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Liposomalα-cyperone targeting bone resorption surfaces suppresses osteoclast differentiation and osteoporosis progression via the PI3K/Akt axis

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Nano Research 2024年第4期17卷 2949-2959页

作者： Lin Yang Xueying An Wang Gong Wenshu Wu bin Liu Xiaoyan Shao Yansi xian Rui Peng Baosheng Guo Qing jiang Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic SurgeryNanjing Drum Tower Hospital Clinical College of Nanjing Medical University321 Zhongshan RoadNanjing 210008China Branch of National Clinical Research Center for Orthopedics Sports Medicine and RehabilitationNanjing 210008China State Key Laboratory of Pharmaceutical Biotechnology Medical SchoolNanjing University&Division of Sports Medicine and Adult Reconstructive SurgeryDepartment of Orthopedic SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China

Osteoporosis is a metabolic dysregulation of bone that occurs mainly in postmenopausal women,and the hyperfunction of osteoclasts is the primary contributor to postmenopausal ***,the development of effective therapeutic drugs and precise delivery systems remains a challenge in the field of anti-absorption ***,we reported theα-cyperone(α-CYP)for anti-osteoporosis and developed a liposome-based nano-drug delivery system ofα-CYP,that specifically targets the bone resorption ***,we found that theα-CYP,one of the major sesquiterpenes of Cyperus rotundus L.,attenuated the progression of osteoporosis in ovariectomized(OVX)mice and down-regulated the expression of phosphorylated proteins of phosphoinositide 3-kinase(PI3K)and protein kinase B(Akt),causing down-regulation of osteoclast-related genes/proteins and curbing osteoclast ***,α-CYP reversed the activation of osteoclastic differentiation and enhanced osteoporosis-related proteins expression caused by PI3K/Akt agonist(YS-49).More importantly,we adopted the osteoclastic resorption surface targeting peptide Asp8 and constructed the liposome(lipαC@Asp8)to deliverα-CYP to osteoclasts and confirmed its anti-osteoporosis effect and enhanced osteoclast inhibition by blocking PI3K/Akt *** conclusion,this study demonstrated thatα-CYP inhibits osteoclast differentiation and osteoporosis development by silencing PI3K/Akt pathway,and the liposome targeting delivery systems loaded withα-CYP might provide a novel and effective strategy to treat osteoporosis.

关键词： osteoporosis α-cyperone osteoclast phosphoinositide 3-kinase/protein kinase B(PI3K/Akt) liposome

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Combustion mechanism of benzene in iron ore sintering process:experimental and simulation

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Journal of Iron and Steel Research International 2024年第1期31卷 195-203页

作者： Zhi-gang Que Jin-ming Shi xian-bin Ai Institute of Energy Research Jiangxi Academy of ScienceNanchang330096JiangxiChina jiangxi Carbon Neutralization Research Center Nanchang330096JiangxiChina

Benzene is a typical component of volatile organic compounds(VOCs)in the iron ore sintering flue *** combustion behavior of benzene directly affects the emission of VOCs in iron ore sintering *** effects of temperature,benzene,and oxygen concentrations on the conversion ratio of benzene were investigated by experiments and numerical *** experiments were carried out in a tube reactor at temperatures of 773-1098 K,benzene concentrations of 0.01-0.03 vol.%,and oxygen concentrations of 10-21 vol.%.The numerical simulation was performed with the plug flow model in the CHEMKIN program based on a kinetic model that consists of 132 chemical species and 772 elementary step-like *** experimental results reveal that increasing the temperature and benzene concentration could signifi-cantly promote benzene *** is attributed to the increase in the reaction rates of all steps in the pathway for forming CO_(2)and H_(2)*** addition,due to the large equivalent ratio of oxygen to benzene,the conversion ratio of benzene remained constant at different oxygen *** simulation results were in good agreement with the experimental results and indicated that six elementary reactions dominated the formations of CO_(2)and H_(2)*** oxidations of C_(6)H_(5)O,CO,and C_(5)H_(4)O intermediates to CO_(2)were the limiting steps in the reaction pathways.

关键词： Benzene Volatile organic compound Iron ore sinter Combustion Simulation Temperature Oxygen

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Adaptive fault-tolerant control for non-minimum phase hypersonic vehicles based on adaptive dynamic programming

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Chinese Journal of Aeronautics 2024年第3期37卷 290-311页

作者： Le WANG Ruiyun QI bin jiang State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China

In this paper,a novel adaptive Fault-Tolerant Control(FTC)strategy is proposed for non-minimum phase Hypersonic Vehicles(HSVs)that are affected by actuator faults and parameter *** strategy is based on the output redefinition method and Adaptive Dynamic Programming(ADP).The intelligent FTC scheme consists of two main parts:a basic fault-tolerant and stable controller and an ADP-based supplementary *** the basic FTC part,an output redefinition approach is designed to make zero-dynamics stable with respect to the new ***,Ideal Internal Dynamic(IID)is obtained using an optimal bounded inversion approach,and a tracking controller is designed for the new output to realize output tracking of the nonminimum phase HSV *** the ADP-based compensation control part,an ActionDependent Heuristic Dynamic Programming(ADHDP)adopting an actor-critic learning structure is utilized to further optimize the tracking performance of the HSV control ***,simulation results are provided to verify the effectiveness and efficiency of the proposed FTC algorithm.

关键词： Hypersonic vehicle Fault-tolerant control Non-minimum phase system Adaptive control Nonlinear control Adaptive dynamic programming

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Controllable chemical redox reactions to couple microbial degradation for organic contaminated sites remediation:A review

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Journal of Environmental Sciences 2024年第5期139卷 428-445页

作者： bin Chen jiang Xu Lizhong Zhu College of Environmental and Resource Sciences Zhejiang UniversityHangzhou 310058China Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control Zhejiang UniversityHangzhou 310058China Zhejiang Agriculture&Forest University Lin'an 311300China

Global environmental concern over organic contaminated sites has been progressively conspicuous during the process of urbanization and industrial *** traditional physical or chemical remediation technologies may significantly destroy the soil structure and function,coupling moderate chemical degradation with microbial remediation becomes a potential way for the green,economic,and efficient remediation of contaminated ***,this work systematically elucidates why and how to couple chemical technology with microbial remediation,mainly focused on the controllable redox reactions of organic *** rational design of materials structure,selective generation of reactive oxygen species,and estimation of degradation pathway are described for chemical ***,current progress on efficient and selective reductions of organic contaminants(i.e.,dechlorination,defluorination,-NO_(2) reduction)is *** with the microbial remediation of contaminated sites,several consideration factors of how to couple chemical and microbial remediation are proposed based on both fundamental and practical points of *** review will advance the understanding and development of chemical-microbial coupled remediation for organic contaminated sites.

关键词： Soil remediation Groundwater remediation Rational design Reactive species Environmental nanotechnology

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FPGA-based position reconstruction method for neutron beam flux spatial distribution measurement in BNCT

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Nuclear Science and Techniques 2024年第3期35卷 96-108页

作者： Wei jiang Ping Cao Yi-Ming Wu xian-Ke Liu Zhu-Jun Fang Zhi-Yong Zhang bin Shi Jun Chen State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China National Key Laboratory for Metrology and Calibration Techniques China Institute of Atomic EnergyBeijing 102413China

A new measurement method for the spatial distribution of neutron beam flux in boron neutron capture therapy(BNCT)is being developed based on the two-dimensional Micromegas *** address the issue of long processing times in traditional offline position reconstruction methods,this paper proposes a field programmable gate array based online position reconstruction method utilizing the micro-time projection chamber *** method encapsulates key technical aspects:a self-adaptive serial link technique built upon the dynamical adjustment of the delay chain length,fast sorting,a coordinate-matching technique based on the mapping between signal timestamps and random access memory(RAM)addresses,and a precise start point-merging technique utilizing a circular combined *** performance test of the selfadaptive serial link shows that the bit error rate of the link is better than 10-12 at a confidence level of 99%,ensuring reliable data *** experiment utilizing the readout electronics and Micromegas detector shows a spatial resolution of approximately 1.4 mm,surpassing the current method’s resolution level of 5 *** beam experiment confirms that the readout electronics system can obtain the flux spatial distribution of neutron beams online,thus validating the feasibility of the position reconstruction *** online position reconstruction method avoids traditional methods,such as bubble sorting and traversal searching,simplifies the design of the logic firmware,and reduces the time complexity from O(n2)to O(n).This study contributes to the advancement in measuring neutron beam flux for BNCT.

关键词： Position reconstruction FPGA Readout electronics Neutron flux spatial distribution

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Functional and numerical responses of Cyrtorhinus lividipennis to eggs of Nilaparvata lugens are not affected by genetically modified herbicide-tolerant rice

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Journal of Integrative Agriculture 2015年第10期14卷 2019-2026页

作者： jiang xian-bin HUANG Qian LING Yan CHEN Yu-chong XIAO Guo-ying HUANG Suo-sheng WU Bi-qiu HUANG Feng-kuan CAI Jian-he LONG Li-ping Guangxi Key Laboratory of Rice Genetics and Breeding Rice Research Institute Guangxi Academy of Agricultural Sciences Plant Protection Research Institute Guangxi Academy of Agricultural Sciences Guangxi Academy of Agricultural Sciences Institute of Subtropical Agriculture Chinese Academy of Sciences

To safely and sustainably utilize genetic breeding techniques for crop production, greater understanding of the potential effects of genetically modified herbicide-tolerant（GMHT） crops on the ecological functions of predators is required. In the laboratory, we examined the functional and numerical responses of Cyrtorhinus lividipennis Reuter to eggs of brown planthopper（BPH）, Nilaparvata lugens（St？l）, which were reared on GMHT rice Bar68-1; the untransformed parental cultivar, D68; or a BPH-susceptive rice variety, Taichung Native 1. All stages of nymphs and female adult of C. lividipennis, either on GMHT rice or control plants, exhibited typical type II functional responses when fed on BPH eggs; the attacking rate and handling time of C. lividipennis on GMHT rice Bar68-1 was not significantly different from that on D68. The numerical responses of C. lividipennis on GMHT rice or controls fit Beddington＇s model; there were no significant differences in the parameters of numerical responses between GMHT rice Bar68-1 and D68. The results indicated that the functional and numerical responses of C. lividipennis to BPH eggs are not affected by GMHT rice Bar68-1.

关键词： transgenic rice green mirid bug brown planthopper natural enemy non-target organisms predator herbicide resistant safety assessm

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Fault-tolerant flocking control against multiple malicious agents under geometric configuration containment

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Science China(Information Sciences) 2024年第10期67卷 261-282页

作者： Chencheng ZHANG Hao YANG bin jiang College of Automation Engineering Nanjing University of Aeronautics and Astronautics Institute of Engineering and Technology (ENTEG) University of Groningen

Flocking control in the presence of malicious decisions is a crucial research topic since agents in swarms are likely to suffer from security issues in practice. This paper considers a swarm containing malicious agents that deliberately alter their controller parameters and disrupt the swarm by causing collisions,divisions, and escapes. Two possible malicious scenarios are considered. The first is that one malicious agent acts selectively on a subset of its neighbors and the second is that multiple malicious agents are either scattered or clustered together. To achieve the flocking control objective:(1) containment conditions based on specific geometric configurations are established;(2) hierarchical fault-tolerant flocking control methods based on those containment conditions are proposed. Compared to existing research dealing with malicious agents in swarms, our approach aims to contain rather than remove them. This guarantees the completeness of the task and takes agents' motions into consideration. Simulations show the effectiveness of the proposed methods.

关键词： flocking control fault-tolerant control multiple malicious agents geometric configuration

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Feasibility of medical radioisotope production based on the proton beams at China Spallation Neutron Source

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Nuclear Science and Techniques 2024年第6期35卷 26-39页

作者： bing jiang bin-bin Tian Han-Tao Jing Qi-Fan Dong Spallation Neutron Source Science Center Dongguan 523803China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China University of Chinese Academy of Sciences Beijing 100049China

The utilization of a proton beam from the China Spallation Neutron Source(CSNS)for producing medical radioisotopes is appealing owing to its high current intensity and high *** medical isotope production based on the proton beam at the CSNS is significant for the development of future radiopharmaceuticals,particularly for theα-emitting *** production yield and activity of typical medical isotopes were estimated using the FLUKA *** results indicate that the 300-MeV proton beam with a power of 100 kW at CSNS-II is highly suitable for proof-of-principle studies of most medical *** particular,this proton beam offers tremendous advantages for the large-scale production of alpha radioisotopes,such as 225Ac,whose theoretical production yield can reach approximately 57 Ci/*** on these results,we provide perspectives on the use of CSNS proton beams to produce radioisotopes for medical applications.

关键词： CSNS proton beam Medical isotope production α-Emitting radionuclides Nuclidic purity analysis

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Lidocaine hydrochloride loaded isomaltulose microneedles for efficient local anesthesia of the skin

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Chinese Chemical Letters 2024年第4期35卷 298-302页

作者： Xuebing jiang Siyi Wang Li Zhang xian jiang Maling Gou State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengdu 610041China Huahang Microcreate Technology Co. Ltd.Chengdu 610042China Department of Dermatology West China HospitalSichuan UniversityChengdu 610041China

Lidocaine hydrochloride(LIDH) as an anesthetic is widely used in local anesthesia. Dissolving microneedles(MNs) have great application value in the field of skin anesthesia. However, the limited drug-loading of dissolving MNs is an existing challenge that affects clinical use. In this study, we have screened isomaltulose(ISO) as the proper matrix material for the MNs by using molecular dynamics(MD) simulation. Our findings indicate that ISO has good compatibility with LIDH, and the LIDH-loaded ISO MNs(LI-MNs) have high drug-loading capacity. The drug-loading capacity of LI-MNs could reach 80%, and it could effectively puncture the skin. In addition, the preparation method of customized LI-MNs was established based on three-dimensional(3D) printing technology. It was shown that the administration time of LI-MNs could be controlled within 3 min. Also, the LI-MNs were able to provide the local anesthetic efficacy within2 min and sustained for more than 2 h. Significantly, LI-MNs had more efficient drug efficacy compared to the topical creams and the majority of existing LIDH-loaded dissolving MNs. They even provided a longer duration of action than the injections. Overall, the LI-MNs with high drug-loading have a promising application prospect.

关键词： Microneedles Local anesthesia Lidocaine hydrochloride Isomaltulose Transdermal delivery

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Real-Time Intelligent Diagnosis of Co-frequency Vibration Faults in Rotating Machinery Based on Lightweight-Convolutional Neural Networks

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 264-282页

作者： Xin Pan xiancheng Zhang Zhinong jiang Guangfu bin Beijing Key Laboratory of Health Monitoring and Self-recovery for High-End Mechanical Equipment College of Mechanical and Electrical EngineeringBeijing University of Chemical TechnologyBeijing 100029China Key Laboratory of Engine Health Monitoring-Control and Networking(Ministry of Education) College of Mechanical and Electrical EngineeringBeijing University of Chemical TechnologyBeijing 100029China College of Mechanical Engineering Hunan University of Science and TechnologyXiangtan 411201China

The co-frequency vibration fault is one of the common faults in the operation of rotating equipment,and realizing the real-time diagnosis of the co-frequency vibration fault is of great significance for monitoring the health state and carrying out vibration suppression of the *** engineering scenarios,co-frequency vibration faults are highlighted by rotational frequency and are difficult to identify,and existing intelligent methods require more hardware conditions and are exclusively ***,Lightweight-convolutional neural networks(LW-CNN)algorithm is proposed in this paper to achieve real-time fault *** critical parameters are discussed and verified by simulated and experimental signals for the sliding window data augmentation *** on LW-CNN and data augmentation,the real-time intelligent diagnosis of co-frequency is ***,a real-time detection method of fault diagnosis algorithm is proposed for data acquisition to fault *** is verified by experiments that the LW-CNN and sliding window methods are used with high accuracy and real-time performance.

关键词： Co-frequency vibration Real-time diagnosis LW-CNN Data augmentation

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