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氯球嫁接L-脯氨酸绿色催化合成香豆素-3-羧酸酯

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化学研究与应用 2024年第3期36卷 674-680页

作者：蒋卫华黄湖滕巧巧孟启常州大学石油化工学院江苏常州213164

将L-脯氨酸嫁接在树脂氯球上,催化水杨醛及其衍生物和丙二酸酯直接合成香豆素-3-羧酸酯类物质,反应具有选择性强、产率高、成本低、三废少、后处理简单、催化剂可以多次重复使用等优点,符合绿色催化的特性。实验表明:反应在100℃下,醛... 详细信息

将L-脯氨酸嫁接在树脂氯球上,催化水杨醛及其衍生物和丙二酸酯直接合成香豆素-3-羧酸酯类物质,反应具有选择性强、产率高、成本低、三废少、后处理简单、催化剂可以多次重复使用等优点,符合绿色催化的特性。实验表明:反应在100℃下,醛和酯的摩尔比为1:1.2,催化剂的用量1 g,10 mL DMF中反应5h,反应的选择性≥98%,产率高达92%;催化剂循环使用6次反应的产率仍在85%以上。在此优化的反应条件下,高效合成了一系列其他香豆素-3-羧酸酯类物质,产品的结构和纯度通过了NMR、IR和熔点等手段进行了鉴定。

关键词：香豆素水杨醛丙二酸二乙酯氯球香豆素-3-羧酸酯

Singularity analysis of Jeffcott rotor-magnetic bearing with time delays

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Applied Mathematics(A Journal of Chinese Universities) 2012年第4期27卷 419-427页

作者： XU Xiu-yan jiang wei-hua Department of Mathematics Heilongjiang Institute of Science and TechnologyHarbin 150027China Department of Mathematics Harbin Institute of TechnologyHarbin 150001China

A Jeffcott rotor-magnetic bearing with time delays is investigated in this paper. Firstly, it is found that the characteristic equation of the system satisfies the conditions of the singularity. Secondly, the center manifold reduction and normal form are employed to study the bifurcation from simple zero and zero-purely imaginary singularities. The results of this paper will help to understand the influence of the time delays in feedback loop on the dynamics of rotor-magnetic bearing system.

关键词： Jeffcott rotor-magnetic bearing time delay singularity normal form.

Bone cement enhanced pedicle screw fixation combined with vertebroplasty for elderly patients with malignant spinal tumors

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Chinese Medical Journal 2013年第13期126卷 2495-2498页

作者： TAN jiang-wei SHEN Bing-hua DU wei LIU jiang-qing LU Shi-qiao Department of Spinal Surgery Yantaishan Hospital Yantai Shandong 264008 China

Background Older patients with malignant spinal tumors are difficult to treat because they have many co-morbidities including osteoporosis. The purpose of this research is to discuss the technique and clinical outcome of bone cement enhanced pedicle screw fixation combined with vertebroplasty （the Sandwich Procedure） for elderly patients with severe osteoporosis and malignant spinal tumors. Methods This study includes 28 consecutive elderly patients with malignant thoracic or lumbar spinal tumors. There were nine patients with myelomas, and 19 patients with metastatic bone tumors. The Sandwich Procedure began with curettage of the tumor and a vertebroplasty with bone cement （polymethyl methacrylate, PMMA）, followed by PMMA enhanced pedicle screw fixation. Patients were evaluated with the visual analogue scale （VAS）, oswestry disability index （ODI）, American Spinal Cord Injury Association （ASIA） neurological function classification, and the radiographic degree of kyphosis （Cobb angle）. Data were analyzed using paired t-test to compare the pre- and post-operative values. The complications, local recurrences, and the survival status were also recorded. Results There was no operative mortality, and the mean operative time was 210 minutes （range 150-250 minutes）. The average blood loss was 1550 ml （range 650-3300 ml）. The average amount of cement for vertebroplasty was 3.6 ml （range 3-5 ml）. The VAS, ODI, and ASIA scores were significantly improved after surgery （P 〈0.05）. However, we found no differences between the pre and post-operative Cobb angles. The shortest survival time was 3 months, and we found no evidence of local recurrence in this group of patients. Conclusion The Sandwich Procedure is a safe operation and provides symptomatic relief in these difficult patients, permitting further treatment with chemotherapy or radiotherapy.

关键词： Sandwich procedure, malignant spinal tumor, osteoporosis bone cement, pedicle screw

基于泰州市药品检验院药品检验数字化实验室建设的方案与实践

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实验室检测

实验室检测 2024年第8期2卷 61-65页

作者：柏大为朱琼张姝丽江卫华泰州市药品检验院泰州市人民医院泰州市市场监督管理局

目的以泰州市药品检验院建设药品检验实验室的数字化方案为例，实现实验室管理的智能化、可视化，有效提高检验工作效率和质量。方法通过“互联网+技术服务”模式，实现药品检验机构科学实验、技术研发、安全评价、产业培育等方面全... 详细信息

目的以泰州市药品检验院建设药品检验实验室的数字化方案为例，实现实验室管理的智能化、可视化，有效提高检验工作效率和质量。方法通过“互联网+技术服务”模式，实现药品检验机构科学实验、技术研发、安全评价、产业培育等方面全流程“一站式”服务。结果泰州市药品检验院数字化实验室运行2年来，完成6700余份药品检验报告，通过“药检通”服务平台免费开放共享价值2500万元的高端仪器设备21台套，为200多个企事业单位提供了高效服务，完成各类委托送检业务2960批次，实验室运营成本降低20%，为医药企业解决各类技术难题280个，直接为医药企业减免费用40万余元，企业通过平台委托后服务周期缩短至10～15个工作日，较以往效率提升30%。结论数字化实验室建设使检测机构各项工作实现全面、高效、准确的管理和协调，提高工作效率和质量，提升检验工作的科学性和规范性，为医药企业发展提供高效率、高质量的服务，为药品监管工作的数字治理、精准治理、智能治理提供坚实的技术支撑。

关键词：泰州市药品检验院数字化实验室三维仿真技术实验室信息管理系统

Micro-porous TiO2 thin films grown on surface of Ti substrate

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中国有色金属学会会刊：英文版 2004年第z1期14卷 178-181页

作者： WU Xiao-hong QIN wei jiang Zhao-hua HU Xin-guo Li Qing-fen Department of Applied Chemistry Harbin Institute of Technology Harbin 150001 China School of Mechanics and Electronics Engineering Harbin Engineering University Harbin 150001 China Department of Applied Chemistry Harbin Institute of Technology Harbin 150001 China Department of Applied Chemistry Harbin Institute of Technology Harbin 150001 China Department of Applied Chemistry Harbin Institute of Technology Harbin 150001 China School of Mechanics and Electronics EngineeringHarbin Engineering University Harbin 150001 China

Microporous titanium dioxide thin films have been grown on titanium plates by the micro-plasma oxidation method with different current densities (4, 6, 10 and 14 A/dm2). X-ray diffraction, scanning electronic microscopy and UV-Vis spectrophotometry were used to characterize the films. It is found that the films grown are microporous and consist of crystalline titanium dioxide. The micropore size and the content of anatase and rutile TiO2 phase increase with the applied voltage. The relatively higher degradation efficiency for rhodamine B is obtained in the film produced with a current density of 10 A/dm2.

关键词： micro-plasma oxidation TiO2 thin film photo-catalytic activity rhodamine B

circAGFG1对非小细胞肺癌生物学行为的影响机制研究

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局解手术学杂志 2024年第4期33卷 306-311页

作者：杨燕君董跃华高永山姜伟华王贵刚王大伟魏玉磊苏华张振明李晓媛河北北方学院附属第一医院胸外科河北张家口075000

目的探讨环状RNA(circRNA)AGFG1通过靶向微小RNA(miR)-374a-5p/血管内皮生长因子C(VEGFC)轴对非小细胞肺癌(NSCLC)生物学行为的影响机制。方法 qRT-PCR检测55例NSCLC患者的癌组织和癌旁组织以及人支气管上皮细胞系(BEAS-2B)、人NSCLC... 详细信息

目的探讨环状RNA(circRNA)AGFG1通过靶向微小RNA(miR)-374a-5p/血管内皮生长因子C(VEGFC)轴对非小细胞肺癌(NSCLC)生物学行为的影响机制。方法 qRT-PCR检测55例NSCLC患者的癌组织和癌旁组织以及人支气管上皮细胞系(BEAS-2B)、人NSCLC细胞系(HCC827、H1975、A549、H1299)中circAGFG1、miR-374a-5p、VEGFC mRNA表达水平。以A549细胞为研究对象,设置对照组、circAGFG1小干扰RNA(si circAGFG1)组及阴性对照(si NC)组、si circAGFG1+miR-374a-5p抑制物(miR-374a-5p inhibitor)组以及si circAGFG1+抑制物对照组(inhibitor NC)组。qRT-PCR检测各组A549细胞中circAGFG1、miR-374a-5p、VEGFC mRNA表达水平;CCK-8及Transwell实验分别检测细胞活力及迁移、侵袭能力;Western blot检测增殖蛋白Ki-67、基质金属蛋白酶-9(MMP-9)以及VEGFC蛋白表达;双荧光素酶报告基因实验验证circAGFG1、VEGFC分别与miR-374a-5p的靶向关系。结果癌组织及人NSCLC细胞系中circAGFG1、VEGFC mRNA表达水平显著增加,miR-374a-5p表达显著降低(P0.05)。circAGFG1、VEGFC分别与miR-374a-5p存在靶向关系。结论干扰circAGFG1表达可通过调控miR-374a-5p/VEGFC轴抑制A549细胞的恶性生物学行为发展。

关键词：非小细胞肺癌 circAGFG1 miR-374a-5p/VEGFC轴生物学行为

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诊断病理学杂志 2024年第2期31卷 140-144页

作者：蔺嘉楠王立中余银平蒋威华新疆医科大学附属肿瘤医院乳腺外科二病区乌鲁木齐830011

目的探讨GATA结合蛋白3(GATA3)、性别决定相关基因簇2(SOX2)在三阴性乳腺癌(triple-negative breast cancer,TNBC)中表达及预后关系。方法收集新疆肿瘤医院140例TNBC和癌旁组织标本,通过免疫组化法染色检测GATA3和SOX2在TNBC中的表达水... 详细信息

目的探讨GATA结合蛋白3(GATA3)、性别决定相关基因簇2(SOX2)在三阴性乳腺癌(triple-negative breast cancer,TNBC)中表达及预后关系。方法收集新疆肿瘤医院140例TNBC和癌旁组织标本,通过免疫组化法染色检测GATA3和SOX2在TNBC中的表达水平,分析GATA3及SOX2在TNBC中的表达特点、临床病理特征及预后的关系。结果GATA3在TNBC及癌旁组织中的表达率为(82.86%、98.00%),SOX2在TNBC及癌旁组织中的表达率分别为(56.43%、5.00%),二者差异均有统计学意义(P<0.05)。GATA3阳性表达与TNBC患者低组织学分级及淋巴结转移有关(P<0.05),SOX2阳性表达与TNBC患者出现低组织学分级、Ki-67增殖表达具有明显相关性(P<0.05)。GATA3阳性表达及SOX2阳性表达者5年无病生存率分别为78.35%(91/116)、62.02%(49/79),差异有统计学意义(P<0.05)。结论TNBC中GATA3阳性率明显低于癌旁组织,SOX2阳性率高于癌旁组织。GATA3缺失表达及SOX2过表达是乳腺癌患者预后差的免疫组化指标,有望成为乳腺癌患者预后评估的重要依据。

关键词：三阴性乳腺癌 GATA结合蛋白3 性别决定相关基因簇2 预后

Enhancing the electrocatalytic performance of nitrate reduction to ammonia by in-situ nitrogen leaching

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Chinese Chemical Letters 2024年第2期35卷 564-569页

作者： Mimi Fu Yini Mao hua Wang wei Luo Yimin jiang wei Shen Ming Li Rongxing He College of Chemistry and Chemical Engineering Southwest UniversityChongqing 400715China

Electrochemical nitrate reduction reaction (NITRR) is regarded as a “two birds-one stone” method for the treatment of nitrate contaminant in polluted water and the synthesis of valuable ammonia, which is retarded by the lack of highly reactive and selective electrocatalysts .Herein, for the first time, nickel foam supported Co_(4) N was designed as a high-performance NITRR catalyst by an in-situ nonmetal leaching-induced *** the optimal potential, the Co_(4) N/NF catalyst achieves ultra-high Faraday efficiency and NH_(3) selectivity of 95.4% and 99.4%, *** situ X-ray absorption spectroscopy (XAS), together with other experiments powerfully reveal that the nitrogen vacancies produced by nitrogen leaching are stable and play a key role in boosting nitrate reduction to *** calculations confirm that Co_(4) N with abundant nitrogen vacancies can optimize the adsorption energies of NO_(3)^(-) and intermediates, lower the free energy (Δ G ) of the potential-determining step (*NH_(3) to NH_(3) ) and inhibit the formation of N-containing *** addition, we also conclude that the nitrogen vacancies can stabilize the adsorbed hydrogen, making H_(2) quite difficult to produce, and lowering ΔG from *NO to *NOH, which facilitates the selective reduction of *** study reveals significant insights about the in-situ nonmetal leaching to enhance the NITRR activity.

关键词： Co4N Nitrate reduction In-situ nonmetal leaching Nitrogen vacancy Mechanism

Synergistic catalysis of the N-hydroxyphthalimide on flower-like bimetallic metal-organic frameworks for boosting oxidative desulfurization

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Petroleum Science 2024年第1期21卷 674-682页

作者： Jing He Kun Zhu wei jiang Dong-Ao Zhu Lin-hua Zhu Hai-Yan huang Wen-Shuai Zhu hua-Ming Li Institute for Energy Research Jiangsu UniversityZhenjiang212013JiangsuChina College of Chemistry and Chemical Engineering Hainan Normal UniversityKey Laboratory of Water Pollution Treatment and Resource Reuse of Hainan ProvinceHaikou571158HainanChina

Synergic catalytic effect between active sites and supports greatly determines the catalytic activity for the aerobic oxidative desulfurization of fuel *** this work,Ni-doped Co-based bimetallic metal-organic framework(CoNi-MOF)is fabricated to disperse N-hydroxyphthalimide(NHPI),in which the whole catalyst provides plentiful synergic catalytic effect to improve the performance of oxidative desulfurization(ODS).As a bimetallic MOF,the second metal Ni doping results in the flower-like morphology and the modification of electronic properties,which ensure the exposure of NHPI and strengthen the synergistic effect of the overall *** with the monometallic Co-MOF and naked NHPI,the NHPI@CoNi-MOF triggers the efficient activation of molecular oxygen and improves the ODS performance without an *** sulfur removal of dibenzothiophene-based model oil reaches 96.4%over the NHPI@CoNi-MOF catalyst in 8 h of ***,the catalytic product of this aerobic ODS reaction is sulfone,which is adsorbed on the catalyst surface due to the difference in *** work provides new insight and strategy for the design of a strong synergic catalytic effect between NHPI and bimetallic supports toward high-activity aerobic ODS materials.

关键词： Metal-organic frameworks Doped Bimetallic N-hydroxyphthalimide Aerobic processes Oxidative desulfurization