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中国科学技术大学学报 2000年第2期30卷 213-217页

作者：何沛吴峰陈祖耀江万权卢越峰张文轩中国科学技术大学化学系中国科学技术大学力学和机械工程系安徽合肥230026 中国科学技术大学少年班安徽合肥230026

采用近邻相互作用近似方法 ,计算了悬浮于液相中旋转椭球颗粒在外场下形成的不同结构的电偶极矩相互作用能 .发现相互作用能随c/a(c、a分别为椭球长、短半轴 )变化而变化 .这一现象显示悬浮颗粒的形状对电流变液的相互作用能有很大影响 .

关键词：电流变液固态结构近邻相互作用悬浮粒子形状

α-萘乙酰硫脲和酰胺衍生物的合成及其抑制作物病菌活性

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应用化学 2006年第12期23卷 1364-1367页

作者：张袖丽吕献海刘铁兵江万权檀华蓉安徽农业大学应用化学系合肥230036 上海大学射线研究所中国科学技术大学化学系

以高活性的α-萘乙酸为前体,通过相转移催化剂,得到萘乙酰异硫氰酸酯,再分别与含吡啶环、吡唑环、萘环、含氟苯环等活性基团的胺反应,合成了3个酰基硫脲衍生物和3个酰胺类化合物,其中3a、3b、3d、3e、3f为新化合物。经IR、MS、1H NMR和... 详细信息

以高活性的α-萘乙酸为前体,通过相转移催化剂,得到萘乙酰异硫氰酸酯,再分别与含吡啶环、吡唑环、萘环、含氟苯环等活性基团的胺反应,合成了3个酰基硫脲衍生物和3个酰胺类化合物,其中3a、3b、3d、3e、3f为新化合物。经IR、MS、1H NMR和元素分析确认了化合物的结构。同时对2种植物病原菌进行了初步的生物活性测试。结果表明,在50 mg/L时,所有化合物对棉花枯萎病菌和棉花红腐病菌都有较好的抑菌活性,其中对棉花红腐病菌的抑制率均在70%以上。

关键词： α-萘乙酸酰基硫脲酰胺相转移催化合成抑菌活性

聚乙烯醇缩对甲酰基苯偶氮变色酸析相液-固萃取镍的研究

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分析试验室 1999年第3期18卷 11-14页

作者：金谷聂磊阚家义朱玉瑞程彬江万权中国科技大学化学系

报道了高分子显色剂聚乙烯醇缩对甲酰基苯偶氮变色酸（简称：ＰＶ·ＢＣｐＦ）做萃取剂时，Ｎｉ２＋等常见过渡金属离子的非有机溶剂液－固萃取行为和影响萃取的各种因素，特别是对高分子显色剂的结构与分析性能的关系做了系统比较研究... 详细信息

报道了高分子显色剂聚乙烯醇缩对甲酰基苯偶氮变色酸（简称：ＰＶ·ＢＣｐＦ）做萃取剂时，Ｎｉ２＋等常见过渡金属离子的非有机溶剂液－固萃取行为和影响萃取的各种因素，特别是对高分子显色剂的结构与分析性能的关系做了系统比较研究，并对萃取机理作了初步探讨。实现了Ｎｉ２＋与常见过渡金属离子定量分离，分离系数Ｓｆ在６．０×１０２～５．０×１０３之间，常见离子不干扰。

关键词：镍高分子显色剂 PV·BCpF 萃取剂液固萃取

Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie quan Hao Liang Yong-Hong Tang Li jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

Enhancement in Magnetorheological Effect of Magnetorheological Elastomers by Surface Modification of Iron Particles

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Chinese Journal of Chemical Physics 2008年第1期21卷 87-92页

作者： wan-quan jiang Jing-jing Yao Xing-long Gong Lin Chen Department of Chemistry University of Science and Technology of China Hefei 230026 China CA5 Key Laboratory of Mechanical Behavior and Design of Materials Department of Mechanics andMechanical Engineering University of Science and Technology of China Hefei 230027 China

In order to obtain magnetorheological （MR） elastomers with high magnetorheological effect, a family of anisotropic rubber-based MR elastomers was developed using a new form of chemical modification. Three different kinds of surfactants, i.e. anionic, nonionic and compound surfactants, were employed separately to modify iron particles. The MR effect was evaluated by measuring the dynamic shear modulus of MR elastomer with a magneto-combined dynamic mechanical analyzer. Results show that the relative MR effect can be up to 188% when the iron particles are modified with 15% Span 80. Besides the surface activity of Span 80, however, such high modifying effect is partly due to the plasticizing effect of Span 80. Compared with the single surfactant, the superior surface activity of compound surfactant makes the relative MR effect reach 77% at a low content of 0.4%. Scanning electron microscope observation shows that the modification of compound surfactant results in perfect compatibility between particles and rubber matrix and special self-assembled structure of particles. Such special structure has been proved beneficial to the improvement of the relative MR effect.

关键词： Magnetorheological elastomers Shear modulus Surfactant Microstructure

2015年晴隆县8月龄～24岁健康人群脊髓灰质炎、流行性脑脊髓膜炎、流行性乙型脑炎抗体水平调查

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实用预防医学 2017年第11期24卷 1357-1360页

作者：郑云孙启刚袁勇蒋万权贵州省晴隆县疾病预防控制中心贵州晴隆561400

目的了解2015年晴隆县8月龄~24岁健康人群脊髓灰质炎、流行性脑脊髓膜炎、流行性乙型脑炎3种传染病特异性Ig G抗体水平,为相应传染病预防和控制提供科学依据。方法 2015年3-4月,以乡镇为单位,每个乡镇随机抽取一个行政村为调查点,每个... 详细信息

目的了解2015年晴隆县8月龄~24岁健康人群脊髓灰质炎、流行性脑脊髓膜炎、流行性乙型脑炎3种传染病特异性Ig G抗体水平,为相应传染病预防和控制提供科学依据。方法 2015年3-4月,以乡镇为单位,每个乡镇随机抽取一个行政村为调查点,每个调查点将8月龄~24岁健康人群分成8个年龄组,每个年龄组抽取30人共3 360人静脉血分离血清,采用酶联免疫吸附法(ELISA)检测3种传染病病源特异性Ig G抗体水平,分析抗体水平差异性。结果 2015年晴隆县8月龄~24岁健康人群脊髓灰质炎、流行性脑脊髓膜炎和流行性乙型脑炎Ig G抗体水平阳性率分别为75.51%、43.87%和31.64%。不同年龄、地区调查人群三项抗体阳性率差异有统计学意义(P<0.05),脊髓灰质炎抗体最高,流行性乙型脑炎最低。不同性别调查人群脊髓灰质炎抗体阳性率差异有统计学意义(P<0.05),女性高,男性低;流行性脑脊髓膜炎和流行性乙型脑炎Ig G抗体阳性率差异无统计学意义。结论 2015年晴隆县8月龄~24岁健康人群脊髓灰质炎、流行性脑脊髓膜炎、流行性乙型脑炎3种特异性Ig G抗体水平均不高,未达到卫生和计划生育委员会规定的85%基本水平,必须采取有效工作措施,提高儿童基础免疫全程接种率。

关键词：脊髓灰质炎流行性脑脊髓膜炎流行性乙型脑炎健康人群抗体水平阳性率

Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian wan Yu-Ming wang Han-Zhou Li Wei-quan Xu Jia-Bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

Transient Response in a Bi-material Cylinder of Soft Ferromagnetic Material Subjected to Magnetic Shock

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Acta Mechanica Solida Sinica 2021年第2期34卷 286-296页

作者： Zhangjianing Cheng quan jiang College of Civil Engineering Tongji UniversityShanghai 200092China School of Transportation and Civil EngiTieering Nantong UniveirsityNantong 226019China

The transient response in a bi-material cylinder of soft ferromagnetic material under magnetic shock is investigated in this *** analytical solutions for displacement and stress have been derived using the finite Hankel transform and the Laplace *** numerical examples show that the displacement and stress fields respond dynamically in the bi-material cylinder under magnetic *** derived displacement at the center and radial stress on the surface of the cylinder satisfy the boundary conditions,showing the correctness of *** displacement and stress waves propagate from the surface to the center of the cylinder when the magnetic field is *** stress fields increase from the center to the surface of the cylinder and are much larger than the quasi-static state since the waves reflect,collide and concentrate in the body of the *** method of this paper can be used in the design of soft ferromagnetic structures.

关键词： Soft ferromagnetic material Bi-material cylinder Transient stress Magnetic shock

Fabrication and biocompatible characterization of magnetic hollow capsules

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Chinese Chemical Letters 2008年第7期19卷 877-880页

作者： Hong Zhang Xing Long Gong Ling Yun Hao wan quan jiang Department of Chemistry Fuyang Normal College Fuyang 236041 China CAS Key Laboratory of Mechanical Behavior and Design of Materials University of Science and Technology of China Hefei 230026 China

Monodispersed Fe3O4/polypyrrole （PPy） hollow particles were synthesized via controllable in-situ deposition and polymerization techniques using poly（styrene-co-acrylic）（PSA） latex as template. Field-dependent magnetization plot illustrates that the capsules are superparamagnetic at 300 K. FTIR spectrum confirms that the myoglobin （Mb） molecule adsorbed on the surface of Fe3O4/PPy hollow particle essentially retains its native structure. Furthermore, direct electrochemistry of Mb can be realized on Fe3O4/PPy capsules modified pyrolytic graphite disk electrode, which indicates that the magnetic conductive polymer capsules can promote the electron transfer of protein.

关键词： Composite capsules Magnetic Biocompatibility

BUCKLING ANALYSIS OF STRETCHABLE FERROELECTRIC THIN FILM ON ELASTOMERIC SUBSTRATES

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Acta Mechanica Solida Sinica 2014年第5期27卷 509-517页

作者： Zhidong Zhou quan jiang Department of Materials Science and Engineering College of MaterialsXiamen University College of Civil Engineering Nantong University

The thin stiff films on pre-stretched compliant substrates can form wrinkles, which can be controlled in micro and nanoscale systems to generate smart structures. Recently, buck- led piezoelectric/ferroelectrie nanoribbons have been reported to show an enhancement in the piezoelectric effect and stretchability, which can be applied in energy harvesting devices, sensors and memory devices instead of polymeric polyvinylidine fluoride （PVDF）. This paper studies the buckling and post-buckling process of ferroelectric thin films bonded to the pre-stretched soft layer, which in turn lies on a rigid support. Nonlinear electromechanical equations for the buckling of thin piezoelectric plates are deduced and employed to model the ferroelectric film poled in the thickness direction. Two buckling modes are analyzed and discussed： partially de-adhered buck- ling and fully adhered buckling. Transition from one buckling mode to the other is predicted and the effect of piezoelectricity on the critical buckling condition of piezoelectric film is examined.

关键词： buckling ferroelectric films energy method variational method