponding to two pacing modalities in AF patients referred for pacing in intermediate *** Uncontrolled tachycardia AF patients with both leads implantation successfully were randomized to either *** measurements,New York Heart Association(NYHA)classification,quality-of-life assessments and leads parameters were obtained at baseline and at each 6-month follow *** ventricular function including the left ventricular endosystolic volume(LVESV),left ventricular ejection fraction(LVEF)and right ventricular(RV)function quantified by tricuspid annular plane systolic excursion(TAPSE)were all *** Consecutively twenty-eight patients implanted with both HBP and LBBP leads successfully were enrolled(69.1±8.1 years,53.6% male,LVEF 59.2%±13.7%).The LVESV was improved by both pacing modalities in all patients(n=23)and the LVEF was improved in patients with baseline LVEF at less than 50%(n=6).The TAPSE was improved by HBP but not LBBP(n=23).CONCLUSION In this crossover comparison between HBP and LBBP,LBBP was found to have an equivalent effect on LV function and remodeling but better and more stable parameters in AF patients with uncontrolled ventricular rates referred for atrioventricular node(AVN)*** could be preferred in patients with reduced TAPSE at baseline rather than LBBP.

关键词： ventricular patients bundle

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Plasma pharmacological study on Da Huang Zhe Chong capsule on platelet aggregation of normal person

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Journal of Central South University of Technology 2005年第z1期12卷 326-330页

作者： wang dong-sheng CHEN Fang-ping XIAO Chang-jiang HE Shi-lin fu Bin li Xin cao Xing-yu CHEN Yan XIE Qin-zhi Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China

Objective To develop a plasma pharmacological method evaluates the effect of Da Huang Zhe Chong capsule on platelet aggregation and its mechanism, which is a representative Traditional Chinese Medicine Patent Prescription Promoting blood circulation by removing blood stasis. Methods Platelets specimens from healthy volunteers made serum and plasma with medicine, while platelet PRP were separated, which were divided into 8groups,i.e. auto-serum, allo-serum, serum with Da Huang Zhe Chong capsule , serum with aspirin, auto-plasma, plasma with Da Huang Zhe Chong capsule, plasma with aspirin, every group added to serum and plasma to hatch. After ADP and adrenalin were added into the specimens and hatched, the effects of specimens on platelet aggregation were observed. Results After ADP adrenalin were added, all the serum groups did not present platelet aggregation,while all the plasma group presented platelet aggregation. P1, P5, Pmax, t and TM have no significant difference (P＞0. 05) between auto-plasma group and allo-plasma group induced by ADP and adrenalin. P1, P5, t and Pmax have significant differences (P＜0. 01) and TM decreased significantly (P＜0. 05) comparing plasma group with Da Huang Zhe Chong capsule and plasma group of aspirin to allo-plasma group. P1, t and Pmax have significant difference (P＜0.05), and P5 and TM are simulate comparing plasma group with Da Huang Zhe Chong capsule to plasma group of aspirin. P1, P5, t and Pmax have significant differences (P＜0. 01), P1, TM have also significant(P＜0. 05), comparing plasma group of Da Huang Zhe Chong capsule with plasma of aspirin to allo-plasma group induced by adrenalin. P1 ,P5 and Pmax have significant differences (P＜0.05), and t and Pmax are simulate comparing plasma group with Da Huang Zhe Chong capsule with plasma group of aspirin. Conclusion The serum pharmacological study is inappropriate to study platelet aggregation in vitro. The plasma pharmacological study is inappropriate to study platelet aggrega

关键词： Da Huang Zhe Chong capsule plasma pharmacology platelet aggregation

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Advances in nuclear detection and readout techniques

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Nuclear Science and Techniques 2023年第12期34卷 281-358页

作者： Rui He Xiao‑Yang Niu Yi wang Hong‑Wei liang Hong‑Bang liu ye Tian Hong‑lin Zhang Chao‑Jie Zou Zhi‑Yi liu Yun‑Long Zhang Hai‑Bo Yang Ju Huang Hong‑Kai wang Wei‑Jia Han Bei cao Gang Chen Cong Dai li‑Min Duan Rui‑Rui Fan Fang‑Fa fu Jian‑Hua Guo dong Han Wei jiang Xian‑Qin li Xin li Zhuo‑Dai li Yu‑Tie liang Shun liao De‑Xu lin Cheng‑Ming liu Guo‑Rui liu Jun‑Tao liu Ze Long Meng‑Chen Niu Hao Qiu Hu Ran Xiang‑Ming Sun Bo‑Tan wang Jia wang Jin‑Xiang wang Qi‑lin wang Yong‑sheng wang Xiao‑Chuan Xia Hao‑qing Xie He‑Run Yang Hong Yin Hong Yuan Chun‑Hui Zhang Rui‑Guang Zhao Ran Zheng Cheng‑Xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China Key Laboratory of Particle and Radiation Imaging Department of Engineering PhysicsTsinghua UniversityBeijing 100084China School of Integrated Circuits Dalian University of TechnologyDalian 116020China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Electronic Engineering School Heilongjiang UniversityHarbin 150080China Spallation Neutron Source Science Center Dongguan 523803China Micro‑electronic Department Harbin Institute of TechnologyHarbin 150001China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210034China liaoning Academy of Materials Shenyang 110167China Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly School of Mathematics and Physics Chengdu University of TechnologyChengdu 620035China PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710129China State Key Lab of Superhard Materials College of PhysicsJilin UniversityChangchun 130012China School of Computer Science Northwestern Polytechnical UniversityXi’an 710129China

“A Craftsman Must Sharpen His Tools to Do His Job,”said *** detection and readout techniques are the foundation of particle physics,nuclear physics,and particle astrophysics to reveal the nature of the ***,they are being increasingly used in other disciplines like nuclear power generation,life sciences,environmental sciences,medical sciences,*** article reviews the short history,recent development,and trend of nuclear detection and readout techniques,covering Semiconductor Detector,Gaseous Detector,Scintillation Detector,Cherenkov Detector,Transition Radiation Detector,and Readout *** explaining the principle and using examples,we hope to help the interested reader underst and this research field and bring exciting information to the community.

关键词： Silicon detector Wide bandgap detector Time projection chamber(TPC) Multigap resistive plate chamber detector(MRPC) Scintillation detector Calorimeters Cherenkov detector Transition radiation detector Artificial intelligence Trigger-less readout

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Updated diagnosis, treatment and prevention of COVID-19 in children: experts' consensus statement (condensed version of the second edition)

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World Journal of Pediatrics 2020年第3期16卷 232-239页

作者： Kun-ling Shen Yong-Hong Yang Rong-Meng jiang Tian-You wang dong-Chi Zhao Yi jiang Xiao-Xia Lu Run-Ming Jin Yue-Jie Zheng Bao-Ping Xu Zheng-De Xie Zhi-sheng liu Xing-wang li li-Kai lin Yun-Xiao Shang Sai-Nan Shu Yan Bai Min Lu Gen Lu Ji-Kui Deng Wan-Jun Luo li-Juan Xiong Miao liu Yu-Xia Cui Le-Ping ye Jia-fu li Jian-Bo Shao li-Wei Gao Yong-Yan wang Xue-Feng wang Global Pediatric Pulmonology Alliance China National Clinical Research Center for Respiratory Diseases Department of Respiratory MedicineBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijingChina Institute of Infectious Disease Beijing Ditan HospitalCapital Medical UniversityBeijingChina Center of Hematologic Oncology National Center for Children's HealthBeijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatrics Zhongnan Hospital of Wuhan UniversityWuhanChina Department of Pediatrics Renmin Hospital of Wuhan UniversityWuhanChina Department of Respiratory Medicine Wuhan Children's HospitalTongji Medical College of Huazhong University of Science and TechnologyWuhanChina Department of Pediatrics Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanChina Department of Respiratory Medicine Shenzhen Children's HospitalShenzhenChina China National Clinical Research Center for Respiratory Diseases Beijing Institute of PediatricsBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthResearch Unit of Critical Infection in ChildrenChinese Academy of Medical SciencesBeijing 2019RU016China Department of Neurology Wuhan Children's HospitalTongji Medical College of Huazhong University of Science and TechnologyWuhanChina Institute of Hospital Management Wuhan UniversityZhongnan Hospital of Wuhan UniversityWuhanChina Department of Pediatric Respiratory Shengjing Hospital of China Medical UniversityShenyangChina Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Respiratory Medicine Children's Hospital of ShanghaiShanghaiChina Department of Respiratory Medicine Guangzhou Women and Children's Medical CenterGuangzhouChina Department of Infectious Diseases Shenzhen Children's HospitalShenzhenChina Office of Infection Management Wuhan Children's Ho

In the early February,2020,we called up an experts' committee with more than 30 Chinese experts from 11 national medical academic organizations to formulate the first edition of consensus statement on diagnosis,treatment and prevention of coronavirus disease 2019 (COVID-19) in children,which has been published in this *** accumulated experiences in the diagnosis and treatment of COVID-19 in children,we have updated the consensus statement and released the second edition *** current version in English is a condensed version of the second edition of consensus statement on diagnosis,treatment and prevention of COVID-19 in *** the current version,diagnosis and treatement criteria have been optimized,and early identification of severe and critical cases is *** early warning indicators for severe pediatric cases have been summarized which is utmost important for clinical *** version of experts consensus will be valuable for better prevention,diagnosis and treatment of COVID-19 in children worldwide.

关键词： Children COVID-19 Infection SARS-CoV-2 Treatment

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Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi Su Sun-Bin ling Qiao-Nan Shan Xu-Yong Wei Rui wang Chang-Ku Jia li Zhuang Tian Shen li-Min Ding Zhi-Dan Xu Lai-Bang Luo li-Bo Sun Guang-Ming li Tai-Shi Fang Nan jiang Kun Zhang Zhao-Jie Su Zhi-Hai Peng Ren Lang Tao jiang Qiang He lin-Sen ye Yang Yang Yu-Ting He Wen-Zhi Guo liu-Gen Lan Xu-Yong Sun dong Chen Zhi-Shui Chen Da-Wei Zhou Shao-Jun ye Qi-Fa ye Min Tian Jian-Hua Shi Bo wang jiang liu Qian Lu Wei Rao Jin-Zhen Cai Tao Lv Jia-Yin Yang Pu-Sen wang lin Zhong Jing-sheng Ma Qi-Gen li sheng-dong Wu Chang-jiang Lu Cai-De Lu dong-Hua Zhang Xuan wang Zi-Qiang li Mu-Jian Teng Jun-Jie li Wen-Tao jiang Jian-Hua li Quan-Bao Zhang Ning-Qi Zhu Zheng-Xin wang Kang He Qiang Xia Shao-Hua Song Zhi-Ren fu Wei Qiu Guo-Yue Lv Rui-Peng Song Ji-Zhou wang Zheng wang Jian Zhou Gang Chen Ying-Peng Zhao li li Ze-Min Hu Qi-Jie Luo Zhong-Zhou Si Bin Xie Xiao-Shun He Zhi-Yong Guo Shu-Sen Zheng Xiao Xu Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of Hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatic Surgery and liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma liver transplantation Conversion

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