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GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer

Acta Pharmaceutica Sinica B 2024年第2期14卷 698-711页

作者： Qiwei jiang Yong Li Songwang Cai Xingyuan Shi Yang Yang Zihao Xing Zhenjie He Shengte Wang Yubin su Meiwan Chen Zhesheng Chen Zhi Shi Department of Cell Biology&Institute of Biomedicine National Engineering Research Center of Genetic MedicineState Key Laboratory of Bioactive Molecules and Druggability AssessmentMOE Key Laboratory of Tumor Molecular BiologyGuangdong Provincial Key Laboratory of Bioengineering MedicineCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China Department of Gastrointestinal surgery&General surgery the Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Thoracic surgery The First Affiliated Hospital of Jinan UniversityGuangzhou 510632China Department of Radiation Oncology The Fifth Hospital of Guangzhou Medical UniversityGuangzhou 510150China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 519000China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA

Glutamate-ammonia ligase(GLUL, also known as glutamine synthetase) is a crucial enzyme that catalyzes ammonium and glutamate into glutamine in the ATP-dependent condensation. Although GLUL plays a critical role in multiple cancers, the expression and function of GLUL in gastric cancer remain unclear. In the present study, we have found that the expression level of GLUL was significantly lower in gastric cancer tissues compared with adjacent normal tissues, and correlated with N stage and TNM stage, and low GLUL expression predicted poor survival for gastric cancer patients. Knockdown of GLUL promoted the growth, migration, invasion and metastasis of gastric cancer cells in vitro and in vivo, and vice versa, which was independent of its enzyme activity. Mechanistically, GLUL competed with β-Catenin to bind to N-Cadherin, increased the stability of N-Cadherin and decreased the stability of β-Catenin by alerting their ubiquitination. Furthermore, there were lower N-Cadherin and higher β-Catenin expression levels in gastric cancer tissues compared with adjacent normal tissues. GLUL protein expression was correlated with that of N-Cadherin, and could be the independent prognostic factor in gastric cancer. Our findings reveal that GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progress of gastric cancer.

关键词： Gastric cancer GLUL N-Cadherin β-Catenin Enzyme

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不同饲料对黄粉虫幼虫水分及粗蛋白和粗脂肪含量的影响

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四川农业大学学报 2012年第2期30卷 243-247页

作者：蒋素容蔡艳周宇爝四川农业大学农学院四川温江611130 四川农业大学风景园林学院四川温江611130

【目的】研究3种饲料原料中添加黄粉虫虫粉对黄粉虫幼虫生长的影响,从而为优化黄粉虫的人工饲养提供依据。【方法】向麦麸、酒糟和豆腐渣3种饲料原料中添加不同比例的黄粉虫成虫粉或蛹粉,饲喂6周后,测定黄粉虫幼虫水分含量、粗蛋白含量... 详细信息

【目的】研究3种饲料原料中添加黄粉虫虫粉对黄粉虫幼虫生长的影响,从而为优化黄粉虫的人工饲养提供依据。【方法】向麦麸、酒糟和豆腐渣3种饲料原料中添加不同比例的黄粉虫成虫粉或蛹粉,饲喂6周后,测定黄粉虫幼虫水分含量、粗蛋白含量和粗脂肪含量。【结果】饲料中添加黄粉虫蛹粉或成虫粉均可降低幼虫水分含量,提高幼虫粗蛋白和粗脂肪含量。不同类型饲料饲养的幼虫水分含量结果比较为,麦麸组酒糟组>豆腐渣组。黄粉虫幼虫水分含量随饲料中添加的黄粉虫蛹粉或成虫粉比例的增加而降低;粗蛋白含量和粗脂肪含量的变化则相反。【结论】麦麸添加20%的黄粉虫蛹粉可获得低水分含量、高粗脂肪和粗蛋白含量的黄粉虫幼虫,可作为黄粉虫饲养的最佳饲料。

关键词：黄粉虫水分含量粗蛋白含量粗脂肪含量

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COP 28: Challenge of coping with climate crisis

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The Innovation 2024年第1期5卷 21-22页

作者： Tong jiang Xiaojia He Buda su Peni Hausia Havea Ke Wei Zbigniew W.Kundzewicz Dong Liu Research Institute of Climatic and Environmental Governance/Institute for Disaster Risk Management School of Geographical ScienceNanjing University of Information Science&TechnologyNanjing 210044China The Administrative Center for China’s Agenda 21 Beijing 100038China Pacific Global Solution Nuku’alofaTongatapu 000676Tonga Centre for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Department of Environmental Engineering and Mechanical Engineering Poznan University of Life Sciences60-637 PoznanPoland The Paper Shanghai United Media GroupShanghai 200040China

The 28th Conference of Parties(COP 28)of the United Nations Framework Convention on Climate Change(UNFCCC)is being held in Dubai,United Arab Emirates,from November 30 to December 12,2023,with the participation of over 160 world leaders(Figure 1).The tone of the COP 28 is set by the observation that,clearly,the nationally determined contributions related to CO_(2) emission reduction are not on track to curb the temperature rise as per the Paris *** order to hold the increase in global mean temperature to well below 2℃ above the pre-industrial level and to pursue efforts to limit the warming to 1.5℃,there is a need for ratcheting up ambition for near-term climate action.

关键词： Figure limit COP

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中国城市PM_(2.5)和PM_(10)时空分布特征和影响因素分析

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环境科学 2024年第4期45卷 1938-1949页

作者：李江苏段良荣张天娇河南大学黄河文明与可持续发展研究中心暨黄河文明省部共建协同创新中心开封475001

PM_(2.5)和PM_(10)浓度超标引发的空气质量问题严重影响公众健康,研究PM_(2.5)和PM_(10)浓度对制定有效的污染防控和治理措施具有重要意义.运用时空分析法,分析2018年季度PM_(2.5)和PM_(10)浓度时空分布,并用GWR探究浓度差异的原因.结... 详细信息

PM_(2.5)和PM_(10)浓度超标引发的空气质量问题严重影响公众健康,研究PM_(2.5)和PM_(10)浓度对制定有效的污染防控和治理措施具有重要意义.运用时空分析法,分析2018年季度PM_(2.5)和PM_(10)浓度时空分布,并用GWR探究浓度差异的原因.结果表明:(1)PM_(2.5)和PM_(10)的浓度均呈冬春高、夏秋低的季节性规律;四季污染物浓度在胡焕庸线两侧存在显著差异,该线以东地区高浓度聚集在京津冀地区,该线以西地区高浓度聚集在新疆中南部.(2)PM_(2.5)和PM_(10)浓度的Moran's I在四季均为正,且均在冬季增至最大值;PM_(2.5)和PM_(10)的分布格局基本一致,“高-高”类和“低-低”类集中分布现象明显.(3)各因素对PM_(2.5)和PM_(10)浓度的影响存在较大空间异质性.温度和坡度对PM_(2.5)和PM_(10)浓度的影响均表现为南部地区呈负相关,北部地区呈正相关.降水和风速对大部分地区PM_(2.5)和PM_(10)浓度的影响呈负相关,且夏季负相关的范围均较小.人类活动强度、二产占比和能源消耗总量对地区PM_(2.5)和PM_(10)浓度的影响在大部分地区呈正相关,各季度的正相关高值区也存在差异.

关键词： PM_(2.5)浓度 PM_(10)浓度时空分布地理加权回归(GWR) 影响因素

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Resolution of myopic macular schisis following cataract phacoemulsification

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1568-1570页

作者： Yan-Ting Li Bo jiang Xin-Zhu Chen Hang Ren Yan-Hui Xiao Zi-Yue Song Pei-rong Lu Department of Ophthalmology the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Ophthalmology Suzhou EENT HospitalSuzhou 215000Jiangsu ProvinceChina

Dear Editor,We write to introduce a case of high myopia who had bilateral macular schisis along with *** the following-up period from 2014 to 2021,the severity of macular schisis gradually ***,following cataract surgery,there was a gradual improvement in the macular schisis,ultimately leading to near-complete *** obtained the written informed consent from the patient,and this case study adhered to the principles in the Declaration of Helsinki.

关键词： cataract sch ultimately

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老年高血压患者中心动脉压与动脉粥样硬化及左心室功能的关系

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中华老年医学杂志 2010年第3期29卷 187-191页

作者：姜苏蓉郭妍张英程蕴琳南京医科大学第一附属医院老年医学科 210029

目的探讨老年高血压患者中心动脉压与动脉硬化及左心功能的关系。方法155例老年高血压患者，分为60～79岁组71例，80～95岁组84例。分别应用脉搏波分析仪计算中心动脉压及反射波增强指数；用全自动动脉硬化测量仪测定动脉硬化相关指标... 详细信息

目的探讨老年高血压患者中心动脉压与动脉硬化及左心功能的关系。方法155例老年高血压患者，分为60～79岁组71例，80～95岁组84例。分别应用脉搏波分析仪计算中心动脉压及反射波增强指数；用全自动动脉硬化测量仪测定动脉硬化相关指标：臂踝脉搏波传导速度、踝臂指数、趾臂指数；用多普勒超声心动仪测定左心功能相关指标：舒张末期室间隔厚度、舒张末期左心室内径、舒张末期左心室后壁厚度、左心室相对厚度、左心室质量指数、二尖瓣前叶EF斜率、左心室射血分数、短轴缩短率。结果80～95岁组收缩压、脉压、中心动脉压、反射波增强指数、臂踝脉搏波传导速度均高于60～79岁组（P〈0．05），踝臂指数、趾臂指数均低于60～79岁组（P〈0．01）。80～95岁组舒张末期室间隔厚度、舒张末期左心室后壁厚度、左心室相对厚度、左心室质量指数均高于60～79岁组（P〈0．05），二尖瓣前叶EF斜率显著低于60～79岁组（P〈0．05），舒张末期左心室内径、左心室射血分数、短轴缩短率两组间差异无统计学意义（均P〉0．05）。经年龄、性别、体质指数、血糖、血脂、血尿酸、血肌酐调整后，中心动脉压与反射波增强指数、臂踝脉搏波传导速度呈正相关（r值分别为0．505和0．284，P〈0．01）；与踝臂指数、趾臂指数无相关性（P〉0．05）。中心动脉压与左心室肥厚及心功能指标舒张末期室间隔厚度、舒张末期左心室后壁厚度、左心室相对厚度、左心室质量指数亦呈正相关（P〈0．05），而与二尖瓣前叶EF斜率呈负相关（P〈0．01），与左心室射血分数、短轴缩短率、舒张末期左心室内径无相关性（P〉0．05）。结论随年龄的增长，老年高血压患者中心动脉压升高，动脉硬化程度加重，并伴随左心室肥厚及舒张功能下降。中心动脉压可用于早期动脉硬化的诊断和筛查。

关键词：高血压动脉粥样硬化心室功能左

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Capturing Plateau-Rayleigh instability in silver nanowires via ultrafast electron microscopy

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Nano Research 2024年第9期17卷 8402-8407页

作者： Shuai jiang Volkan Ortalan Department of Materials Science and Engineering University of ConnecticutStorrsCT 06269USA

Understanding the structural stability of nanomaterials such as nanowires is imperative for their practical ***,using single-shot ultrafast transmission electron microscopy,we captured the Plateau-Rayleigh instability behavior of silver nanowires decomposing into silver nanoparticles upon laser irradiation on nanosecond time *** found that this dynamic process can be accelerated by a factor of 10 through increasing the peak laser fluence from 6.03 to 14.60 mJ/cm^(2).Moreover,by comparing the laser fluence required to initiate the Plateau-Rayleigh instability in silver nanowires on carbon and Formvar membranes,it was found that the main driving force for the Plateau-Rayleigh instability in this study was substrate *** element analysis and molecular dynamics simulations are also applied to estimate the temperature jump of the nanowires and atomistic behavior,*** addition,the complex motions of silver nanowires under laser irradiation were systematically investigated by combining the results of ultrafast transmission electron microscopy with scanning electron microscopy characterizations and were determined to be related to nanowire-membrane interactions or pre-existing stresses on the nanowires,which in turn demonstrated the potential of ultrafast transmission electron microscopy for the characterization of nanomaterials and devices under extreme conditions.

关键词： silver nanowire Plateau-Rayleigh instability ultrafast transmission electron microscopy molecular dynamics simulation

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Security of quantum key distribution with virtual mutually unbiased bases

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 13-21页

作者： Hong-Wei Li Chen-Peng Hao Zhi-jiang Chen Li Gong Yi-Fei Lu Yang Wang Jia-Ji Li Chun-Mei Zhang rong Wang Zhen-Qiang Yin Qing-Yu Cai Henan Key Laboratory of Quantum Information and Cryptography SSF IEUZhengzhou 450000China Institute of Quantum Information and Technology Nanjing University of Posts and TelecommunicationsNanjing 210003China Department of Physics University of Hong KongHong Kong 999077China Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China School of Information and Communication Engineering Hainan UniversityHaikou 570228China

In a perfect quantum key distribution(QKD)protocol,quantum states should be prepared and measured with mutually unbiased bases(MUBs).However,in a practical QKD system,quantum states are generally prepared and measured with imperfect MUBs using imperfect devices,possibly reducing the secret key rate and transmission *** analyze the security of a QKD system with imperfect MUBs,we propose virtual MUBs to characterize the quantum channel against collective attack,and analyze the corresponding secret key rate under imperfect state preparation and measurement *** generally,we apply the advantage distillation method for analyzing the security of QKD with imperfect MUBs,where the error tolerance and transmission distance can be sharply *** analysis method can be applied to benchmark and standardize a practical QKD system,elucidating the security analysis of different QKD protocols with imperfect devices.

关键词： quantum key distribution mutually unbiased bases advantage distillation

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Feedback processing in the primate brain and in AI systems

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Science China(Technological Sciences) 2024年第8期67卷 2297-2309页

作者： jiang Yong HE Sheng Institute of Biophysics Chinese Academy of SciencesBeijing 100101China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei 230088China University of Chinese Academy of Sciences Beijing 100049China

The primate brain and artificial intelligence(AI) can both be conceptualized as information processing systems, each with its own distinct biological and computational architectures. While there are parallels between them, their respective structural and functional connections show significant differences. In this paper, we examine the central role of feedback processing in both the primate brain and AI systems, which has been shown to be crucial in shaping neural processing. By reviewing the key features of feedback processes in the primate brain, which allows the brain to incorporate prior knowledge, contextual information, and taskdemands into early-stage processing, we highlight the divergence in goals and functions between biological and AI *** these differences is crucial for elucidating the cognitive capabilities of the primate brain and for addressing computational challenges in AI. In advocating “Cognition-Inspired-Computation”, we suggest that integrating insights from feedback processing in the primate brain into AI research will offer potentially significant improvements for the advancement of AI systems.

关键词： cognitive neuroscience artificial intelligence feedback processing attention learning

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陕西省康养旅游资源的空间分布格局及其影响因素

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国土资源科技管理 2023年第3期40卷 85-94页

作者：杜鹏韩荣菲姜苏容辽宁师范大学地理科学学院辽宁大连116029

康养旅游资源是发展康养旅游业的载体。文章运用GIS空间分析方法识别陕西省康养旅游资源的空间分布特征,采用地理探测器探究其影响因素。结果表明:(1)空间分布类型上,陕西省康养旅游资源呈集聚分布,但不同类型的康养旅游资源呈现出不同... 详细信息

康养旅游资源是发展康养旅游业的载体。文章运用GIS空间分析方法识别陕西省康养旅游资源的空间分布特征,采用地理探测器探究其影响因素。结果表明:(1)空间分布类型上,陕西省康养旅游资源呈集聚分布,但不同类型的康养旅游资源呈现出不同的集聚类型。(2)空间分布形态上,陕西省康养旅游资源集中分布在安康市和西安市,总体呈现出“大分散,小集聚”的空间分布格局。(3)空间分布密度上,陕西省康养旅游资源的分布具有明显的集聚优势,在西安市形成了高密度核心区,核密度强度呈圈层状结构由西安市逐渐向外递减。(4)在影响因素上,陕西省康养旅游资源的空间分异格局是在多种因子的综合影响下形成的,且各因素对其影响存在显著差异。

关键词：康养旅游资源空间分布格局影响因素陕西省

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