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Chemical Research in Chinese Universities 2002年第4期18卷 375-379页

作者： CHEN Wei yuAN Hong-ming jiang yu-sheng HUO Hua CHEN Jie-sheng State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin UniversityChangchun 130023P.R.China

A new layered zincophosphate was synthesized under solvothermal conditions by employing racemic 1,2-diaminopropane as the structure-directing agent. The structure of the compound was solved by means of single-crystal X-ray diffraction analysis. It crystallized in the monoclinic space group P2_1/c (No. 14) with a= 1.047 0(3) nm, b=0.787 31(18) nm, c=0.662 68(16) nm, β=103.120(5)°, V=0.532 0(2) nm 3 and Z=4. The structure is made up of anionic zincophosphate sheets stacked in an AAAA sequence. The individual sheet contains three- and four-membered rings and the infinite Zn-O-Zn chains can also be envisaged in the sheet. The charge-balancing diprotonated racemic 1,2-diaminopropane cations are sandwiched between the layers, whereas the inorganic layers are stabilized by strong H-bonds formed between the N atoms of the amine and the O atoms in the inorganic sheets.

关键词： Layered zincophosphate X-ray diffraction Crystal structure Racemic system

The gasdermin family:emerging therapeutic targets in diseases

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1905-1937页

作者： Chenglong Zhu sheng Xu Ruoyu jiang Yizhi yu Jinjun Bian Zui Zou Faculty of Anesthesiology Changhai HospitalNaval Medical UniversityShanghai 200433China School of Anesthesiology Naval Medical UniversityShanghai 200433China National Key Laboratory of Immunity&Inflammation Naval Medical UniversityShanghai 200433China d 4 Department of Biochemistry and Molecular Biology College of Basic Medical SciencesNaval Medical UniversityShanghai 200433China

The gasdermin(GSDM)family has garnered significant attention for its pivotal role in immunity and disease as a key player in *** recently characterized class of pore-forming effector proteins is pivotal in orchestrating processes such as membrane permeabilization,pyroptosis,and the follow-up inflammatory response,which are crucial self-defense mechanisms against irritants and *** have been implicated in a range of diseases including,but not limited to,sepsis,viral infections,and cancer,either through involvement in pyroptosis or independently of this *** regulation of GSDM-mediated pyroptosis is gaining recognition as a promising therapeutic strategy for the treatment of various *** strategies for inhibiting GSDMD primarily involve binding to GSDMD,blocking GSDMD cleavage or inhibiting GSDMD-N-terminal(NT)oligomerization,albeit with some off-target *** this review,we delve into the cutting-edge understanding of the interplay between GSDMs and pyroptosis,elucidate the activation mechanisms of GSDMs,explore their associations with a range of diseases,and discuss recent advancements and potential strategies for developing GSDMD inhibitors.

关键词： diseases therapeutic immunity

Segregation of Mg-6Gd alloy under natural convection:From macro solute distribution to micro dendrite growth

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China Foundry 2024年第5期21卷 613-624页

作者： Hong-xu Chen Ang Zhang Hao Li yu Gao yu-hong Cui Guang-sheng Huang Bin jiang Fu-sheng Pan National Engineering Research Center for Magnesium Alloys National Key Laboratory of Advanced Casting TechnologiesCollege of Materials Science and EngineeringChongqing UniversityChongqing 400044China

Segregation is a serious defect in alloy ingots which severely deteriorates materials *** segregation defect in Mg-6Gd alloy is studied by coupling macro thermal-solutal-convection transport and micro dendrite *** macroscopic fluid dynamics and mass transfer equations are resolved to forecast the segregation behavior under conditions of continuous temperature variation during the solidification *** numerical model is validated by testing double-diffusive natural convection in a closed square cavity.A phase field model is then applied to simulate the micro dendrite growth,using macro undercooling and liquid flow velocity as boundary *** show that the multiscale segregation behavior,including macro solute distribution and micro dendritic morphology,is strongly dependent on the temperature condition and the liquid convection,which provides guidance for reducing and eliminating the segregation defect.

关键词： magnesium alloy segregation numerical simulation phase-field simulation multiscale

Feedback processing in the primate brain and in AI systems

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Science China(Technological Sciences) 2024年第8期67卷 2297-2309页

作者： jiang Yong HE sheng Institute of Biophysics Chinese Academy of SciencesBeijing 100101China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei 230088China University of Chinese Academy of Sciences Beijing 100049China

The primate brain and artificial intelligence(AI) can both be conceptualized as information processing systems, each with its own distinct biological and computational architectures. While there are parallels between them, their respective structural and functional connections show significant differences. In this paper, we examine the central role of feedback processing in both the primate brain and AI systems, which has been shown to be crucial in shaping neural processing. By reviewing the key features of feedback processes in the primate brain, which allows the brain to incorporate prior knowledge, contextual information, and taskdemands into early-stage processing, we highlight the divergence in goals and functions between biological and AI *** these differences is crucial for elucidating the cognitive capabilities of the primate brain and for addressing computational challenges in AI. In advocating “Cognition-Inspired-Computation”, we suggest that integrating insights from feedback processing in the primate brain into AI research will offer potentially significant improvements for the advancement of AI systems.

关键词： cognitive neuroscience artificial intelligence feedback processing attention learning

Multi-UAV Collaborative Edge Computing Algorithm for Joint Task Offloading and Channel Resource Allocation

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Journal of Communications and Information Networks 2024年第2期9卷 137-150页

作者： yuting Wei sheng Wu Zhe Ji Zhigang yu Chunxiao jiang Linling Kuang School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China China Academy of Electronics and Information Technology Beijing 100041China Beijing National Research Center for Information Science and Technology Tsinghua Space CenterTsinghua UniversityBeijing 100084China

Unmanned aerial vehicle (UAV)-based edge computing is an emerging technology that provides fast task processing for a wider area. To address the issues of limited computation resource of a single UAV and finite communication resource in multi-UAV networks, this paper joints consideration of task offloading and wireless channel allocation on a collaborative multi-UAV computing network, where a high altitude platform station (HAPS)is adopted as the relay device for communication between UAV clusters consisting of UAV cluster heads (ch-UAVs) and mission UAVs (m-UAVs). We propose an algorithm, jointing task offloading and wireless channel allocation to maximize the average service success rate (ASSR)of a period time. In particular,the simulated annealing(SA)algorithm with random perturbations is used for optimal channel allocation,aiming to reduce interference and minimize transmission delay.A multi-agent deep deterministic policy gradient (MADDPG) is proposed to get the best task offloading strategy. Simulation results demonstrate the effectiveness of the SA algorithm in channel allocation. Meanwhile,when jointly considering computation and channel resources,the proposed scheme effectively enhances the ASSR in comparison to other benchmark algorithms.

关键词： UAV-based edge computing multi-UAV collaboration joint task offloading and wireless channel allocation simulated annealing(SA)algorithm multi-agent deep deterministic policy gradient(MADDPG)

Exploration of Strong Metal-Support Interaction in Heterogeneous Catalysts by in situ Transmission Electron Microscopy

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Chinese Journal of Chemistry 2024年第9期42卷 1004-1008页

作者： Yongjun jiang sheng Dai Key Laboratoryfor Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center Institute of Fine ChemicalsSchool of Chemistry&Molecular EngineeringEast China Universityof Science and TechnologyShanghai 200237China

The phenomenon of strong metal-support interaction(SMSI)observed in supported metal catalysts,usually accompanied by the formation of the encapsulation layer on metal nanoparticles,has attracted extensive research attention due to its significance in heterogeneous ***,great progress has been made in recent years in investigating SMSI by in situ transmission electron microscopy(TEM),along with an enhanced comprehension of the underlying mechanisms governing SMSI *** emerging topic summarizes recent progress utilizing in situ TEM to study the interaction between metal and support and the relationship between the structure and performance of the supported catalyst under reaction conditions.A brief perspective about the use of in situ TEM for further study of SMSI is also presented,showing prospects in this field that will stimulate further upsurging research in promoting the catalytic efficiency of supported catalysts.

关键词： Heterogeneous catalysis In situ TEM Strong metal-support interaction Structure changes Interfaces Structural evolution

Composite laminar membranes for electricity generation from water evaporation

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Nano Research 2024年第1期17卷 307-311页

作者： Xiao Wang Gang yuan Han Zhou yu jiang Shuo Wang Jiaojiao Ma Chongyang Yang sheng Hu State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials(iChEM)College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China

Harvesting clean energy from water evaporation has been extensively investigated due to its *** achieve high efficiency,energy conversion materials should contain multiple features which are difficult to be simultaneously obtained from single-component *** we use composite laminar membranes assembled by nanosheets of graphene oxide and mica,and find a sustained power density induced by water evaporation that is two orders of magnitude larger than that from membranes made by either of the *** power output is attributed to selective proton transport driven by water evaporation through the interlayer nanochannels in the *** process relies on the synergistic effects from negatively charged and hydrophilic mica surfaces that are important for proton selectivity and water transport,and the tunable electrical conductivity of graphene oxide that provides optimized internal *** demonstrated composite membranes offer a strategy of enhancing power generation by combining the advantages from each of their components.

关键词： graphene oxide mica water evaporation electrical double layer surface charge ion selectivity

Active components of Dengzhan shengmai ameliorate cognitive impairment by facilitating hippocampal long-term potentiation via the NMDA receptor-mediated Ca^(2+)/CaMKII pathway

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Journal of Pharmaceutical Analysis 2024年第3期14卷 435-438页

作者： Congyu Ma Ning sheng Jun Wu Lulu Wang Jiandong jiang Haibo yu Jinlan Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100050China Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100050China

Abnormal synaptic plasticity causes cognitive *** long-term potentiation(LTP)is a critical synaptic plasticity process[1].Rescuing impaired LTP is challenging;hence,novel agents are required for LTP *** medicine Dengzhan shengmai(DzSM)has shown notable clinical efficacy against cognitive deficits[2].However,it remains unclear how DzSM modulates *** previous study[3]revealed the influence of DZSM on glutamatergic and GABAergic synapses following chronic cerebral hypoperfusion(CCH),which motivated us to assess how DzSM affects synaptic functions.

关键词： impaired impairment hence

Universal and efficient hybrid modeling and direct slicing method for additive manufacturing processes

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Advances in Manufacturing 2024年第2期12卷 300-316页

作者： Sen-Lin Wang Li-Chao Zhang Chao Cai Ming-Kai Tang Si Chen jiang Huang yu-sheng Shi State Key Laboratory of Materials Processing and Die and Mould Technology Huazhong University of Science and TechnologyWuhan430074People’s Republic of China School of Machinery and Automation Wuhan University of Science and TechnologyWuhan430081People’s Republic of China

Model design and slicing contour generation in additive manufacturing(AM)data processing face challenges in terms of efficiency and scalability when stereolithography files generated by complex functionally graded structures have millions of *** paper proposes a hybrid modeling and direct slicing method for AM to efficiently construct and handle complex three-dimensional(3D)*** 3D solids,including conformal multigradient structures,were uniformly described using a small amount of data via signed distance *** hybrid representations were quickly discretized into numerous disordered directed lines using an improved marching squares *** establishing a directional HashMap to construct the topological relationship between lines,a connecting algorithm with linear time complexity is proposed to generate slicing contours for *** method replaces the mesh reconstruction and Boolean operation stages and can efficiently construct complex conformal gradient models of arbitrary topologies through hybrid ***,the time and memory consumption of direct slicing are much lower than those of previous methods when handling hybrid models with hundreds of millions of faces after mesh reconstruction.

关键词： Additive manufacturing(AM) Hybrid modeling Direct slicing Signed distance field

Narrowband blue emitter based on fused nitrogen/carbonyl combination with external quantum efficiency approaching 30%

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Science China Chemistry 2024年第1期67卷 351-359页

作者： Long Chen Jia-Heng Cai You-Jun yu Yang-Kun Qu sheng-Yi Yang sheng-Nan Zou Rui-Hong Liu Dong-Ying Zhou Liang-sheng Liao Zuo-Quan jiang Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China Macao Institute of Materials Science and Engineering Macao University of Science and TechnologyMacao 999078China

Multi-resonance thermally activated delayed fluorescence(MR-TADF)emitters can enable narrowband emission with high color purity and electroluminescence ***/carbonyl(N/C=O)system is receiving increasing attention while the nitrogen/boron(N/B)system has been widely *** decoration is an effective approach for N/B type MR-TADF system but always leads to broadening and red-shifting of the emission band in N/C=O MR-TADF *** attribute these unfavorable phenomena to the formation of intramolecular charge transfer between the MR-core and peripheral *** address this issue,we have developed a new strategy by decorating DMQAO(a fused N/C=O MR-core)with a triazine acceptor and a neutral terphenyl group to construct MTDMQAO and MBDMQAO,*** introduction of the triazine acceptor not only realizes efficient narrowband emission in MTDMQAO,but also accelerates the reverse intersystem crossing process through enhanced spin-orbital *** a result,MTDMQAO exhibits a significantly higher external quantum efficiency of 29.4%compared to the referent emitters,validating the rationality of our derivation *** study highlights the potential of the N/C=O system for MR-TADF emitters and provides important insights for understanding the difference between N/B and N/C=O systems.

关键词： carbonyl group narrowband acceptor decoration thermally activated delayed fluorescence OLEDs