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Bioinspired Hemostatic Strategy via Pulse Ejections for Severe Bleeding Wounds

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Research 2024年第1期2023卷 281-299页

作者： bitao Lu Enling Hu Weiwei Ding Wenyi Wang Ruiqi Xie Kun Yu Fei Lu Guangqian Lan Fangyin Dai State Key Laboratory of Silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing 400715China Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile Chongqing 400715China Division of Trauma and Surgical Intensive Care Unit Research Institute of General SurgeryJinling HospitalMedical School of Nanjing UniversityNanjing210002 Jiangsu ProvinceChina Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHong KongChina

Efficient hemostasis during emergency trauma with massive bleeding remains a critical challenge in prehospital settings.Thus,multiple hemostatic strategies are critical for treating large bleeding wounds.In this study,inspired by bombardier beetles to eject toxic spray for defense,a shape-memory aerogel with an aligned microchannel structure was proposed,employing thrombin-carrying microparticles loaded as a built-in engine to generate pulse ejections for enhanced drug permeation.Bioinspired aerogels,after contact with blood,can rapidly expand inside the wound,offering robust physical barrier blocking,sealing the bleeding wound,and generating a spontaneous local chemical reaction causing an explosivelike generation of CO_(2) microbubbles,which provide propulsion thrust to accelerate burst ejection from arrays of microchannels for deeper and faster drug diffusion.The ejection behavior,drug release kinetics,and permeation capacity were evaluated using a theoretical model and experimentally demonstrated.This novel aerogel showed remarkable hemostatic performance in severely bleeding wounds in a swine model and demonstrated good degradability and biocompatibility,displaying great potential for clinical application in humans.

关键词： wound sealing offering

Quercetin regulates depression-like behavior in CUMS rat models via TLR4/NF-κB signaling

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BIOCELL 2024年第5期48卷 731-744页

作者： YUANYUAN LI bitao ZHANG ZILONG CUI PEIJIAN FAN SHAOXIAN WANG College of Basic Medicine Hebei University of Chinese MedicineShijiazhuang050200China Hebei Key Laboratory of Integrated Chinese and Western Medicine for Lung Disease Research Shijiazhuang050091China

Background:Depression is becoming increasingly prevalent around the world,imposing a substantial burden on individuals,families,as well as society.Quercetin is known to be highly effective in treating depression.However,additional research is needed to dissect the mechanisms of its anti-depressive effects.Methods:For this study,Sprague-Dawley(SD)rats were randomized into the control,model,quercetin,or fluoxetine group.The latter three groups were exposed to chronic unpredictable mild stress(CUMS)for 42 d.The first two groups received saline solution daily via oral gavage.Meanwhile,the quercetin group was orally administered a quercetin suspension(52.08 mg/kg)every day,while the fluoxetine group was orally administered a fluoxetine solution(2.08 mg/kg).Here,fluoxetine served as the positive control drug to compare the therapeutic effects of quercetin.The experimental period was 6 weeks.Depressive behaviors in rats were assessed through various physiological and behavioral measures.Additionally,pathological changes in hippocampal tissues were examined using Nissl staining.Serum cytokines were detected using an enzymelinked immunosorbent assay(ELISA),and immunohistochemistry was employed to quantify the levels and integral optical density(IOD)values of ionized calcium binding adaptor molecule-1(Iba-1)expression in the brain.Real-time fluorescence quantitative PCR(RT-qPCR)was utilized to evaluate the mRNA levels of inflammatory indicators as well as toll-like receptor 4(TLR4),and nuclear factor-κappa B P65(NF-κB P65)in hippocampus.Western blot(WB)technique was employed to observe the protein levels of TLR4,NF-κB P65,and phospho-NF-κB P65(p-NF-κB P65).Results:After 42 d of exposure to CUMS,rats exhibited a slow increase in body weight,a reduction in food intake,an abnormal preference for sugar water,and aberrant open-field behaviors.Pathological analysis revealed the disintegration,rupture,interruption,and disorganization of hippocampal neuronal cells after CUMS exposure,along with a decrease in Nissl bodies in the CA

关键词： Quercetin Chronic unpredictable mild stress Depression Microglia TLR4/NF-κB inflammatory pathway

Versatile photonic molecule switch in multimode microresonators

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Light(Science & Applications) 2024年第3期13卷 498-509页

作者： Zihan Tao bitao Shen Wencan Li Luwen Xing Haoyu Wang Yichen Wu Yuansheng Tao Yan Zhou Yandong He Chao Peng Haowen Shu Xingjun Wang State Key Laboratory of Advanced Optical Communications System and Networks School of ElectronicsPeking UniversityBeijing 100871China College of Engineering Peking UniversityBeijing 100871China School of Integrated Circuits Peking University100871 BejingChina Peking University Yangtze Delta Institute of Optoelectronics Nantong 226010China Frontiers Science Center for Nano-optoelectronics Peking UniversityBeijing 100871China Peng Cheng Laboratory Shenzhen 518055China

Harnessing optical supermode interaction to construct artificial photonic molecules has uncovered a series of fundamental optical phenomena analogous to atomic physics.Previously,the distinct energy levels and interactions in such two-level systems were provided by coupled microresonators.The reconfigurability is limited,as they often require delicate external field stimuli or mechanically altering the geometric factors.These highly specific approaches also limit potential applications.Here,we propose a versatile on-chip photonic molecule in a multimode microring,utilizing a flexible regulation methodology to dynamically control the existence and interaction strength of spatial modes.The transition between single/multi-mode states enables the“switched-off/on”functionality of the photonic molecule,supporting wider generalized applications scenarios.In particular,“switched-on”state shows flexible and multidimensional mode splitting control in aspects of both coupling strength and phase difference,equivalent to the a.***.and d.c.Stark effect.“Switched-off”state allows for perfect low-loss single-mode transition(Qi~10 million)under an ultra-compact bend size(FSR~115 GHz)in a foundry-based silicon microring.It breaks the stereotyped image of the FSR-Q factor trade-off,enabling ultra-wideband and high-resolution millimeter-wave photonic operations.Our demonstration provides a flexible and portable solution for the integrated photonic molecule system,extending its research scope from fundamental physics to real-world applications such as nonlinear optical signal processing and sixth-generation wireless communication.

关键词： switched multimode millimeter

智能无人集群系统跨域协同技术研究现状与展望

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中国工程科学 2024年第1期26卷 117-126页

作者：江碧涛温广辉周佳玲郑德智卫星信息智能处理与应用技术重点实验室北京100192 东南大学数学学院南京211189 北京理工大学前沿交叉科学研究院北京100081 空地一体新航行系统技术全国重点实验室北京100081

随着智能化技术和无人系统技术的快速发展,智能无人集群系统跨域协同的概念应运而生并得到了广泛关注与深入研究,智能无人集群系统跨域协同技术逐渐成为世界各国抢占无人系统技术竞争中的制高点。本文从我国智能无人集群系统跨域协同技... 详细信息

随着智能化技术和无人系统技术的快速发展,智能无人集群系统跨域协同的概念应运而生并得到了广泛关注与深入研究,智能无人集群系统跨域协同技术逐渐成为世界各国抢占无人系统技术竞争中的制高点。本文从我国智能无人集群系统跨域协同技术的发展需求出发,梳理了海空、空地以及海陆/海陆空等典型无人场景跨域协同技术的研究现状;深入分析了智能无人集群系统跨域协同技术的发展现状、技术需求以及未来的重点研究方向。最后,从总体思路、体系架构、理论创新和技术攻关4个层面,提出了推动智能无人集群系统跨域协同技术稳健与快速发展的对策建议,以期促进我国无人系统应用能力的持续提升。

关键词：智能无人集群系统跨域协同协同控制 “空天地海”一体化网络

面向探索式搜索的领域知识图谱构建及实验探索

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图书情报工作 2024年第3期68卷 105-116页

作者：王娟曹树金王志红彭碧涛广东外语外贸大学信息科学与技术学院广州510420 山东理工大学信息管理研究院淄博255000 中关村实验室北京100094

[目的/意义]特定领域中的信息检索系统,往往因为用户自身领域知识不足存在检索效率低下的问题。现有的面向特定领域的知识组织工具,如领域知识图谱,可以有效缓解这一问题,但是如何将其更好地嵌入到现有信息检索系统中是目前尚未解决的... 详细信息

[目的/意义]特定领域中的信息检索系统,往往因为用户自身领域知识不足存在检索效率低下的问题。现有的面向特定领域的知识组织工具,如领域知识图谱,可以有效缓解这一问题,但是如何将其更好地嵌入到现有信息检索系统中是目前尚未解决的问题。因此,提出一套基于领域知识图谱的探索式搜索系统的全流程解决方案,包括从实体及关系的联合抽取、领域知识图谱构建到探索式搜索系统的实现。[方法/过程]以图情领域学术文献为研究对象,对图情领域的实体及其间关系的形式化定义进行深入的探索、提出基于Paddle UIE实现实体及关系的联合抽取任务方法,并构建一个基于可交互图情领域知识图谱的原型检索系统。[结果/结论 ]通过比较不同实体及关系联合抽取方法的效果,包括Paddle UIE、Cas Rel、Sp ERT和CORE,发现基于提示学习的预训练大语言模型Paddle UIE具有更好的抽取效果,特别是在样本量较少的情况下。此外,从进一步设计的两个搜索实验任务结果中可以发现,与通用搜索引擎相比,本文系统可以显著提高用户满意度,有效解决用户领域知识不足(如跨学科场景)下检索性能低下的问题,表明本文提出的全流程解决方案可以为学术文献服务提供方开发用户支持工具提供流程指导和建议。

关键词：领域知识图谱提示学习大模型联合抽取探索式搜索

Learning power Gaussian modeling loss for dense rotated object detection in remote sensing images

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Chinese Journal of Aeronautics 2023年第10期36卷 353-365页

作者： Yang LI Haining WANG Yuqiang FANG Shengjin WANG Zhi LI bitao jiang Department of Space Information Space Engineering UniversityBeijing 101416China Beijing Institute of Remote Sensing Information Beijing 100192China Department of Electronic Engineering Tsinghua UniversityBeijing 100084China

Object detection in Remote Sensing(RS)has achieved tremendous advances in recent years,but it remains challenging for rotated object detection due to cluttered backgrounds,dense object arrangements and the wide range of size variations among objects.To tackle this problem,Dense Context Feature Pyramid Network(DCFPN)and a powerα-Gaussian loss are designed for rotated object detection in this paper.The proposed DCFPN can extract multi-scale information densely and accurately by leveraging a dense multi-path dilation layer to cover all sizes of objects in remote sensing scenarios.For more accurate detection while avoiding bottlenecks such as boundary discontinuity in rotated bounding box regression,a-Gaussian loss,a unified power generalization of existing Gaussian modeling losses is proposed.Furthermore,the properties ofα-Gaussian loss are analyzed comprehensively for a wider range of applications.Experimental results on four datasets(UCAS-AOD,HRSC2016,DIOR-R,and DOTA)show the effectiveness of the proposed method using different detectors,and are superior to the existing methods in both feature extraction and bounding box regression。

关键词： Convolutional neural networks Distribution metric Losses Remote sensing Rotated object detection

SRS-Net: Training object detectors from scratch for remote sensing images without pretraining

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Chinese Journal of Aeronautics 2023年第8期36卷 269-283页

作者： Haining WANG Yang LI Yuqiang FANG Yurong LIAO bitao jiang Xitao ZHANG Shuyan NI Space Engineering University Beijing 101416China Beijing Institute of Remote Sensing Information Beijing 100192China

Most of the current object detection algorithms use pretrained models that are trained on ImageNet and then fine-tuned in the network,which can achieve good performance in terms of general object detectors.However,in the field of remote sensing image object detection,as pretrained models are significantly different from remote sensing data,it is meaningful to explore a train-fromscratch technique for remote sensing images.This paper proposes an object detection framework trained from scratch,SRS-Net,and describes the design of a densely connected backbone network to provide integrated hidden layer supervision for the convolution module.Then,two necessary improvement principles are proposed:studying the role of normalization in the network structure,and improving data augmentation methods for remote sensing images.To evaluate the proposed framework,we performed many ablation experiments on the DIOR,DOTA,and AS datasets.The results show that whether using the improved backbone network,the normalization method or training data enhancement strategy,the performance of the object detection network trained from scratch increased.These principles compensate for the lack of pretrained models.Furthermore,we found that SRS-Net could achieve similar to or slightly better performance than baseline methods,and surpassed most advanced general detectors.

关键词： Denseconnection Object detection Pretraining Remote sensing image Trainfrom scratch

抢险车对92m跨度复合材料桁架桥动态响应的影响

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江苏大学学报（自然科学版） 2024年第3期45卷 346-353页

作者：孙泽阳刘阳杨俊锋吴必涛赵启林东南大学混凝土及预应力混凝土结构教育部重点实验室江苏南京211189 广州地铁设计研究院股份有限公司广东广州510010 华东交通大学轨道交通基础设施性能监测与保障国家重点实验室江西南昌330013 南京工业大学机械与动力工程学院江苏南京211816

为研究大跨径桁架式纤维增强复合材料(FRP)应急抢修桥梁成桥后的动力性能,基于导梁推送施工92 m跨度的FRP桁架桥模型,编制FRP桁架桥的车桥耦合算法,研究抢险车辆的车速、质量及路面不平顺对FRP桁架桥的跨中竖向位移、竖向加速度和关键... 详细信息

为研究大跨径桁架式纤维增强复合材料(FRP)应急抢修桥梁成桥后的动力性能,基于导梁推送施工92 m跨度的FRP桁架桥模型,编制FRP桁架桥的车桥耦合算法,研究抢险车辆的车速、质量及路面不平顺对FRP桁架桥的跨中竖向位移、竖向加速度和关键杆件轴向应力等指标的影响.结果表明:路面越不平顺,车辆对桥梁结构的冲击作用越大,且路面等级对竖向位移的影响大于对关键杆件轴向应力的影响;车速为20~50 km/h时,车速变化对冲击系数影响较小,但车速超过50 km/h时,车速的影响逐渐增大;车辆质量对桥梁各项指标动力响应的峰值曲线呈线性增大趋势.当车辆质量为2.80×10^(4)kg,车速30 km/h时,最大跨中竖向位移为167 mm,未超过抢修桥梁位移限值(L/120),表明该桥梁的设计可以满足抢险的通行要求.

关键词：纤维增强复合材料桁架桥车桥耦合位移接触法动态响应路面不平顺

酒曲中产酶微生物的筛选及其对发酵米酒品质的影响

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食品科学 2024年第10期45卷 108-117页

作者：邹玉婷贺紫涵许碧涛陈兰钗张庆西华大学食品与生物工程学院四川成都610039 食品微生物四川省重点实验室四川成都610039

为解决商业米酒品质稳定但风味寡淡,而传统米酒口感醇厚但品质难于控制的问题,本研究从不同地区的酒曲中筛选出产淀粉酶、蛋白酶、酯化酶的可培养真菌,将其与商业甜酒曲进行复配发酵米酒,测定米酒的各项指标以评估其对发酵米酒品质的影... 详细信息

为解决商业米酒品质稳定但风味寡淡,而传统米酒口感醇厚但品质难于控制的问题,本研究从不同地区的酒曲中筛选出产淀粉酶、蛋白酶、酯化酶的可培养真菌,将其与商业甜酒曲进行复配发酵米酒,测定米酒的各项指标以评估其对发酵米酒品质的影响。根据产酶特性及18S rDNA分子鉴定,筛选获得5株产酶真菌,分别为米根霉(Rhizopus oryzae)、卷枝毛霉(Mucor circinelloides)、兰瑟毛霉(M.lanceolatus)、两株扣囊复膜酵母(Saccharomycopsisfibuligera)。添加了S.fibuligeraHB单菌曲发酵的米酒提高了乙醇、氨基酸态氮的含量,丰富了有机酸的种类和含量,降低了苦味氨基酸的含量和占比,同时增加了挥发性物质含量,其中苯乙醇和乙酸乙酯的含量明显高于其他组。因此,S.fibuligeraHB能显著提升米酒品质,具有应用于强化曲进行发酵米酒的潜力。

关键词：酒曲产酶微生物扣囊复膜酵母米酒发酵挥发性成分